p73 Expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy

Clinical Cancer Research

Volumn 10, Issue 10, 2004, Pages 3309-3316

  Liu, Stephanie Si ^a   Leung, Rebecca Ching Yu ^a   Chan, Kelvin Yuen Kwong ^a   Chiu, Pui Man ^a   Cheung, Annie Nga Yin ^a   Tam, Kar Fai ^a   Ng, Tong Yow ^a   Wong, Ling Chui ^a   Ngan, Hextan Yuen Sheung ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN P21; PROTEIN P73;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL LINE, TUMOR; CERVIX UTERI; DNA; DNA METHYLATION; DNA PRIMERS; DNA, COMPLEMENTARY; DNA, VIRAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO GTP-BINDING PROTEINS; RNA; SEQUENCE ANALYSIS, DNA; SULFITES; TEMPERATURE; TIME FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 2542433039     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-03-0119     Document Type: Article

References (46)

1. rd ed., Chp. 9, Philadelphia: Lippincott, Williams & Wilkins; 2000. p. 345-406.
2. Liu SS, Tsang BK, Cheung et al. Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma. Eur J Cancer 2001;37:1104-10.
3. Dyson N, Howley PM, Munger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (Wash. DC) 1989;243:934-7.
4. Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science (Wash. DC) 1990;248:76-9.
5. Kessis TD, Slebos RJ, Nelson WG, et al. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc Natl Acad Sci USA 1993;90:3988-92.
6. Kaghad M, Bonnet H, Yang A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-19.
7. Jost CA, Marin MC, Kaelin WG Jr. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature (Lond.) 1997;389:191-4.
8. Melino G, De Laurenzi V, Vousden KH. p73: friend or foe in tumorigenesis. Nat Rev Cancer 2002;2:605-15.
9. Agami R, Blandino G, Oren M, Shaul Y, Interaction of c-Abl and p73α and their collaboration to induce apoptosis. Nature (Lond.) 1999;399:809-13.
10. Gong JG, Costanzo A, Yang HQ, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature (Lond.) 1999;399:806-9.
11. Yuan ZM, Shioya H, Ishiko T, et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature (Lond.) 1999;399:814-7.
12. Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998;2:305-16.
13. Zhu J, Jiang J, Zhou W, Chen X. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res 1998;58:5061-5.
14. Nomoto S, Haruki N, Kondo M, et al. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Res 1998;58:1380-3.
15. Takahashi H, Ichimiya S, Nimura Y, et al. Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. Cancer Res 1998;58:2076-7.
16. Ichimiya S, Nimura Y, Kageyama H, et al. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene 1999;18:1061-6.
17. Han S, Semba S, Abe T, et al. Infrequent somatic mutations of the p73 gene in various human cancers. Eur J Surg Oncol 1999;25:194-8.
18. Banelli B, Casciano I, Romani M. Methylation-independent silencing of the p73 gene in neuroblastoma. Oncogene 2000;19:4553-6.
19. Com PG, Kuerbitz SJ, van Noesel MM, et al. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation. Cancer Res 1999;59:3352-6.
20. Kawano S, Miller CW, Gombart AF et al. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation. Blood 1999;94:1113-20.
21. Martinez-Delgado B, Melendez B, Cuadros M, et al. Frequent inactivation of the p73 gene by abnormal methylation or LOH in non-Hodgkin's lymphomas. Int J Cancer 2002;102:15-9.
22. Garcia-Manero G, Bueso-Ramos C, Daniel J, Williamson J, Kantarjian HM, Issa JP. DNA methylation patterns at relapse in adult acute lymphocytic leukemia. Clin Cancer Res 2002;8:1897-903.
23. Watanabe T, Huang H, Nakamura M, et al. Methylation of the p73 gene in gliomas. Acta Neuropathol (Berl.) 2002;104:357-62.
24. Dong S, Pang JC, Hu J, Zhou LF, Ng HK. Transcriptional inactivation of TP73 expression in oligodendroglial tumors. Int J Cancer 2002;98:370-5.
25. Chen CL, lp SM, Cheng D, Wong LC, Ngan HY. p73 gene expression in ovarian cancer tissues and cell lines. Clin Cancer Res 2000;6:3910-5.
26. International Federation of Gynecology and Obstetrics. Cancer committee. Staging announcement. Gynecol Oncol 1986;25:383-5.
27. Liu SS, Cheung AN, Ngan HY. Differential gene expression in cervical cancer cell lines before and after ionizing radiation. Int J Oncol 2003;22:1091-9.
28. Ngan HY, Tsao SW, Liu SS, Stanley M. Abnormal expression and mutation of p53 in cervical cancer: a study at protein, RNA and DNA levels. Genitourin Med 1997;73:54-8,
29. Chan KY, Ozcelik H, Cheung AN, Ngan HY, Khoo US. Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer. Cancer Res 2002;62:4151-6.
30. Siu LL, Chan JK, Wong KF, Kwong YL. Specific patterns of gene methylation in natural killer cell lymphomas: p73 is consistently involved. Am J Pathol 2002;160:59-66.
31. De Laurenzi V, Costanzo A, Barcaroli D, et al. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J Exp Med 1998;188:1763-8.
32. Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J Cell Sci 2000;113(Pt 10):1661-70.
33. Flores ER, Tsai KY, Crowley D, et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature (Lond.) 2002;416:560-4.
34. Costanzo A, Merlo P, Pediconi N, et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell 2002;9:175-86.
35. Steegenga WT, Shvarts A, Riteco N, Bos JL, Jochemsen AG. Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins. Mol Cell Biol 1999;19:3885-94.
36. Kovalev S, Marchenko N, Swendeman S, LaQuaglia M, Moll UM. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Differ 1998;9:897-903.
37. Mai M, Huang H, Reed C, et al. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. Genomics 1998;51:359-63.
38. Sunahara M, Ichimiya S, Nimura Y, et al. Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. Int J Oncol 1998;13:319-23.
39. Mai M, Qian C, Yokomizo A, et al. Loss of imprinting and allele switching of p73 in renal cell carcinoma. Oncogene 1998;17:1739-41.
40. Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-9.
41. Ngan HY, Stanley M, Liu SS, Ma HK. HPV and p53 in cervical cancer. Genitourin Med 1994;70:167-70.
42. zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst (Bethesda) 2000;92:690-8.
43. Park JS, Kim EJ, Lee JY, Sin HS, Namkoong SE, Um SJ. Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins. Int J Cancer 2001;91:822-7.
44. Marin MC, Jost CA, Irwin MS, DeCaprio JA, Caput D, Kaelin WG Jr. Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol Cell Biol 1998;18:6316-24.
45. Prabhu NS, Somasundaram K, Satyamoorthy K, Herlyn M, El Deiry WS. p73β, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells. Int J Oncol 1998;13:5-9.
46. Brooks LA, Sullivan A, O'Nions J, et al. E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia. Br J Cancer 2002;86:263-8.