Hypoxia-inducible factor 1α is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes

Arthritis and Rheumatism

Volumn 56, Issue 12, 2007, Pages 4084-4094

  Grimmer, C ^a   Pfander, D ^a,b   Swoboda, B ^a   Aigner, T ^c   Mueller, L ^a   Hennig, F F ^d   Gelse, K ^a,d  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Hufeland Clinic   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PHOSPHOGLYCERATE KINASE; PROSTAGLANDIN E SYNTHASE 1;

ADULT; AGED; ARTICLE; CARTILAGE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; OSTEOARTHRITIS; OXYGEN TENSION; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

AGED; AMINO ACIDS, DICARBOXYLIC; CARTILAGE, ARTICULAR; CELL HYPOXIA; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; ESTRADIOL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRAMOLECULAR OXIDOREDUCTASES; MICROSOMES; MIDDLE AGED; NITROBENZENES; OSTEOARTHRITIS; PROSTAGLANDINS; SULFONAMIDES; TUBULIN MODULATORS; UP-REGULATION;

EID: 37149052447     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23136     Document Type: Article

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