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Volumn 109, Issue 2, 2009, Pages 242-250

Induction of multiple drug transporters by efavirenz

Author keywords

Drug drug interaction; Efavirenz; Induction; Transporter

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER C1; ABC TRANSPORTER C2; ABC TRANSPORTER C3; ABC TRANSPORTER C4; ABC TRANSPORTER C5; BREAST CANCER RESISTANCE PROTEIN; EFAVIRENZ; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN SLCO2B1; PROTEIN SLCO3A1; RIFAMPICIN; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOXAZINE DERIVATIVE; CYTOCHROME P450; ORGANIC ANION TRANSPORTER;

EID: 65449141703     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08209FP     Document Type: Article
Times cited : (61)

References (41)
  • 1
    • 67649313777 scopus 로고    scopus 로고
    • Panel on antiretroviral guidelines for adult and adolescents
    • Department of Health and Human Services January 29, (8 April 2008, date last accessed)
    • Panel on Antiretroviral Guidelines for Adult and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. Department of Health and Human Services. 2008, January 29. pp 1-128, http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf (8 April 2008, date last accessed)
    • (2008) Guidelines for the use of Antiretroviral Agents in HIV-1 Infected Adults and Adolescents , pp. 1-128
  • 2
    • 0035967245 scopus 로고    scopus 로고
    • Interactions among drugs for HIV and opportunistic infections
    • Piscitelli SC, Gallicano KD. Interactions among drugs for HIV and opportunistic infections. New Engl J Med. 2001;344:984-996.
    • (2001) New Engl J Med. , vol.34 , pp. 984-996
    • Piscitelli, S.C.1    Gallicano, K.D.2
  • 3
    • 34248392975 scopus 로고    scopus 로고
    • Why do patients fail HIV therapy?
    • Waters L, Nelson M. Why do patients fail HIV therapy? Int J Clin Pract. 2007;61:983-990.
    • (2007) Int J Clin Pract. , vol.6 , pp. 983-990
    • Waters, L.1    Nelson, M.2
  • 5
    • 33845881481 scopus 로고    scopus 로고
    • Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers
    • Faucette S, Zhang T-C, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, et al. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther. 2007;320:72-80.
    • (2007) J Pharmacol Exp Ther. , vol.32 , pp. 72-80
    • Faucette, S.1    Zhang, T.-C.2    Moore, R.3    Sueyoshi, T.4    Omiecinski, C.J.5    LeCluyse, E.L.6
  • 6
    • 6344240478 scopus 로고    scopus 로고
    • Induction of CYP3A4 by efavirenz in primary human hepatocytes: Comparison with rifampin and phenobarbital
    • Hariparsad N, Nallani SC, Sane RS, Buckley DJ, Buckley AR, Desai PB. Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J Clin Pharmacol. 2004;44:1273-1281.
    • (2004) J Clin Pharmacol. , vol.4 , pp. 1273-1281
    • Hariparsad, N.1    Nallani, S.C.2    Sane, R.S.3    Buckley, D.J.4    Buckley, A.R.5    Desai, P.B.6
  • 7
    • 37549018985 scopus 로고    scopus 로고
    • Comparison of the induction of P-glycoprotein activity by nucleotide nucleoside and non-nucleoside reverse transcriptase inhibitors
    • Weiss J, Weis N, Ketabi-Kiyanvash, Storch CH, Haefeli WE. Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors. Eur J Pharmacol. 2008;579:104-109.
    • (2008) Eur J Pharmacol. , vol.57 , pp. 104-109
    • Weiss, J.1    Weis, N.2    Ketabi-Kiyanvash3    Storch, C.H.4    Haefeli, W.E.5
  • 8
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med. 2001;7:584-590.
    • (2001) Nat Med. , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 9
    • 0038798874 scopus 로고    scopus 로고
    • Drug-activated nuclear receptors CAR and PXR
    • Honkakoski P, Sueyoshi T, Negishi M. Drug-activated nuclear receptors CAR and PXR. Ann Med. 2003;35:172-182.
    • (2003) Ann Med. , vol.3 , pp. 172-182
    • Honkakoski, P.1    Sueyoshi, T.2    Negishi, M.3
  • 10
    • 0034052258 scopus 로고    scopus 로고
    • Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors
    • Huisman MT, Smit JW, Schinkel AH. Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors. AIDS. 2000;14:237-242.
    • (2000) AIDS , vol.1 , pp. 237-242
    • Huisman, M.T.1    Smit, J.W.2    Schinkel, A.H.3
  • 11
    • 0037159933 scopus 로고    scopus 로고
    • Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors and transport can be enhanced by other drugs
    • Huisman MT, Smit JW, Crommentuyn KM, Zelcer N, Wiltshire HR, Beijnen JH, et al. Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. 2002;16:2295-2301.
    • (2002) AIDS , vol.1 , pp. 2295-2301
    • Huisman, M.T.1    Smit, J.W.2    Crommentuyn, K.M.3    Zelcer, N.4    Wiltshire, H.R.5    Beijnen, J.H.6
  • 12
    • 0035958776 scopus 로고    scopus 로고
    • P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?
    • Jones K, Bray PG, Khoo SH, Davey RA, Meaden ER, Ward SA, et al. P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance? AIDS. 2001;27:1353-1358.
    • (2001) AIDS , vol.2 , pp. 1353-1358
    • Jones, K.1    Bray, P.G.2    Khoo, S.H.3    Davey, R.A.4    Meaden, E.R.5    Ward, S.A.6
  • 13
    • 0032879904 scopus 로고    scopus 로고
    • MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
    • Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, et al. MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med. 1999; 5:1048-1051.
    • (1999) Nat Med. , vol.5 , pp. 1048-1051
    • Schuetz, J.D.1    Connelly, M.C.2    Sun, D.3    Paibir, S.G.4    Flynn, P.M.5    Srinivas, R.V.6
  • 14
    • 34548103493 scopus 로고    scopus 로고
    • Role of OATP transporters in the disposition of drugs
    • Niemi M. Role of OATP transporters in the disposition of drugs. Pharmacogenomics. 2007;8:787-802.
    • (2007) Pharmacogenomics , vol.8 , pp. 787-802
    • Niemi, M.1
  • 15
    • 34748887980 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes and transporters induced by anti- human immunodeficiency virus protease inhibitors in human hepatocytes: Implications for predicting clinical drug interactions
    • Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD. Cytochrome P450 enzymes and transporters induced by anti- human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007;35:1853-1859.
    • (2007) Drug Metab Dispos. , vol.3 , pp. 1853-1859
    • Dixit, V.1    Hariparsad, N.2    Li, F.3    Desai, P.4    Thummel, K.E.5    Unadkat, J.D.6
  • 17
    • 0042627777 scopus 로고    scopus 로고
    • The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro
    • Chandler B, Almond L, Ford J, Owen A, Hoggard P, Khoo S, et al. The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro. J Acquir Immune Defic Syndr. 2003;33:551-556.
    • (2003) J Acquir Immune Defic Syndr. , vol.3 , pp. 551-556
    • Chandler, B.1    Almond, L.2    Ford, J.3    Owen, A.4    Hoggard, P.5    Khoo, S.6
  • 18
    • 0036796994 scopus 로고    scopus 로고
    • P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals
    • Meaden ER, Hoggard PG, Newton P, Tjia JF, Aldam D, Cornforth D, et al. P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals. J Antimicrob Chemother. 2002;50:583-588.
    • (2002) J Antimicrob Chemother. , vol.5 , pp. 583-588
    • Meaden, E.R.1    Hoggard, P.G.2    Newton, P.3    Tjia, J.F.4    Aldam, D.5    Cornforth, D.6
  • 19
    • 35448967118 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes
    • Janneh O, Jones E, Chandler B, Owen A, Khoo SH. Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes. J Antimicrob Chemother. 2007;60:987-993.
    • (2007) J Antimicrob Chemother. , vol.6 , pp. 987-993
    • Janneh, O.1    Jones, E.2    Chandler, B.3    Owen, A.4    Khoo, S.H.5
  • 21
    • 23744464363 scopus 로고    scopus 로고
    • Expression of the drug transporters MDR1 /ABCB1, MRP1 /ABCC1, MRP2 /ABCC2, BCRP /ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver
    • Albermann N, Schmitz-Winnenthal FH, Z'graggen K, Volk C, Hoffmann MM, Haefeli WE, et al. Expression of the drug transporters MDR1 /ABCB1, MRP1 /ABCC1, MRP2 /ABCC2, BCRP /ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem Pharmacol. 2005;70:949-958.
    • (2005) Biochem Pharmacol. , vol.7 , pp. 949-958
    • Albermann, N.1    Schmitz-Winnenthal, F.H.2    Z'graggen, K.3    Volk, C.4    Hoffmann, M.M.5    Haefeli, W.E.6
  • 22
    • 33748894676 scopus 로고    scopus 로고
    • Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug- sensing receptors in primary human hepatocytes
    • Jigorel E, Le Vee M, Boursier-Neyret C, Parmentier Y, Fardel O. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug- sensing receptors in primary human hepatocytes. Drug Metab Dispos. 2006;34:1756-1763.
    • (2006) Drug Metab Dispos. , vol.3 , pp. 1756-1763
    • Jigorel, E.1    Le Vee, M.2    Boursier-Neyret, C.3    Parmentier Y4    Fardel, O.5
  • 23
    • 42149171256 scopus 로고    scopus 로고
    • Ritonavir-Boosted Protease Inhibitor Monotherapy for the Treatment of HIV-1 Infection
    • Sahali S, Chaix ML, Delfraissy JF, Ghosn J. Ritonavir-Boosted Protease Inhibitor Monotherapy for the Treatment of HIV-1 Infection. AIDS Rev. 2008;10:4-14.
    • (2008) AIDS Rev. , vol.1 , pp. 4-14
    • Sahali, S.1    Chaix, M.L.2    Delfraissy, J.F.3    Ghosn, J.4
  • 25
    • 3042568988 scopus 로고    scopus 로고
    • Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers
    • Ding R, Tayrouz Y, Riedel KD, Burhenne J, Weiss J, Mikus G, et al. Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers. Clin Pharmacol Ther. 2004;76:73-84.
    • (2004) Clin Pharmacol Ther. , vol.7 , pp. 73-84
    • Ding, R.1    Tayrouz, Y.2    Riedel, K.D.3    Burhenne, J.4    Weiss, J.5    Mikus, G.6
  • 26
    • 33745618418 scopus 로고    scopus 로고
    • Efavirenz does not interact with the ABCB1 transporter at the blood-brain barrier
    • Dirson G, Fernandez C, Hindlet P, Roux F, German-Fattal M, Gimenez F, et al. Efavirenz does not interact with the ABCB1 transporter at the blood-brain barrier. Pharm Res. 2006;23:1525-1532.
    • (2006) Pharm Res. , vol.2 , pp. 1525-1532
    • Dirson, G.1    Fernandez, C.2    Hindlet P Roux, F.3    German-Fattal, M.4    Gimenez, F.5
  • 28
    • 34748821996 scopus 로고    scopus 로고
    • Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport
    • Petrick JS, Klaassen CD. Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. Drug Metab Dispos. 2007;35:1806-1815.
    • (2007) Drug Metab Dispos. , vol.3 , pp. 1806-1815
    • Petrick, J.S.1    Klaassen, C.D.2
  • 29
    • 29944436187 scopus 로고    scopus 로고
    • Nuclear receptor expression in fetal and pediatric liver: Correlation with CYP3A expression
    • Vyhlidal CA, Gaedigk R, Leeder JS. Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression. Drug Metab Dispos. 2006;34:131-137.
    • (2006) Drug Metab Dispos. , vol.3 , pp. 131-137
    • Vyhlidal, C.A.1    Gaedigk, R.2    Leeder, J.S.3
  • 30
    • 0346099111 scopus 로고    scopus 로고
    • Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes
    • Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet. 2003;42:1331-1357.
    • (2003) Clin Pharmacokinet. , vol.4 , pp. 1331-1357
    • Wang, H.1    LeCluyse, E.L.2
  • 31
    • 44149109915 scopus 로고    scopus 로고
    • Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors
    • Gupta A, Mugundu GM, Desai PB, Thummel KE, Unadkat JD. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. Drug Metab Dispos. 2008;36:1172-1180.
    • (2008) Drug Metab Dispos. , vol.3 , pp. 1172-1180
    • Gupta, A.1    Mugundu, G.M.2    Desai, P.B.3    Thummel, K.E.4    Unadkat, J.D.5
  • 32
    • 27144483358 scopus 로고    scopus 로고
    • Identification of BCRP as transporter of benzo(a)pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    • Ebert B, Seidel A, Lampen A. Identification of BCRP as transporter of benzo(a)pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis. 2005;26:1754-1763.
    • (2005) Carcinogenesis , vol.2 , pp. 1754-1763
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 33
    • 35348846046 scopus 로고    scopus 로고
    • Transcriptional upregulation of breast cancer resistance protein by 17beta-estradiol in ERalpha-positive MCF-7 breast cancer cells
    • Zhang Y, Zhou G, Wang H, Zhang X, Wei F, Cai Y, et al. Transcriptional upregulation of breast cancer resistance protein by 17beta-estradiol in ERalpha-positive MCF-7 breast cancer cells. Oncology. 2006;71:446-455.
    • (2006) Oncology , vol.7 , pp. 446-455
    • Zhang, Y.1    Zhou, G.2    Wang, H.3    Zhang, X.4    Wei, F.5    Cai, Y.6
  • 34
    • 33747640562 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells
    • Szatmari I, Vamosi G, Brazda P, Balint BL, Benko S, Szeles L, et al. Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells. J Biol Chem. 2006;281:23812-23823.
    • (2006) J Biol Chem. , vol.28 , pp. 23812-23823
    • Szatmari, I.1    Vamosi, G.2    Brazda, P.3    Balint, B.L.4    Benko, S.5    Szeles, L.6
  • 36
    • 21544472342 scopus 로고    scopus 로고
    • AIDS clinical trials group A5108 team. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: Results of AIDS clinical trials group 5108 study
    • Gerber J.G., Rosenkranz S.L., Fichtenbaum C.J., Vega J.M., Yang A., Alston B.L., et al. AIDS clinical trials group A5108 team. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: Results of AIDS clinical trials group 5108 study. J Acquir Immune Defic Syndr. 2005;3:307-312.
    • (2005) J Acquir Immune Defic Syndr. , vol.3 , pp. 307-312
    • Gerber, J.G.1    Rosenkranz, S.L.2    Fichtenbaum, C.J.3    Vega, J.M.4    Yang, A.5    Alston, B.L.6
  • 37
    • 33847366629 scopus 로고    scopus 로고
    • Inhibition of MRP1 /ABCC1 MRP2/ABCC2 and MRP3 /ABCC3 by nucleoside nucleotide and non-nucleoside reverse transcriptase inhibitors
    • Weiss J, Theile D, Ketabi-Kiyanvash N, Lindenmaier H, Haefeli WE. Inhibition of MRP1 /ABCC1, MRP2/ABCC2, and MRP3 /ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors. Drug Metab Dispos. 2007;35:340-344.
    • (2007) Drug Metab Dispos. , vol.3 , pp. 340-344
    • Weiss, J.1    Theile, D.2    Ketabi-Kiyanvash, N.3    Lindenmaier, H.4    Haefeli, W.E.5
  • 39
    • 33845524038 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 2B1 is a high- affinity transporter for atorvastatin and is expressed in the human heart
    • Grube M, Kock K, Oswald S, Draber K, Meissner K, Eckel L, et al. Organic anion transporting polypeptide 2B1 is a high- affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther. 2006;80:607-620.
    • (2006) Clin Pharmacol Ther. , vol.8 , pp. 607-620
    • Grube, M.1    Kock, K.2    Oswald, S.3    Draber, K.4    Meissner, K.5    Eckel, L.6
  • 40
    • 12444261717 scopus 로고    scopus 로고
    • Expression and functional analyses of breast cancer resistance protein in lung cancer
    • Kawabata S, Oka M, Soda H, Shiozawa K, Nakatomi K, Tsurutani J, et al. Expression and functional analyses of breast cancer resistance protein in lung cancer. Clin Cancer Res. 2003;9:3052-3057.
    • (2003) Clin Cancer Res. , vol.9 , pp. 3052-3057
    • Kawabata, S.1    Oka, M.2    Soda, H.3    Shiozawa, K.4    Nakatomi, K.5    Tsurutani, J.6
  • 41
    • 29344440700 scopus 로고    scopus 로고
    • Expression of multidrug resistance-associated proteins predicts prognosis in childhood and adult acute lymphoblastic leukemia
    • Plasschaert SL, de Bont ES, Boezen M, vander Kolk DM, Daenen SM, Faber KN, et al. Expression of multidrug resistance-associated proteins predicts prognosis in childhood and adult acute lymphoblastic leukemia. Clin Cancer Res. 2005;11:8661-8668.
    • (2005) Clin Cancer Res. , vol.11
    • Plasschaert, S.L.1    De Bont, E.S.2    Boezen, M.3    Vander Kolk, D.M.4    Daenen, S.M.5    Faber, K.N.6


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