Retinoid, retinoic acid receptor β and breast cancer

Breast Cancer Research and Treatment

Volumn 76, Issue 2, 2002, Pages 167-173

  Yang, Qifeng ^a,b   Sakurai, Takeo ^b   Kakudo, Kennichi ^b  

^a SHANDONG UNIVERSITY   (China)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Breast cancer; Demethylation; Hypermethylation; Loss of heterozygosity; Retinoid; Retinoid acid receptor

Indexed keywords

ALITRETINOIN; BEXAROTENE; FENRETINIDE; RETINOIC ACID RECEPTOR BETA; RETINOID; RETINOID X RECEPTOR; TAMOXIFEN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CLINICAL TRIAL; DRUG ACTIVITY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG RECEPTOR BINDING; GENE EXPRESSION; GENE INACTIVATION; GENE INDUCTION; GENE LOCATION; GENE TARGETING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; RECEPTORS, RETINOIC ACID; RETINOIDS; TRETINOIN; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0036828569     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020576606004     Document Type: Article

References (61)

1. American Cancer Society: Cancer Facts and Figures. American Cancer Society, Atlanta, GA, 1994
2. Harris JR, Lippman ME, Verounesi U, Willett W: Breast cancer. N Engl J Med 327: 319-328, 1992
3. Weston A, Harris CC: Chemical carcinogenesis. In: Holland JF, Frei E, Bast RC et al. (eds) Cancer Medicine. 4th Edn, Vol 1, Williams and Wikins, Baltimore, MD, 1997, pp 261-276
4. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N: Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90: 1371-1388, 1998
5. Sporn MB, Newton DL: Chemoprevention of cancer with retinoids. Fed Proc 38: 2528-2534, 1979
6. Hong WKI, Sporn MB: Recent advances in chemoprevention of cancer. Science 278: 1073-1077, 1997
7. Dragen KH, Rigas JR. Dmitrovsky E: The retinoids and cancer prevention mechanisms. The Oncologist 5: 361-368, 2000
8. Sporn MB, Roberts AB, Goodman DS: The Retinoids: Biology, Chemistry, and Medicine. 2nd Edn, Raven Press, New York, 1994
9. Hong WK, Lippman SM, Itri LM, Karp DD, Lee JS, Byers RM, Schantz SS, Kramer AM, Lotan R, Peters LL, Dimery IW, Brown BW, Goepfert H: Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 323: 795-801, 1990
10. Lippman SM, Lee JJ, Sabichi AL: Cancer chemoprevention: progress and promise. J Natl Cancer Inst 90: 1514-1528, 1998
11. Veronesi U, De Palo G, Marubini E, Costa A, Formelli F, Mariani L, Decensi A, Camerini T, Del Turco MR, Di Mauro MG, Muraca MG, Del Vecchio M, Pinto C, D'Aiuto G, Boni C, Campa T, Magni A, Miceli R, Perloff M, Malone WF, Sporn MB: Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst 91: 1847-1856, 1999
12. Pfahl M: Vertebrate receptors: Molecular biology, dimerization and response elements. Semin Cell Biol 5: 95-103, 1994
13. Mangelsdorf DJ, Evans RM: The RXR heterodimers and orphan receptors. Cell 83: 841-850, 1995
14. Chambon PA: Decade of molecular biology of retinoic acid receptors. FASEB J 10: 940-954, 1996
15. Li E: Structure and function of cytoplasmic retinoid binding proteins. Mol Cell Biochem 192: 105-108, 1999
16. Moon RC: Vitamin A, retinoids and breast cancer. Adv Exp Med Biol 364: 101-107, 1994
17. Lee PP, Lee MT, Darcy KM, Shudo K, Ip MM: Modulation of normal mammary epithelial cell proliferation, morphogenesis, and functional differentiation by retinoids: A comparison of the retinobenzoic acid derivative RE80 with retinoic acid. Endocrinology 136: 1707-1717, 1995
18. Zhu WY, Jones CS, Kiss A, Matsukuma K, Amin S, De Luca LM: Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells. Exp Cell Res 234: 293-299, 1997
19. Ng J-H. Nesaretnam K, Reimann K, Lai LC: Effect of retinoic acid and palm oil carotenoids on oestrone sulphatase and oestradiol-17β hydroxysteroid dehydrogenase activities in MCF-7 and MDA-MB-231 breast cancer cell lines. Int J Cancer 88: 135-138, 2000
20. Evans TRJ, Kaye SB: Retinoids: Present role and future potential. Br J Cancer 80: 1-8, 1999
21. Wilcken NRC, Musgrove EA. Sutherland RL: Different points of action of retinoids and anti-estrogen in G1 phase identified in synchronized T-47D breast cancer cells. Int J Cancer 70: 291-296, 1997
22. Anzano MA, Byers SW, Smith JM, Peer CW, Mullen LT, Brown CC, Roberts AB, Sporn MB: Prevention of breast cancer in the rat with 9-cis retinoid acid as a single agent and in combination with tamoxifen. Cancer Res 54: 4614-4617, 1994
23. Cobleigh MA, Dowlashahi K, Deutsch TA, Mehta RG, Moon RC, Minn F, Benson AD, Rademaker AW, Ashenhurst JB, Wade JL, Walter J: Phase I/II trial of tamoxifen with or without fenretinide, an analog of vitamin A, in women with metastatic breast cancer. J Clin Oncol 11: 474-477, 1993
24. Boccardo F, Canobbio L, Resasco M, Decensi AU, Pastorino G, Brema F: Phase II study of tamoxifen and high-dose retinyl acetate in patients with advanced breast cancer. J Cancer Res Clin Oncol 116: 503-506, 1990
25. Gottardis MM, Bischoff ED, Shirley MA, Wagoner MA, Lamph WW, Heyman RA: Chemoprevention of mammary carcinoma by LGD1069 (targretin): An RXR-selective ligand. Cancer Res 56: 5566-5570, 1996
26. Bischoff ED, Gottardis MM, Moon TE, Heyman RA, Lamph WW: Beyond tamoxifen: The retinoid X receptor-selective ligand LGD1069 (targretin) causes complete regression of mammary carcinoma. Cancer Res 58: 479-484, 1998
27. Bischoff ED, Heyman RA, Lamph WW: Effect of the retinoid X receptor-selective ligand LGD1069 on mammary carcinoma after tamoxifen failure. J Natl Cancer Inst 91: 2118, 1999
28. Wu Q, Dawson MI, Zheng Y, Hobbs PD, Agadir A, Jong L, Li Y, Liu R, Lin B, Zhang XK: Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids. Mol Cell Biol 17: 6598-6608, 1997
29. Nason-Burchenal K, Dmitrovsky E: Retinoic acid, its rearranged receptor, and acute promyelocytic leukemia. In: Bertino JR (ed) Encyclopedia of Cancer. Vol II, Academic Press, New York, NY, 1997, pp 1547-1560
30. Jing Y, Zhang J, Bleiweiss IJ, Waxman S, Zelent A, Mira-Lopez R: Defective expression of cellular retinal binding protein type I and retinoic acid receptors α2, β2, γ2 in human breast cancer cells. FASEB J 10: 1064-1070, 1996
31. Kuppumbatti YS, Bleiweiss IJ, Mandeli JP, Waxman S, Mira-y-Lopez R: Cellular retinol-binding protein expression and breast cancer. J Natl Cancer Inst 92: 475-480, 2000
32. Picard E, Seguin C, Monhoven N, Rochette-Egly C, Siat J, Borrelly J, Martinet Y, Martinet N, Vignaud JM: Expression of retinoid receptor genes and proteins in non-small-lung cancer. J Natl Cancer Inst 91: 1059-1066, 1999
33. Xu X-C, Liu X, Tahara E, Lippman SM, Lotan R: Expression and up-regulation of retinoic acid receptor-β is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines. Cancer Res 59: 2477-2483, 1999
34. Xu X-C, Sneige N, Liu X. Nandagiri R, Lee JJ, Lukmanji F, Hortobagyi G, Lippman SM, Dhingra K, Lotan R: Progressive decrease in nuclear retinoic acid receptor β messenger RNA level during breast carcinogenesis. Cancer Res 57: 4992-4996, 1997
35. Widschwendter M, Berger J, Daxenbichler G, Muller-Holzner E, Widschwendter A, Mayr A, Marth C, Zeimet AG: Loss of retinoic acid receptor β expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer. Cancer Res 57: 4158-4161, 1997
36. Liu Y, Lee MO, Wang HG, Li Y, Hashimoto Y, Klaus M, Reed JC, Zhang X: Retinoic acid receptor β mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol Cell Biol 16: 1138-1149, 1996
37. Lotan R, Xu XC, Lippman SM, Ro JY, Lee JS, Lee JJ, Hong WK: Suppression of retinoic acid receptor β in premalignant oral lesions and its up-regulation by isotretinoin. N Engl J Med 332: 1405-1410, 1995
38. Sun SY, Wan H, Yue P, Hong WK, Lotan R: Evidence that retinoic acid receptor β induction by retinoids is important for tumor cell growth inhibition. J Biol Chem 275: 17, 149-17, 153, 2000
39. De The'H, del Mar Vivanco-Ruiz M, Tiollais P, Stunnenberg HG, Dejan A: Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature 343: 177-180, 1990
40. Valcarel R, Holz H, Garcia Jimenez C, Barettino D, Stunnenberg HG: Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer. Genes Dev 8: 3068-3079, 1994
41. Yang Q, Mori I, Shan L, Nakamura M, Nakamura Y, Utsunomiya H, Yoshimura G, Suzuma T, Tamaki T, Umemura T, Sakurai T, Kakudo K: Biallelic inactivation of retinoic acid receptor β2 gene by epigenetic change in breast cancer. Am J Pathol 158: 299-303, 2001
42. Bartsch D, Boye B, Baust C, zur Hausen H, Schwarz E: Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells. EMBO J 11: 2283-2291, 1992
43. Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS: Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274: 2057-2059, 1996
44. Yang Q, Yoshimura G, Sakurai T, Nakamura M, Nakamura Y, Shan L, Suzuma T, Takashi Y, Umemura T, Mori I, Kakudo K: Allelic loss of chromosome 3p24 correlates with tumor progression rather than with retinoic acid receptor β2 expression in breast carcinoma. Breast Cancer Res Treat 70: 39-45, 2001
45. Bix M, Locksley RM: Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science 281: 1352-1354, 1998
46. Hollander GA, Zuklya S, Morel C, Mizoguchi E, Mobisson K, Simpson S, Terhorst C, Wishart W, Golan DE, Bhan AK, Burakoff SJ: Monoallelic expression of the interleukin-2 locus. Science 279: 2118-2121, 1998
47. Qiu H, Lotan R, Lippman SM, Xu X-C: Lack of correlation between expression of retinoic acid receptor-beta and loss of heterozygosity on chromosome band 3p24 in esophageal cancer. Genes Chromosomes Cancer 28: 196-202, 2000
48. Cote S, Sinnett D, Momparler RL: Demethylation by 5-aza-2′-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor β gene in human colon carcinoma cells. Anticancer Drugs 9: 743-750, 1998
49. Sirchia SM, Ferguson AT, Sironi E, Subramanyan S, Orlandi R, Sukumar S, Sacchi N: Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells. Oncogene 19: 1556-1563, 2000
50. Widschwendter M, Berger J, Hermann M, Muller HM, Amberger A, Zeschnigk M, Widschwendter A, Abendstein B, Zeimet AG, Daxenbichler G, Marth C: Methylation and silencing of the retinoic acid receptor β2 gene in breast cancer. J Natl Cancer Inst 92: 826-832, 2000
51. Arapshian A, Kuppumbatti YS, Mira-y-Lopez R: Methylation of conserved CpG site neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells. Oncogene 19: 4066-4070, 2000
52. Yang Q, Sakurai T, Yoshimura G, Mori I, Nakamura M, Nakamura Y, Suzuma T, Tamaki T, Umemura T, Kakudo K: Hypermethylation does not account for the frequent loss of the retinoic acid receptor β2 in breast carcinoma. Anticancer Res 21: 1829-1833, 2001
53. Kinzler K, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 87: 159-170, 1996
54. Zou CP, Youssef EM, Zou CC, Carey TE, Lotan R: Differential effects of chromosome 3p deletion on the expression of the putative tumor suppressor RARβ and on retinoid resistance in human squamous carcinoma cells. Oncogene 20: 6820-6827, 2001
55. Kato S, Mano H, Kumazwa T, Yoshizuwa Y, Kojima R, Masushige S: Effect of retinoid status on alpha, beta and gamma retinoic acid receptor mRNA levels in various rat tissues. Biochem J 286: 755-760, 1992
56. Verma AK, Schoemaker A, Simsimm R, Denning M, Zachman RD: Expression of retinoic acid nuclear receptors and tissue transglutaminase is altered in various tissues of rats fed 1 vitamin A-deficient diet. J Nutr 122: 2144-2152, 1992
57. Lin B, Chen GQ, Xiao D, Kolluri SK, Cao X, Su H, Zhang XK: Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells. Mol Cell Biol 20: 957-970, 2000
58. Napoli JL: Interactions of retinoid binding proteins and enzymes in retinoid metabolism. Biochim Biophys Acta 1440: 139-162, 1999
59. Spinella MJ, Freemantle SJ, Sekula D, Chang JH, Christie AJ, Dmitrovsky E: Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. J Biol Chem 274: 22.013-22,018, 1999
60. Langenfeld J, Kiyokawa H, Sekula D, Boyle J, Dmitrovsky E: Posttranslational regulation of cyclin D1 by retinoic acid: A chemoprevention mechanism. Proc Natl Acad Sci USA 94: 12,070-12,074, 1997
61. Spinella MJ, Dmitrovsky E: Aberrant retinoid signaling and breast cancer: The view from outside the nucleus. J Natl Cancer Inst 92: 438-440, 2000