메뉴 건너뛰기




Volumn 69, Issue 3, 2005, Pages 531-539

Mechanisms involved in spironolactone-induced choleresis in the rat: Role of multidrug resistance-associated protein 2

Author keywords

AE2; Bile flow; Bsep; Glutathione; Mrp2; Spironolactone

Indexed keywords

2,4 DINITROPHENOL; ANTIPORTER; BICARBONATE; DEOXYCHOLIC ACID; GLUTATHIONE; MULTIDRUG RESISTANCE PROTEIN 2; PROTEIN; SPIRONOLACTONE;

EID: 19944429478     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.10.017     Document Type: Article
Times cited : (23)

References (43)
  • 1
    • 0032540277 scopus 로고    scopus 로고
    • The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
    • T. Gerloff, B. Stieger, B. Hagenbuch, J. Madon, L. Landmann, and J. Roth The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver J Biol Chem 273 1998 10046 10050
    • (1998) J Biol Chem , vol.273 , pp. 10046-10050
    • Gerloff, T.1    Stieger, B.2    Hagenbuch, B.3    Madon, J.4    Landmann, L.5    Roth, J.6
  • 2
    • 0026497882 scopus 로고
    • Glutathione as a primary osmotic driving force in hepatic bile formation
    • N. Ballatori, and A.T. Troung Glutathione as a primary osmotic driving force in hepatic bile formation Am J Physiol 263 1992 617 624
    • (1992) Am J Physiol , vol.263 , pp. 617-624
    • Ballatori, N.1    Troung, A.T.2
  • 3
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • J. Konig, A.T. Nies, Y. Cui, I. Leier, and D. Keppler Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance Biochim Biophys Acta 1461 1999 377 394
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 377-394
    • Konig, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 4
    • 0037084149 scopus 로고    scopus 로고
    • Inhibition of Mrp2- and Ycf1 p-mediated transport by reducing agents: Evidence for GSH transport on rat Mrp2
    • J.F. Rebbeor, G.C. Connolly, and N. Ballatori Inhibition of Mrp2- and Ycf1 p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2 Biochim Biophys Acta 1559 2002 171 178
    • (2002) Biochim Biophys Acta , vol.1559 , pp. 171-178
    • Rebbeor, J.F.1    Connolly, G.C.2    Ballatori, N.3
  • 5
    • 0021975908 scopus 로고
    • Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles
    • P.J. Meier, R. Knickelbein, R.H. Moseley, J.W. Dobbins, and J.L. Boyer Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles J Clin Invest 75 1985 1256 1263
    • (1985) J Clin Invest , vol.75 , pp. 1256-1263
    • Meier, P.J.1    Knickelbein, R.2    Moseley, R.H.3    Dobbins, J.W.4    Boyer, J.L.5
  • 6
    • 0018003268 scopus 로고
    • Importance of bicarbonate in bile salt independent fraction of bile flow
    • W.G.M. Hardison, and C.A. Wood Importance of bicarbonate in bile salt independent fraction of bile flow Am J Physiol 235 1978 158 164
    • (1978) Am J Physiol , vol.235 , pp. 158-164
    • Hardison, W.G.M.1    Wood, C.A.2
  • 8
    • 0015979590 scopus 로고
    • Increased canalicular bile production induced by pregnenolone 16α-carbonitrile, spironolactone and cortisol in rats
    • G. Zsigmond, and B. Solymoss Increased canalicular bile production induced by pregnenolone 16α-carbonitrile, spironolactone and cortisol in rats Proc Exp Biol Med 145 1974 631 635
    • (1974) Proc Exp Biol Med , vol.145 , pp. 631-635
    • Zsigmond, G.1    Solymoss, B.2
  • 9
    • 34250397270 scopus 로고
    • Effect of phenobarbital, spironolactone and pregnenolone 16α-carbonitrile on bile formation in the rat
    • D. von Bergmann, H.P. Schwarz, and G. Paumgartner Effect of phenobarbital, spironolactone and pregnenolone 16α-carbonitrile on bile formation in the rat Naunyn-Schmiedebergs Arch Pharmacol 287 1975 33 45
    • (1975) Naunyn-Schmiedebergs Arch Pharmacol , vol.287 , pp. 33-45
    • Von Bergmann, D.1    Schwarz, H.P.2    Paumgartner, G.3
  • 10
    • 0032553581 scopus 로고    scopus 로고
    • Differential induction of glutathione S-transferase subunits by spironolactone in rat liver, jejunum and colon
    • V.A. Catania, M.G. Luquita, E.J. Sanchez Pozzi, and A.D. Mottino Differential induction of glutathione S-transferase subunits by spironolactone in rat liver, jejunum and colon Life Sci 63 1998 2285 2293
    • (1998) Life Sci , vol.63 , pp. 2285-2293
    • Catania, V.A.1    Luquita, M.G.2    Sanchez Pozzi, E.J.3    Mottino, A.D.4
  • 12
    • 0036303955 scopus 로고    scopus 로고
    • Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways
    • D.R. Johnson, and C.D. Klaassen Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways Toxicol Sci 67 2002 182 189
    • (2002) Toxicol Sci , vol.67 , pp. 182-189
    • Johnson, D.R.1    Klaassen, C.D.2
  • 13
    • 0024519450 scopus 로고
    • Additive effect of combined spironolactone and phenobarbital treatment on hepatic bilirubin UDP-glucuronyltransferase
    • A.D. Mottino, E.E. Guibert, and E.A. Rodriguez Garay Additive effect of combined spironolactone and phenobarbital treatment on hepatic bilirubin UDP-glucuronyltransferase Biochem Pharmacol 38 1989 851 853
    • (1989) Biochem Pharmacol , vol.38 , pp. 851-853
    • Mottino, A.D.1    Guibert, E.E.2    Rodriguez Garay, E.A.3
  • 14
    • 72849179070 scopus 로고
    • Enzymatic analysis of steroid hormones
    • P. Talalay Enzymatic analysis of steroid hormones Methods Biochem Anal 8 1960 119 143
    • (1960) Methods Biochem Anal , vol.8 , pp. 119-143
    • Talalay, P.1
  • 15
    • 0019167355 scopus 로고
    • Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpiridine
    • O.W. Griffith Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpiridine Anal Biochem 106 1980 207 212
    • (1980) Anal Biochem , vol.106 , pp. 207-212
    • Griffith, O.W.1
  • 16
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • F. Tietze Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues Anal Biochem 27 1969 502 522
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 17
    • 0034928369 scopus 로고    scopus 로고
    • Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: A study in vivo and in isolated hepatocyte couplets
    • F.A. Crocenzi, E.J. Sanchez Pozzi, J.M. Pellegrino, C.O. Favre, E.A. Rodriguez Garay, and A.D. Mottino Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets Hepatology 34 2001 329 339
    • (2001) Hepatology , vol.34 , pp. 329-339
    • Crocenzi, F.A.1    Sanchez Pozzi, E.J.2    Pellegrino, J.M.3    Favre, C.O.4    Rodriguez Garay, E.A.5    Mottino, A.D.6
  • 18
    • 0021708185 scopus 로고
    • Development and validation of a method for measuring the glycine and taurine conjugates of bile acids in bile by high-performance liquid chromatography
    • P.S. Tietz, J.L. Thiestle, L.J. Miller, and N.F. LaRusso Development and validation of a method for measuring the glycine and taurine conjugates of bile acids in bile by high-performance liquid chromatography J Chromatogr 336 1984 249 257
    • (1984) J Chromatogr , vol.336 , pp. 249-257
    • Tietz, P.S.1    Thiestle, J.L.2    Miller, L.J.3    Larusso, N.F.4
  • 21
    • 0002966509 scopus 로고
    • Bile flow
    • I.M. Arias J.L. Boyer N. Fausto W.B. Jakoby D.A. Schachter D.S. Shafritz 3rd ed. Raven Press New York
    • S. Erlinger Bile flow I.M. Arias J.L. Boyer N. Fausto W.B. Jakoby D.A. Schachter D.S. Shafritz The liver: biology and pathobiology 3rd ed. 1994 Raven Press New York 769 786
    • (1994) The Liver: Biology and Pathobiology , pp. 769-786
    • Erlinger, S.1
  • 22
    • 0021349075 scopus 로고
    • Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver
    • P.J. Meier, E.S. Sztul, A. Reuben, and J.L. Boyer Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver J Cell Biol 98 1984 991 1000
    • (1984) J Cell Biol , vol.98 , pp. 991-1000
    • Meier, P.J.1    Sztul, E.S.2    Reuben, A.3    Boyer, J.L.4
  • 25
    • 0015752890 scopus 로고
    • Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion
    • P.O. Seglen Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion Exp Cell Res 82 1973 391 398
    • (1973) Exp Cell Res , vol.82 , pp. 391-398
    • Seglen, P.O.1
  • 26
    • 0024312957 scopus 로고
    • Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia
    • R.P.J. Oude Elferink, R. Ottenhoff, W. Liefting, J. de Hann, and P.L.M. Jansen Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia J Clin Invest 84 1989 476 483
    • (1989) J Clin Invest , vol.84 , pp. 476-483
    • Oude Elferink, R.P.J.1    Ottenhoff, R.2    Liefting, W.3    De Hann, J.4    Jansen, P.L.M.5
  • 27
    • 0025888299 scopus 로고
    • Intrahepatic conversion of a glutathione conjugate to its mercapturic acid. Metabolism of 1-chloro-2,4-dinitrobenzene in isolated perfused rat and guinea pig livers
    • C.A. Hinchman, H. Matsumoto, T.W. Simmons, and N. Ballatori Intrahepatic conversion of a glutathione conjugate to its mercapturic acid. Metabolism of 1-chloro-2,4-dinitrobenzene in isolated perfused rat and guinea pig livers J Biol Chem 266 1991 22179 22185
    • (1991) J Biol Chem , vol.266 , pp. 22179-22185
    • Hinchman, C.A.1    Matsumoto, H.2    Simmons, T.W.3    Ballatori, N.4
  • 28
    • 33947557927 scopus 로고
    • Nonenzymatic cleavages of peptide chains at the cysteine and serine residues through their conversion to dehydroalanine (DHAL). II. The specific chemical cleavage of cysteinyl peptides
    • M. Sokolovsky, T. Sadeh, and A. Patchornik Nonenzymatic cleavages of peptide chains at the cysteine and serine residues through their conversion to dehydroalanine (DHAL). II. The specific chemical cleavage of cysteinyl peptides J Am Chem Soc 86 1964 1210 1217
    • (1964) J Am Chem Soc , vol.86 , pp. 1210-1217
    • Sokolovsky, M.1    Sadeh, T.2    Patchornik, A.3
  • 29
    • 0036186927 scopus 로고    scopus 로고
    • Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2
    • D.R. Johnson, S.S.M. Habeebu, and C.D. Klaassen Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2 Toxicol Sci 66 2002 16 26
    • (2002) Toxicol Sci , vol.66 , pp. 16-26
    • Johnson, D.R.1    Habeebu, S.S.M.2    Klaassen, C.D.3
  • 30
    • 0015415160 scopus 로고
    • Hepatic synthesis of bile acids biochemical steps and mechanisms of rate control
    • E.H. Mosbach Hepatic synthesis of bile acids biochemical steps and mechanisms of rate control Arch Intern Med 130 1972 478 487
    • (1972) Arch Intern Med , vol.130 , pp. 478-487
    • Mosbach, E.H.1
  • 31
    • 0036086427 scopus 로고    scopus 로고
    • Nuclear receptors. I. Nuclear receptors and bile acids homeostasis
    • B. Goodwin, and S.A. Kliewer Nuclear receptors. I. Nuclear receptors and bile acids homeostasis Am J Physiol 282 2002 926 931
    • (2002) Am J Physiol , vol.282 , pp. 926-931
    • Goodwin, B.1    Kliewer, S.A.2
  • 32
    • 0034782509 scopus 로고    scopus 로고
    • Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor
    • J.L. Staudinger, Y. Liu, A. Madan, S. Habeebu, and C.D. Klaassen Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor Drug Metab Dispos 29 2001 1467 1472
    • (2001) Drug Metab Dispos , vol.29 , pp. 1467-1472
    • Staudinger, J.L.1    Liu, Y.2    Madan, A.3    Habeebu, S.4    Klaassen, C.D.5
  • 33
    • 0032437889 scopus 로고    scopus 로고
    • Environmental xenobiotics and the antihormone cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the Cyp3A23 hormone response element
    • E.G. Schuetz, C. Brimer, and J.D. Schuetz Environmental xenobiotics and the antihormone cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the Cyp3A23 hormone response element Mol Pharmacol 54 1998 1113 1117
    • (1998) Mol Pharmacol , vol.54 , pp. 1113-1117
    • Schuetz, E.G.1    Brimer, C.2    Schuetz, J.D.3
  • 34
    • 0024499938 scopus 로고
    • Relation between biliary glutathione excretion and bile acid-independent bile flow
    • N. Ballatori, and A.T. Troung Relation between biliary glutathione excretion and bile acid-independent bile flow Am J Physiol 256 1989 22 30
    • (1989) Am J Physiol , vol.256 , pp. 22-30
    • Ballatori, N.1    Troung, A.T.2
  • 35
    • 0031393668 scopus 로고    scopus 로고
    • Is intracellular pH and/or intracellular bicarbonate a determinant of bile salt independent canalicular bile formation? the subject revisited
    • H.-G. Krenhuber, F.X. Felberbauer, and J. Graf Is intracellular pH and/or intracellular bicarbonate a determinant of bile salt independent canalicular bile formation? The subject revisited Yale J Biol Med 70 1998 459 469
    • (1998) Yale J Biol Med , vol.70 , pp. 459-469
    • Krenhuber, H.-G.1    Felberbauer, F.X.2    Graf, J.3
  • 36
    • 0034910651 scopus 로고    scopus 로고
    • Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver
    • K. Hirata, and M.H. Nathanson Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver Gastroenterology 121 2001 396 406
    • (2001) Gastroenterology , vol.121 , pp. 396-406
    • Hirata, K.1    Nathanson, M.H.2
  • 37
    • 0036070539 scopus 로고    scopus 로고
    • Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition
    • P.M. Gerk, and M. Vore Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition J Pharmacol Exp Ther 302 2002 407 415
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 407-415
    • Gerk, P.M.1    Vore, M.2
  • 38
    • 0017125012 scopus 로고
    • Effect of spironolactone on blood bile-acid levels
    • T. Feher, A. Varadi, and A. Tanko Effect of spironolactone on blood bile-acid levels Lancet 308 1976 51
    • (1976) Lancet , vol.308 , pp. 51
    • Feher, T.1    Varadi, A.2    Tanko, A.3
  • 39
    • 11844280235 scopus 로고
    • Effect of spironolactone on bilirubin conjugation by the rat liver
    • A.D. Mottino, J.A. Rasero, and E.A. Rodriguez Garay Effect of spironolactone on bilirubin conjugation by the rat liver Biochem Pharmacol 51 1979 319 323
    • (1979) Biochem Pharmacol , vol.51 , pp. 319-323
    • Mottino, A.D.1    Rasero, J.A.2    Rodriguez Garay, E.A.3
  • 40
    • 0032769284 scopus 로고    scopus 로고
    • Transport of monoglucuronosyi and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2
    • T. Kamisako, I. Leier, Y. Cui, J. Koning, U. Buchholz, and J. Hummel-Eisenbeiss Transport of monoglucuronosyi and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2 Hepatology 30 1999 485 490
    • (1999) Hepatology , vol.30 , pp. 485-490
    • Kamisako, T.1    Leier, I.2    Cui, Y.3    Koning, J.4    Buchholz, U.5    Hummel-Eisenbeiss, J.6
  • 41
    • 0036209248 scopus 로고    scopus 로고
    • Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
    • S.A. Kliewer, and T.M. Willson Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor J Lipid Res 43 2002 359 364
    • (2002) J Lipid Res , vol.43 , pp. 359-364
    • Kliewer, S.A.1    Willson, T.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.