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Volumn 13, Issue 2, 2012, Pages 263-271

Physiological and pathological functions of acid-sensing ion channels in the central nervous system

Author keywords

Acid sensing ion channel; Acidosis; CNS; Function; Neurological disease; Neuron

Indexed keywords

A 317567; ACID SENSING ION CHANNEL; AMILORIDE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; CENTRAL NERVOUS SYSTEM AGENTS; PCTX 1; PCTX1; PENTETRAZOLE; PILOCARPINE; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84857133159     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012799201685     Document Type: Review
Times cited : (81)

References (111)
  • 1
    • 0025320647 scopus 로고
    • The regulation and modulation of pH in the nervous system
    • Chesler M. The regulation and modulation of pH in the nervous system. Prog Neurobiol 1990; 34: 401-427.
    • (1990) Prog Neurobiol , vol.34 , pp. 401-427
    • Chesler, M.1
  • 2
    • 0025817497 scopus 로고
    • Dynamics of interstitial and intracellular pH in evolving brain infarct
    • Nedergaard M, Kraig RP, Tanabe J, Pulsinelli WA. Dynamics of interstitial and intracellular pH in evolving brain infarct. Am J Physiol 1991; 260: R581-R588.
    • (1991) Am J Physiol , vol.260
    • Nedergaard, M.1    Kraig, R.P.2    Tanabe, J.3    Pulsinelli, W.A.4
  • 3
    • 0034037673 scopus 로고    scopus 로고
    • Penumbral tissue alkalosis in focal cerebral ischemia: Relationship to energy metabolism, blood flow, and steady potential
    • Back T, Hoehn M, Mies G, et al. Penumbral tissue alkalosis in focal cerebral ischemia: relationship to energy metabolism, blood flow, and steady potential. Ann Neurol 2000; 47: 485-492.
    • (2000) Ann Neurol , vol.47 , pp. 485-492
    • Back, T.1    Hoehn, M.2    Mies, G.3
  • 4
    • 0013363399 scopus 로고
    • Changes in tissue pH after circulatory arrest
    • Crowell JW, Kaufmann BN. Changes in tissue pH after circulatory arrest. Am J Physiol 1961; 200: 743-745.
    • (1961) Am J Physiol , vol.200 , pp. 743-745
    • Crowell, J.W.1    Kaufmann, B.N.2
  • 5
    • 0016153650 scopus 로고
    • Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemia
    • Ljunggren B, Norberg K, Siesjo BK. Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemia. Brain Res 1974; 77: 173-186.
    • (1974) Brain Res , vol.77 , pp. 173-186
    • Ljunggren, B.1    Norberg, K.2    Siesjo, B.K.3
  • 6
    • 0022004281 scopus 로고
    • Brain acidosis
    • Rehncrona S. Brain acidosis. Ann Emerg Med 1985; 14: 770-716.
    • (1985) Ann Emerg Med , vol.14 , pp. 770-776
    • Rehncrona, S.1
  • 7
    • 0024153902 scopus 로고
    • Acidosis and ischemic brain damage
    • Siesjo BK. Acidosis and ischemic brain damage. Neurochem Pathol 1988; 9: 31-88.
    • (1988) Neurochem Pathol , vol.9 , pp. 31-88
    • Siesjo, B.K.1
  • 9
    • 0027324191 scopus 로고
    • Evolving concepts about the role of acidosis in ischemic neuropathology
    • Tombaugh GC, Sapolsky RM. Evolving concepts about the role of acidosis in ischemic neuropathology. J Neurochem 1993; 61: 793-803.
    • (1993) J Neurochem , vol.61 , pp. 793-803
    • Tombaugh, G.C.1    Sapolsky, R.M.2
  • 10
    • 0001995299 scopus 로고
    • The painful focus. II. The relation of pain to local physico-chemical changes
    • Revici E, Stoopen E, Frenk E, Ravich RA. The painful focus. II. The relation of pain to local physico-chemical changes. Bull Inst Appl Biol 1949; 1: 21.
    • (1949) Bull Inst Appl Biol , vol.1 , pp. 21
    • Revici, E.1    Stoopen, E.2    Frenk, E.3    Ravich, R.A.4
  • 11
    • 0034589334 scopus 로고    scopus 로고
    • Chemical mediators of pain due to tissue damage and ischemia
    • Sutherland SP, Cook SP, McCleskey EW. Chemical mediators of pain due to tissue damage and ischemia. Prog Brain Res 2000; 129: 21-38.
    • (2000) Prog Brain Res , vol.129 , pp. 21-38
    • Sutherland, S.P.1    Cook, S.P.2    McCleskey, E.W.3
  • 12
    • 0025142479 scopus 로고
    • Modulation of the N-methyl-Daspartate channel by extracellular H+
    • Tang CM, Dichter M, Morad M. Modulation of the N-methyl-Daspartate channel by extracellular H+. Proc Natl Acad Sci USA 1990; 87: 6445-6449.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6445-6449
    • Tang, C.M.1    Dichter, M.2    Morad, M.3
  • 13
    • 0025350861 scopus 로고
    • Proton inhibition of N-methyl-Daspartate receptors in cerebellar neurons
    • Traynelis SF, Cull-Candy SG. Proton inhibition of N-methyl-Daspartate receptors in cerebellar neurons. Nature 1990; 345: 347-350.
    • (1990) Nature , vol.345 , pp. 347-350
    • Traynelis, S.F.1    Cull-Candy, S.G.2
  • 14
    • 0032103129 scopus 로고    scopus 로고
    • H(+)-gated cation channels: Neuronal acid sensors in the ENaC/DEG family of ion channels
    • Waldmann R, Lazdunski M. H(+)-gated cation channels: neuronal acid sensors in the ENaC/DEG family of ion channels. Curr Opin Neurobiol 1998; 8: 418-424.
    • (1998) Curr Opin Neurobiol , vol.8 , pp. 418-424
    • Waldmann, R.1    Lazdunski, M.2
  • 16
    • 0036521882 scopus 로고    scopus 로고
    • ASIC-like, proton-activated currents in rat hippocampal neurons
    • Baron A, Waldmann R, Lazdunski M. ASIC-like, proton-activated currents in rat hippocampal neurons. J Physiol 2002; 539: 485-494.
    • (2002) J Physiol , vol.539 , pp. 485-494
    • Baron, A.1    Waldmann, R.2    Lazdunski, M.3
  • 17
    • 0029922113 scopus 로고    scopus 로고
    • Cloning and expression of a novel human brain Na+ channel
    • Price MP, Snyder PM, Welsh MJ. Cloning and expression of a novel human brain Na+ channel. J Biol Chem 1996; 271: 7879-7882.
    • (1996) J Biol Chem , vol.271 , pp. 7879-7882
    • Price, M.P.1    Snyder, P.M.2    Welsh, M.J.3
  • 18
    • 18344371345 scopus 로고    scopus 로고
    • The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory
    • Wemmie JA, Chen J, Askwith CC, et al. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 2002; 34: 463-477.
    • (2002) Neuron , vol.34 , pp. 463-477
    • Wemmie, J.A.1    Chen, J.2    Askwith, C.C.3
  • 19
    • 0037235086 scopus 로고    scopus 로고
    • Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system
    • De La Rosa DA, Krueger SR, Kolar A, Shao D, Fitzsimonds RM, Canessa CM. Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system. J Physiol 2003; 546: 77-87.
    • (2003) J Physiol , vol.546 , pp. 77-87
    • de la Rosa, D.A.1    Krueger, S.R.2    Kolar, A.3    Shao, D.4    Fitzsimonds, R.M.5    Canessa, C.M.6
  • 20
    • 0019185036 scopus 로고
    • A receptor for protons in the nerve cell membrane
    • Krishtal OA, Pidoplichko VI. A receptor for protons in the nerve cell membrane. Neuroscience 1980; 5: 2325-2327.
    • (1980) Neuroscience , vol.5 , pp. 2325-2327
    • Krishtal, O.A.1    Pidoplichko, V.I.2
  • 21
    • 0025303235 scopus 로고
    • The proton-activated inward current of rat sensory neurons includes a calcium component
    • Kovalchuk Y, Krishtal OA, Nowycky MC. The proton-activated inward current of rat sensory neurons includes a calcium component. Neurosci Lett 1990; 115: 237-242.
    • (1990) Neurosci Lett , vol.115 , pp. 237-242
    • Kovalchuk, Y.1    Krishtal, O.A.2    Nowycky, M.C.3
  • 22
    • 0024429202 scopus 로고
    • Expression of depolarizing voltage- and transmitter-activated currents in neuronal precursor cells from the rat brain is preceded by a proton- activated sodium current
    • Grantyn R, Perouansky M, Rodriguez-Tebar A, Lux HD. Expression of depolarizing voltage- and transmitter-activated currents in neuronal precursor cells from the rat brain is preceded by a proton- activated sodium current. Brain Res Dev Brain Res 1989; 49: 150-155.
    • (1989) Brain Res Dev Brain Res , vol.49 , pp. 150-155
    • Grantyn, R.1    Perouansky, M.2    Rodriguez-Tebar, A.3    Lux, H.D.4
  • 23
    • 0026548134 scopus 로고
    • Proton-induced sodium current in freshly dissociated hypothalamic neurones of the rat
    • Ueno S, Nakaye T, Akaike N. Proton-induced sodium current in freshly dissociated hypothalamic neurones of the rat. J Physiol (Lond) 1992; 447: 309-327.
    • (1992) J Physiol (Lond) , vol.447 , pp. 309-327
    • Ueno, S.1    Nakaye, T.2    Akaike, N.3
  • 24
    • 0032757391 scopus 로고    scopus 로고
    • Proton-gated ion channels in cultured mouse cortical neurons
    • Varming T. Proton-gated ion channels in cultured mouse cortical neurons. Neuropharmacology 1999; 38: 1875-1881.
    • (1999) Neuropharmacology , vol.38 , pp. 1875-1881
    • Varming, T.1
  • 25
    • 0037235086 scopus 로고    scopus 로고
    • Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system
    • Alvarezdl R, Krueger SR, Kolar A, Shao D, Fitzsimonds RM, Canessa CM. Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system. J Physiol 2003; 546: 77-87.
    • (2003) J Physiol , vol.546 , pp. 77-87
    • Alvarezdl, R.1    Krueger, S.R.2    Kolar, A.3    Shao, D.4    Fitzsimonds, R.M.5    Canessa, C.M.6
  • 26
    • 2942575801 scopus 로고    scopus 로고
    • Acid-sensing ion channels (ASICs): New targets for the analgesic effects of non-steroid anti-Inflammatory drugs (NSAIDs)
    • Voilley N. Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-Inflammatory drugs (NSAIDs). Curr Drug Targets Inflamm Allergy 2004; 3: 71-79.
    • (2004) Curr Drug Targets Inflamm Allergy , vol.3 , pp. 71-79
    • Voilley, N.1
  • 27
    • 34249776660 scopus 로고    scopus 로고
    • Acid sensing ion channels-novel therapeutic targets for ischemic brain injury
    • Xiong ZG, Chu XP, Simon RP. Acid sensing ion channels-novel therapeutic targets for ischemic brain injury. Front Biosci 2007; 12: 1376-1386.
    • (2007) Front Biosci , vol.12 , pp. 1376-1386
    • Xiong, Z.G.1    Chu, X.P.2    Simon, R.P.3
  • 28
    • 33748797928 scopus 로고    scopus 로고
    • Acid-sensing ion channels: Advances, questions and therapeutic opportunities
    • Wemmie JA, Price MP, Welsh MJ. Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci 2006; 29: 578-586.
    • (2006) Trends Neurosci , vol.29 , pp. 578-586
    • Wemmie, J.A.1    Price, M.P.2    Welsh, M.J.3
  • 29
    • 4544230902 scopus 로고    scopus 로고
    • Neuroprotection in ischemia: Blocking calcium-permeable Acid-sensing ion channels
    • Xiong ZG, Zhu XM, Chu XP, et al. Neuroprotection in ischemia: blocking calcium-permeable Acid-sensing ion channels. Cell 2004; 118: 687-698.
    • (2004) Cell , vol.118 , pp. 687-698
    • Xiong, Z.G.1    Zhu, X.M.2    Chu, X.P.3
  • 30
    • 11344294298 scopus 로고    scopus 로고
    • Limiting stroke-induced damage by targeting an acid channel
    • Benveniste M, Dingledine R. Limiting stroke-induced damage by targeting an acid channel. N Engl J Med 2005; 352: 85-86.
    • (2005) N Engl J Med , vol.352 , pp. 85-86
    • Benveniste, M.1    Dingledine, R.2
  • 31
    • 4544356494 scopus 로고    scopus 로고
    • Ischemic stroke: Acidotoxicity is a perpetrator
    • Huang Y, McNamara JO. Ischemic stroke: acidotoxicity is a perpetrator. Cell 2004; 118: 665-666.
    • (2004) Cell , vol.118 , pp. 665-666
    • Huang, Y.1    McNamara, J.O.2
  • 32
    • 70149084337 scopus 로고    scopus 로고
    • Acid-sensing ion channels: A new target for pain and CNS diseases
    • Sluka KA, Winter OC, Wemmie JA. Acid-sensing ion channels: a new target for pain and CNS diseases. Curr Opin Drug Discov Devel 2009; 12: 693-704.
    • (2009) Curr Opin Drug Discov Devel , vol.12 , pp. 693-704
    • Sluka, K.A.1    Winter, O.C.2    Wemmie, J.A.3
  • 33
    • 0033858350 scopus 로고    scopus 로고
    • Structure and regulation of amiloride-sensitive sodium channels
    • Alvarezdl R, Canessa CM, Fyfe GK, Zhang P. Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol 2000; 62: 573-594.
    • (2000) Annu Rev Physiol , vol.62 , pp. 573-594
    • Alvarezdl, R.1    Canessa, C.M.2    Fyfe, G.K.3    Zhang, P.4
  • 34
    • 34548813656 scopus 로고    scopus 로고
    • Structure of acidsensing ion channel 1 at 1.9 A resolution and low pH
    • Jasti J, Furukawa H, Gonzales EB, Gouaux E. Structure of acidsensing ion channel 1 at 1.9 A resolution and low pH. Nature 2007; 449: 316-323.
    • (2007) Nature , vol.449 , pp. 316-323
    • Jasti, J.1    Furukawa, H.2    Gonzales, E.B.3    Gouaux, E.4
  • 35
    • 67949092829 scopus 로고    scopus 로고
    • Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
    • Gonzales EB, Kawate T, Gouaux E. Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature 2009; 460: 599-604.
    • (2009) Nature , vol.460 , pp. 599-604
    • Gonzales, E.B.1    Kawate, T.2    Gouaux, E.3
  • 36
    • 0042926849 scopus 로고    scopus 로고
    • The ASICs: Signaling molecules? Modulators?
    • Krishtal O. The ASICs: signaling molecules? Modulators? Trends Neurosci 2003; 26: 477-483.
    • (2003) Trends Neurosci , vol.26 , pp. 477-483
    • Krishtal, O.1
  • 37
    • 77954727554 scopus 로고    scopus 로고
    • Structure, function, and pharmacology of acidsensing ion channels (ASICs): Focus on ASIC1a
    • Grunder S, Chen X. Structure, function, and pharmacology of acidsensing ion channels (ASICs): focus on ASIC1a. Int J Physiol Pathophysiol Pharmacol 2010; 2: 73-94.
    • (2010) Int J Physiol Pathophysiol Pharmacol , vol.2 , pp. 73-94
    • Grunder, S.1    Chen, X.2
  • 38
  • 39
    • 79960024474 scopus 로고    scopus 로고
    • Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death
    • Sherwood TW, Lee KG, Gormley MG, Askwith CC. Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. J Neurosci 2011; 31: 9723-9734.
    • (2011) J Neurosci , vol.31 , pp. 9723-9734
    • Sherwood, T.W.1    Lee, K.G.2    Gormley, M.G.3    Askwith, C.C.4
  • 40
    • 77956010489 scopus 로고    scopus 로고
    • ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis
    • Mari Y, Katnik C, Cuevas J. ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. Cell Calcium 2010; 48: 70-82.
    • (2010) Cell Calcium , vol.48 , pp. 70-82
    • Mari, Y.1    Katnik, C.2    Cuevas, J.3
  • 41
    • 33750840489 scopus 로고    scopus 로고
    • Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines
    • Zha XM, Wemmie JA, Green SH, Welsh MJ. Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proc Natl Acad Sci USA 2006; 103: 16556-16561.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16556-16561
    • Zha, X.M.1    Wemmie, J.A.2    Green, S.H.3    Welsh, M.J.4
  • 42
    • 62549093076 scopus 로고    scopus 로고
    • Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry
    • Samways DS, Harkins AB, Egan TM. Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry. Cell Calcium 2009; 45: 319-325.
    • (2009) Cell Calcium , vol.45 , pp. 319-325
    • Samways, D.S.1    Harkins, A.B.2    Egan, T.M.3
  • 43
    • 54349098256 scopus 로고    scopus 로고
    • Sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1ainduced Ca2+ influx in rat cortical neurons
    • Herrera Y, Katnik C, Rodriguez JD, et al. Sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1ainduced Ca2+ influx in rat cortical neurons. J Pharmacol Exp Ther 2008; 327: 491-502.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 491-502
    • Herrera, Y.1    Katnik, C.2    Rodriguez, J.D.3
  • 44
    • 0026100801 scopus 로고
    • Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones
    • Bevan S, Yeats J. Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones. J Physiol (Lond) 1991; 433: 145-161.
    • (1991) J Physiol (Lond) , vol.433 , pp. 145-161
    • Bevan, S.1    Yeats, J.2
  • 45
    • 0019869717 scopus 로고
    • A receptor for protons in the membrane of sensory neurons may participate in nociception
    • Krishtal OA, Pidoplichko VI. A receptor for protons in the membrane of sensory neurons may participate in nociception. Neuroscience 1981; 6: 2599-2601.
    • (1981) Neuroscience , vol.6 , pp. 2599-2601
    • Krishtal, O.A.1    Pidoplichko, V.I.2
  • 46
    • 0036802854 scopus 로고    scopus 로고
    • Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors
    • Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S. Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest 2002; 110: 1185-1190.
    • (2002) J Clin Invest , vol.110 , pp. 1185-1190
    • Ugawa, S.1    Ueda, T.2    Ishida, Y.3    Nishigaki, M.4    Shibata, Y.5    Shimada, S.6
  • 47
    • 0344305593 scopus 로고    scopus 로고
    • Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
    • Sluka KA, Price MP, Breese NM, Stucky CL, Wemmie JA, Welsh MJ. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain 2003; 106: 229-239.
    • (2003) Pain , vol.106 , pp. 229-239
    • Sluka, K.A.1    Price, M.P.2    Breese, N.M.3    Stucky, C.L.4    Wemmie, J.A.5    Welsh, M.J.6
  • 49
    • 6344281041 scopus 로고    scopus 로고
    • Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord
    • Wu LJ, Duan B, Mei YD, et al. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem 2004; 279: 43716-43724.
    • (2004) J Biol Chem , vol.279 , pp. 43716-43724
    • Wu, L.J.1    Duan, B.2    Mei, Y.D.3
  • 50
    • 0033617361 scopus 로고    scopus 로고
    • Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation
    • Benson CJ, Eckert SP, McCleskey EW. Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation. Circ Res 1999; 84: 921-928.
    • (1999) Circ Res , vol.84 , pp. 921-928
    • Benson, C.J.1    Eckert, S.P.2    McCleskey, E.W.3
  • 51
    • 0034718899 scopus 로고    scopus 로고
    • The mammalian sodium channel BNC1 is required for normal touch sensation
    • Price MP, Lewin GR, McIlwrath SL, et al. The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 2000; 407: 1007-1011.
    • (2000) Nature , vol.407 , pp. 1007-1011
    • Price, M.P.1    Lewin, G.R.2    McIlwrath, S.L.3
  • 52
    • 18244402692 scopus 로고    scopus 로고
    • The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
    • Price MP, McIlwrath SL, Xie J, et al. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 2001; 32: 1071-1083.
    • (2001) Neuron , vol.32 , pp. 1071-1083
    • Price, M.P.1    McIlwrath, S.L.2    Xie, J.3
  • 53
    • 25444506199 scopus 로고    scopus 로고
    • Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function
    • Page AJ, Brierley SM, Martin CM, et al. Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut 2005; 54: 1408-1415.
    • (2005) Gut , vol.54 , pp. 1408-1415
    • Page, A.J.1    Brierley, S.M.2    Martin, C.M.3
  • 54
    • 0038206592 scopus 로고    scopus 로고
    • Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel
    • Ugawa S, Yamamoto T, Ueda T, et al. Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel. J Neurosci 2003; 23: 3616-3622.
    • (2003) J Neurosci , vol.23 , pp. 3616-3622
    • Ugawa, S.1    Yamamoto, T.2    Ueda, T.3
  • 55
    • 0344308302 scopus 로고    scopus 로고
    • Identification of sour-taste receptor genes
    • Ugawa S. Identification of sour-taste receptor genes. Anat Sci Int 2003; 78: 205-210.
    • (2003) Anat Sci Int , vol.78 , pp. 205-210
    • Ugawa, S.1
  • 56
    • 0036317716 scopus 로고    scopus 로고
    • Acid-activated cation currents in rat vallate taste receptor cells
    • Lin W, Ogura T, Kinnamon SC. Acid-activated cation currents in rat vallate taste receptor cells. J Neurophysiol 2002; 88: 133-141.
    • (2002) J Neurophysiol , vol.88 , pp. 133-141
    • Lin, W.1    Ogura, T.2    Kinnamon, S.C.3
  • 57
    • 0038384013 scopus 로고    scopus 로고
    • Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning
    • Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH, Jr., Welsh MJ. Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci 2003; 23: 5496-5502.
    • (2003) J Neurosci , vol.23 , pp. 5496-5502
    • Wemmie, J.A.1    Askwith, C.C.2    Lamani, E.3    Cassell, M.D.4    Freeman Jr., J.H.5    Welsh, M.J.6
  • 58
    • 0842347349 scopus 로고    scopus 로고
    • Acidsensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration
    • Ettaiche M, Guy N, Hofman P, Lazdunski M, Waldmann R. Acidsensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci 2004; 24: 1005-1012.
    • (2004) J Neurosci , vol.24 , pp. 1005-1012
    • Ettaiche, M.1    Guy, N.2    Hofman, P.3    Lazdunski, M.4    Waldmann, R.5
  • 59
    • 0034987184 scopus 로고    scopus 로고
    • Global ischemia induces expression of acid-sensing ion channel 2a in rat brain
    • Johnson MB, Jin K, Minami M, Chen D, Simon RP. Global ischemia induces expression of acid-sensing ion channel 2a in rat brain. J Cereb Blood Flow Metab 2001; 21: 734-740.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 734-740
    • Johnson, M.B.1    Jin, K.2    Minami, M.3    Chen, D.4    Simon, R.P.5
  • 60
    • 33845897638 scopus 로고    scopus 로고
    • Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia
    • Pignataro G, Simon RP, Xiong ZG. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 2007; 130: 151-158.
    • (2007) Brain , vol.130 , pp. 151-158
    • Pignataro, G.1    Simon, R.P.2    Xiong, Z.G.3
  • 61
    • 27844502151 scopus 로고    scopus 로고
    • Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death
    • Gao J, Duan B, Wang DG, et al. Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron 2005; 48: 635-646.
    • (2005) Neuron , vol.48 , pp. 635-646
    • Gao, J.1    Duan, B.2    Wang, D.G.3
  • 63
    • 36849009834 scopus 로고    scopus 로고
    • Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
    • Friese MA, Craner MJ, Etzensperger R, et al. Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med 2007; 13: 1483-1489.
    • (2007) Nat Med , vol.13 , pp. 1483-1489
    • Friese, M.A.1    Craner, M.J.2    Etzensperger, R.3
  • 64
    • 77953706080 scopus 로고    scopus 로고
    • ASICs aggravate acidosisinduced injuries during ischemic reperfusion
    • Gu L, Liu X, Yang Y, Luo D, Zheng X. ASICs aggravate acidosisinduced injuries during ischemic reperfusion. Neurosci Lett 2010; 479: 63-68.
    • (2010) Neurosci Lett , vol.479 , pp. 63-68
    • Gu, L.1    Liu, X.2    Yang, Y.3    Luo, D.4    Zheng, X.5
  • 65
    • 70449623627 scopus 로고    scopus 로고
    • Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death
    • Sherwood TW, Askwith CC. Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death. J Neurosci 2009; 29: 14371-14380.
    • (2009) J Neurosci , vol.29 , pp. 14371-14380
    • Sherwood, T.W.1    Askwith, C.C.2
  • 66
    • 49349115297 scopus 로고    scopus 로고
    • Amiloride is neuroprotective in an MPTP model of Parkinson's disease
    • Arias RL, Sung ML, Vasylyev D, et al. Amiloride is neuroprotective in an MPTP model of Parkinson's disease. Neurobiol Dis 2008; 31: 334-341.
    • (2008) Neurobiol Dis , vol.31 , pp. 334-341
    • Arias, R.L.1    Sung, M.L.2    Vasylyev, D.3
  • 67
    • 77953133213 scopus 로고    scopus 로고
    • Acid-sensing ion channels in acidosis-induced injury of human brain neurons
    • Li M, Inoue K, Branigan D, et al. Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab 2010; 30: 1247-1260.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1247-1260
    • Li, M.1    Inoue, K.2    Branigan, D.3
  • 68
    • 3142751119 scopus 로고    scopus 로고
    • Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons
    • Gao J, Wu LJ, Xu L, Xu TL. Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons. Brain Res 2004; 1017: 197-207.
    • (2004) Brain Res , vol.1017 , pp. 197-207
    • Gao, J.1    Wu, L.J.2    Xu, L.3    Xu, T.L.4
  • 69
    • 67649974460 scopus 로고    scopus 로고
    • ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95
    • Zha XM, Costa V, Harding AM, Reznikov L, Benson CJ, Welsh MJ. ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci 2009; 29: 8438-8446.
    • (2009) J Neurosci , vol.29 , pp. 8438-8446
    • Zha, X.M.1    Costa, V.2    Harding, A.M.3    Reznikov, L.4    Benson, C.J.5    Welsh, M.J.6
  • 70
    • 0036472120 scopus 로고    scopus 로고
    • Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)
    • Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ. Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). Biochem J 2002; 361: 443-450.
    • (2002) Biochem J , vol.361 , pp. 443-450
    • Hruska-Hageman, A.M.1    Wemmie, J.A.2    Price, M.P.3    Welsh, M.J.4
  • 71
    • 39149086985 scopus 로고    scopus 로고
    • Presynaptic Release Probability Is Increased in Hippocampal Neurons From ASIC1 Knockout Mice
    • Cho JH, Askwith CC. Presynaptic Release Probability Is Increased in Hippocampal Neurons From ASIC1 Knockout Mice. J Neurophysiol 2008; 99: 426-441.
    • (2008) J Neurophysiol , vol.99 , pp. 426-441
    • Cho, J.H.1    Askwith, C.C.2
  • 73
    • 35648992042 scopus 로고    scopus 로고
    • Targeting ASIC1a Reduces Innate Fear and Alters Neuronal Activity in the Fear Circuit
    • Coryell MW, Ziemann AE, Westmoreland PJ, et al. Targeting ASIC1a Reduces Innate Fear and Alters Neuronal Activity in the Fear Circuit. Biol Psychiatry 2007; 62: 1140-1188.
    • (2007) Biol Psychiatry , vol.62 , pp. 1140-1188
    • Coryell, M.W.1    Ziemann, A.E.2    Westmoreland, P.J.3
  • 74
    • 1542723399 scopus 로고    scopus 로고
    • Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior
    • Wemmie JA, Coryell MW, Askwith CC, et al. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci USA 2004; 101: 3621-3626.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3621-3626
    • Wemmie, J.A.1    Coryell, M.W.2    Askwith, C.C.3
  • 75
    • 58149389463 scopus 로고    scopus 로고
    • Restoring Acidsensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses
    • Coryell MW, Wunsch AM, Haenfler JM, et al. Restoring Acidsensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses. J Neurosci 2008; 28: 13738-13741.
    • (2008) J Neurosci , vol.28 , pp. 13738-13741
    • Coryell, M.W.1    Wunsch, A.M.2    Haenfler, J.M.3
  • 76
    • 70449753801 scopus 로고    scopus 로고
    • The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior
    • Ziemann AE, Allen JE, Dahdaleh NS, et al. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 2009; 139: 1012-1021.
    • (2009) Cell , vol.139 , pp. 1012-1021
    • Ziemann, A.E.1    Allen, J.E.2    Dahdaleh, N.S.3
  • 77
    • 0027239781 scopus 로고
    • Carbon dioxide hypersensitivity, hyperventilation, and panic disorder
    • Papp LA, Klein DF, Gorman JM. Carbon dioxide hypersensitivity, hyperventilation, and panic disorder. Am J Psychiatry 1993; 150: 1149-1157.
    • (1993) Am J Psychiatry , vol.150 , pp. 1149-1157
    • Papp, L.A.1    Klein, D.F.2    Gorman, J.M.3
  • 78
    • 33744988614 scopus 로고    scopus 로고
    • Silencing acid-sensing ion channel 1a alters cone-mediated retinal function
    • Ettaiche M, Deval E, Cougnon M, Lazdunski M, Voilley N. Silencing acid-sensing ion channel 1a alters cone-mediated retinal function. J Neurosci 2006; 26: 5800-5809.
    • (2006) J Neurosci , vol.26 , pp. 5800-5809
    • Ettaiche, M.1    Deval, E.2    Cougnon, M.3    Lazdunski, M.4    Voilley, N.5
  • 81
    • 79951542315 scopus 로고    scopus 로고
    • Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis
    • Duan B, Wang YZ, Yang T, et al. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci 2011; 31: 2101-2112.
    • (2011) J Neurosci , vol.31 , pp. 2101-2112
    • Duan, B.1    Wang, Y.Z.2    Yang, T.3
  • 82
    • 79961044889 scopus 로고    scopus 로고
    • Role of Acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury
    • Hu R, Duan B, Wang D, et al. Role of Acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Ann Surg 2011; 254: 353-362.
    • (2011) Ann Surg , vol.254 , pp. 353-362
    • Hu, R.1    Duan, B.2    Wang, D.3
  • 84
    • 33751180140 scopus 로고    scopus 로고
    • Axonal conduction and injury in multiple sclerosis: The role of sodium channels
    • Waxman SG. Axonal conduction and injury in multiple sclerosis: the role of sodium channels. Nat Rev Neurosci 2006; 7: 932-941.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 932-941
    • Waxman, S.G.1
  • 85
    • 0030966265 scopus 로고    scopus 로고
    • Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons
    • Stys PK, LoPachin RM. Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons. Neuroscience 1998; 82: 21-32.
    • (1998) Neuroscience , vol.82 , pp. 21-32
    • Stys, P.K.1    Lopachin, R.M.2
  • 86
    • 79551700814 scopus 로고    scopus 로고
    • Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model
    • Vergo S, Craner MJ, Etzensperger R, et al. Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model. Brain 2011; 134: 571-584.
    • (2011) Brain , vol.134 , pp. 571-584
    • Vergo, S.1    Craner, M.J.2    Etzensperger, R.3
  • 87
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003; 39: 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 88
    • 33746619968 scopus 로고    scopus 로고
    • Acid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage
    • Pidoplichko VI, Dani JA. Acid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage. Proc Natl Acad Sci USA 2006; 103: 11376-11380.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11376-11380
    • Pidoplichko, V.I.1    Dani, J.A.2
  • 89
    • 53349127249 scopus 로고    scopus 로고
    • Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism
    • Wong HK, Bauer PO, Kurosawa M, et al. Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism. Hum Mol Genet 2008; 17: 3223-3235.
    • (2008) Hum Mol Genet , vol.17 , pp. 3223-3235
    • Wong, H.K.1    Bauer, P.O.2    Kurosawa, M.3
  • 90
    • 65649108552 scopus 로고    scopus 로고
    • Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior
    • Coryell MW, Wunsch AM, Haenfler JM, et al. Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. J Neurosci 2009; 29: 5381-5388.
    • (2009) J Neurosci , vol.29 , pp. 5381-5388
    • Coryell, M.W.1    Wunsch, A.M.2    Haenfler, J.M.3
  • 91
    • 60449100825 scopus 로고    scopus 로고
    • Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models
    • Dwyer JM, Rizzo SJ, Neal SJ, et al. Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models. Psychopharmacology (Berl) 2009; 203: 41-52.
    • (2009) Psychopharmacology (Berl) , vol.203 , pp. 41-52
    • Dwyer, J.M.1    Rizzo, S.J.2    Neal, S.J.3
  • 92
    • 77955144561 scopus 로고    scopus 로고
    • Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression
    • Wu WL, Lin YW, Min MY, Chen CC. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. Genes Brain Behav 2010; 9: 603-614.
    • (2010) Genes Brain Behav , vol.9 , pp. 603-614
    • Wu, W.L.1    Lin, Y.W.2    Min, M.Y.3    Chen, C.C.4
  • 93
    • 62249172184 scopus 로고    scopus 로고
    • Distribution of acid-sensing ion channel 3 in the rat hypothalamus
    • Meng QY, Wang W, Chen XN, Xu TL, Zhou JN. Distribution of acid-sensing ion channel 3 in the rat hypothalamus. Neuroscience 2009; 159: 1126-1134.
    • (2009) Neuroscience , vol.159 , pp. 1126-1134
    • Meng, Q.Y.1    Wang, W.2    Chen, X.N.3    Xu, T.L.4    Zhou, J.N.5
  • 95
    • 0021926748 scopus 로고
    • Influence of the blood-brain pH gradient on brain phenobarbital uptake during status epilepticus
    • Simon RP, Benowitz N, Hedlund R, Copeland J. Influence of the blood-brain pH gradient on brain phenobarbital uptake during status epilepticus. J Pharmacol Exp Ther 1985; 234: 830-835.
    • (1985) J Pharmacol Exp Ther , vol.234 , pp. 830-835
    • Simon, R.P.1    Benowitz, N.2    Hedlund, R.3    Copeland, J.4
  • 96
    • 0021163253 scopus 로고
    • Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression
    • Somjen GG. Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression. Brain Res 1984; 311: 186-188.
    • (1984) Brain Res , vol.311 , pp. 186-188
    • Somjen, G.G.1
  • 97
    • 0026705552 scopus 로고
    • Modulation of pH by neuronal activity
    • Chesler M, Kaila K. Modulation of pH by neuronal activity. Trends Neurosci 1992; 15: 396-402.
    • (1992) Trends Neurosci , vol.15 , pp. 396-402
    • Chesler, M.1    Kaila, K.2
  • 98
    • 0024267243 scopus 로고
    • Stimulus-induced extracellular pH transients in the in vitro turtle cerebellum
    • Chesler M, Chan CY. Stimulus-induced extracellular pH transients in the in vitro turtle cerebellum. Neuroscience 1988; 27: 941-948.
    • (1988) Neuroscience , vol.27 , pp. 941-948
    • Chesler, M.1    Chan, C.Y.2
  • 99
    • 0018114701 scopus 로고
    • Time course of changes of extracellular H+ and K+ activities during and after direct electrical stimulation of the brain cortex
    • Urbanics R, Leniger-Follert E, Lubbers DW. Time course of changes of extracellular H+ and K+ activities during and after direct electrical stimulation of the brain cortex. Pflugers Arch 1978; 378: 47-53.
    • (1978) Pflugers Arch , vol.378 , pp. 47-53
    • Urbanics, R.1    Leniger-Follert, E.2    Lubbers, D.W.3
  • 100
    • 0035109992 scopus 로고    scopus 로고
    • Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy
    • Biagini G, Babinski K, Avoli M, Marcinkiewicz M, Seguela P. Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy. Neurobiol Dis 2001; 8: 45-58.
    • (2001) Neurobiol Dis , vol.8 , pp. 45-58
    • Biagini, G.1    Babinski, K.2    Avoli, M.3    Marcinkiewicz, M.4    Seguela, P.5
  • 101
    • 3042673221 scopus 로고    scopus 로고
    • Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior
    • Ali A, Ahmad FJ, Pillai KK, Vohora D. Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior. Epilepsy Behav 2004; 5: 322-328.
    • (2004) Epilepsy Behav , vol.5 , pp. 322-328
    • Ali, A.1    Ahmad, F.J.2    Pillai, K.K.3    Vohora, D.4
  • 102
    • 33646757231 scopus 로고    scopus 로고
    • Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice
    • Ali A, Pillai KP, Ahmad FJ, Dua Y, Vohora D. Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice. Pharmacol Rep 2006; 58: 242-245.
    • (2006) Pharmacol Rep , vol.58 , pp. 242-245
    • Ali, A.1    Pillai, K.P.2    Ahmad, F.J.3    Dua, Y.4    Vohora, D.5
  • 103
    • 46749138207 scopus 로고    scopus 로고
    • Amiloride delays the onset of pilocarpine-induced seizures in rats
    • N'Gouemo P. Amiloride delays the onset of pilocarpine-induced seizures in rats. Brain Res 2008; 1222: 230-232.
    • (2008) Brain Res , vol.1222 , pp. 230-232
    • N'Gouemo, P.1
  • 104
    • 84873072284 scopus 로고    scopus 로고
    • Involvement of acid-sensing ion channels in the generation of epileptic seizure activity
    • Chang SY, Li MH, Li TF, et al. Involvement of acid-sensing ion channels in the generation of epileptic seizure activity. Soc.Neurosci.Abstr. 257.5. 2007.
    • (2007) Soc.Neurosci.Abstr , vol.257 , pp. 5
    • Chang, S.Y.1    Li, M.H.2    Li, T.F.3
  • 105
    • 46049117310 scopus 로고    scopus 로고
    • Seizure termination by acidosis depends on ASIC1a
    • Ziemann AE, Schnizler MK, Albert GW, et al. Seizure termination by acidosis depends on ASIC1a. Nat Neurosci 2008; 11: 816-822.
    • (2008) Nat Neurosci , vol.11 , pp. 816-822
    • Ziemann, A.E.1    Schnizler, M.K.2    Albert, G.W.3
  • 106
    • 77958193903 scopus 로고    scopus 로고
    • Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons
    • Li M, Kratzer E, Inoue K, Simon RP, Xiong ZG. Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons. J Physiol 2010; 588: 3883-3900.
    • (2010) J Physiol , vol.588 , pp. 3883-3900
    • Li, M.1    Kratzer, E.2    Inoue, K.3    Simon, R.P.4    Xiong, Z.G.5
  • 107
    • 77952382875 scopus 로고    scopus 로고
    • Cell type-specific expression of acidsensing ion channels in hippocampal interneurons
    • Weng JY, Lin YC, Lien CC. Cell type-specific expression of acidsensing ion channels in hippocampal interneurons. J Neurosci 2010; 30: 6548-6558.
    • (2010) J Neurosci , vol.30 , pp. 6548-6558
    • Weng, J.Y.1    Lin, Y.C.2    Lien, C.C.3
  • 108
    • 0038351735 scopus 로고    scopus 로고
    • Acid-sensing ion channels in malignant gliomas
    • Berdiev BK, Xia J, McLean LA, et al. Acid-sensing ion channels in malignant gliomas. J Biol Chem 2003; 278: 15023-15034.
    • (2003) J Biol Chem , vol.278 , pp. 15023-15034
    • Berdiev, B.K.1    Xia, J.2    McLean, L.A.3
  • 109
    • 69949158818 scopus 로고    scopus 로고
    • Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration
    • Kapoor N, Bartoszewski R, Qadri YJ, et al. Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. J Biol Chem 2009; 284: 24526-24541.
    • (2009) J Biol Chem , vol.284 , pp. 24526-24541
    • Kapoor, N.1    Bartoszewski, R.2    Qadri, Y.J.3
  • 110
    • 33745863036 scopus 로고    scopus 로고
    • Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells
    • Vila-Carriles WH, Kovacs GG, Jovov B, et al. Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. J Biol Chem 2006; 281: 19220-19232.
    • (2006) J Biol Chem , vol.281 , pp. 19220-19232
    • Vila-Carriles, W.H.1    Kovacs, G.G.2    Jovov, B.3
  • 111
    • 34547451001 scopus 로고    scopus 로고
    • Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators
    • Xu TL, Xiong ZG. Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators. Curr Med Chem 2007; 14: 1753-17563.
    • (2007) Curr Med Chem , vol.14 , pp. 1753-17563
    • Xu, T.L.1    Xiong, Z.G.2


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