Carbamazepine level-A in vivo-in vitro correlation (IVIVC): A scaled convolution based predictive approach

Biopharmaceutics and Drug Disposition

Volumn 21, Issue 1, 2000, Pages 1-6

  Veng Pedersen, P ^a   Gobburu, J V S ^b   Meyer, M C ^c   Straughn, A B ^c  

^a UNIVERSITY OF IOWA   (United States)

^b Suny ^*  (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Carbamazepine; Convolution; Cross validation estimation; Dissolution rate; In vivo in vitro correlation

Indexed keywords

CARBAMAZEPINE;

ADULT; ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; HUMAN; HUMAN EXPERIMENT; STATISTICAL ANALYSIS; TABLET;

ANALGESICS, NON-NARCOTIC; BIOPHARMACEUTICS; CARBAMAZEPINE; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; HUMANS; MODELS, THEORETICAL; PREDICTIVE VALUE OF TESTS; TABLETS;

EID: 0033759666     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-081X(200001)21:1<1::AID-BDD207>3.0.CO;2-D     Document Type: Article

References (5)

1. Predictive conversion of in vitro drug dissolution data into in vivo drug response versus time profiles exemplified for plasma levels of warfarin
2. A convolution approach to in vivo/in vitro correlation (IVIVC) that does not require an iv or solution reference dose
3. Linear systems analysis in pharmacokinetics
4. Gastro-intestinal bioavailability: Determination of in vivo release profiles of solid dosage forms by deconvolution
5. A monotonic regression method