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Volumn 37, Issue 1, 2013, Pages 1-15

Pharmacotherapy for childhood obesity: Present and future prospects

Author keywords

adolescent; anti obesity agents; child; clinical trials; obesity drug therapy; review

Indexed keywords

ACARBOSE; AMFEBUTAMONE; AMFEPRAMONE; AMPHETAMINE; ANOREXIGENIC AGENT; CETILISTAT; DAPAGLIFLOZIN; DEXFENFLURAMINE; EXENDIN 4; FENFLURAMINE; FLUOXETINE; LIRAGLUTIDE; LORCASERIN; MAZINDOL; METFORMIN; METRELEPTIN; PHENTERMINE; PHENYLPROPANOLAMINE; PRAMLINTIDE; RECOMBINANT LEPTIN; RIMONABANT; SERGLIFLOZIN ETABONATE; SIBUTRAMINE; SITAGLIPTIN; TARANABANT; TESOFENSINE; TETRAHYDROLIPSTATIN; TOPIRAMATE; UNINDEXED DRUG; VILDAGLIPTIN;

EID: 84872101944     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2012.144     Document Type: Review
Times cited : (51)

References (299)
  • 1
    • 84856433589 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
    • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 2012; 307: 483-490.
    • (2012) JAMA , vol.307 , pp. 483-490
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 2
    • 84872110745 scopus 로고    scopus 로고
    • World Health Organization. Obesity and Overweight Fact sheet Number 311 Accessed: 25 November 2011
    • World Health Organization. Obesity and Overweight Fact sheet Number 311. http://www.who.int/mediacentre/factsheets/fs311/en/index.html. Accessed: 25 November 2011.
  • 3
    • 74549159752 scopus 로고    scopus 로고
    • Prevalence of high body mass index in US children and adolescents, 2007-2008
    • Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA 2010; 303: 242-249.
    • (2010) JAMA , vol.303 , pp. 242-249
    • Ogden, C.L.1    Carroll, M.D.2    Curtin, L.R.3    Lamb, M.M.4    Flegal, K.M.5
  • 4
    • 78649473912 scopus 로고    scopus 로고
    • The levelling off of the obesity epidemic since the year 1999 - A review of evidence and perspectives
    • Rokholm B, Baker JL, Sorensen TI. The levelling off of the obesity epidemic since the year 1999 - a review of evidence and perspectives. Obes Rev 2010; 11: 835-846.
    • (2010) Obes Rev , vol.11 , pp. 835-846
    • Rokholm, B.1    Baker, J.L.2    Sorensen, T.I.3
  • 5
    • 53849114637 scopus 로고    scopus 로고
    • Childhood overweight and obesity prevalences levelling off in Stockholm but socioeconomic differ-ences persist
    • Sundblom E, Petzold M, Rasmussen F, Callmer E, Lissner L. Childhood overweight and obesity prevalences levelling off in Stockholm but socioeconomic differ-ences persist. Int J Obes (Lond) 2008; 32: 1525-1530.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 1525-1530
    • Sundblom, E.1    Petzold, M.2    Rasmussen, F.3    Callmer, E.4    Lissner, L.5
  • 7
    • 64849095087 scopus 로고    scopus 로고
    • Prevalence ofoverweight in 6- to 15-year-old children in central/ western France from 1996 to 2006: Trends toward stabilization
    • Peneau S, Salanave B, Maillard-Teyssier L, Rolland-Cachera MF, Vergnaud AC, Mejean C et al. Prevalence ofoverweight in 6- to 15-year-old children in central/ western France from 1996 to 2006: trends toward stabilization. Int J Obes (Lond) 2009; 33: 401-407.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 401-407
    • Peneau, S.1    Salanave, B.2    Maillard-Teyssier, L.3    Rolland-Cachera, M.F.4    Vergnaud, A.C.5    Mejean, C.6
  • 8
    • 80052880082 scopus 로고    scopus 로고
    • Evidence that the prevalence ofchildhood overweight is plateauing: Data from nine countries
    • Olds T, Maher C, Zumin S, Peneau S, Lioret S, Castetbon K et al. Evidence that the prevalence ofchildhood overweight is plateauing: data from nine countries. Int J Pediatr Obes 2011; 6: 342-360.
    • (2011) Int J Pediatr Obes , vol.6 , pp. 342-360
    • Olds, T.1    Maher, C.2    Zumin, S.3    Peneau, S.4    Lioret, S.5    Castetbon, K.6
  • 9
    • 33749446753 scopus 로고    scopus 로고
    • Worldwide trends in childhood overweight and obesity
    • Wang Y, Lobstein T.Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006; 1: 11-25.
    • (2006) Int J Pediatr Obes , vol.1 , pp. 11-25
    • Wang, Y.1    Lobstein, T.2
  • 10
    • 54549113348 scopus 로고    scopus 로고
    • Obesity in children Part 1: Epidemiology, mea-surement, risk factors, and screening
    • Kipping RR, Jago R, Lawlor DA. Obesity in children. Part 1: Epidemiology, mea-surement, risk factors, and screening. BMJ 2008; 337: a1824.
    • (2008) BMJ , vol.337
    • Kipping, R.R.1    Jago, R.2    Lawlor, D.A.3
  • 12
    • 41849141673 scopus 로고    scopus 로고
    • Pre-vention and treatment of pediatric obesity: An endocrine society clinical practice guideline based on expert opinion
    • August GP, Caprio S, Fennoy I, Freemark M, Kaufman FR, Lustig RH et al. Pre-vention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion. J Clin Endocrinol Metab 2008; 93: 4576-4599.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4576-4599
    • August, G.P.1    Caprio, S.2    Fennoy, I.3    Freemark, M.4    Kaufman, F.R.5    Lustig, R.H.6
  • 13
    • 30844462089 scopus 로고    scopus 로고
    • The world health organization' s global strategy on diet, physical activity, and health: Turning strategy into action
    • Lee E. The world health organization's global strategy on diet, physical activity, and health: Turning strategy into action. Food Drug Law J 2005; 60: 569-601.
    • (2005) Food Drug Law J , vol.60 , pp. 569-601
    • Lee, E.1
  • 14
    • 34447261863 scopus 로고    scopus 로고
    • Relation of body mass index and waist-to-height ratio to cardiovascular disease risk factors in children and adolescents: The Bogalusa Heart Study
    • Freedman DS, Kahn HS, Mei Z, Grummer-Strawn LM, Dietz WH, Srinivasan SR et al. Relation of body mass index and waist-to-height ratio to cardiovascular disease risk factors in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr 2007; 86: 33-40.
    • (2007) Am J Clin Nutr , vol.86 , pp. 33-40
    • Freedman, D.S.1    Kahn, H.S.2    Mei, Z.3    Grummer-Strawn, L.M.4    Dietz, W.H.5    Srinivasan, S.R.6
  • 15
    • 67649853281 scopus 로고    scopus 로고
    • Relation of body mass index and skinfold thicknesses to cardiovascular disease riskfactors in children: The Bogalusa Heart Study
    • Freedman DS, Katzmarzyk PT, Dietz WH, Srinivasan SR, Berenson GS. Relation of body mass index and skinfold thicknesses to cardiovascular disease riskfactors in children: the Bogalusa Heart Study. Am J Clin Nutr 2009; 90: 210-216.
    • (2009) Am J Clin Nutr , vol.90 , pp. 210-216
    • Freedman, D.S.1    Katzmarzyk, P.T.2    Dietz, W.H.3    Srinivasan, S.R.4    Berenson, G.S.5
  • 16
    • 0035430207 scopus 로고    scopus 로고
    • Evaluation of the insulin resistance syndrome in 5- to 10-year-old overweight/obese African-American children
    • Young-Hyman D, Schlundt DG, Herman L, De Luca F, Counts D. Evaluation of the insulin resistance syndrome in 5- to 10-year-old overweight/obese African-American children. Diabetes Care 2001; 24: 1359-1364.
    • (2001) Diabetes Care , vol.24 , pp. 1359-1364
    • Young-Hyman, D.1    Schlundt, D.G.2    Herman, L.3    De Luca, F.4    Counts, D.5
  • 17
    • 0033995603 scopus 로고    scopus 로고
    • Presence of metabolic cardiovascular syn-drome in obese children
    • Csabi G, Torok K, Jeges S, Molnar D. Presence of metabolic cardiovascular syn-drome in obese children. Eur J Pediatr 2000; 159: 91-94.
    • (2000) Eur J Pediatr , vol.159 , pp. 91-94
    • Csabi, G.1    Torok, K.2    Jeges, S.3    Molnar, D.4
  • 18
    • 64949086459 scopus 로고    scopus 로고
    • Complications of obesity in children and adolescents
    • Daniels SR. Complications of obesity in children and adolescents. Int J Obes (Lond) 2009; 33(Suppl 1): S60-S65.
    • (2009) Int J Obes (Lond) , vol.33 , Issue.SUPPL. 1
    • Daniels, S.R.1
  • 19
    • 36849015926 scopus 로고    scopus 로고
    • Childhood body-mass index and the risk of coronary heart disease in adulthood
    • Baker JL, Olsen LW, Sorensen TI. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med 2007; 357: 2329-2337.
    • (2007) N Engl J Med , vol.357 , pp. 2329-2337
    • Baker, J.L.1    Olsen, L.W.2    Sorensen, T.I.3
  • 21
    • 0026672612 scopus 로고
    • Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935
    • Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med 1992; 327: 1350-1355.
    • (1992) N Engl J Med , vol.327 , pp. 1350-1355
    • Must, A.1    Jacques, P.F.2    Dallal, G.E.3    Bajema, C.J.4    Dietz, W.H.5
  • 22
    • 57349174466 scopus 로고    scopus 로고
    • Clinical review: Treatment of pediatric obesity: A systematic review and meta-analysis of randomized trials
    • Mc Govern L, Johnson JN, Paulo R, Hettinger A, Singhal V, Kamath C etal. Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials. J Clin Endocrinol Metab 2008; 93: 4600-4605.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4600-4605
    • Mc Govern, L.1    Johnson, J.N.2    Paulo, R.3    Hettinger, A.4    Singhal, V.5    Kamath, C.6
  • 23
    • 33645102431 scopus 로고    scopus 로고
    • Reducing Obesity and Related Chronic Disease Risk in Children and Youth: A Synthesis of Evidence with 'best practice' recommendations
    • Flynn MA, Mc Neil DA, Maloff B, Mutasingwa D, Wu M, Ford C et al. Reducing obesity and related chronic disease risk in children and youth: a synthesis of evidence with 'best practice' recommendations. Obes Rev 2006; 7(Suppl 1): 7-66.
    • (2006) Obes Rev , vol.7 , Issue.SUPPL. 1 , pp. 7-66
    • Flynn, M.A.1    Mc Neil, D.A.2    Maloff, B.3    Mutasingwa, D.4    Wu, M.5    Ford, C.6
  • 28
    • 2642534355 scopus 로고    scopus 로고
    • Prevention and treatment of overweight in chil-dren and adolescents
    • Fowler-Brown A, Kahwati LC. Prevention and treatment of overweight in chil-dren and adolescents. Am Fam Physician 2004; 69: 2591-2598.
    • (2004) Am Fam Physician , vol.69 , pp. 2591-2598
    • Fowler-Brown, A.1    Kahwati, L.C.2
  • 30
    • 0028509888 scopus 로고
    • Ten-year outcomes of behavioral family-based treatment for childhood obesity
    • Epstein LH, Valoski A, Wing RR, Mc Curley J. Ten-year outcomes of behavioral family-based treatment for childhood obesity. Health Psychol1994; 13: 373-383.
    • (1994) Health Psychol , vol.13 , pp. 373-383
    • Epstein, L.H.1    Valoski, A.2    Wing, R.R.3    Mc Curley, J.4
  • 31
    • 77949484958 scopus 로고    scopus 로고
    • A meta-analysis of obesity interventions among U.S. minority children
    • Seo DC, Sa J. A meta-analysis of obesity interventions among U.S. minority children. JAdolesc Health 2010; 46: 309-323.
    • (2010) JAdolesc Health , vol.46 , pp. 309-323
    • Seo, D.C.1    Sa, J.2
  • 32
    • 34547671002 scopus 로고    scopus 로고
    • Family-based obesity treat-ment, then and now: Twenty-five years of pediatric obesity treatment
    • Epstein LH, Paluch RA, Roemmich JN, Beecher MD. Family-based obesity treat-ment, then and now: twenty-five years of pediatric obesity treatment. Health Psychol 2007; 26: 381-391.
    • (2007) Health Psychol , vol.26 , pp. 381-391
    • Epstein, L.H.1    Paluch, R.A.2    Roemmich, J.N.3    Beecher, M.D.4
  • 34
    • 38449095758 scopus 로고    scopus 로고
    • Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: Summary report
    • Barlow SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007; 120(Suppl 4): S164-S192.
    • (2007) Pediatrics , vol.120 , Issue.SUPPL. 4
    • Barlow, S.E.1
  • 35
    • 84055213533 scopus 로고    scopus 로고
    • Expert panel on integrated guidelines for cardiovascular health and risk reduc-tion in children and adolescents: Summary report
    • Expert panel on integrated guidelines for cardiovascular health and risk reduc-tion in children and adolescents: summary report. Pediatrics 2011; 128(Suppl 5): S213-S256.
    • (2011) Pediatrics , vol.128 , Issue.SUPPL. 5
  • 37
    • 0037840394 scopus 로고    scopus 로고
    • Behavior therapy and sibutramine for the treatment of adolescent obesity: A randomized controlled trial
    • Berkowitz RI, Wadden TA, Tershakovec AM, Cronquist JL. Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trial. JAMA 2003; 289: 1805-1812.
    • (2003) JAMA , vol.289 , pp. 1805-1812
    • Berkowitz, R.I.1    Wadden, T.A.2    Tershakovec, A.M.3    Cronquist, J.L.4
  • 38
    • 0034909757 scopus 로고    scopus 로고
    • Intensive therapiesfor pediatric obesity
    • Yanovski JA. Intensive therapiesfor pediatric obesity. Pediatr Clin North Am 2001; 48: 1041-1053.
    • (2001) Pediatr Clin North Am , vol.48 , pp. 1041-1053
    • Yanovski, J.A.1
  • 41
    • 0027260870 scopus 로고
    • Neurochemical mechanism of action ofanorectic drugs
    • Samanin R, Garattini S. Neurochemical mechanism of action ofanorectic drugs. Pharmacol Toxicol 1993; 73: 63-68.
    • (1993) Pharmacol Toxicol , vol.73 , pp. 63-68
    • Samanin, R.1    Garattini, S.2
  • 42
    • 0013850437 scopus 로고
    • Phentermine resinate in obesity Clinical trial of Mirapront in adipose children
    • von Spranger J. Phentermine resinate in obesity. Clinical trial of Mirapront in adipose children. Munch Med Wochenschr 1965; 107: 1833-1834.
    • (1965) Munch Med Wochenschr , vol.107 , pp. 1833-1834
    • Von Spranger, J.1
  • 43
    • 0014095264 scopus 로고
    • Treatment of obesity in underprivileged adolescents. Comparison of diethylpropion hydrochloride with placebo in a double-blind study
    • Andelman MB, Jones C, Nathan S. Treatment of obesity in underprivileged adolescents. Comparison of diethylpropion hydrochloride with placebo in a double-blind study. Clin Pediatr (Phila) 1967; 6: 327-330.
    • (1967) Clin Pediatr (Phila) , vol.6 , pp. 327-330
    • Andelman, M.B.1    Jones, C.2    Nathan, S.3
  • 44
    • 0018850844 scopus 로고
    • Endocrine studies with mazindol in obese patients
    • Dolecek R. Endocrine studies with mazindol in obese patients. Pharmather-apeutica 1980; 2: 309-316.
    • (1980) Pharmather-apeutica , vol.2 , pp. 309-316
    • Dolecek, R.1
  • 45
    • 17944391462 scopus 로고
    • Clinical evaluation of Teronac (mazindol) in the treatment of obesity in children. Part II. Anorectic properties and side effects (author's transl)
    • Golebiowska M, Chlebna-Sokol D, Kobierska I, Konopinska A, Malek M, Mastalska A et al. Clinical evaluation of Teronac (mazindol) in the treatment of obesity in children. Part II. Anorectic properties and side effects (author's transl). Przegl Lek 1981; 38: 355-358.
    • (1981) Przegl Lek , vol.38 , pp. 355-358
    • Golebiowska, M.1    Chlebna-Sokol, D.2    Kobierska, I.3    Konopinska, A.4    Malek, M.5    Mastalska, A.6
  • 46
    • 17944389899 scopus 로고
    • The clin-ical evaluation of teronac (Mazindol) in the treatment of children with obesity. Part I. Effect of the drug on somatic patterns and exercise capacity (author's transl)
    • Golebiowska M, Chlebna-Sokol D, Mastalska A, Zwaigzne-Raczynska J. The clin-ical evaluation of teronac (Mazindol) in the treatment of children with obesity. Part I. Effect of the drug on somatic patterns and exercise capacity (author's transl). Przegl Lek 1981; 38: 311-314.
    • (1981) Przegl Lek , vol.38 , pp. 311-314
    • Golebiowska, M.1    Chlebna-Sokol, D.2    Mastalska, A.3    Zwaigzne-Raczynska, J.4
  • 48
    • 0035218082 scopus 로고    scopus 로고
    • Amphetamine-type central nervous system stimulants release norepinephrine more potently than they releasedopamineand serotonin
    • Rothman RB, Baumann MH, Dersch CM, Romero DV, Rice KC, Carroll FI et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they releasedopamineand serotonin.Synapse2001; 39:32-41.
    • (2001) Synapse , vol.39 , pp. 32-41
    • Rothman, R.B.1    Baumann, M.H.2    Dersch, C.M.3    Romero, D.V.4    Rice, K.C.5    Carroll, F.I.6
  • 49
    • 77349115193 scopus 로고    scopus 로고
    • Pharmacologic therapies for obesity
    • Kaplan LM. Pharmacologic therapies for obesity. Gastroenterol Clin North Am 2010; 39: 69-79.
    • (2010) Gastroenterol Clin North Am , vol.39 , pp. 69-79
    • Kaplan, L.M.1
  • 50
    • 0033600538 scopus 로고    scopus 로고
    • Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates Implications for primary pulmonary hypertension
    • Rothman RB, Ayestas MA, Dersch CM, Baumann MH. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation 1999; 100: 869-875.
    • (1999) Circulation , vol.100 , pp. 869-875
    • Rothman, R.B.1    Ayestas, M.A.2    Dersch, C.M.3    Baumann, M.H.4
  • 51
    • 84872120963 scopus 로고    scopus 로고
    • Drug Enforcement Administration Office Of Diversion Control. List Of Scheduling Actions Controlled Substances Regulated Chemicals U.S. Department of Justice Accessed: 1 February 2012
    • Drug Enforcement Administration, Office of Diversion Control. List of scheduling actions controlled substances regulated chemicals, U.S. Department of Justice. http://www.deadiversion.usdoj.gov/schedules/index.html. Accessed: 1 February 2012.
  • 52
  • 55
    • 84862023939 scopus 로고    scopus 로고
    • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c m RNA but not for feeding-dependent expression
    • Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME et al. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c m RNA but not for feeding-dependent expression. Cell Metab 2012; 15: 873-884.
    • (2012) Cell Metab , vol.15 , pp. 873-884
    • Haas, J.T.1    Miao, J.2    Chanda, D.3    Wang, Y.4    Zhao, E.5    Haas, M.E.6
  • 56
    • 84906416668 scopus 로고
    • Obesity in childhood. Acontrolled trial ofanorectic drugs
    • Lorber J. Obesity in childhood. Acontrolled trial ofanorectic drugs.Arch Dis Child 1966; 41: 309-312.
    • (1966) Arch Dis Child , vol.41 , pp. 309-312
    • Lorber, J.1
  • 57
    • 0014783328 scopus 로고
    • Tenuate dospan as an appetitie suppressant in the treatment of obese children
    • Stewart DA, Bailey JD, Patell H. Tenuate dospan as an appetitie suppressant in the treatment of obese children. Appl Ther 1970; 12: 34-36.
    • (1970) Appl Ther , vol.12 , pp. 34-36
    • Stewart, D.A.1    Bailey, J.D.2    Patell, H.3
  • 59
    • 0014184304 scopus 로고
    • A clinical trial offenfluramine in obese children
    • Bacon GE, Lowrey GH. A clinical trial offenfluramine in obese children. Curr Ther Res Clin Exp 1967; 9: 626-630.
    • (1967) Curr Ther Res Clin Exp , vol.9 , pp. 626-630
    • Bacon, G.E.1    Lowrey, G.H.2
  • 61
    • 0002323687 scopus 로고
    • Is DL-fenfluramine a poten-tially helpful drug therapy in overweight adolescent subjects?
    • Pedrinola F, Cavaliere H, Lima N, Medeiros-Neto G. Is DL-fenfluramine a poten-tially helpful drug therapy in overweight adolescent subjects? Obes Res 1994; 2: 1-4.
    • (1994) Obes Res , vol.2 , pp. 1-4
    • Pedrinola, F.1    Cavaliere, H.2    Lima, N.3    Medeiros-Neto, G.4
  • 62
    • 0030278088 scopus 로고    scopus 로고
    • The addition of dexfenfluramine to fluoxetine in the treatment of obesity: A randomized clinical trial
    • Pedrinola F, Sztejnsznajd C, Lima N, Halpern A, Medeiros-Neto G. The addition of dexfenfluramine to fluoxetine in the treatment of obesity: a randomized clinical trial. Obes Res 1996; 4: 549-554.
    • (1996) Obes Res , vol.4 , pp. 549-554
    • Pedrinola, F.1    Sztejnsznajd, C.2    Lima, N.3    Halpern, A.4    Medeiros-Neto, G.5
  • 63
    • 0014265033 scopus 로고
    • Chlorphentermine as an anorexigenic agent in adolescent obesity. Report of its efficacy in a double-blind study of 30 teen-agers
    • Rauh JL, Lipp R. Chlorphentermine as an anorexigenic agent in adolescent obesity. Report of its efficacy in a double-blind study of 30 teen-agers. Clin Pediatr (Phila) 1968; 7: 138-140.
    • (1968) Clin Pediatr (Phila) , vol.7 , pp. 138-140
    • Rauh, J.L.1    Lipp, R.2
  • 64
    • 0031567756 scopus 로고    scopus 로고
    • Anon. Cardiac Valvulopathy Associated With Exposure To Fenfluramine Or Dex-fenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997
    • Anon. Cardiac valvulopathy associated with exposure to fenfluramine or dex-fenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997. MMWR Morb Mortal Wkly Rep 1997; 46: 1061-1066.
    • (1997) MMWR Morb Mortal Wkly Rep , vol.46 , pp. 1061-1066
  • 66
    • 9444287592 scopus 로고    scopus 로고
    • Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group
    • Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X et al. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group. N Engl J Med 1996; 335: 609-616.
    • (1996) N Engl J Med , vol.335 , pp. 609-616
    • Abenhaim, L.1    Moride, Y.2    Brenot, F.3    Rich, S.4    Benichou, J.5    Kurz, X.6
  • 67
    • 0021242404 scopus 로고
    • A double-blind clinical trial in weight control. Use offenfluramine and phentermine alone and in combi-nation
    • Weintraub M, Hasday JD, Mushlin AI, Lockwood DH. A double-blind clinical trial in weight control. Use offenfluramine and phentermine alone and in combi-nation. Arch Intern Med 1984; 144: 1143-1148.
    • (1984) Arch Intern Med , vol.144 , pp. 1143-1148
    • Weintraub, M.1    Hasday, J.D.2    Mushlin, A.I.3    Lockwood, D.H.4
  • 68
    • 0036766420 scopus 로고    scopus 로고
    • The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma
    • Mason PW, Krawiecki N, Meacham LR. The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatr Adolesc Med 2002; 156: 887-892.
    • (2002) Arch Pediatr Adolesc Med , vol.156 , pp. 887-892
    • Mason, P.W.1    Krawiecki, N.2    Meacham, L.R.3
  • 69
    • 84872108548 scopus 로고    scopus 로고
    • The suppression ofappetite and food consumption by methylphenidate: The moderating effects of gender and weight status in healthy adults
    • Davis C, Fattore L, Kaplan AS, Carter JC, Levitan RD, Kennedy JL. The suppression ofappetite and food consumption by methylphenidate: the moderating effects of gender and weight status in healthy adults. Int J Neuropsychopharmacol 2011 1-7.
    • Int J Neuropsychopharmacol , vol.2011 , pp. 1-7
    • Davis, C.1    Fattore, L.2    Kaplan, A.S.3    Carter, J.C.4    Levitan, R.D.5    Kennedy, J.L.6
  • 70
    • 16744362910 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyper-activity disorder
    • Greenhill LL, Findling RL, Swanson JM. A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/ hyper-activity disorder. Pediatrics 2002; 109: E39.
    • (2002) Pediatrics , vol.109
    • Greenhill, L.L.1    Findling, R.L.2    Swanson, J.M.3
  • 72
    • 0036123886 scopus 로고    scopus 로고
    • Abuse and toxicity of methylphenidate
    • Klein-Schwartz W. Abuse and toxicity of methylphenidate. Curr Opin Pediatr 2002; 14: 219-223.
    • (2002) Curr Opin Pediatr , vol.14 , pp. 219-223
    • Klein-Schwartz, W.1
  • 73
    • 84857425784 scopus 로고    scopus 로고
    • Pharmacotherapies for obesity: Past, current, and future therapies
    • Ioannides-Demos LL, Piccenna L, Mc Neil JJ. Pharmacotherapies for obesity: past, current, and future therapies. J Obes 2011 2011 179674.
    • J Obes , vol.2011 , Issue.2011 , pp. 179674
    • Ioannides-Demos, L.L.1    Piccenna, L.2    Mc Neil, J.J.3
  • 74
    • 70350210505 scopus 로고    scopus 로고
    • Pharmacotherapy in pediatric obesity: Current agents and future directions
    • Wald AB, Uli NK. Pharmacotherapy in pediatric obesity: current agents and future directions. Rev Endocr Metab Disord 2009; 10: 205-214.
    • (2009) Rev Endocr Metab Disord , vol.10 , pp. 205-214
    • Wald, A.B.1    Uli, N.K.2
  • 80
    • 30944440108 scopus 로고    scopus 로고
    • Sibutramine as an adjuvant therapy in adolescents suffering from morbid obesity
    • Reisler G, Tauber T, Afriat R, Bortnik O, Goldman M. Sibutramine as an adjuvant therapy in adolescents suffering from morbid obesity. Isr Med Assoc J 2006; 8: 30-32.
    • (2006) Isr Med Assoc J , vol.8 , pp. 30-32
    • Reisler, G.1    Tauber, T.2    Afriat, R.3    Bortnik, O.4    Goldman, M.5
  • 81
    • 34250863948 scopus 로고    scopus 로고
    • Weight loss in obese African American and Caucasian adolescents: Secondary analysis of a randomized clinical trial of behavioral therapy plus sibutramine
    • Budd GM, Hayman LL, Crump E, Pollydore C, Hawley KD, Cronquist JL et al. Weight loss in obese African American and Caucasian adolescents: secondary analysis of a randomized clinical trial of behavioral therapy plus sibutramine. J Cardiovasc Nurs 2007; 22: 288-296.
    • (2007) J Cardiovasc Nurs , vol.22 , pp. 288-296
    • Budd, G.M.1    Hayman, L.L.2    Crump, E.3    Pollydore, C.4    Hawley, K.D.5    Cronquist, J.L.6
  • 82
    • 34447126288 scopus 로고    scopus 로고
    • Car-diovascular effects of sibutramine in the treatment ofobese adolescents: Results of a randomized, double-blind, placebo-controlled study
    • Daniels SR, Long B, Crow S, Styne D, Sothern M, Vargas-Rodriguez I et al. Car-diovascular effects of sibutramine in the treatment ofobese adolescents: results of a randomized, double-blind, placebo-controlled study. Pediatrics 2007; 120: e147-e157.
    • (2007) Pediatrics , vol.120
    • Daniels, S.R.1    Long, B.2    Crow, S.3    Styne, D.4    Sothern, M.5    Vargas-Rodriguez, I.6
  • 83
    • 35948962283 scopus 로고    scopus 로고
    • Impact sibutramine therapy in children with hypothalamic obesity or obesity with aggravating syndromes
    • Danielsson P, Janson A, Norgren S, Marcus C. Impact sibutramine therapy in children with hypothalamic obesity or obesity with aggravating syndromes. J Clin Endocrinol Metab 2007; 92: 4101-4106.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4101-4106
    • Danielsson, P.1    Janson, A.2    Norgren, S.3    Marcus, C.4
  • 85
    • 84872103912 scopus 로고    scopus 로고
    • Behavior therapy and sibutramine for the treatment of adolescent obesity
    • Yanovski JA. Behavior therapy and sibutramine for the treatment of adolescent obesity. J Pediatr 2003; 143: 686.
    • (2003) J Pediatr , vol.143 , pp. 686
    • Yanovski, J.A.1
  • 86
    • 0036736799 scopus 로고    scopus 로고
    • Recent developments in the treatment of obesity-related hypertension
    • Pischon T, Sharma AM. Recent developments in the treatment of obesity-related hypertension. Curr Opin Nephrol Hypertens 2002; 11: 497-502.
    • (2002) Curr Opin Nephrol Hypertens , vol.11 , pp. 497-502
    • Pischon, T.1    Sharma, A.M.2
  • 87
    • 36849095595 scopus 로고    scopus 로고
    • Cardiovascular responses to weight management and sibutramine in high-risk subjects: An analysis from the SCOUT trial
    • Torp-Pedersen C, Caterson I, Coutinho W, Finer N, Van Gaal L, Maggioni A et al. Cardiovascular responses to weight management and sibutramine in high-risk subjects: an analysis from the SCOUT trial. Eur Heart J 2007; 28: 2915-2923.
    • (2007) Eur Heart J , vol.28 , pp. 2915-2923
    • Torp-Pedersen, C.1    Caterson, I.2    Coutinho, W.3    Finer, N.4    Van Gaal, L.5    Maggioni, A.6
  • 92
    • 0036177867 scopus 로고    scopus 로고
    • Control of energy homeostasis and insulin action by adipocyte hor-mones: Leptin, acylation stimulating protein, and adiponectin
    • Havel PJ. Control of energy homeostasis and insulin action by adipocyte hor-mones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 2002; 13: 51-59.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 51-59
    • Havel, P.J.1
  • 93
    • 0033009882 scopus 로고    scopus 로고
    • High-fat meals reduce 24-h circulating leptin concentrations in women
    • Havel PJ, Townsend R, Chaump L, Teff K. High-fat meals reduce 24-h circulating leptin concentrations in women. Diabetes 1999; 48: 334-341.
    • (1999) Diabetes , vol.48 , pp. 334-341
    • Havel, P.J.1    Townsend, R.2    Chaump, L.3    Teff, K.4
  • 96
    • 0035757975 scopus 로고    scopus 로고
    • Brain pathways controlling food intake and body weight
    • Schwartz MW. Brain pathways controlling food intake and body weight. Exp Biol Med (Maywood) 2001; 226: 978-981.
    • (2001) Exp Biol Med (Maywood) , vol.226 , pp. 978-981
    • Schwartz, M.W.1
  • 99
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks [see comments]
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks [see comments]. Science 1995; 269: 546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 101
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110: 1093-1103.
    • (2002) J Clin Invest , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3    Keogh, J.M.4    Lawrence, E.5    Agwu, C.6
  • 102
    • 6344221594 scopus 로고    scopus 로고
    • Congenital leptin deficiency due to homozygosity for the Delta133G mutation: Reportofanother caseand evaluation ofresponse tofouryears of leptin therapy
    • Gibson WT, Farooqi IS, Moreau M, De Paoli AM, Lawrence E, O'Rahilly S et al. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: reportofanother caseand evaluation ofresponse tofouryears of leptin therapy. J Clin Endocrinol Metab 2004; 89: 4821-4826.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4821-4826
    • Gibson, W.T.1    Farooqi, I.S.2    Moreau, M.3    De Paoli, A.M.4    Lawrence, E.5    O'Rahilly, S.6
  • 103
    • 79955043136 scopus 로고    scopus 로고
    • Ten years of leptin replacement therapy
    • Paz-Filho G, Wong ML, Licinio J. Ten years of leptin replacement therapy. Obes Rev 2011; 12: e315-e323.
    • (2011) Obes Rev , vol.12
    • Paz-Filho, G.1    Wong, M.L.2    Licinio, J.3
  • 104
    • 72449185147 scopus 로고    scopus 로고
    • Efficacy of leptin therapy in the different forms of human lipodystrophy
    • Chong AY, Lupsa BC, Cochran EK, Gorden P. Efficacy of leptin therapy in the different forms of human lipodystrophy. Diabetologia 2010; 53: 27-35.
    • (2010) Diabetologia , vol.53 , pp. 27-35
    • Chong, A.Y.1    Lupsa, B.C.2    Cochran, E.K.3    Gorden, P.4
  • 106
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
    • Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999; 282: 1568-1575.
    • (1999) JAMA , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3    Dixon, R.M.4    Kushner, R.5    Hunt, T.6
  • 107
    • 79959409408 scopus 로고    scopus 로고
    • Efficacy of metreleptin in obese patients with type 2 diabetes: Cellular and molecular pathways underlying leptin tolerance
    • Moon HS, Matarese G, Brennan AM, Chamberland JP, Liu X, Fiorenza CG et al. Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance. Diabetes 2011; 60: 1647-1656.
    • (2011) Diabetes , vol.60 , pp. 1647-1656
    • Moon, H.S.1    Matarese, G.2    Brennan, A.M.3    Chamberland, J.P.4    Liu, X.5    Fiorenza, C.G.6
  • 108
    • 0036093071 scopus 로고    scopus 로고
    • Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
    • Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endo-crinol Metab 2002; 87: 2391-2394.
    • (2002) J Clin Endo-crinol Metab , vol.87 , pp. 2391-2394
    • Rosenbaum, M.1    Murphy, E.M.2    Heymsfield, S.B.3    Matthews, D.E.4    Leibel, R.L.5
  • 109
    • 31044444463 scopus 로고    scopus 로고
    • Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
    • Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005; 115: 3579-3586.
    • (2005) J Clin Invest , vol.115 , pp. 3579-3586
    • Rosenbaum, M.1    Goldsmith, R.2    Bloomfield, D.3    Magnano, A.4    Weimer, L.5    Heymsfield, S.6
  • 110
    • 46749099010 scopus 로고    scopus 로고
    • Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    • Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest 2008; 118: 2583-2591.
    • (2008) J Clin Invest , vol.118 , pp. 2583-2591
    • Rosenbaum, M.1    Sy, M.2    Pavlovich, K.3    Leibel, R.L.4    Hirsch, J.5
  • 114
    • 33947232740 scopus 로고    scopus 로고
    • Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice
    • Billes SK, Cowley MA. Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice. Neu-ropsychopharmacology 2007; 32: 822-834.
    • (2007) Neu-ropsychopharmacology , vol.32 , pp. 822-834
    • Billes, S.K.1    Cowley, M.A.2
  • 116
    • 0036778351 scopus 로고    scopus 로고
    • Bupropion SR vs. placebo for weight loss in obese patients with depressive symptoms
    • Jain AK, Kaplan RA, Gadde KM, Wadden TA, Allison DB, Brewer ER et al. Bupropion SR vs. placebo for weight loss in obese patients with depressive symptoms. Obes Res 2002; 10: 1049-1056.
    • (2002) Obes Res , vol.10 , pp. 1049-1056
    • Jain, A.K.1    Kaplan, R.A.2    Gadde, K.M.3    Wadden, T.A.4    Allison, D.B.5    Brewer, E.R.6
  • 118
    • 25644460463 scopus 로고    scopus 로고
    • Weight changes in teens on psychotropic medication combinations at Austin State Hospital
    • Becker EA, Shafer A, Anderson R. Weight changes in teens on psychotropic medication combinations at Austin State Hospital. Tex Med 2005; 101: 62-70.
    • (2005) Tex Med , vol.101 , pp. 62-70
    • Becker, E.A.1    Shafer, A.2    Anderson, R.3
  • 119
    • 79952297237 scopus 로고    scopus 로고
    • Lorcaserin, a 5-HT(2C) receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure
    • Martin CK, Redman LM, Zhang J, Sanchez M, Anderson CM, Smith SR et al. Lorcaserin, a 5-HT(2C) receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure. J Clin Endocrinol Metab 2011; 96: 837-845.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 837-845
    • Martin, C.K.1    Redman, L.M.2    Zhang, J.3    Sanchez, M.4    Anderson, C.M.5    Smith, S.R.6
  • 121
    • 80053539943 scopus 로고    scopus 로고
    • A one-year randomized trial of lorcaserin for weight loss in obese and over-weight adults: The BLOSSOM trial
    • Fidler MC, Sanchez M, Raether B, Weissman NJ, Smith SR, Shanahan WR et al. A one-year randomized trial of lorcaserin for weight loss in obese and over-weight adults: the BLOSSOM trial. J Clin Endocrinol Metab 2011; 96: 3067-3077.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3067-3077
    • Fidler, M.C.1    Sanchez, M.2    Raether, B.3    Weissman, N.J.4    Smith, S.R.5    Shanahan, W.R.6
  • 122
    • 84862869642 scopus 로고    scopus 로고
    • Rando-mized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 dia-betes mellitus: The BLOOM-DM study
    • O'Neil PM, Smith SR, Weissman NJ, Fidler MC, Sanchez M, Zhang J et al. Rando-mized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 dia-betes mellitus: the BLOOM-DM study. Obesity (Silver Spring) 2012; 20: 1426-1436.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 1426-1436
    • O'Neil, P.M.1    Smith, S.R.2    Weissman, N.J.3    Fidler, M.C.4    Sanchez, M.5    Zhang, J.6
  • 125
    • 56649112848 scopus 로고    scopus 로고
    • Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: A randomised, double-blind, placebo-controlled trial
    • Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 372: 1906-1913.
    • (2008) Lancet , vol.372 , pp. 1906-1913
    • Astrup, A.1    Madsbad, S.2    Breum, L.3    Jensen, T.J.4    Kroustrup, J.P.5    Larsen, T.M.6
  • 127
    • 78349310073 scopus 로고    scopus 로고
    • The effect of the triple monoamine reuptake inhibitor tesofensine on energy metabolism and appetite in overweight and moderately obese men
    • Sjodin A, Gasteyger C, Nielsen AL, Raben A, Mikkelsen JD, Jensen JK et al. The effect of the triple monoamine reuptake inhibitor tesofensine on energy metabolism and appetite in overweight and moderately obese men. Int J Obes (Lond) 2010; 34: 1634-1643.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 1634-1643
    • Sjodin, A.1    Gasteyger, C.2    Nielsen, A.L.3    Raben, A.4    Mikkelsen, J.D.5    Jensen, J.K.6
  • 128
    • 36048995288 scopus 로고    scopus 로고
    • Efficacy and safety of the weight-loss drug rimonabant: A meta-analysis ofrandomised trials
    • Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis ofrandomised trials. Lancet 2007; 370: 1706-1713.
    • (2007) Lancet , vol.370 , pp. 1706-1713
    • Christensen, R.1    Kristensen, P.K.2    Bartels, E.M.3    Bliddal, H.4    Astrup, A.5
  • 129
    • 41149130137 scopus 로고    scopus 로고
    • Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in over-weight/obese patients: Pooled 1-year data from the Rimonabant in Obesity (RIO) program
    • Van Gaal L, Pi-Sunyer X, Despres JP, Mc Carthy C, Scheen A. Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in over-weight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program. Diabetes Care 2008; 31(Suppl 2): S229-S240.
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 2
    • Van Gaal, L.1    Pi-Sunyer, X.2    Despres, J.P.3    Mc Carthy, C.4    Scheen, A.5
  • 130
    • 84872107496 scopus 로고    scopus 로고
    • US Food and Drug Administration Briefing Document -NDA 21-888. May 20, 2007 Accessed: 30 March 2012
    • US Food and Drug Administration. Endocrine and Metabolic Drugs Advisory Committee Meeting. Sanofi Aventis: Zimulti (Rimonabant) Briefing Document -NDA 21-888. May 20, 2007. http://www.scribd.com/doc/1117189/US-Food-and-Drug- Administration-20074306b101sponsorbackgrounder. Accessed: 30 March 2012.
    • Endocrine and Metabolic Drugs Advisory Committee Meeting. Sanofi Aventis: Zimulti (Rimonabant)
  • 132
    • 70849120492 scopus 로고    scopus 로고
    • Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders
    • Heal DJ, Gosden J, Smith SL. Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders. Br J Clin Pharmacol 2009; 68: 861-874.
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 861-874
    • Heal, D.J.1    Gosden, J.2    Smith, S.L.3
  • 133
    • 77952923643 scopus 로고    scopus 로고
    • Obesity: Taranabant no longer developed as an antiobesity agent
    • Koch L. Obesity: Taranabant no longer developed as an antiobesity agent. Nat Rev Endocrinol 2010; 6: 300.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 300
    • Koch, L.1
  • 134
    • 51349153318 scopus 로고    scopus 로고
    • Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
    • Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI et al. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest 2008; 118: 3160-3169.
    • (2008) J Clin Invest , vol.118 , pp. 3160-3169
    • Osei-Hyiaman, D.1    Liu, J.2    Zhou, L.3    Godlewski, G.4    Harvey-White, J.5    Jeong, W.I.6
  • 135
    • 58149128824 scopus 로고    scopus 로고
    • Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats
    • Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschop J, Caldwell C et al. Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes 2008; 57: 2977-2991.
    • (2008) Diabetes , vol.57 , pp. 2977-2991
    • Nogueiras, R.1    Veyrat-Durebex, C.2    Suchanek, P.M.3    Klein, M.4    Tschop, J.5    Caldwell, C.6
  • 136
    • 37349059404 scopus 로고    scopus 로고
    • Cannabinoids inhibit insulin secretion and cytosolic Ca2 + oscillation in islet beta-cells via CB1 receptors
    • Nakata M, Yada T. Cannabinoids inhibit insulin secretion and cytosolic Ca2 + oscillation in islet beta-cells via CB1 receptors. Regul Pept 2008; 145: 49-53.
    • (2008) Regul Pept , vol.145 , pp. 49-53
    • Nakata, M.1    Yada, T.2
  • 137
    • 55749095211 scopus 로고    scopus 로고
    • Over-active endocannabinoid signaling impairs apolipoprotein E-mediated clearance oftriglyceride-rich lipoproteins
    • Ruby MA, Nomura DK, Hudak CS, Mangravite LM, Chiu S, Casida JE et al. Over-active endocannabinoid signaling impairs apolipoprotein E-mediated clearance oftriglyceride-rich lipoproteins. Proc Natl Acad Sci USA 2008; 105: 14561-14566.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14561-14566
    • Ruby, M.A.1    Nomura, D.K.2    Hudak, C.S.3    Mangravite, L.M.4    Chiu, S.5    Casida, J.E.6
  • 138
    • 79954991696 scopus 로고    scopus 로고
    • Efficacy and safety of topiramate on weight loss: A meta-analysis of randomized controlled trials
    • Kramer CK, Leitao CB, Pinto LC, Canani LH, Azevedo MJ, Gross JL. Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trials. Obes Rev 2011; 12: e338-e347.
    • (2011) Obes Rev , vol.12
    • Kramer, C.K.1    Leitao, C.B.2    Pinto, L.C.3    Canani, L.H.4    Azevedo, M.J.5    Gross, J.L.6
  • 139
    • 77951975951 scopus 로고    scopus 로고
    • Topiramate for prevention of olanzapine associated weight gain and metabolic dysfunction in schizophrenia: A double-blind, placebo-controlled trial
    • Narula PK, Rehan HS, Unni KE, Gupta N. Topiramate for prevention of olanzapine associated weight gain and metabolic dysfunction in schizophrenia: a double-blind, placebo-controlled trial. Schizophr Res 2010; 118: 218-223.
    • (2010) Schizophr Res , vol.118 , pp. 218-223
    • Narula, P.K.1    Rehan, H.S.2    Unni, K.E.3    Gupta, N.4
  • 141
    • 44249094151 scopus 로고    scopus 로고
    • Topiramate in the prevention of pediatric migraine: Literature review
    • Ferraro D, Di Trapani G. Topiramate in the prevention of pediatric migraine: literature review. J Headache Pain 2008; 9: 147-150.
    • (2008) J Headache Pain , vol.9 , pp. 147-150
    • Ferraro, D.1    Di Trapani, G.2
  • 143
    • 0036750910 scopus 로고    scopus 로고
    • Topiramate plus risperidone for controlling weight gain and symptoms in preschool mania
    • Pavuluri MN, Janicak PG, Carbray J. Topiramate plus risperidone for controlling weight gain and symptoms in preschool mania. J Child Adolesc Psychopharmacol 2002; 12: 271-273.
    • (2002) J Child Adolesc Psychopharmacol , vol.12 , pp. 271-273
    • Pavuluri, M.N.1    Janicak, P.G.2    Carbray, J.3
  • 144
    • 14644423907 scopus 로고    scopus 로고
    • Clinical experience with Topiramate to counteract neuroleptic induced weight gain in 10 individuals with autistic spectrum disorders
    • Canitano R. Clinical experience with Topiramate to counteract neuroleptic induced weight gain in 10 individuals with autistic spectrum disorders. Brain Dev 2005; 27: 228-232.
    • (2005) Brain Dev , vol.27 , pp. 228-232
    • Canitano, R.1
  • 145
    • 19544379331 scopus 로고    scopus 로고
    • Topiramate for weight reduction in Duchenne muscular dystrophy
    • Carter GT, Yudkowsky MP, Han JJ, Mc Crory MA. Topiramate for weight reduction in Duchenne muscular dystrophy. Muscle Nerve 2005; 31: 788-789.
    • (2005) Muscle Nerve , vol.31 , pp. 788-789
    • Carter, G.T.1    Yudkowsky, M.P.2    Han, J.J.3    Mc Crory, M.A.4
  • 147
    • 77953227564 scopus 로고    scopus 로고
    • A pregnant pause toconsider teratogenicity of topiramate
    • Fountain NB.A pregnant pause toconsider teratogenicity of topiramate. Epilepsy Curr 2009; 9: 36-38.
    • (2009) Epilepsy Curr , vol.9 , pp. 36-38
    • Fountain, N.B.1
  • 149
    • 77953707385 scopus 로고    scopus 로고
    • Brainstem mechanisms of amylin-induced anorexia
    • Potes CS, Lutz TA. Brainstem mechanisms of amylin-induced anorexia. Physiol Behav 2010; 100: 511-518.
    • (2010) Physiol Behav , vol.100 , pp. 511-518
    • Potes, C.S.1    Lutz, T.A.2
  • 151
    • 78650636365 scopus 로고    scopus 로고
    • The effect of pramlintide acetate on glycemic control and weight in patients with type 2 diabetes mellitus and in obese patients without diabetes: A systematic review and meta-analysis
    • Singh-Franco D, Perez A, Harrington C. The effect of pramlintide acetate on glycemic control and weight in patients with type 2 diabetes mellitus and in obese patients without diabetes: a systematic review and meta-analysis. Diabetes Obes Metab 2011; 13: 169-180.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 169-180
    • Singh-Franco, D.1    Perez, A.2    Harrington, C.3
  • 152
    • 0346368339 scopus 로고    scopus 로고
    • Effect of pramlintide on A1C and body weight in insulin-treated African Americans and Hispanics with type 2 diabetes: A pooled post hoc analysis
    • Maggs D, Shen L, Strobel S, Brown D, Kolterman O, Weyer C. Effect of pramlintide on A1C and body weight in insulin-treated African Americans and Hispanics with type 2 diabetes: a pooled post hoc analysis. Metabolism 2003; 52: 1638-1642.
    • (2003) Metabolism , vol.52 , pp. 1638-1642
    • Maggs, D.1    Shen, L.2    Strobel, S.3    Brown, D.4    Kolterman, O.5    Weyer, C.6
  • 153
    • 34547739135 scopus 로고    scopus 로고
    • Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: A phase 2, randomized, placebo-controlled, dose-escalation study
    • Aronne L, Fujioka K, Aroda V, Chen K, Halseth A, Kesty NC et al. Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study. J Clin Endocrinol Metab 2007; 92: 2977-2983.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2977-2983
    • Aronne, L.1    Fujioka, K.2    Aroda, V.3    Chen, K.4    Halseth, A.5    Kesty, N.C.6
  • 154
    • 56149124659 scopus 로고    scopus 로고
    • Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle inter-vention in obesity
    • Smith SR, Aronne LJ, Burns CM, Kesty NC, Halseth AE, Weyer C. Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle inter-vention in obesity. Diabetes Care 2008; 31: 1816-1823.
    • (2008) Diabetes Care , vol.31 , pp. 1816-1823
    • Smith, S.R.1    Aronne, L.J.2    Burns, C.M.3    Kesty, N.C.4    Halseth, A.E.5    Weyer, C.6
  • 155
    • 69249228579 scopus 로고    scopus 로고
    • Pramlintide lowered glucose excursions and was well-tolerated in adolescents with type 1 diabetes: Results from a randomized, single-blind, placebo-controlled, crossover study
    • Chase HP, Lutz K, Pencek R, Zhang B, Porter L. Pramlintide lowered glucose excursions and was well-tolerated in adolescents with type 1 diabetes: results from a randomized, single-blind, placebo-controlled, crossover study. J Pediatr 2009; 155: 369-373.
    • (2009) J Pediatr , vol.155 , pp. 369-373
    • Chase, H.P.1    Lutz, K.2    Pencek, R.3    Zhang, B.4    Porter, L.5
  • 159
    • 54049083786 scopus 로고    scopus 로고
    • Long-acting octreotide treatment causes a sustained decrease in ghrelin con-centrations but does not affect weight, behaviour and appetite in subjects with Prader-Willi syndrome
    • De Waele K, Ishkanian SL, Bogarin R, Miranda CA, Ghatei MA, Bloom SR et al. Long-acting octreotide treatment causes a sustained decrease in ghrelin con-centrations but does not affect weight, behaviour and appetite in subjects with Prader-Willi syndrome. Eur J Endocrinol 2008; 159: 381-388.
    • (2008) Eur J Endocrinol , vol.159 , pp. 381-388
    • De Waele, K.1    Ishkanian, S.L.2    Bogarin, R.3    Miranda, C.A.4    Ghatei, M.A.5    Bloom, S.R.6
  • 160
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup A, Rossner S, Van Gaal L, Rissanen A, Niskanen L, Al Hakim M etal. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009; 374: 1606-1616.
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rossner, S.2    Van Gaal, L.3    Rissanen, A.4    Niskanen, L.5    Al Hakim, M.6
  • 161
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met + TZD)
    • Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met + TZD). Diabetes Care 2009; 32: 1224-1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6
  • 162
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met + SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, Sethi BK, Lalic N, Antic S et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met + SU): a randomised controlled trial. Diabetologia 2009; 52: 2046-2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3    Sethi, B.K.4    Lalic, N.5    Antic, S.6
  • 163
    • 67649523294 scopus 로고    scopus 로고
    • Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combina-tion with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: A double-blind placebo-controlled study
    • Nauck MA, Ratner RE, Kapitza C, Berria R, Boldrin M, Balena R. Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combina-tion with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care 2009; 32: 1237-1243.
    • (2009) Diabetes Care , vol.32 , pp. 1237-1243
    • Nauck, M.A.1    Ratner, R.E.2    Kapitza, C.3    Berria, R.4    Boldrin, M.5    Balena, R.6
  • 164
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 2009; 32: 84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3    Shah, N.S.4    Tankova, T.5    Mitha, I.H.6
  • 165
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treat-ment trial
    • Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera-Alvarez I et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treat-ment trial. Lancet 2009; 373: 473-481.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia-Hernandez, P.A.4    Rodriguez-Pattzi, H.5    Olvera-Alvarez, I.6
  • 166
    • 79958268386 scopus 로고    scopus 로고
    • Exenatide once weekly treatment maintained improvements in glycemic control and weight loss over 2 years
    • Taylor K, Gurney K, Han J, Pencek R, Walsh B, Trautmann M. Exenatide once weekly treatment maintained improvements in glycemic control and weight loss over 2 years. BMC Endocr Disord 2011; 11: 9.
    • (2011) BMC Endocr Disord , vol.11 , pp. 9
    • Taylor, K.1    Gurney, K.2    Han, J.3    Pencek, R.4    Walsh, B.5    Trautmann, M.6
  • 167
    • 77956090389 scopus 로고    scopus 로고
    • Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes
    • Rosenstock J, Klaff LJ, Schwartz S, Northrup J, Holcombe JH, Wilhelm K et al. Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes. Diabetes Care 2010; 33: 1173-1175.
    • (2010) Diabetes Care , vol.33 , pp. 1173-1175
    • Rosenstock, J.1    Klaff, L.J.2    Schwartz, S.3    Northrup, J.4    Holcombe, J.H.5    Wilhelm, K.6
  • 168
    • 84856242456 scopus 로고    scopus 로고
    • Exenatide as a weight-loss therapy in extreme pediatric obesity: A randomized, controlled pilot study
    • Kelly AS, Metzig AM, Rudser KD, Fitch AK, Fox CK, Nathan BM et al. Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study. Obesity (Silver Spring) 2012; 20: 364-370.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 364-370
    • Kelly, A.S.1    Metzig, A.M.2    Rudser, K.D.3    Fitch, A.K.4    Fox, C.K.5    Nathan, B.M.6
  • 169
    • 84872112680 scopus 로고    scopus 로고
    • US Food and Drug Administration Orlistat Update Accessed: 30 March 2012
    • Mathis LL. US Food and Drug Administration. Pediatric Advisory Committee Meeting March 22, 2010. Orlistat Update. http://www.fda.gov/downloads/Advi-sory Committees/Committees Meeting Materials/Pediatric Advisory Committee/ UCM205380.pdf. Accessed: 30 March 2012.
    • (2010) Pediatric Advisory Committee Meeting March , vol.22
    • Mathis, L.L.1
  • 170
    • 0036633087 scopus 로고    scopus 로고
    • Three-month tolerability of orlistat in adolescents with obesity-related comorbid conditions
    • Mc Duffie JR, Calis KA, Uwaifo GI, Sebring NG, Fallon EM, Hubbard VS et al. Three-month tolerability of orlistat in adolescents with obesity-related comorbid conditions. Obes Res 2002; 10: 642-650.
    • (2002) Obes Res , vol.10 , pp. 642-650
    • Mc Duffie, J.R.1    Calis, K.A.2    Uwaifo, G.I.3    Sebring, N.G.4    Fallon, E.M.5    Hubbard, V.S.6
  • 171
    • 0141988881 scopus 로고    scopus 로고
    • The effect ofshort-term (21-day) orlistat treatment on the physiologic balance of six selected macrominerals and microminerals in obese adolescents
    • Zhi J, Moore R, Kanitra L. The effect ofshort-term (21-day) orlistat treatment on the physiologic balance of six selected macrominerals and microminerals in obese adolescents. J Am Coll Nutr 2003; 22: 357-362.
    • (2003) J Am Coll Nutr , vol.22 , pp. 357-362
    • Zhi, J.1    Moore, R.2    Kanitra, L.3
  • 173
    • 11244356604 scopus 로고    scopus 로고
    • Addition of orlistat to conventional treatment in adolescents with severe obesity
    • Ozkan B, Bereket A, Turan S, Keskin S. Addition of orlistat to conventional treatment in adolescents with severe obesity. Eur J Pediatr 2004; 163: 738-741.
    • (2004) Eur J Pediatr , vol.163 , pp. 738-741
    • Ozkan, B.1    Bereket, A.2    Turan, S.3    Keskin, S.4
  • 174
    • 3142701722 scopus 로고    scopus 로고
    • Efficacy of orlistat as an adjunct to behavioral treatment in overweight African American and Caucasian adolescents with obesity-related co-morbid conditions
    • Mc Duffie JR, Calis KA, Uwaifo GI, Sebring NG, Fallon EM, Frazer TE et al. Efficacy of orlistat as an adjunct to behavioral treatment in overweight African American and Caucasian adolescents with obesity-related co-morbid conditions. J Pediatr Endocrinol Metab 2004; 17: 307-319.
    • (2004) J Pediatr Endocrinol Metab , vol.17 , pp. 307-319
    • Mc Duffie, J.R.1    Calis, K.A.2    Uwaifo, G.I.3    Sebring, N.G.4    Fallon, E.M.5    Frazer, T.E.6
  • 175
    • 20444446770 scopus 로고    scopus 로고
    • Effect of orlistat on weight and body composition in obese adolescents: A randomized controlled trial
    • Chanoine JP, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial. Jama 2005; 293: 2873-2883.
    • (2005) JAMA , vol.293 , pp. 2873-2883
    • Chanoine, J.P.1    Hampl, S.2    Jensen, C.3    Boldrin, M.4    Hauptman, J.5
  • 176
    • 33646842569 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of orlistat for weight loss in adolescents
    • Maahs D, de Serna DG, Kolotkin RL, Ralston S, Sandate J, Qualls C et al. Randomized, double-blind, placebo-controlled trial of orlistat for weight loss in adolescents. Endocr Pract 2006; 12: 18-28.
    • (2006) Endocr Pract , vol.12 , pp. 18-28
    • Maahs, D.1    De Serna, D.G.2    Kolotkin, R.L.3    Ralston, S.4    Sandate, J.5    Qualls, C.6
  • 177
    • 79957468976 scopus 로고    scopus 로고
    • Early weight loss and outcome at one year in obese adolescents treated with orlistat or placebo
    • Chanoine JP, Richard M. Early weight loss and outcome at one year in obese adolescents treated with orlistat or placebo. Int J Pediatr Obes 2011; 6: 95-101.
    • (2011) Int J Pediatr Obes , vol.6 , pp. 95-101
    • Chanoine, J.P.1    Richard, M.2
  • 178
    • 84872118968 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of the effects of orlistat on body weight and body composition in african american and caucasian adolescents with obesity-related comorbid conditions
    • Yanovski JA, Mc Duffie JR, Salaita CS, Tanofsky-Kraff M, Sebring NG, Young-Hyman D et al. A randomized, placebo-controlled trial of the effects of orlistat on body weight and body composition in African American and Caucasian adolescents with obesity-related comorbid conditions. Obesity2008; 16(Suppl. 1): S63.
    • (2008) Obesity , vol.16 , Issue.SUPPL. 1
    • Yanovski, J.A.1    Mc Duffie, J.R.2    Salaita, C.S.3    Tanofsky-Kraff, M.4    Sebring, N.G.5    Young-Hyman, D.6
  • 180
    • 70449534919 scopus 로고    scopus 로고
    • Pattern of orlistat exposures in children aged 5 years or less
    • Forrester MB. Pattern of orlistat exposures in children aged 5 years or less. J Emerg Med 2009; 37: 396-399.
    • (2009) J Emerg Med , vol.37 , pp. 396-399
    • Forrester, M.B.1
  • 181
    • 77954424747 scopus 로고    scopus 로고
    • An Orlistat 'overdose' in a child
    • O'Connor MB. An orlistat 'overdose' in a child. Ir JMed Sci 2010; 179: 315.
    • (2010) Ir JMed Sci , vol.179 , pp. 315
    • O'Connor, M.B.1
  • 182
    • 1042303480 scopus 로고    scopus 로고
    • XENical in the prevention of diabetes in obese subjects (XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    • Torgerson JS, Hauptman J, Boldrin MN, Sjostrom L. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004; 27: 155-161.
    • (2004) Diabetes Care , vol.27 , pp. 155-161
    • Torgerson, J.S.1    Hauptman, J.2    Boldrin, M.N.3    Sjostrom, L.4
  • 184
    • 37549010380 scopus 로고    scopus 로고
    • FDA Accessed: 9 July 2012
    • FDA. Approves Orlistat for Over-the-Counter Use. http://www.fda.gov/News Events/Newsroom/Press Announcements/2007/ucm108839.htm. Accessed: 9 July 2012.
    • Approves Orlistat for Over-the-Counter Use
  • 185
    • 33847261129 scopus 로고    scopus 로고
    • Cetilistat (ATL-962), a novel lipase inhibitor: A 12-week randomized, placebo-controlled study of weight reduction in obese patients
    • Kopelman P, Bryson A, Hickling R, Rissanen A, Rossner S, Toubro S et al. Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond) 2007; 31: 494-499.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 494-499
    • Kopelman, P.1    Bryson, A.2    Hickling, R.3    Rissanen, A.4    Rossner, S.5    Toubro, S.6
  • 186
    • 73949084345 scopus 로고    scopus 로고
    • Weight loss, Hb A 1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: Comparison with orlistat (xenical)
    • Kopelman P, Groot Gde H, Groot G, Rissanen A, Rossner S, Toubro S et al. Weight loss, Hb A 1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (xenical). Obesity2010; 18: 108-115.
    • (2010) Obesity , vol.18 , pp. 108-115
    • Kopelman, P.1    Groot Gde, H.2    Groot, G.3    Rissanen, A.4    Rossner, S.5    Toubro, S.6
  • 187
    • 73949084345 scopus 로고    scopus 로고
    • Weight loss, Hb A1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: Comparison with orlistat (Xenical)
    • Kopelman P, Groot Gde H, Rissanen A, Rossner S, Toubro S, Palmer R et al. Weight loss, Hb A1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical). Obesity (Silver Spring) 2010; 18: 108-115.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 108-115
    • Kopelman, P.1    Groot Gde, H.2    Rissanen, A.3    Rossner, S.4    Toubro, S.5    Palmer, R.6
  • 188
    • 0030066421 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of Acarbose
    • Salvatore T, Giugliano D. Pharmacokinetic-pharmacodynamic relationships of Acarbose. Clin Pharmacokinet 1996; 30: 94-106.
    • (1996) Clin Pharmacokinet , vol.30 , pp. 94-106
    • Salvatore, T.1    Giugliano, D.2
  • 189
    • 83455220076 scopus 로고    scopus 로고
    • Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: A 24-week, randomized, open-label, parallel-group comparison
    • Wang JS, Lin SD, Lee WJ, Su SL, Lee IT, Tu ST et al. Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group comparison. Clin Ther 2011; 33: 1932-1942.
    • (2011) Clin Ther , vol.33 , pp. 1932-1942
    • Wang, J.S.1    Lin, S.D.2    Lee, W.J.3    Su, S.L.4    Lee, I.T.5    Tu, S.T.6
  • 190
    • 0030870853 scopus 로고    scopus 로고
    • Small weight loss on long-term acarbose therapy with no change in dietary pattern or nutrient intake of individuals with non-insulin-dependent diabetes
    • Wolever TM, Chiasson JL, Josse RG, Hunt JA, Palmason C, Rodger NW et al. Small weight loss on long-term acarbose therapy with no change in dietary pattern or nutrient intake of individuals with non-insulin-dependent diabetes. Int J Obes Relat Metab Disord 1997; 21: 756-763.
    • (1997) Int J Obes Relat Metab Disord , vol.21 , pp. 756-763
    • Wolever, T.M.1    Chiasson, J.L.2    Josse, R.G.3    Hunt, J.A.4    Palmason, C.5    Rodger, N.W.6
  • 191
    • 52949100161 scopus 로고    scopus 로고
    • Clinical, endocrine, and metabolic effects of acarbose, a alpha-glucosidase inhibitor, in overweight and nonoverweight patients with polycystic ovarian syndrome
    • Tugrul S, Kutlu T, Pekin O, Baglam E, Kiyak H, Oral O. Clinical, endocrine, and metabolic effects of acarbose, a alpha-glucosidase inhibitor, in overweight and nonoverweight patients with polycystic ovarian syndrome. Fertil Steril 2008; 90: 1144-1148.
    • (2008) Fertil Steril , vol.90 , pp. 1144-1148
    • Tugrul, S.1    Kutlu, T.2    Pekin, O.3    Baglam, E.4    Kiyak, H.5    Oral, O.6
  • 192
    • 77953734934 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and pharmacodynamics of sergliflozin eta-bonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus
    • Hussey EK, Clark RV, Amin DM, Kipnes MS, O'Connor-Semmes RL, O'Driscoll EC et al. Single-dose pharmacokinetics and pharmacodynamics of sergliflozin eta-bonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus. J Clin Pharmacol 2010; 50: 623-635.
    • (2010) J Clin Pharmacol , vol.50 , pp. 623-635
    • Hussey, E.K.1    Clark, R.V.2    Amin, D.M.3    Kipnes, M.S.4    O'Connor-Semmes, R.L.5    O'Driscoll, E.C.6
  • 193
    • 77953801665 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor ofglucose reabsorption, in healthy overweight and obese subjects: A randomized double-blind study
    • Hussey EK, Dobbins RL, Stoltz RR, Stockman NL, O'Connor-Semmes RL, Kapur A et al. Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor ofglucose reabsorption, in healthy overweight and obese subjects: a randomized double-blind study. J Clin Pharmacol 2010; 50: 636-646.
    • (2010) J Clin Pharmacol , vol.50 , pp. 636-646
    • Hussey, E.K.1    Dobbins, R.L.2    Stoltz, R.R.3    Stockman, N.L.4    O'Connor-Semmes, R.L.5    Kapur, A.6
  • 195
    • 77953181310 scopus 로고    scopus 로고
    • Dapagliflozin treatment in patients with different stages oftype 2 diabetes mellitus: Effects on glycaemic control and body weight
    • Zhang L, Feng Y, List J, Kasichayanula S, Pfister M. Dapagliflozin treatment in patients with different stages oftype 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab 2010; 12: 510-516.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 510-516
    • Zhang, L.1    Feng, Y.2    List, J.3    Kasichayanula, S.4    Pfister, M.5
  • 196
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagli-flozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K, Yoon KH, Hruba V, Elze M, Langkilde AM, Parikh S. Effect of dapagli-flozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab 2011; 13: 928-938.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Elze, M.4    Langkilde, A.M.5    Parikh, S.6
  • 197
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del Prato S, Meier JJ, Duran-Garcia S, Rohwedder K, Elze M et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care 2011; 34: 2015-2022.
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.A.1    Del Prato, S.2    Meier, J.J.3    Duran-Garcia, S.4    Rohwedder, K.5    Elze, M.6
  • 198
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • Bolinder J, Ljunggren O, Kullberg J, Johansson L, Wilding J, Langkilde AM et al. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab 2012; 97: 1020-1031.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, O.2    Kullberg, J.3    Johansson, L.4    Wilding, J.5    Langkilde, A.M.6
  • 199
    • 84872109163 scopus 로고    scopus 로고
    • Pharma Times Online. Published on-line 07/20/2011 Accessed: 25 November 2011
    • Grogan K. FDA panel rejects B-MS/AZ's diabetes drug...but only just. Pharma Times Online. Published on-line 07/20/2011 http://www.pharmatimes.com/ Arti-cle/11-07-20/FDA-panel-rejects-B-MS-AZ-s-diabetes-drug-but-only-just.aspx. Accessed: 25 November 2011.
    • FDA Panel Rejects B-MS/AZ's Diabetes Drug..But only Just
    • Grogan, K.1
  • 200
    • 0034968529 scopus 로고    scopus 로고
    • Metformin, the rebirth of a biguanide: Mechanism of action and place in the prevention and treatment of insulin resistance
    • Mehnert H. Metformin, the rebirth of a biguanide: mechanism of action and place in the prevention and treatment of insulin resistance. Exp Clin Endocrinol Diabetes 2001; 109(Suppl 2): S259-S264.
    • (2001) Exp Clin Endocrinol Diabetes , vol.109 , Issue.SUPPL. 2
    • Mehnert, H.1
  • 201
    • 0041736553 scopus 로고    scopus 로고
    • Metformin: New understandings, new uses
    • Hundal RS, Inzucchi SE. Metformin: new understandings, new uses. Drugs 2003; 63: 1879-1894.
    • (2003) Drugs , vol.63 , pp. 1879-1894
    • Hundal, R.S.1    Inzucchi, S.E.2
  • 202
    • 20544470723 scopus 로고    scopus 로고
    • Addressing theglobal cardiovascular riskofhypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome in the southeastern United States, part II: Treatment recommendations for management of the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome
    • Bestermann W, Houston MC, Basile J, Egan B, Ferrario CM, Lackland D et al. Addressing theglobal cardiovascular riskofhypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome in the southeastern United States, part II: treatment recommendations for management of the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome. Am J Med Sci 2005; 329: 292-305.
    • (2005) Am J Med Sci , vol.329 , pp. 292-305
    • Bestermann, W.1    Houston, M.C.2    Basile, J.3    Egan, B.4    Ferrario, C.M.5    Lackland, D.6
  • 204
    • 78649638455 scopus 로고    scopus 로고
    • A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity
    • Rezvanian H, Hashemipour M, Kelishadi R,Tavakoli N, Poursafa P. A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity. World J Pediatr 2010;6:317-322.
    • (2010) World J Pediatr , vol.6 , pp. 317-322
    • Rezvanian, H.1    Hashemipour, M.2    Kelishadi, R.3    Tavakoli, N.4    Poursafa, P.5
  • 205
    • 0035321014 scopus 로고    scopus 로고
    • The effects of metformin on body mass index and glu-cose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes
    • Freemark M, Bursey D. The effects of metformin on body mass index and glu-cose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics 2001; 107: E55.
    • (2001) Pediatrics , vol.107
    • Freemark, M.1    Bursey, D.2
  • 206
    • 75849124826 scopus 로고    scopus 로고
    • Metformin extended release treatment of adolescent obesity: A 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up
    • Wilson DM, Abrams SH, Aye T, Lee PD, Lenders C, Lustig RH et al. Metformin extended release treatment of adolescent obesity: a 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up. Arch Pediatr Adolesc Med 2010; 164: 116-123.
    • (2010) Arch Pediatr Adolesc Med , vol.164 , pp. 116-123
    • Wilson, D.M.1    Abrams, S.H.2    Aye, T.3    Lee, P.D.4    Lenders, C.5    Lustig, R.H.6
  • 207
    • 79551597310 scopus 로고    scopus 로고
    • Effects of metformin on body weight and body composition in obese insulin-resistant children: A randomized clinical trial
    • Yanovski JA, Krakoff J, Salaita CG, Mc Duffie JR, Kozlosky M, Sebring NG et al. Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial. Diabetes 2011; 60: 477-485.
    • (2011) Diabetes , vol.60 , pp. 477-485
    • Yanovski, J.A.1    Krakoff, J.2    Salaita, C.G.3    Mc Duffie, J.R.4    Kozlosky, M.5    Sebring, N.G.6
  • 208
    • 33845809235 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention
    • Fu JF, Liang L, Zou CC, Hong F, Wang CL, Wang XM et al. Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention. Int J Obes (Lond) 2007; 31: 15-22.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 15-22
    • Fu, J.F.1    Liang, L.2    Zou, C.C.3    Hong, F.4    Wang, C.L.5    Wang, X.M.6
  • 209
    • 44949253252 scopus 로고    scopus 로고
    • Use of metformin in obese adolescents with hyper-insulinemia: A 6-month, randomized, double-blind, placebo-controlled clinical trial
    • Atabek ME, Pirgon O. Use of metformin in obese adolescents with hyper-insulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial. J Pediatr Endocrinol Metab 2008; 21: 339-348.
    • (2008) J Pediatr Endocrinol Metab , vol.21 , pp. 339-348
    • Atabek, M.E.1    Pirgon, O.2
  • 210
    • 70349578941 scopus 로고    scopus 로고
    • Metformin in combination with structured lifestyle intervention improved body mass index in obese adolescents, but did not improve insulin resistance
    • Clarson CL, Mahmud FH, Baker JE, Clark HE, Mc Kay WM, Schauteet VD et al. Metformin in combination with structured lifestyle intervention improved body mass index in obese adolescents, but did not improve insulin resistance. Endocrine 2009; 36: 141-146.
    • (2009) Endocrine , vol.36 , pp. 141-146
    • Clarson, C.L.1    Mahmud, F.H.2    Baker, J.E.3    Clark, H.E.4    Mc Kay, W.M.5    Schauteet, V.D.6
  • 211
    • 77957117682 scopus 로고    scopus 로고
    • Met-formin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: A prospective, placebo-controlled, randomized study
    • Wiegand S, l'Allemand D, Hubel H, Krude H, Burmann M, Martus P et al. Met-formin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study. Eur J Endocrinol 2010; 163: 585-592.
    • (2010) Eur J Endocrinol , vol.163 , pp. 585-592
    • Wiegand, S.1    L'Allemand, D.2    Hubel, H.3    Krude, H.4    Burmann, M.5    Martus, P.6
  • 212
    • 57349135982 scopus 로고    scopus 로고
    • Impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women: Do we need a new drug?
    • Legro RS. Impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women: do we need a new drug? J Clin Endocrinol Metab 2008; 93: 4218-4220.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4218-4220
    • Legro, R.S.1
  • 213
    • 31644449390 scopus 로고    scopus 로고
    • Effects of two forms of combined oral contraceptives on carbohydrate metabolism in adolescents with polycystic ovary syndrome
    • Mastorakos G, Koliopoulos C, Deligeoroglou E, Diamanti-Kandarakis E, Creatsas G. Effects of two forms of combined oral contraceptives on carbohydrate metabolism in adolescents with polycystic ovary syndrome. Fertil Steril 2006; 85: 420-427.
    • (2006) Fertil Steril , vol.85 , pp. 420-427
    • Mastorakos, G.1    Koliopoulos, C.2    Deligeoroglou, E.3    Diamanti-Kandarakis, E.4    Creatsas, G.5
  • 214
    • 57349113274 scopus 로고    scopus 로고
    • The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials
    • Hoeger K, Davidson K, Kochman L, Cherry T, Kopin L, Guzick DS. The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials. J Clin Endocrinol Metab 2008; 93: 4299-4306.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4299-4306
    • Hoeger, K.1    Davidson, K.2    Kochman, L.3    Cherry, T.4    Kopin, L.5    Guzick, D.S.6
  • 215
    • 11144354560 scopus 로고    scopus 로고
    • Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: Opposite effects on adipocytokines and body adiposity
    • Ibanez L, de Zegher F. Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity. J Clin Endocrinol Metab 2004; 89: 1592-1597.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1592-1597
    • Ibanez, L.1    De Zegher, F.2
  • 216
    • 33644868321 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome
    • Bridger T, Mac Donald S, Baltzer F, Rodd C. Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome. Arch Pediatr Adolesc Med 2006; 160: 241-246.
    • (2006) Arch Pediatr Adolesc Med , vol.160 , pp. 241-246
    • Bridger, T.1    Mac Donald, S.2    Baltzer, F.3    Rodd, C.4
  • 217
    • 24944480071 scopus 로고    scopus 로고
    • Rando-mized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome
    • Allen HF, Mazzoni C, Heptulla RA, Murray MA, Miller N, Koenigs L et al. Rando-mized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome. J Pediatr Endocrinol Metab 2005; 18: 761-768.
    • (2005) J Pediatr Endocrinol Metab , vol.18 , pp. 761-768
    • Allen, H.F.1    Mazzoni, C.2    Heptulla, R.A.3    Murray, M.A.4    Miller, N.5    Koenigs, L.6
  • 218
    • 0036283875 scopus 로고    scopus 로고
    • Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: Amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance
    • Arslanian SA, Lewy V, Danadian K, Saad R. Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab 2002; 87: 1555-1559.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1555-1559
    • Arslanian, S.A.1    Lewy, V.2    Danadian, K.3    Saad, R.4
  • 219
    • 33846294762 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents
    • Klein DJ, Cottingham EM, Sorter M, Barton BA, Morrison JA. A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. Am J Psychiatry 2006; 163: 2072-2079.
    • (2006) Am J Psychiatry , vol.163 , pp. 2072-2079
    • Klein, D.J.1    Cottingham, E.M.2    Sorter, M.3    Barton, B.A.4    Morrison, J.A.5
  • 220
    • 79251617420 scopus 로고    scopus 로고
    • Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: A systematic review and meta-analysis
    • Bjorkhem-Bergman L, Asplund AB, Lindh JD. Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis. J Psychopharmacol 2011; 25: 299-305.
    • (2011) J Psychopharmacol , vol.25 , pp. 299-305
    • Bjorkhem-Bergman, L.1    Asplund, A.B.2    Lindh, J.D.3
  • 221
    • 84859027506 scopus 로고    scopus 로고
    • Association of bio-chemical B12 deficiency with metformin therapy and vitamin B12 supplements: The national health and nutrition examination survey, 1999-2006
    • Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley Jr. GP . Association of bio-chemical B12 deficiency with metformin therapy and vitamin B12 supplements: the national health and nutrition examination survey, 1999-2006. Diabetes Care 2012; 35: 327-333.
    • (2012) Diabetes Care , vol.35 , pp. 327-333
    • Reinstatler, L.1    Qi, Y.P.2    Williamson, R.S.3    Garn, J.V.4    Oakley Jr., G.P.5
  • 224
    • 0042885664 scopus 로고    scopus 로고
    • Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome
    • Haqq AM, Stadler DD, Rosenfeld RG, Pratt KL, Weigle DS, Frayo RS et al. Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome. J Clin Endocrinol Metab 2003; 88: 3573-3576.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3573-3576
    • Haqq, A.M.1    Stadler, D.D.2    Rosenfeld, R.G.3    Pratt, K.L.4    Weigle, D.S.5    Frayo, R.S.6
  • 225
    • 0025915596 scopus 로고
    • Growth hormone alters lipolysis and hormone-sensitive lipase activity in 3T3-F442A adipocytes
    • Dietz J, Schwartz J. Growth hormone alters lipolysis and hormone-sensitive lipase activity in 3T3-F442A adipocytes. Metabolism 1991; 40: 800-806.
    • (1991) Metabolism , vol.40 , pp. 800-806
    • Dietz, J.1    Schwartz, J.2
  • 226
    • 0028895104 scopus 로고
    • Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replace-ment therapy
    • Snel YE, Doerga ME, Brummer RJ, Zelissen PM, Zonderland ML, Koppeschaar HP. Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replace-ment therapy. Eur J Endocrinol 1995; 133: 445-450.
    • (1995) Eur J Endocrinol , vol.133 , pp. 445-450
    • Snel, Y.E.1    Doerga, M.E.2    Brummer, R.J.3    Zelissen, P.M.4    Zonderland, M.L.5    Koppeschaar, H.P.6
  • 227
    • 0025808935 scopus 로고
    • Changes in body composition and energy expenditure after six weeks' growth hormone treat-ment
    • Gregory JW, Greene SA, Jung RT, Scrimgeour CM, Rennie MJ. Changes in body composition and energy expenditure after six weeks' growth hormone treat-ment. Arch Dis Child 1991; 66: 598-602.
    • (1991) Arch Dis Child , vol.66 , pp. 598-602
    • Gregory, J.W.1    Greene, S.A.2    Jung, R.T.3    Scrimgeour, C.M.4    Rennie, M.J.5
  • 228
    • 0038305741 scopus 로고    scopus 로고
    • Short-term effects of growth hormone on body composition as a predictor of growth
    • Hoos MB, Westerterp KR, Gerver WJ. Short-term effects of growth hormone on body composition as a predictor of growth. J Clin Endocrinol Metab 2003; 88: 2569-2572.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2569-2572
    • Hoos, M.B.1    Westerterp, K.R.2    Gerver, W.J.3
  • 229
    • 0344826523 scopus 로고    scopus 로고
    • Effects of growth hor-mone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients
    • Eden Engstrom B, Burman P, Holdstock C, Karlsson FA. Effects of growth hor-mone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 2003; 88: 5193-5198.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5193-5198
    • Eden Engstrom, B.1    Burman, P.2    Holdstock, C.3    Karlsson, F.A.4
  • 230
    • 0037656509 scopus 로고    scopus 로고
    • Growth hormone treatment improves body composition in adults with Prader-Willi syndrome
    • Hoybye C, Hilding A, Jacobsson H, Thoren M. Growth hormone treatment improves body composition in adults with Prader-Willi syndrome. Clin Endocrinol (Oxf) 2003; 58: 653-661.
    • (2003) Clin Endocrinol (Oxf) , vol.58 , pp. 653-661
    • Hoybye, C.1    Hilding, A.2    Jacobsson, H.3    Thoren, M.4
  • 231
    • 0036277762 scopus 로고    scopus 로고
    • Benefits of long-term GH therapy in Prader-Willi syndrome: A 4-year study
    • Carrel AL, Myers SE, Whitman BY, Allen DB. Benefits of long-term GH therapy in Prader-Willi syndrome: a 4-year study. J Clin Endocrinol Metab 2002; 87: 1581-1585.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1581-1585
    • Carrel, A.L.1    Myers, S.E.2    Whitman, B.Y.3    Allen, D.B.4
  • 232
    • 0033966287 scopus 로고    scopus 로고
    • Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement
    • Myers SE, Davis A, Whitman BY, Santiago JV, Landt M. Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement. Clin Endocrinol (Oxf) 2000; 52: 101-105.
    • (2000) Clin Endocrinol (Oxf) , vol.52 , pp. 101-105
    • Myers, S.E.1    Davis, A.2    Whitman, B.Y.3    Santiago, J.V.4    Landt, M.5
  • 233
    • 0043231590 scopus 로고    scopus 로고
    • Effects of growth hormone administration in human obesity
    • Shadid S, Jensen MD. Effects of growth hormone administration in human obesity. Obes Res 2003; 11: 170-175.
    • (2003) Obes Res , vol.11 , pp. 170-175
    • Shadid, S.1    Jensen, M.D.2
  • 235
    • 34247195576 scopus 로고    scopus 로고
    • [Changes in carbohydrate metabolism and insulin resistance in patients with Prader-Willi Syndrome (PWS) under growth hormone therapy]
    • Lammer C, Weimann E. [Changes in carbohydrate metabolism and insulin resistance in patients with Prader-Willi Syndrome (PWS) under growth hormone therapy]. Wien Med Wochenschr 2007; 157: 82-88.
    • (2007) Wien Med Wochenschr , vol.157 , pp. 82-88
    • Lammer, C.1    Weimann, E.2
  • 236
    • 79151480433 scopus 로고    scopus 로고
    • Effects ofgrowth hormone therapy on cardiac dimensions in children and adolescents with Prader-Willi syndrome
    • Hauffa BP, Knaup K, Lehmann N, Neudorf U, Nagel B. Effects ofgrowth hormone therapy on cardiac dimensions in children and adolescents with Prader-Willi syndrome. Horm Res Paediatr 2011; 75: 56-62.
    • (2011) Horm Res Paediatr , vol.75 , pp. 56-62
    • Hauffa, B.P.1    Knaup, K.2    Lehmann, N.3    Neudorf, U.4    Nagel, B.5
  • 238
    • 33845472885 scopus 로고    scopus 로고
    • Hokken-Koelega AC Sleep-related breathing disorders in prepubertal children with Prader-Willi syndrome and effects of growth hormone treatment
    • Festen DA, de Weerd AW, van den Bossche RA, Joosten K, Hoeve H, Hokken-Koelega AC Sleep-related breathing disorders in prepubertal children with Prader-Willi syndrome and effects of growth hormone treatment. J Clin Endo-crinol Metab 2006; 91: 4911-4915.
    • (2006) J Clin Endo-crinol Metab , vol.91 , pp. 4911-4915
    • Festen, D.A.1    De Weerd, A.W.2    Van Den Bossche, R.A.3    Joosten, K.4    Hoeve, H.5
  • 239
    • 84872104221 scopus 로고    scopus 로고
    • Genotropin (somatropin [r DNA origin] for injection) Accessed: 10 Jyly 2012
    • Genotropin (somatropin [r DNA origin] for injection). http://www.fda.gov/Safety/ Med Watch/Safety Information/Safety Alertsfor Human Medical Products/ucm153317. htm. Accessed: 10 Jyly 2012.
  • 240
    • 84872111418 scopus 로고    scopus 로고
    • US Food Drug Administration. Med Watch The FDA Safety Information and Adverse Event Reporting Program. Recombinant Human Growth Hormone (somatropin): Ongoing Safety Review - Possible Increased Risk of Death. Posted 12/22/2010 Accessed: 30 March 2012
    • US Food and Drug Administration. Med Watch The FDA Safety Information and Adverse Event Reporting Program. Recombinant Human Growth Hormone (somatropin): Ongoing Safety Review - Possible Increased Risk of Death. Posted 12/22/2010. http://www.fda.gov/Safety/Med Watch/Safety Information/Safety Alerts for Human Medical Products/ucm237969.htm. Accessed: 30 March 2012.
  • 241
    • 0033305646 scopus 로고    scopus 로고
    • Current and potential drugs for treatment of obesity
    • Bray GA, Greenway FL. Current and potential drugs for treatment of obesity. Endocr Rev 1999; 20: 805-875.
    • (1999) Endocr Rev , vol.20 , pp. 805-875
    • Bray, G.A.1    Greenway, F.L.2
  • 242
    • 0033942504 scopus 로고    scopus 로고
    • Thyroid hormones and treatment of obesity
    • Krotkiewski M. Thyroid hormones and treatment of obesity. Int J Obes Relat Metab Disord 2000; 24(Suppl 2): S116-S119.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , Issue.SUPPL. 2
    • Krotkiewski, M.1
  • 243
    • 0019782813 scopus 로고
    • Sudden death associated with thyroid hormone abuse
    • Bhasin S, Wallace W, Lawrence JB, Lesch M. Sudden death associated with thyroid hormone abuse. Am J Med 1981; 71: 887-890.
    • (1981) Am J Med , vol.71 , pp. 887-890
    • Bhasin, S.1    Wallace, W.2    Lawrence, J.B.3    Lesch, M.4
  • 244
    • 1942453725 scopus 로고    scopus 로고
    • Selective activation of thyroid hormone signaling pathways by GC-1: A new approach to controlling cholesterol and body weight
    • Baxter JD, Webb P, Grover G, Scanlan TS. Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight. Trends Endocrinol Metab 2004; 15: 154-157.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 154-157
    • Baxter, J.D.1    Webb, P.2    Grover, G.3    Scanlan, T.S.4
  • 245
    • 38649135692 scopus 로고    scopus 로고
    • The thyroid hormone mimetic compound KB2115 lowers plasma LDLcholesterol and stimulates bile acid synthesis without cardiac effects in humans
    • Berkenstam A, Kristensen J, Mellstrom K, Carlsson B, Malm J, Rehnmark S et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDLcholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci USA 2008; 105: 663-667.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 663-667
    • Berkenstam, A.1    Kristensen, J.2    Mellstrom, K.3    Carlsson, B.4    Malm, J.5    Rehnmark, S.6
  • 246
    • 0036783754 scopus 로고    scopus 로고
    • Effect of a 28-d treatment with L-796568, a novel beta (3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men
    • Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH et al. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr 2002; 76: 780-788.
    • (2002) Am J Clin Nutr , vol.76 , pp. 780-788
    • Larsen, T.M.1    Toubro, S.2    Van Baak, M.A.3    Gottesdiener, K.M.4    Larson, P.5    Saris, W.H.6
  • 247
    • 33846961446 scopus 로고    scopus 로고
    • Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabo-lism in obese individuals: A double-blind, placebo-controlled randomized study
    • Redman LM, de Jonge L, Fang X, Gamlin B, Recker D, Greenway FL et al. Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabo-lism in obese individuals: a double-blind, placebo-controlled randomized study. J Clin Endocrinol Metab 2007; 92: 527-531.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 527-531
    • Redman, L.M.1    De Jonge, L.2    Fang, X.3    Gamlin, B.4    Recker, D.5    Greenway, F.L.6
  • 248
    • 0033653610 scopus 로고    scopus 로고
    • Effects of the two beta3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects
    • Buemann B, Toubro S, Astrup A. Effects of the two beta3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects. Int J Obes Relat Metab Disord 2000; 24: 1553-1560.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 1553-1560
    • Buemann, B.1    Toubro, S.2    Astrup, A.3
  • 249
    • 0033763692 scopus 로고    scopus 로고
    • Thermogenic drugs as a strategy for treatment of obesity
    • Astrup A. Thermogenic drugs as a strategy for treatment of obesity. Endocrine 2000; 13: 207-212.
    • (2000) Endocrine , vol.13 , pp. 207-212
    • Astrup, A.1
  • 251
    • 64749097994 scopus 로고    scopus 로고
    • Treatment of hypothalamic obesity with caffeine and ephedrine
    • Greenway FL, Bray GA. Treatment of hypothalamic obesity with caffeine and ephedrine. Endocr Pract 2008; 14: 697-703.
    • (2008) Endocr Pract , vol.14 , pp. 697-703
    • Greenway, F.L.1    Bray, G.A.2
  • 252
    • 0033646869 scopus 로고    scopus 로고
    • Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents
    • Molnar D, Torok K, Erhardt E, Jeges S. Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents. Int J Obes Relat Metab Disord 2000; 24: 1573-1578.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 1573-1578
    • Molnar, D.1    Torok, K.2    Erhardt, E.3    Jeges, S.4
  • 253
    • 0345831912 scopus 로고    scopus 로고
    • Elec-trocardiographic and hemodynamic effects of a multicomponent dietary sup-plement containing ephedra and caffeine: A randomized controlled trial
    • Mc Bride BF, Karapanos AK, Krudysz A, Kluger J, Coleman CI, White CM. Elec-trocardiographic and hemodynamic effects of a multicomponent dietary sup-plement containing ephedra and caffeine: a randomized controlled trial. JAMA 2004; 291: 216-221.
    • (2004) JAMA , vol.291 , pp. 216-221
    • Mc Bride, B.F.1    Karapanos, A.K.2    Krudysz, A.3    Kluger, J.4    Coleman, C.I.5    White, C.M.6
  • 254
    • 0030728020 scopus 로고    scopus 로고
    • The effectiveness of long-term supplementation of carbohydrate, chromium, fibre and caffeine on weight maintenance
    • Pasman WJ, Westerterp-Plantenga MS, Saris WH. The effectiveness of long-term supplementation of carbohydrate, chromium, fibre and caffeine on weight maintenance. Int JObes Relat Metab Disord 1997; 21: 1143-1151.
    • (1997) Int J Obes Relat Metab Disord , vol.21 , pp. 1143-1151
    • Pasman, W.J.1    Westerterp-Plantenga, M.S.2    Saris, W.H.3
  • 256
    • 33749121586 scopus 로고    scopus 로고
    • Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: A randomized controlled trial
    • Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM et al. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial. Int J Obes (Lond) 2006; 30: 1545-1556.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1545-1556
    • Hackman, R.M.1    Havel, P.J.2    Schwartz, H.J.3    Rutledge, J.C.4    Watnik, M.R.5    Noceti, E.M.6
  • 257
    • 0027483543 scopus 로고
    • Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture
    • Toubro S, Astrup AV, Breum L, Quaade F. Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture. Int JObes Relat Metab Disord 1993; 17(Suppl 1): S69-S72.
    • (1993) Int JObes Relat Metab Disord , vol.17 , Issue.SUPPL. 1
    • Toubro, S.1    Astrup, A.V.2    Breum, L.3    Quaade, F.4
  • 259
    • 33845765350 scopus 로고    scopus 로고
    • Body fat loss achieved by stimulation of ther-mogenesis by a combination ofbioactivefood ingredients: A placebo-controlled, double-blind 8-week intervention in obese subjects
    • Belza A, Frandsen E, Kondrup J. Body fat loss achieved by stimulation of ther-mogenesis by a combination ofbioactivefood ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond) 2007; 31: 121-130.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 121-130
    • Belza, A.1    Frandsen, E.2    Kondrup, J.3
  • 260
    • 0035427921 scopus 로고    scopus 로고
    • The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent
    • Greenway FL. The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent. Obes Rev2001; 2: 199-211.
    • (2001) Obes Rev , vol.2 , pp. 199-211
    • Greenway, F.L.1
  • 261
    • 0026517115 scopus 로고
    • Long-term weight control: The National Heart, Lung, and Blood Insti-tute funded multimodal intervention study
    • Weintraub M. Long-term weight control: the National Heart, Lung, and Blood Insti-tute funded multimodal intervention study. Clin Pharmacol Ther 1992; 51: 581-585.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 581-585
    • Weintraub, M.1
  • 263
    • 79954561234 scopus 로고    scopus 로고
    • Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): A randomised, placebo-controlled, phase 3 trial
    • Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet 2011; 377: 1341-1352.
    • (2011) Lancet , vol.377 , pp. 1341-1352
    • Gadde, K.M.1    Allison, D.B.2    Ryan, D.H.3    Peterson, C.A.4    Troupin, B.5    Schwiers, M.L.6
  • 264
    • 84856388467 scopus 로고    scopus 로고
    • Two-year sustained weight loss and metabolic benefits with controlled-release phenter-mine/topiramate in obese and overweight adults (SEQUEL): A randomized, pla-cebo-controlled, phase 3 extension study
    • Garvey WT, Ryan DH, Look M, Gadde KM, Allison DB, Peterson CA et al. Two-year sustained weight loss and metabolic benefits with controlled-release phenter-mine/topiramate in obese and overweight adults (SEQUEL): a randomized, pla-cebo-controlled, phase 3 extension study. Am J Clin Nutr 2012; 95: 297-308.
    • (2012) Am J Clin Nutr , vol.95 , pp. 297-308
    • Garvey, W.T.1    Ryan, D.H.2    Look, M.3    Gadde, K.M.4    Allison, D.B.5    Peterson, C.A.6
  • 266
    • 0029919239 scopus 로고    scopus 로고
    • Adiposity and body mass indices in children: Benn's index and other weight for height indices as measures of relative adip-osity
    • Lazarus R, Baur L, Webb K, Blyth F. Adiposity and body mass indices in children: Benn's index and other weight for height indices as measures of relative adip-osity. Int J Obes Relat Metab Disord 1996; 20: 406-412.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 406-412
    • Lazarus, R.1    Baur, L.2    Webb, K.3    Blyth, F.4
  • 267
    • 84872109172 scopus 로고    scopus 로고
    • FDA. approves weight-management drug Qsymia Accessed: 18 July 2012
    • FDA. approves weight-management drug Qsymia. http://www.fda.gov/News Events/Newsroom/Press Announcements/ucm312468.htm. Accessed: 18 July 2012.
  • 268
    • 34548549373 scopus 로고    scopus 로고
    • Combination therapy of zonisa-mide and bupropion for weight reduction in obese women: A preliminary, randomized, open-label study
    • Gadde KM, Yonish GM, Foust MS, Wagner HR. Combination therapy of zonisa-mide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. J Clin Psychiatry 2007; 68: 1226-1229.
    • (2007) J Clin Psychiatry , vol.68 , pp. 1226-1229
    • Gadde, K.M.1    Yonish, G.M.2    Foust, M.S.3    Wagner, H.R.4
  • 270
    • 0029665733 scopus 로고    scopus 로고
    • Impaired glucose toler-ance in patients with chronic hypoxic pulmonary disease
    • Hjalmarsen A, Aasebo U, Birkeland K, Sager G, Jorde R. Impaired glucose toler-ance in patients with chronic hypoxic pulmonary disease. Diabetes Metab 1996; 22: 37-42.
    • (1996) Diabetes Metab , vol.22 , pp. 37-42
    • Hjalmarsen, A.1    Aasebo, U.2    Birkeland, K.3    Sager, G.4    Jorde, R.5
  • 272
    • 77956904326 scopus 로고    scopus 로고
    • Weight loss with naltrexone SR/Bupropion SR combination therapy as an adjunct to behavior modification: The COR-BMOD trial
    • Wadden TA, Foreyt JP, Foster GD, Hill JO, Klein S, O'Neil PM et al. Weight loss with naltrexone SR/Bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. Obesity (Silver Spring) 2011; 19: 110-120.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 110-120
    • Wadden, T.A.1    Foreyt, J.P.2    Foster, G.D.3    Hill, J.O.4    Klein, S.5    O'Neil, P.M.6
  • 273
    • 77956057548 scopus 로고    scopus 로고
    • Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): A multicentre, randomised, double-blind, placebo-con-trolled, phase 3 trial
    • Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-con-trolled, phase 3 trial. Lancet 2010; 376: 595-605.
    • (2010) Lancet , vol.376 , pp. 595-605
    • Greenway, F.L.1    Fujioka, K.2    Plodkowski, R.A.3    Mudaliar, S.4    Guttadauria, M.5    Erickson, J.6
  • 274
    • 77956904326 scopus 로고    scopus 로고
    • Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to beha-vior modification: The COR-BMOD trial
    • Wadden TA, Foreyt JP, Foster GD, Hill JO, Klein S, O'Neil PM et al. Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to beha-vior modification: the COR-BMOD trial. Obesity (Silver Spring) 2011; 19: 110-120.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 110-120
    • Wadden, T.A.1    Foreyt, J.P.2    Foster, G.D.3    Hill, J.O.4    Klein, S.5    O'Neil, P.M.6
  • 275
    • 70349757017 scopus 로고    scopus 로고
    • Contrave, a bupropion and naltrexone combination therapy for the potential treatment of obesity
    • Padwal R. Contrave, a bupropion and naltrexone combination therapy for the potential treatment of obesity. Curr Opin Investig Drugs 2009; 10: 1117-1125.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1117-1125
    • Padwal, R.1
  • 276
    • 84872108687 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration Centerfor Drug Evaluation and Research. U.S. Food and Drug Administration Silver Spring, Maryland Accessed: 5 November 2011
    • Tran PT, Thomas A. Summary Minutes of the Endocrinologic and Metabolic Drugs Advisory Committee. U.S. Food and Drug Administration Centerfor Drug Evaluation and Research. U.S. Food and Drug Administration Silver Spring, Maryland, 2010, pp 1-8http://www.fda.gov/Advisory Committees/Committees Meeting Materials/ Drugs/Endocrinologicand Metabolic Drugs Advisory Committee/ucm191113. htm. Accessed: 5 November 2011.
    • (2010) Summary Minutes of the Endocrinologic and Metabolic Drugs Advisory Committee , pp. 1-8
    • Tran, P.T.1    Thomas, A.2
  • 279
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • Ravussin E, Smith SR, Mitchell JA, Shringarpure R, Shan K, Maier H et al. Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity (Silver Spring) 2009; 17: 1736-1743.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3    Shringarpure, R.4    Shan, K.5    Maier, H.6
  • 280
    • 44449175729 scopus 로고    scopus 로고
    • Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies
    • Roth JD, Roland BL, Cole RL, Trevaskis JL, Weyer C, Koda JE et al. Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc Natl Acad Sci USA 2008; 105: 7257-7262.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7257-7262
    • Roth, J.D.1    Roland, B.L.2    Cole, R.L.3    Trevaskis, J.L.4    Weyer, C.5    Koda, J.E.6
  • 281
    • 49449114438 scopus 로고    scopus 로고
    • Antiobesity effects of the beta-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats
    • Roth JD, Trevaskis JL, Wilson J, Lei C, Athanacio J, Mack C et al. Antiobesity effects of the beta-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats. Int J Obes (Lond) 2008; 32: 1201-1210.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 1201-1210
    • Roth, J.D.1    Trevaskis, J.L.2    Wilson, J.3    Lei, C.4    Athanacio, J.5    MacK, C.6
  • 282
    • 77956094570 scopus 로고    scopus 로고
    • Enhanced weight loss fol-lowing coadministration of pramlintide with sibutramine or phentermine in a multicenter trial
    • Aronne LJ, Halseth AE, Burns CM, Miller S, Shen LZ. Enhanced weight loss fol-lowing coadministration of pramlintide with sibutramine or phentermine in a multicenter trial. Obesity (Silver Spring) 2010; 18: 1739-1746.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 1739-1746
    • Aronne, L.J.1    Halseth, A.E.2    Burns, C.M.3    Miller, S.4    Shen, L.Z.5
  • 284
    • 78049249912 scopus 로고    scopus 로고
    • Genetic susceptibility to obesity and related traits in childhood and adolescence: Influ-ence of loci identified by genome-wide association studies
    • den Hoed M, Ekelund U, Brage S, Grontved A, Zhao JH, Sharp SJ et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influ-ence of loci identified by genome-wide association studies. Diabetes 2010; 59: 2980-2988.
    • (2010) Diabetes , vol.59 , pp. 2980-2988
    • Den Hoed, M.1    Ekelund, U.2    Brage, S.3    Grontved, A.4    Zhao, J.H.5    Sharp, S.J.6
  • 285
    • 81855221882 scopus 로고    scopus 로고
    • Role of BMI-associated loci identified in GWAS meta-analyses in the context of common child-hood obesity in European Americans
    • Zhao J, Bradfield JP, Zhang H, Sleiman PM, Kim CE, Glessner JT et al. Role of BMI-associated loci identified in GWAS meta-analyses in the context of common child-hood obesity in European Americans. Obesity (Silver Spring) 2011; 19: 2436-2439.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 2436-2439
    • Zhao, J.1    Bradfield, J.P.2    Zhang, H.3    Sleiman, P.M.4    Kim, C.E.5    Glessner, J.T.6
  • 286
    • 70449851433 scopus 로고    scopus 로고
    • Reappraisal of European guidelines on hypertension management: A European Society of Hypertension Task Force document
    • Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document.J Hypertens 2009; 27: 2121-2158.
    • (2009) J Hypertens , vol.27 , pp. 2121-2158
    • Mancia, G.1    Laurent, S.2    Agabiti-Rosei, E.3    Ambrosioni, E.4    Burnier, M.5    Caulfield, M.J.6
  • 287
    • 79955039550 scopus 로고    scopus 로고
    • Attrition in paediatric weight management: A review of the literature and new directions
    • Skelton JA, Beech BM. Attrition in paediatric weight management: a review of the literature and new directions. Obes Rev 2011; 12: e273-e281.
    • (2011) Obes Rev , vol.12
    • Skelton, J.A.1    Beech, B.M.2
  • 288
    • 77950189829 scopus 로고    scopus 로고
    • CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials
    • Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Bmj 2010; 340: c332.
    • (2010) Bmj , vol.340
    • Schulz, K.F.1    Altman, D.G.2    Moher, D.3
  • 289
    • 15544363770 scopus 로고    scopus 로고
    • What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile?
    • Cole TJ, Faith MS, Pietrobelli A, Heo M. What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile? Eur J Clin Nutr 2005; 59: 419-425.
    • (2005) Eur J Clin Nutr , vol.59 , pp. 419-425
    • Cole, T.J.1    Faith, M.S.2    Pietrobelli, A.3    Heo, M.4
  • 290
    • 33845519508 scopus 로고    scopus 로고
    • Adiposity in adolescents: Change in actual BMI works better than change in BMI z score for longitudinal studies
    • Berkey CS, Colditz GA. Adiposity in adolescents: change in actual BMI works better than change in BMI z score for longitudinal studies. Ann Epidemiol 2007; 17: 44-50.
    • (2007) Ann Epidemiol , vol.17 , pp. 44-50
    • Berkey, C.S.1    Colditz, G.A.2
  • 291
    • 85047695511 scopus 로고    scopus 로고
    • Pharmacotherapy for obesity: A quantitative analysis offour decades ofpublished randomized clinical trials
    • Haddock CK, Poston WS, Dill PL, Foreyt JP, Ericsson M. Pharmacotherapy for obesity: a quantitative analysis offour decades ofpublished randomized clinical trials. Int J Obes Relat Metab Disord 2002; 26: 262-273.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. 262-273
    • Haddock, C.K.1    Poston, W.S.2    Dill, P.L.3    Foreyt, J.P.4    Ericsson, M.5
  • 292
    • 34648836960 scopus 로고    scopus 로고
    • Weight-loss outcomes: A systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up
    • Franz MJ, Van Wormer JJ, Crain AL, Boucher JL, Histon T, Caplan W et al. Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. J Am Diet Assoc 2007; 107: 1755-1767.
    • (2007) J Am Diet Assoc , vol.107 , pp. 1755-1767
    • Franz, M.J.1    Van Wormer, J.J.2    Crain, A.L.3    Boucher, J.L.4    Histon, T.5    Caplan, W.6
  • 293
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brandle M, Bebakar WM, Kamaruddin NA, Strand J et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009; 26: 268-278.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3    Bebakar, W.M.4    Kamaruddin, N.A.5    Strand, J.6
  • 294
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week ran-domised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week ran-domised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009; 374: 39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6
  • 295
    • 34548016826 scopus 로고    scopus 로고
    • Sitagliptin: A novel drug for the treatment of type 2 diabetes
    • Choy M, Lam S. Sitagliptin: a novel drug for the treatment of type 2 diabetes. Cardiol Rev 2007; 15: 264-271.
    • (2007) Cardiol Rev , vol.15 , pp. 264-271
    • Choy, M.1    Lam, S.2
  • 296
    • 80051872773 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin and the fixed-dose combination of sitagliptin and metformin vs. pioglitazone in drug-naive patients with type 2 diabetes
    • Perez-Monteverde A, Seck T, Xu L, Lee MA, Sisk CM, Williams-Herman DE et al. Efficacy and safety of sitagliptin and the fixed-dose combination of sitagliptin and metformin vs. pioglitazone in drug-naive patients with type 2 diabetes. Int J Clin Pract 2011; 65: 930-938.
    • (2011) Int J Clin Pract , vol.65 , pp. 930-938
    • Perez-Monteverde, A.1    Seck, T.2    Xu, L.3    Lee, M.A.4    Sisk, C.M.5    Williams-Herman, D.E.6
  • 297
    • 34547639141 scopus 로고    scopus 로고
    • Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males
    • Sloth B, Davidsen L, Holst JJ, Flint A, Astrup A. Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males. Am J Physiol Endocrinol Metab 2007; 293: E604-E609.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Sloth, B.1    Davidsen, L.2    Holst, J.J.3    Flint, A.4    Astrup, A.5
  • 299
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 2010; 375: 2223-2233.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5


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