Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

PLoS Neglected Tropical Diseases

Volumn 6, Issue 12, 2012, Pages

  Rigalli, Juan P ^a,b   Perdomo, Virginia G ^a   Luquita, Marcelo G ^a   Villanueva, Silvina S M ^a   Arias, Agostina ^a   Theile, Dirk ^b   Weiss, Johanna ^b   Mottino, Aldo D ^a   Ruiz, María L ^a   Catania, Viviana A ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BENZNIDAZOLE; CYTOCHROME P450 3A4; GLUTATHIONE TRANSFERASE; MULTIDRUG RESISTANCE PROTEIN; PREGNANE X RECEPTOR; SMALL INTERFERING RNA; VERAPAMIL;

ARTICLE; BIOTRANSFORMATION; CELL VIABILITY; CHAGAS DISEASE; CONTROLLED STUDY; DRUG TRANSPORT; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MESSENGER RNA; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANTIPROTOZOAL AGENTS; BIOTRANSFORMATION; BLOTTING, WESTERN; GENE EXPRESSION PROFILING; HEP G2 CELLS; HEPATOCYTES; HUMANS; METABOLIC NETWORKS AND PATHWAYS; NITROIMIDAZOLES; P-GLYCOPROTEIN; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, STEROID; UP-REGULATION;

EID: 84872038118     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001951     Document Type: Article

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