A novel beads-based dissolution method for the in vitro evaluation of extended release HPMC matrix tablets and the correlation with the in vivo data

AAPS Journal

Volumn 15, Issue 1, 2013, Pages 267-277

  Klančar, Uroš ^a   Markun, Boštjan ^a   Baumgartner, Saša ^b   Legen, Igor ^a  

^a Lek dd   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

dissolution method; extended release; HPMC; IVIVC; matrix tablets; quality by design

Indexed keywords

AEROSIL; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; POVIDONE; SULFONAMIDE; THIAZIDE DIURETIC AGENT;

APPARATUS; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DISSOLUTION APPARATUS; DISSOLUTION METHOD; DRUG ANALYSIS; DRUG DISCRIMINATION; DRUG SCREENING; DRUG SOLUBILITY; FORCE; IN VITRO STUDY; IN VIVO STUDY; MATRIX TABLET; MECHANICAL STRESS; PREDICTION;

CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; HUMANS; LACTOSE; METHYLCELLULOSE; SOLUBILITY; TABLETS;

EID: 84871949775     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9422-x     Document Type: Article

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