The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke intervention

Acta Pharmacologica Sinica

Volumn 34, Issue 1, 2013, Pages 33-38

  Leng, Tian Dong ^a   Xiong, Zhi Gang ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

acidosis; ASIC; ion channels; neurological disorders; proton; stroke

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; 6 [2 (1,2,3,4 TETRAHYDRO 1 ISOPROPYL 2 METHYL 7 ISOQUINOLINYL)CYCLOPROPYL] 2 NAPHTHALENECARBOXAMIDINE; ACETYLSALICYLIC ACID; ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL BLOCKING AGENT; AMILORIDE; BUPIVACAINE; DIAMIDINE DERIVATIVE; DIMINAZENE; FLURBIPROFEN; HYDROXYSTILBAMIDINE; IBUPROFEN; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; NONSTEROID ANTIINFLAMMATORY AGENT; PENTAMIDINE; ROPIVACAINE; TETRACAINE;

ANALGESIC ACTIVITY; ANTINOCICEPTION; BRAIN ELECTROPHYSIOLOGY; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CHRONIC PAIN; DRUG MECHANISM; HIPPOCAMPUS; HUMAN; LEARNING; LOCAL ANESTHESIA; MEMORY; NERVE CELL PLASTICITY; NEUROPROTECTION; NOCICEPTION; NONHUMAN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

ACID SENSING ION CHANNEL BLOCKERS; ACID SENSING ION CHANNELS; ANIMALS; BRAIN; HUMANS; SMALL MOLECULE LIBRARIES; STROKE;

EID: 84872053810     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.81     Document Type: Review

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