Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3283-3290

  Szajnman, Sergio H ^a   García Liñares, Guadalupe E ^a,b   Li, Zhu Hong ^b   Jiang, Cuiying ^b   Galizzi, Melina ^b   Bontempi, Esteban J ^c   Ferella, Marcela ^b   Moreno, Silvia N J ^b   Docampo, Roberto ^b   Rodriguez, Juan B ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITY OF GEORGIA   (United States)

^c Administracion Nacional de Laboratorios E Institutos de Salud Dr Carlos G Malbran   (Argentina)

Author keywords

Bisphosphonates; Chagas' disease; Farnesyl diphosphate synthase; Solanesyl diphosphate synthase; Toxoplasma gondii; Toxoplasmosis; Trypanosoma cruzi

Indexed keywords

1 [(2 METHYLPROP 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(2 PIPERIDIN 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(2 PYRROLIDIN 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(3 METHYL BUT 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(BUT 2 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(CYCLOHEXYLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N BUT 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N HEPT 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N HEX 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N OCT 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(N PENT 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(PROP 1 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(PROP 2 YLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; 1 [(TERT BUTYLAMINO)ETHYL] 1,1 BISPHOSPHONIC ACID; ANTIPROTOZOAL AGENT; BISPHOSPHONIC ACID DERIVATIVE; GERANYLTRANSFERASE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CHAGAS DISEASE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INDICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FOOD AND DRUG ADMINISTRATION; GROWTH INHIBITION; IC 50; NONHUMAN; PARASITE CULTIVATION; TOXICITY TESTING; TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPROTOZOAL AGENTS; DIPHOSPHONATES; ENZYME INHIBITORS; GERANYLTRANSTRANSFERASE; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; TOXOPLASMA; TRYPANOSOMA CRUZI;

TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

EID: 41249085709     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.010     Document Type: Article

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