Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 4, 2009, Pages 605-613

  Song, Yinhong ^a   Zhang, Changju ^a,b  

^a Medical College of Three Gorges University   (China)

^b CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

APC; Cervical cancer; DNA methylation, catenin; Hydralazine

Indexed keywords

APC PROTEIN; BETA CATENIN; HYDRALAZINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; DNA MODIFICATION; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERINE CERVIX CANCER;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANTIHYPERTENSIVE AGENTS; APOPTOSIS; BETA CATENIN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDRALAZINE; IMMUNOENZYME TECHNIQUES; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; S PHASE; UTERINE CERVICAL NEOPLASMS;

EID: 58849128287     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0773-z     Document Type: Article

References (31)

1. KW Kinzler B Vogelstein 1996 Lessons from hereditary colorectal cancer Cell 87 2 159 170
2. J Papkoff B Rubinfeld B Schryver P Polakis 1996 Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes Mol Cell Biol 16 5 2128 2134
3. K Orford C Crockett JP Jensen AM Weissman SW Byers 1997 Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin J Biol Chem 272 40 24735 24738
4. PJ Morin AB Sparks V Korinek N Barker H Clevers B Vogelstein KW Kinzler 1997 Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 275 5307 1787 1790
5. V Korinek N Barker PJ Morin D van Wichen R de Weger KW Kinzler B Vogelstein H Clevers 1997 Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma Science 275 5307 1784 1787
6. AB Spark PJ Morin B Vogelstein KW Kinzler 1998 Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer Cancer Res 58 6 1130 1134
7. M Toyota JP Issa 2000 The role of DNA hypermethylation in human neoplasia Electrophoresis 21 2 329 333
8. M Esteller 2002 CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future Oncogene 21 35 5427 5440
9. T Tsuchiya G Tamura K Sato Y Endoh K Sakata Z Jin T Motoyama O Usuba W Kimura S Nishizuka KT Wilson SP James J Yin AS Fleisher T Zou SG Silverberg D Kong SJ Meltzer 2000 Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia Oncogene 19 32 3642 3646
10. M Esteller A Sparks M Toyota M Sanchez-Cespedes G Capella MA Peinado S Gonzalez G Tarafa D Sidransky SJ Meltzer SB Baylin JG Herman 2000 Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer Cancer Res 60 16 4366 4371
11. AK Virmani A Rathi UG Sathyanarayana A Padar CX Huang HT Cunnigham AJ Farinas S Milchgrub DM Euhus M Gilcrease J Herman JD Minna AF Gazdar 2001 Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas Clin Cancer Res 7 7 1998 2004
12. M Zysman A Saka A Millar J Knight W Chapman B Bapat 2002 Methylation of adenomatous polyosis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype Cancer Res 62 13 3663 3666
13. Z Jin G Tamura T Tsuchiya K Sakata M Kashiwaba M Osakabe T Motoyama 2001 Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancer Br J Cancer 85 1 69 73
14. CA Eads RV Lord K Wickramasinghe TI Long SK Kurumboor L Bernstein JH Peters SR DeMeester TR DeMeester KA Skinner PW Laird 2001 Epigenetic patterns in the progression of esophageal adenocarcinoma Cancer Res 61 8 3410 3418
15. R Maruyama S Toyooka KO Toyooka K Harada AK Virmani S Zöchbauer-Müller AJ Farinas F Vakar-Lopez JD Minna A Sagalowsky B Czerniak AF Gazdar 2001 Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features Cancer Res 61 24 8659 8663
16. Y Yang S Takeuchi K Tsukasaki Y Yamada T Hata N Mori A Fukushima H Seo HP Koeffler H Taguchi 2005 Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma Leuk Res 29 1 47 51
17. B Segura-Pacheco C Trejo-Becerril E Perez-Cardenas L Taja-Chayeb I Mariscal A Chavez C Acuna AM Salazar M Lizano A Duenas-Gonzalez 2003 Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy Clin Cancer Res 9 5 1596 1603
18. E Angeles VH Vázquez-Valadez O Vázquez-Valadez AM Velázquez-Sánchez A Ramírez L Martínez S Díaz-Barriga A Romero-Rojas G Cabrera R López-Castanares A Duenas-González 2005 Computational studies of 1-hydrazinophtalazine (hydralazine) as antineoplastic agent. Docking studies on methyltransferase Lett Drug Design Discov 2 282 286
19. C Arce M Candelaria B Segura-Pacheco E Perez-Cardenas L Taja- Chayeb A Duenas-Gonzalez 2006 Hydralazine target: From blood vessels to the epigenoma J Transl Med 4 10
20. P Zambrano B Segura-Pacheco E Pérez-Cárdenas L Cetina A Revilla-Vázquez L Taja-Chayeb A Chávez-Blanco E Angeles G Cabrera K Sandoval C Trejo-Becerril J Chanona-Vilchis A Duenas-González 2005 A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes BMC Cancer 5 1 44 55
21. HS Liu CY Chen CH Lee YI Chou 1998 Selective activation of oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells Br J Cancer 77 11 1777 1789
22. SM Dong HS Kim SH Rha D Sidransky 2001 Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix Clin Carcinoma Res 7 7 1982 1986
23. JP Issa 2003 Decitabine Curr Opin Oncol 15 6 446 451
24. SD Gore 2005 Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies Nat Clin Pract Oncol 2 suppl 1 S30 S35
25. JC Cheng DJ Weisenberger FA Gonzales G Liang GL Xu YG Hu VE Marquez PA Jones 2004 Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells Mol Cell Biol 24 3 1270 1278
26. JC Cheng CB Matsen FA Gonzales W Ye S Greer VE Marquez PA Jones EU Selker 2003 Inhibition of DNA methylation and reactivation of silenced genes by zebularine J Natl Cancer Inst 95 5 399 409
27. R Kirsten K Nelson D Kirsten B Heintz 1998 Clinical pharmacokinetics of vasodilators. Part II Clin Pharmacokinet 35 1 9 36
28. LA Magee C Cham EJ Waterman A Ohlsson P von Dadelszen 2003 Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis BMJ 327 7421 955 960
29. L Klein CM O'Connor WA Gattis WA Gattis M Zampino L de Luca A Vitarelli F Fedele M Gheorghiade 2003 Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations Am J Cardiol 91 9A 18F 40F
30. R Yung S Chang N Hemati K Johnson B Richardson 1997 Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo Arthritis Rheum 40 8 1436 1443
31. A Chavez-Blanco C Perez-Plasencia E Perez-Cardenas C Carrasco-Legleu E Rangel-Lopez B Segura-Pacheco L Taja-Chayeb C Trejo-Becerril A Gonzalez-Fierro M Candelaria G Cabrera A Duenas-Gonzalez 2006 Antineoplastic effects of the DNA methylation inhibitor Hydralazine and the histone deacetylase inhibitor valproic acid in carcinoma cell lines Carcinoma Cell Int 6 2