Changes in carbohydrate metabolism and insulin resistance in patients with Prader-Willi Syndrome (PWS) under growth hormone therapy;Veränderung des kohlenhydratstoffwechsels und der insulinresistenz bei patienten mit Prader-Willi-syndrom unter einer wachstumshormontherapie

Wiener Medizinische Wochenschrift

Volumn 157, Issue 3-4, 2007, Pages 82-88

  Lämmer, Constanze ^a   Weimann, Edda ^a  

^a ST BERNWARD KRANKENHAUS   (Germany)

Author keywords

Growth hormone therapy; HOMA; Impaired carbohydrate metabolism; Insulin resistance; Prader Willi syndrome

Indexed keywords

C PEPTIDE; GROWTH HORMONE; HEMOGLOBIN A1C; INSULIN;

ARTICLE; BODY MASS; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; INFANT; INSULIN RESISTANCE; NEWBORN; ORAL GLUCOSE TOLERANCE TEST; PRADER WILLI SYNDROME;

ADOLESCENT; AGE FACTORS; ANTHROPOMETRY; BODY COMPOSITION; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HUMAN GROWTH HORMONE; HUMANS; INFANT; INSULIN RESISTANCE; MALE; PRADER-WILLI SYNDROME;

EID: 34247195576     PISSN: 00435341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10354-007-0382-1     Document Type: Article

References (20)

1. Prader A, Labhart A, Willi H (1956) Ein Syndrom von Adipositas, Kleinwuchs, Kryptorchismus und Oligophrenie nach myotonieartigem Zustand im Neugeborenenalter. Schweiz Med Wochenschr 86: 1260-1261
2. Cassidy SB (1984) Prader-Willi syndrom. Curr Probl Pediatr 14: 1-55
3. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glukcose and insulin concentrations in man. Diabetologia 28: 412-419
4. Marshall W A, Tanner J M (1969) Variations in the pattern of pubertal changes in girls. Arch Dis Childh 44: 291
5. Marshall W A, Tanner J M (1970) Variations in the pattern of pubertal changes in boys. Arch Dis Childh 45: 13
6. Nationale Versorgungsleitlinie (NVL, Aktualisierung 24.04.03) modifiziert nach http://www.leitlinien.de/versorgungsleitlinien
7. Eiholzer U, Stutz K, Weinmann T, Torresani T, Molinari L, Prader A (1998) Low insulin, IGF-1 and IGFBP-3 levels in children with Prader-Labhart-Willi syndrome, Eur J Pediatr 157: 890-893
8. L'Allemand D, Eiholzer U, Schlumpf M, Torresani T, Gilrard J (2000) Prader-Willi syndrome (PWS): Glucose homeostasia and insulin secretion remain unchanged after 3 years of treatment with hGH as an effect of improved body composition. Horm Res 53(Suppl 2): 131
9. Burman P, Ritzen M, Lindgren AC (2001) Endocrine dysfunction in Prader-Willi syndrome. A review with special reference to GH. Endocrine Reviews 22(6): 787-799
10. Grundy SM, Hansen B, Smith SC Jr, Cleeman JI, Kahn RA (2004) Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 109(4): 551-556
11. Hauffa BP (1997) One year of results of growth hormon treatment of short stature in Prader-Willi syndrome. Acta Paediatr Suppl 423: 63-65
12. Schuster DP, Osei K, Zipf WB (1996) Characterization of Alterations in Glucose and Insulin Metabolism in Prader-Willi subjects. Metabolism 45(12): 1514-1520
13. Angulo M, Castro-Magana M, Mazur B, Canas JA, Vitollo PM, Sarrantonio M (1996) Growth hormon secretion and effects of growth hormon therapy on growth velocity and weight gain in children with Prader-Willi syndrome. J Pediatr Endocrinol Metab 9: 393-400
14. Myers SE, Carrel AL, Whitman BY, Allen DB (2000) Sustained benefit after 2 years og growth hormone on body composition, fat utilisation, physical strength and agility, and growth in Prader-Willi syndrome. J Pediatr 137: 42-49
15. Carrel AL, Myers SE, Whitman BY, Allen DB (1999) Growth hormon improves body composition, fat utilization, physical srength and agility, and growth in Prader-Willi syndrome. A controlled study. J Pediatr 134: 215-221
16. Lindgren AC, Hagenäs L, Ritzen AE (1999) Growth hormon treatment of children with Prader-Willi syndrome: Effects on glucose and insulin homeostasis. Horm Res 51: 157-161
17. Reaven GM (1995) Pathophysiology of Insulin Resistance in Human Disease. Physiol Res 75: 473-486
18. Paterson WF, Donaldson MDC (2003) Growth hormone therapy in the Prader-Willi syndrome. Arch Dis Child 88: 283-285
19. Lindgren AC, Ritzen EM (1999) Five years of growth hormone treatment in children with Prader-Willi syndrome. Acta Paediatr Suppl 88: 109-111
20. Eiholzer U, l'Allemand D (2000) Growth hormone normalises height, prediction of final height and length in children with Prader-Willi syndrome after 4 years of therapy. Horm Res 53: 185-192