Stronger Toll-like receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children

Immunobiology

Volumn 218, Issue 2, 2013, Pages 192-200

  Lee, Wen I ^a,b   Yao, Tsung Chieh ^a,b   Yeh, Kuo Wei ^a,b   Chen, Li Chen ^a,b   Ou, Liang Shiou ^a,b   Huang, Jing Long ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Children; IFN ; IL 6; Noninfectious asthma exacerbation; T regulatory (Treg) cell; TNF ; Toll like receptors (TLR)

Indexed keywords

BETA INTERFERON; INTERLEUKIN 6; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ARTICLE; ASTHMA; CD4+ CD25+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; MALE; MOLECULAR DYNAMICS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; SIGNAL TRANSDUCTION;

ADAPTIVE IMMUNITY; ASTHMA; CHILD; CYTOKINES; DISEASE PROGRESSION; HUMANS; IMIDAZOLES; IMMUNITY, INNATE; LEUKOCYTES, MONONUCLEAR; LIPOPEPTIDES; LIPOPOLYSACCHARIDES; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTOR 9;

EID: 84871927771     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2012.04.002     Document Type: Article

References (48)

1. Abbas A.K., Lichman A.H. Cytokines in Cellular and Molecular Immunology 2005, Elsevier Science, Philadelphia, pp. 243-274. 5th ed.
2. Akdis M., Verhagen J., Taylor A., Karamloo F., Karagiannidis C., Crameri R., Thunberg S., Deniz G., Valenta R., Fiebig H., Kegel C., Disch R., Schmidt-Weber C.B., Blaser K., Akdis C.A. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 2004, 199:1567-1575.
3. Alexander C., Rietschel E.T. Bacterial lipopolysaccharides and innate immunity. J. Endotoxin Res. 2001, 7:167-202.
4. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
5. Ben-Zvi Z., Lam C., Hoffman J., Teets-Grimm K.C., Kattan M. An evaluation of the initial treatment of acute asthma. Pediatrics 1982, 70:348-353.
6. Berry M.A., Hargadon B., Shelley M., Parker D., Shaw D.E., Green R.H., Bradding P., Brightling C.E., Wardlaw A.J., Pavord I.D. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N. Engl. J. Med. 2006, 354:697-708.
7. Bousquet J., Clark T.J., Hurd S., Khaltaev N., Lenfant C., O'byrne P., Sheffer A. GINA guidelines on asthma and beyond. Allergy 2007, 62:102-112.
8. Creticos P.S., Schroeder J.T., Hamilton R.G., Balcer-Whaley S.L., Khattignavong A.P., Lindblad R., Li H., Coffman R., Seyfert V., Eiden J.J., Broide D., Immune Tolerance Network Group Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N. Engl. J. Med. 2006, 355:1445-1455.
9. Deering R.P., Orange J.S. Development of a clinical assay to evaluate toll-like receptor function. Clin. Vaccine Immunol. 2006, 13:68-76.
10. Diebold S.S., Kaisho T., Hemmi H., Akira S., Reis e Sousa C. Innate anti-viral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004, 303:1529-1531.
11. Eder W., Klimecki W., Yu L., von Mutius E., Riedler J., Braun-Fahrländer C., Nowak D., Martinez F.D., ALEX Study Team Toll-like receptor 2 as a major gene for asthma in children of European farmers. J. Allergy Clin. Immunol. 2004, 113:482-488.
12. Fagerås Böttcher M., Hmani-Aifa M., Lindström A., Jenmalm M.C., Mai X.M., Nilsson L., Zdolsek H.A., Björkstén B., Söderkvist P., Vaarala O. A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. J. Allergy Clin. Immunol. 2004, 114:561-567.
13. Grindebacke H., Wing K., Andersson A.C., Suri-Payer E., Rak S., Rudin A. Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season. Clin. Exp. Allergy 2004, 34:1364-1372.
14. Hamid Q., Tulic M. Immunobiology of asthma. Annu. Rev. Physiol. 2009, 71:489-507.
15. high regulatory T cells in pediatric asthma. J. Allergy Clin. Immunol. 2007, 119:1258-1266.
16. Haynes L.M., Moore D.D., Kurt-Jones E.A., Finberg R.W., Anderson L.J., Tripp R.A. Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J. Virol. 2001, 75:10730-10737.
17. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004, 303:1526-1529.
18. Heumann D., Lauener R., Ryffel B. The dual role of LBP and CD14 in response to Gram-negative bacteria or Gram-negative compounds. J. Endotoxin Res. 2003, 9:381-384.
19. Homma T., Kato A., Hashimoto N., Batchelor J., Yoshikawa M., Imai S., Wakiguchi H., Saito H., Matsumoto K. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am. J. Respir. Cell Mol. Biol. 2004, 31:463-469.
20. Howarth P.H., Babu K.S., Arshad H.S., Lau L., Buckley M., McConnell W., Beckett P., Al Ali M., Chauhan A., Wilson S.J., Reynolds A., Davies D.E., Holgate S.T. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 2005, 60:1012-1018.
21. Huang J.L., Chen L.C., Yeh K.W., Lin S.J., Hsieh K.H., Kuo M.L. TH1 and TH2 cytokine production among asthmatic children after immunotherapy. J. Asthma 2003, 40:273-279.
22. Kawai T., Akira S. Pathogen recognition with Toll-like receptors. Curr. Opin. Immunol. 2005, 17:338-344.
23. Koppelman G.H., Reijmerink N.E., Colin Stine O., Howard T.D., Whittaker P.A., Meyers D.A., Postma D.S., Bleecker E.R. Association of a promoter polymorphism of the CD14 gene and atopy. Am. J. Respir. Crit. Care Med. 2001, 163:965-969.
24. Kulkarni R., Behboudi S., Sharif S. Insights into the role of Toll-like receptors in modulation of T cell responses. Cell Tissue Res. 2011, 343:141-152.
25. Kurt-Jones E.A., Popova L., Kwinn L., Haynes L.M., Jones L.P., Tripp R.A., Walsh E.E., Freeman M.W., Golenbock D.T., Anderson L.J., Finberg R.W. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 2000, 1:398-401.
26. Lin T.Y., Chiang B.L. Specific immune response in adult medical personnel immunized with acellular pertusis vaccine with special emphasis on T helper cell response. Vaccine 1997, 15:1917-1921.
27. high T-regulatory cells in allergic asthma is subjected to TNF-α modulation. Allergy 2008, 63:67-74.
28. Liu G., Zhang L., Zhao Y. Modulation of immune responses through direct activation of Toll-like receptors to T cells. Clin. Exp. Immunol. 2010, 160:168-175.
29. Lukacs N.W., Strieter R.M., Chensue S.W., Widmer M., Kunkel S.L. TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation. J. Immunol. 1995, 154:5411-5417.
30. Lun S.W., Wong C.K., Ko F.W., Hui D.S., Lam C.W. Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma. J. Clin. Immunol. 2009, 29:330-342.
31. Medzhitov R., Janeway C. Innate immune recognition: mechanisms and pathways. Immunol. Rev. 2000, 173:89-97.
32. Miller E.K., Griffin M.R., Edwards K.M., Weinberg G.A., Szilagyi P.G., Staat M.A., Iwane M.K., Zhu Y., Hall C.B., Fairbrother G., Seither R., Erdman D., Lu P., Poehling K.A., New Vaccine Surveillance Network Influenza burden for children with asthma. Pediatrics 2008, 121:1-8.
33. Niu C.K., Chen W.Y., Huang J.L., Lue K.H., Wang J.Y. Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan. Respir. Med. 2006, 100:1374-1383.
34. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998, 282:2085-2088.
35. Rock K.L., Kono H. The inflammatory response to cell death. Annu. Rev. Pathol. 2008, 3:99-126.
36. Schaub B., Lauener R., von Mutius E. The many faces of the hygiene hypothesis. J. Allergy Clin. Immunol. 2006, 117:969-977.
37. Sheikh A., Alves B., Dhami S. Pneumococcal vaccine for asthma. Cochrane Database Syst. Rev. 2002, CD002165.
38. Simpson J.L., Moric I., Wark P.A., Johnston S.L., Gibson P.G. Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques. J. Clin. Virol. 2003, 26:339-346.
39. Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell 2010, 140:805-820.
40. Takeuchi O., Sato S., Horiuchi T., Hoshino K., Takeda K., Dong Z., Modlin R.L., Akira S. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 2002, 169:10-14.
41. Thorburn A.N., Hansbro P.M., Gibson P.G. Pneumococcal vaccines for allergic airways diseases. Expert Opin. Biol. Ther. 2009, 9:621-629.
42. Thorburn A.N., O'Sullivan B.J., Thomas R., Kumar R.K., Foster P.S., Gibson P.G., Hansbro P.M. Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease. Thorax 2010, 65:1053-1060.
43. Trompette A., Divanovic S., Visintin A., Blanchard C., Hegde R.S., Madan R., Thorne P.S., Wills-Karp M., Gioannini T.L., Weiss J.P., Karp C.L. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009, 457:585-588.
44. Wark P.A., Bucchieri F., Johnston S.L., Gibson P.G., Hamilton L., Mimica J., Zummo G., Holgate S.T., Attia J., Thakkinstian A., Davies D.E. IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J. Allergy Clin. Immunol. 2007, 120:586-593.
45. Wark P.A., Johnston S.L., Moric I., Simpson J.L., Hensley M.J., Gibson P.G. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur. Respir. J. 2002, 19:68-75.
46. Weinberger M. Respiratory infections and asthma: current treatment strategies. Drug Discov. Today 2004, 9:831-837.
47. Wood L.G., Simpson J.L., Wark P.A., Powell H., Gibson P.G. Characterization of innate immune signalling receptors in virus-induced acute asthma. Clin. Exp. Allergy 2011, 41:640-648.
48. Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., Akira S. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J. Immunol. 2002, 169:6668-6672.