Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding

Biochemical Journal

Volumn 382, Issue 2, 2004, Pages 711-716

  Alqawi, Omar ^a   Bates, Susan ^b   Georges, Elias ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Breast cancer resistance protein (BCRP); Drug interactions; Multidrug resistance; Photoaffinity labelling; Rhodamine 123

Indexed keywords

BINDING ENERGY; CELLS; DRUG DOSAGE; ENZYME INHIBITION; MUTAGENESIS; TUMORS;

BREAST CANCER; MULTIDRUG; THREONINE MUTATION;

PROTEINS;

ARGININE; BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; IODOARYLAZIDO RHODAMINE 123; METHOTREXATE; MITOXANTRONE; MUTANT PROTEIN; PACLITAXEL; RHODAMINE 123; THREONINE; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; TUMOR PROTEIN;

ARTICLE; BINDING AFFINITY; CELL GROWTH; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; PHOTOAFFINITY LABELING; POINT MUTATION; PRIORITY JOURNAL; TRANSPORT AND BINDING PHENOMENA; TRANSPORT KINETICS; WILD TYPE; ACTIVE TRANSPORT; AMINO ACID SUBSTITUTION; BREAST TUMOR; GENETICS; METABOLISM; MISSENSE MUTATION; MULTIDRUG RESISTANCE; PATHOLOGY; PROTEIN BINDING; TUMOR CELL LINE;

MINK CELL FOCUS-FORMING VIRUS;

AMINO ACID SUBSTITUTION; ARGININE; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT, ACTIVE; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; HUMANS; MUTATION, MISSENSE; NEOPLASM PROTEINS; PROTEIN BINDING; RHODAMINE 123; THREONINE;

EID: 4544275886     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040355     Document Type: Article

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