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Volumn 5, Issue 11, 2010, Pages

The D299G/T399I toll-like receptor 4 variant associates with body and liver fat: Results from the TULIP and METSIM studies

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR 4;

EID: 78649750164     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013980     Document Type: Article
Times cited : (27)

References (49)
  • 1
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, et al. (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17: 4-12.
    • (2006) Eur Cytokine Netw , vol.17 , pp. 4-12
    • Bastard, J.P.1    Maachi, M.2    Lagathu, C.3    Kim, M.J.4    Caron, M.5
  • 2
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782-787.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 3
    • 73349117487 scopus 로고    scopus 로고
    • Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome
    • Fessler MB, Rudel LL., Brown JM. (2009) Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol.
    • (2009) Curr Opin Lipidol
    • Fessler, M.B.1    Rudel, L.L.2    Brown, J.M.3
  • 4
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1: 135-145.
    • (2001) Nat Rev Immunol , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 5
    • 34548459868 scopus 로고    scopus 로고
    • Structure and function of Toll receptors and their ligands
    • Gay NJ, Gangloff M (2007) Structure and function of Toll receptors and their ligands. Annu Rev Biochem 76: 141-165.
    • (2007) Annu Rev Biochem , vol.76 , pp. 141-165
    • Gay, N.J.1    Gangloff, M.2
  • 6
    • 55149105005 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
    • O'Neill LA (2008) The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev 226: 10-18.
    • (2008) Immunol Rev , vol.226 , pp. 10-18
    • O'Neill, L.A.1
  • 8
  • 9
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D (2001) Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276: 16683-16689.
    • (2001) J Biol Chem , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 10
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, Kim JB (2006) Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346: 739-745.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 11
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116: 3015-3025.
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5
  • 12
    • 37549013749 scopus 로고    scopus 로고
    • Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle
    • Radin MS, Sinha S, Bhatt BA, Dedousis N, O'Doherty RM (2008) Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle. Diabetologia 51: 336-346.
    • (2008) Diabetologia , vol.51 , pp. 336-346
    • Radin, M.S.1    Sinha, S.2    Bhatt, B.A.3    Dedousis, N.4    O'Doherty, R.M.5
  • 13
    • 33846323706 scopus 로고    scopus 로고
    • Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acidinduced inflammatory changes in the interaction between adipocytes and macrophages
    • Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, et al. (2007) Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acidinduced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27: 84-91.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 84-91
    • Suganami, T.1    Tanimoto-Koyama, K.2    Nishida, J.3    Itoh, M.4    Yuan, X.5
  • 14
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents dietinduced obesity and insulin resistance
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, et al. (2007) Loss-of-function mutation in Toll-like receptor 4 prevents dietinduced obesity and insulin resistance. Diabetes 56: 1986-1998.
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3    Prada, P.O.4    Hirabara, S.M.5
  • 15
    • 34247884376 scopus 로고    scopus 로고
    • C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a highfat diet
    • Poggi M, Bastelica D, Gual P, Iglesias MA, Gremeaux T, et al. (2007) C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a highfat diet. Diabetologia 50: 1267-1276.
    • (2007) Diabetologia , vol.50 , pp. 1267-1276
    • Poggi, M.1    Bastelica, D.2    Gual, P.3    Iglesias, M.A.4    Gremeaux, T.5
  • 16
    • 70350482557 scopus 로고    scopus 로고
    • Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a ros-dependent manner
    • Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, et al. (2009) Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a ros-dependent manner. J Biol Chem.
    • (2009) J Biol Chem
    • Wong, S.W.1    Kwon, M.J.2    Choi, A.M.3    Kim, H.P.4    Nakahira, K.5
  • 17
    • 58149359307 scopus 로고    scopus 로고
    • Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects
    • Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, et al. (2008) Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes 57: 2595-2602.
    • (2008) Diabetes , vol.57 , pp. 2595-2602
    • Reyna, S.M.1    Ghosh, S.2    Tantiwong, P.3    Meka, C.S.4    Eagan, P.5
  • 18
    • 53549084045 scopus 로고    scopus 로고
    • Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: The GENOBIN study
    • de Mello VD, Kolehmainen M, Pulkkinen L, Schwab U, Mager U, et al. (2008) Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study. Diabetologia 51: 2060-2067.
    • (2008) Diabetologia , vol.51 , pp. 2060-2067
    • de Mello, V.D.1    Kolehmainen, M.2    Pulkkinen, L.3    Schwab, U.4    Mager, U.5
  • 23
    • 38449087761 scopus 로고    scopus 로고
    • Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children
    • Awomoyi AA, Rallabhandi P, Pollin TI, Lorenz E, Sztein MB, et al. (2007) Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol 179: 3171-3177.
    • (2007) J Immunol , vol.179 , pp. 3171-3177
    • Awomoyi, A.A.1    Rallabhandi, P.2    Pollin, T.I.3    Lorenz, E.4    Sztein, M.B.5
  • 24
    • 54949144335 scopus 로고    scopus 로고
    • Tolllike receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
    • Bochud PY, Chien JW, Marr KA, Leisenring WM, Upton A, et al. (2008) Tolllike receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 359: 1766-1777.
    • (2008) N Engl J Med , vol.359 , pp. 1766-1777
    • Bochud, P.Y.1    Chien, J.W.2    Marr, K.A.3    Leisenring, W.M.4    Upton, A.5
  • 25
    • 0034084438 scopus 로고    scopus 로고
    • TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    • Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25: 187-191.
    • (2000) Nat Genet , vol.25 , pp. 187-191
    • Arbour, N.C.1    Lorenz, E.2    Schutte, B.C.3    Zabner, J.4    Kline, J.N.5
  • 26
    • 0037947560 scopus 로고    scopus 로고
    • Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
    • Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, et al. (2003) Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A 100: 6075-6080.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6075-6080
    • Smirnova, I.1    Mann, N.2    Dols, A.3    Derkx, H.H.4    Hibberd, M.L.5
  • 28
    • 0038466078 scopus 로고    scopus 로고
    • Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis
    • Feterowski C, Emmanuilidis K, Miethke T, Gerauer K, Rump M, et al. (2003) Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis. Immunology 109: 426-431.
    • (2003) Immunology , vol.109 , pp. 426-431
    • Feterowski, C.1    Emmanuilidis, K.2    Miethke, T.3    Gerauer, K.4    Rump, M.5
  • 29
    • 10744226206 scopus 로고    scopus 로고
    • The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome
    • Illig T, Bongardt F, Schopfer A, Holle R, Muller S, et al. (2003) The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome. Diabetes 52: 2861-2864.
    • (2003) Diabetes , vol.52 , pp. 2861-2864
    • Illig, T.1    Bongardt, F.2    Schopfer, A.3    Holle, R.4    Muller, S.5
  • 30
    • 42049098225 scopus 로고    scopus 로고
    • Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
    • Kolz M, Baumert J, Muller M, Khuseyinova N, Klopp N, et al. (2008) Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol. BMC Med Genet 9: 9.
    • (2008) BMC Med Genet , vol.9 , pp. 9
    • Kolz, M.1    Baumert, J.2    Muller, M.3    Khuseyinova, N.4    Klopp, N.5
  • 31
    • 59649101088 scopus 로고    scopus 로고
    • Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes
    • Buraczynska M, Baranowicz-Gaszczyk I, Tarach J, Ksiazek A (2009) Toll-like receptor 4 gene polymorphism and early onset of diabetic retinopathy in patients with type 2 diabetes. Hum Immunol 70: 121-124.
    • (2009) Hum Immunol , vol.70 , pp. 121-124
    • Buraczynska, M.1    Baranowicz-Gaszczyk, I.2    Tarach, J.3    Ksiazek, A.4
  • 32
    • 10744224562 scopus 로고    scopus 로고
    • Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes
    • Rudofsky G, Jr., Reismann P, Witte S, Humpert PM, Isermann B, et al. (2004) Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Diabetes Care 27: 179-183.
    • (2004) Diabetes Care , vol.27 , pp. 179-183
    • Rudofsky Jr., G.1    Reismann, P.2    Witte, S.3    Humpert, P.M.4    Isermann, B.5
  • 33
    • 77950845384 scopus 로고    scopus 로고
    • Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes
    • Bagarolli RA, Saad MJ, Saad ST (2009) Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes. J Diabetes Complications.
    • (2009) J Diabetes Complications
    • Bagarolli, R.A.1    Saad, M.J.2    Saad, S.T.3
  • 34
    • 77950792795 scopus 로고    scopus 로고
    • A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation
    • Steinhardt AP, Aranguren F, Tellechea ML, Gomez Rosso LA, Brites FD, et al. (2010) A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation. Metabolism 59: 711-717.
    • (2010) Metabolism , vol.59 , pp. 711-717
    • Steinhardt, A.P.1    Aranguren, F.2    Tellechea, M.L.3    Gomez, R.L.A.4    Brites, F.D.5
  • 36
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 37
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome-a new worldwide definition
    • Alberti KG, Zimmet P, Shaw J (2005) The metabolic syndrome-a new worldwide definition. Lancet 366: 1059-1062.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 39
    • 27744492082 scopus 로고    scopus 로고
    • Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
    • Stefan N, Machicao F, Staiger H, Machann J, Schick F, et al. (2005) Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 48: 2282-2291.
    • (2005) Diabetologia , vol.48 , pp. 2282-2291
    • Stefan, N.1    Machicao, F.2    Staiger, H.3    Machann, J.4    Schick, F.5
  • 40
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    Defronzo, R.A.2
  • 41
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5
  • 42
    • 34548499864 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase gamma 3 genetic variability in glucose and lipid metabolism in non-diabetic whites
    • Weyrich P, Machicao F, Staiger H, Simon P, Thamer C, et al. (2007) Role of AMP-activated protein kinase gamma 3 genetic variability in glucose and lipid metabolism in non-diabetic whites. Diabetologia 50: 2097-2106.
    • (2007) Diabetologia , vol.50 , pp. 2097-2106
    • Weyrich, P.1    Machicao, F.2    Staiger, H.3    Simon, P.4    Thamer, C.5
  • 43
    • 57349116780 scopus 로고    scopus 로고
    • Causes and metabolic consequencesof Fatty liver
    • Stefan N, Kantartzis K, Haring HU (2008) Causes and metabolic consequencesof Fatty liver. Endocr Rev 29: 939-960.
    • (2008) Endocr Rev , vol.29 , pp. 939-960
    • Stefan, N.1    Kantartzis, K.2    Haring, H.U.3
  • 44
    • 58149347247 scopus 로고    scopus 로고
    • Adipokines and the immune system: An adipocentric view
    • MacLaren R, Cui W, Cianflone K (2008) Adipokines and the immune system: an adipocentric view. Adv Exp Med Biol 632: 1-21.
    • (2008) Adv Exp Med Biol , vol.632 , pp. 1-21
    • Maclaren, R.1    Cui, W.2    Cianflone, K.3
  • 45
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280: E745-751.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 46
    • 73549084484 scopus 로고    scopus 로고
    • Comparison of Gene Transcription between Subcutaneous and Visceral Adipose Tissue in Chinese Adults
    • Zha JM, Di WJ, Zhu T, Xie Y, Yu J, et al. (2009) Comparison of Gene Transcription between Subcutaneous and Visceral Adipose Tissue in Chinese Adults. Endocr J.
    • (2009) Endocr J
    • Zha, J.M.1    Di, W.J.2    Zhu, T.3    Xie, Y.4    Yu, J.5
  • 47
    • 70449530862 scopus 로고    scopus 로고
    • Macrophage infiltrates with high levels of Toll-like receptor 4 expression in white adipose tissues of male Chinese
    • Zhang HM, Chen LL, Wang L, Xu S, Wang X, et al. (2009) Macrophage infiltrates with high levels of Toll-like receptor 4 expression in white adipose tissues of male Chinese. Nutr Metab Cardiovasc Dis.
    • (2009) Nutr Metab Cardiovasc Dis
    • Zhang, H.M.1    Chen, L.L.2    Wang, L.3    Xu, S.4    Wang, X.5
  • 48
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, et al. (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87: 3023-3028.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1    Vehkavaara, S.2    Hakkinen, A.M.3    Goto, T.4    Westerbacka, J.5
  • 49
    • 33947153419 scopus 로고    scopus 로고
    • High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention
    • Thamer C, Machann J, Stefan N, Haap M, Schafer S, et al. (2007) High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention. Obesity (Silver Spring) 15: 531-538.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 531-538
    • Thamer, C.1    Machann, J.2    Stefan, N.3    Haap, M.4    Schafer, S.5


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