Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 103-109

  Weng, Hsing Yu ^a,b   Hsu, Ming Jen ^a   Chen, Chien Chih ^c   Chen, Bing Chang ^a   Hong, Chuang Ye ^d   Teng, Che Ming ^e   Pan, Shiow Lin ^e   Chiu, Wen Ta ^a   Lin, Chien Huang ^a,f  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Akt; Denbinobin; FKHR; Glioblastoma multiforme; IKK

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; DENBINOBIN; I KAPPA B KINASE ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; ENZYME ACTIVATION; FORKHEAD TRANSCRIPTION FACTORS; GLIOBLASTOMA; HUMANS; I-KAPPA B KINASE; PHENANTHRENES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84871920050     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.10.029     Document Type: Article

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