Influence of water soluble fillers in hydroxypropylmethylcellulose matrices on in vitro and in vivo drug release

Journal of Controlled Release

Volumn 81, Issue 1-2, 2002, Pages 165-172

  Sako, Kazuhiro ^a   Sawada, Toyohiro ^a   Nakashima, Hiroshi ^a   Yokohama, Shigeharu ^a   Sonobe, Takashi ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Acetaminophen; Colonic release; Controlled release; In vitro in vivo relationship; Mechanical destructive forces

Indexed keywords

FILLER; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MACROGOL 6000; PARACETAMOL; WATER;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DISSOLUTION; DOG; DRUG ABSORPTION; GASTROINTESTINAL MOTILITY; GELATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; DELAYED-ACTION PREPARATIONS; DOGS; GELS; LACTOSE; MALE; METHYLCELLULOSE; POLYETHYLENE GLYCOLS; SOLUBILITY; SOLVENTS; TABLETS; WATER;

EID: 0037123711     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00067-6     Document Type: Article

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