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Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7100-7110

Synthesis of 6-(het) ary Xylocydine analogues and evaluating their inhibitory activities of CDK1 and CDK2 in vitro

(8) Xiao, Chuan a Sun, Chao a Han, Weiwei a Pan, Feng a Dan, Zhu a Li, Yu a Song, Zhi Guang a Jin, Ying Hua a

a JILIN UNIVERSITY (China)

Author keywords

CDK2; Inhibitory effect; Molecular docking; Purine nucleoside; Xylocydine

Indexed keywords

4 AMINO 6 (1H PYRROL 2 YL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (1H PYRROL 2 YL) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (3 BROMOPHENYL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (3 BROMOPHENYL) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (3 METHOXY) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (3 METHOXYPHENYL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (4 BROMOPHENYL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (4 BROMOPHENYL) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (4 METHOXY) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (4 METHOXYPHENYL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (4 TOLYL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (4 TOLYL) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (5 BROMOTHIOPHEN 2 YL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (5 BROMOTHIOPHEN 2 YL) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (FURAN 2 YL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (FURAN 2 YL) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 (THIOPHEN 2 YL) 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 4 AMINO 6 (THIOPHEN 2 YL) 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 [4 (TERT BUTYL)PHENYL] 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE 5 CARBOXAMIDE; 4 AMINO 6 [4(TERT BUTYL)PHENYL] 5 CYANO 7 (BETA LEVO XYLOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; CYCLIN A2; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 1 INHIBITOR; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; UNCLASSIFIED DRUG; XYLOCYDINE DERIVATIVE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; REACTION ANALYSIS; SIGNAL TRANSDUCTION;

CDC2 PROTEIN KINASE; CYCLIN-DEPENDENT KINASE 2; HELA CELLS; HUMANS; NUCLEOSIDES; PURINE NUCLEOSIDES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80655132884 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.10.003 Document Type: Article

Times cited : (10)

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