Denbinobin inhibits nuclear factor-κB and induces apoptosis via reactive oxygen species generation in human leukemic cells

Biochemical Pharmacology

Volumn 77, Issue 8, 2009, Pages 1401-1409

  Sánchez Duffhues, Gonzalo ^a   Calzado, Marco A ^a   de Vinuesa, Amaya García ^a   Appendino, Giovanni ^b   Fiebich, Bernd L ^c   Loock, Ulich ^d   Lefarth Risse, Annette ^d   Krohn, Karsten ^d   Muñoz, Eduardo ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF PADERBORN   (Germany)

Author keywords

1,4 Phenanthrenequinones; Apoptosis; Denbinobin; MAPKs; NF B; ROS

Indexed keywords

1,4 PHENANTHREQUINONE; CANNABIS; CASPASE; DENBINOBIN; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; PHENANTHRENEQUINONE; PROTEIN NOXA; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DENDROBIUM; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CANNABIS; CELL CYCLE; CELL SURVIVAL; DENDROBIUM; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; JURKAT CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; PHENANTHRENES; PLANT STEMS; PLASMIDS; REACTIVE OXYGEN SPECIES; TRANSFECTION;

EID: 62749098228     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.01.004     Document Type: Article

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