Cytochrome P450 1A1/2 induction by antiparasitic drugs: Dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells

European Journal of Clinical Pharmacology

Volumn 58, Issue 8, 2002, Pages 537-542

  Bapiro, Tashinga E ^a   Andersson, Tommy B ^b   Otter, Charlotta ^b   Hasler, Julia A ^a   Masimirembwa, Collen M ^b  

^a UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Albendazole; CYP1A induction; Quinine

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 CHLOROPHENYLBIGUANIDE; ALBENDAZOLE; AMODIAQUINE; ANTIPARASITIC AGENT; ARTEMISININ; ARTESUNATE; ATOVAQUONE; BIGUANIDE DERIVATIVE; CYCLOGUANIL; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DAPSONE; DEETHYLAMODIAQUINE; DIETHYLCARBAMAZINE; DIHYDROARTEMISININ; ETHOXYRESORUFIN DEETHYLASE; IVERMECTIN; MELARSOPROL; METRIFONATE; NICLOSAMIDE; PRAZIQUANTEL; PRIMAQUINE; PROGUANIL; PYRANTEL; PYRIMETHAMINE; QUININE; SURAMIN; TIABENDAZOLE; TINIDAZOLE; UNCLASSIFIED DRUG; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CONCENTRATION; DRUG EFFECT; DRUG EXPOSURE; DRUG RESEARCH; ENZYME ACTIVITY; ENZYME INDUCTION; FLUOROMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; METABOLISM;

ALBENDAZOLE; ANTIPARASITIC AGENTS; CELL SURVIVAL; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; HUMANS; PRIMAQUINE; QUININE; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TUMOR CELLS, CULTURED;

EID: 0036835707     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-002-0512-z     Document Type: Article

References (21)

1. Abdi YA, Gustafsson LL, Ericsson O, Hellgren U (1995) Handbook of Drugs for Tropical Parasitic Infections. Taylor and Francis, London
2. Asteinza J, Camacho-Carranza R, Reyes-Reyes RE, Dorado-Gonzalez V, Espinosa-Aguirre (2000) Induction of cytochrome P450 enzymes by albendazole treatment in the rat. Environ Toxicol Pharmacol 9:31-37
3. Bozdech V, Mason P (1992) The Chemotherapy of Human Parasitic Disease. University of Zimbabwe Publications, Harare
4. Cusack BJ, Dawson GW, Mercer GD, Vestal RE (1985) Cigarette smoking and theophylline metabolism: Effects of cimetidine. Clin Pharmacol Ther 37:330-336
5. Delescluse C, Ledirac N, Li R, Piechocki MP, Hines RN, Gidrol X, Rahmani R (2001) Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochem Pharmacol 61:399-407
6. Fontaine F, Delescluse C, de Sousa G, Lesca P, Rahmani R (1999) Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: Absence of binding to the aryl hydrocarbon receptor. Biochem Pharmacol 57:255-262
7. Gonzalez FJ, Gelboin HV (1994) Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab Rev 26:165-183
8. Karbwang J, Molunto P, Bunnag D, Harinasuta T (1991) Plasma quinine levels in patients with falciparum malaria when given alone or in combination with tetracycline with or without primaquine. Southeast Asian J Trop Med Public Health 22:72-76
9. Kashfi K, McDougall CJ and Dannenberg AJ (1995) Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human. Clin Pharmacol Ther 58:625-630
10. Kikuchi H, Kato H, Mizuno M, Hossain A, Ikawa S, Miyazaki J, Watanabe M (1996) Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: Evidences of a human-specific signal transduction pathway for CYP1A1 induction. Arch Biochem Biophys 334:235-240
11. Kleeberg U, Frötschl R, Krusekopf S, Brockmöller J, Roots I, Ruckpaul K, Hildebrandt A (1999) Induction of CYP1A by various benzimidazoles and its significance in administrative drug regulation. Drug Metab Rev 31:381-392
12. Marriner SE, Morris DL, Dickson B, Bogan JA (1986) Phamacokinetics of albendazole in man. Eur J Clin Pharmacol 30:705-708
13. Orzechowski A, Schrenk D, Schut HAJ, Bock KW (1994) Consequences of 3-methylcholanthrene-type induction for the metabolism of 4-aminophenyl in isolated ra hepatocytes. Carcinogenesis 15:489-494
14. Souhaili-El Amri H, Fargetton X, Benoit E, Totis M, Bati A-M (1988a) Inducing effect of albendazole on rat liver drug metabolizing enzymes and metabolite pharmacokinetics. Toxicol Appl Pharmacol 92:141-149
15. Souhaili-El Amri H, Mothe O, Totis M, Masson C, Batt A-M, Delatour P, Siest G (1988b) Albendazole sulphonation by rat liver cytochrome P-450c. J Pharmacol Exp Ther 246:758-764
16. Steiger U, Cotting J, Reichen J (1990) Albendazole treatment of echinococcosis in humans: Effects on microsomal metabolism and drug tolerance. Clin Pharmacol Ther 47:347-353
17. Sumida A, Fukuen S, Yamamoto I, Matsuda H, Naohara M, Azuma J (2000) Quantitative analysis of constitutive and inducible CYPs mRNA expression in the HepG2 cell line using reverse transcription-competitive PCR. Biochem Biophys Res Commun 267:756-760
18. Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky L (2001) Polycyclic aromatic hydrocarbon/metal mixtures: Effect on PAH induction of CYP1A1 in human HepG2 cells. Drug Metab Dispos 29:999-1006
19. Van Hensbroek MB, Onyiorah E, Jaffaar S, Schneider G, Palmer A, Frenkel J, Enwere G, Forck S, Nusmeijer A, Bennett S, Greenwood B, Kwiatkowski D (1996) A trial of artemether or quinine in children with cerebral malaria. N Engl J Med 335:69-75
20. Wanwimolruk S, Wong SM, Zhang H, Coville PF, Walker RJ (1995) Metabolism of quinine in man: Identification of a major metabolite, and effects of smoking and rifampicin pretreatment. J Pharm Pharmacol 47:957-963
21. Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki A (1996) Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther 3:1327-1334