메뉴 건너뛰기




Volumn 304, Issue 1, 2013, Pages

The opposite roles of glucocorticoid and α1-adrenergic receptors in stress triggered apoptosis of rat Leydig cells

Author keywords

Adrenaline; Apoptosis; Corticosterone; Immobilization stress; Leydig cells; Testis

Indexed keywords

ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR; ANDROGEN; CASPASE 3; CASPASE 9; CORTICOSTERONE; CYTOCHROME C; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MIFEPRISTONE; PRAZOSIN; PROTEIN KINASE B; SOMATOMEDIN BINDING PROTEIN 3;

EID: 84871867476     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00443.2012     Document Type: Article
Times cited : (21)

References (56)
  • 1
    • 33746084479 scopus 로고    scopus 로고
    • Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis
    • Allen JA, Shankara T, Janus P, Buck S, Diemer T, Hales KH, Hales DB. Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. Endocrinology 147: 3924-3935, 2006.
    • (2006) Endocrinology , vol.147 , pp. 3924-3935
    • Allen, J.A.1    Shankara, T.2    Janus, P.3    Buck, S.4    Diemer, T.5    Hales, K.H.6    Hales, D.B.7
  • 2
    • 0022913214 scopus 로고
    • Catecholamine stimulation of androgen production by rat Leydig cells. Interactions with luteinizing hormone and luteinizing hormone-releasing hormone
    • Anakwe OO, Moger WH. Catecholamine stimulation of androgen production by rat Leydig cells. Interactions with luteinizing hormone and luteinizing hormone-releasing hormone. Biol Reprod 35: 806-814, 1986.
    • (1986) Biol Reprod , vol.35 , pp. 806-814
    • Anakwe, O.O.1    Moger, W.H.2
  • 3
    • 0022221937 scopus 로고
    • Characterization of beta-adrenergic binding sites on rodent Leydig cells
    • Anakwe OO, Murphy PR, Moger WH. Characterization of beta-adrenergic binding sites on rodent Leydig cells. Biol Reprod 33: 815-826, 1985.
    • (1985) Biol Reprod , vol.33 , pp. 815-826
    • Anakwe, O.O.1    Murphy, P.R.2    Moger, W.H.3
  • 5
    • 79952733790 scopus 로고    scopus 로고
    • Human testicular insulin-like factor 3: In relation to development, reproductive hormones and andrological disorders
    • Bay K, Andersson AM. Human testicular insulin-like factor 3: in relation to development, reproductive hormones and andrological disorders. Int J Androl 34: 97-109, 2011.
    • (2011) Int J Androl , vol.34 , pp. 97-109
    • Bay, K.1    Andersson, A.M.2
  • 6
    • 37349019686 scopus 로고    scopus 로고
    • Characterization of the alpha1-adrenoceptor subtype activating extracellular signal-regulated kinase in submandibular gland acinar cells
    • Bruchas MR, Toews ML, Bockman CS, Abel PW. Characterization of the alpha1-adrenoceptor subtype activating extracellular signal-regulated kinase in submandibular gland acinar cells. Eur J Pharmacol 578: 349-358, 2008.
    • (2008) Eur J Pharmacol , vol.578 , pp. 349-358
    • Bruchas, M.R.1    Toews, M.L.2    Bockman, C.S.3    Abel, P.W.4
  • 7
    • 0031051692 scopus 로고    scopus 로고
    • RU486 (mifepristone): Mechanisms of action and clinical uses
    • Cadepond F, Ulmann A, Baulieu EE. RU486 (mifepristone): mechanisms of action and clinical uses. Annu Rev Med 48: 129-156, 1997.
    • (1997) Annu Rev Med , vol.48 , pp. 129-156
    • Cadepond, F.1    Ulmann, A.2    Baulieu, E.E.3
  • 11
    • 83455195502 scopus 로고    scopus 로고
    • Stress induces glucocorticoid-mediated apoptosis of rat Leydig cells in vivo
    • Chen Y, Wang Q, Wang FF, Gao HB, Zhang P. Stress induces glucocorticoid-mediated apoptosis of rat Leydig cells in vivo. Stress 15: 74-84, 2012.
    • (2012) Stress , vol.15 , pp. 74-84
    • Chen, Y.1    Wang, Q.2    Wang, F.F.3    Gao, H.B.4    Zhang, P.5
  • 14
    • 83655165092 scopus 로고    scopus 로고
    • Advances in the design and synthesis of prazosin derivatives over the last ten years
    • Desiniotis A, Kyprianou N. Advances in the design and synthesis of prazosin derivatives over the last ten years. Expert Opin Ther Targets 15: 1405-1418, 2011.
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 1405-1418
    • Desiniotis, A.1    Kyprianou, N.2
  • 15
    • 7044251877 scopus 로고    scopus 로고
    • Rapid glucocorticoid mediation of suppressed testosterone biosynthesis in male mice subjected to immobilization stress
    • Dong Q, Salva A, Sottas CM, Niu E, Holmes M, Hardy MP. Rapid glucocorticoid mediation of suppressed testosterone biosynthesis in male mice subjected to immobilization stress. J Androl 25: 973-981, 2004.
    • (2004) J Androl , vol.25 , pp. 973-981
    • Dong, Q.1    Salva, A.2    Sottas, C.M.3    Niu, E.4    Holmes, M.5    Hardy, M.P.6
  • 17
    • 2442670195 scopus 로고    scopus 로고
    • Perturbations in brain monoamine systems during stress
    • Flugge G, Van Kampen M, Mijnster MJ. Perturbations in brain monoamine systems during stress. Cell Tissue Res 315: 1-14, 2004.
    • (2004) Cell Tissue Res , vol.315 , pp. 1-14
    • Flugge, G.1    van Kampen, M.2    Mijnster, M.J.3
  • 18
    • 0031016402 scopus 로고    scopus 로고
    • Hormonal regulation of oxidative and reductive activities of 11 beta-hydroxysteroid dehydrogenase in rat Leydig cells
    • Gao HB, Ge RS, Lakshmi V, Marandici A, Hardy MP. Hormonal regulation of oxidative and reductive activities of 11 beta-hydroxysteroid dehydrogenase in rat Leydig cells. Endocrinology 138: 156-161, 1997.
    • (1997) Endocrinology , vol.138 , pp. 156-161
    • Gao, H.B.1    Ge, R.S.2    Lakshmi, V.3    Marandici, A.4    Hardy, M.P.5
  • 19
    • 0029958795 scopus 로고    scopus 로고
    • Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro
    • Gao HB, Shan LX, Monder C, Hardy MP. Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro. Endocrinology 137: 1714-1718, 1996.
    • (1996) Endocrinology , vol.137 , pp. 1714-1718
    • Gao, H.B.1    Shan, L.X.2    Monder, C.3    Hardy, M.P.4
  • 21
    • 0030925023 scopus 로고    scopus 로고
    • Identification of a kinetically distinct activity of 11beta-hydroxysteroid dehydrogenase in rat Leydig cells
    • Ge RS, Gao HB, Nacharaju VL, Gunsalus GL, Hardy MP. Identification of a kinetically distinct activity of 11beta-hydroxysteroid dehydrogenase in rat Leydig cells. Endocrinology 138: 2435-2442, 1997.
    • (1997) Endocrinology , vol.138 , pp. 2435-2442
    • Ge, R.S.1    Gao, H.B.2    Nacharaju, V.L.3    Gunsalus, G.L.4    Hardy, M.P.5
  • 22
    • 63149132002 scopus 로고    scopus 로고
    • Deprival of testicular innervation induces apoptosis of Leydig cells via caspase-8dependent signaling: A novel survival pathway revealed
    • Gong YG, Wang YQ, Gu M, Feng MM, Zhang W, Ge RS. Deprival of testicular innervation induces apoptosis of Leydig cells via caspase-8dependent signaling: a novel survival pathway revealed. Biochem Biophys Res Commun 382: 165-170, 2009.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 165-170
    • Gong, Y.G.1    Wang, Y.Q.2    Gu, M.3    Feng, M.M.4    Zhang, W.5    Ge, R.S.6
  • 23
    • 0035919207 scopus 로고    scopus 로고
    • Origin, differentiation and regulation of fetal and adult Leydig cells
    • Habert R, Lejeune H, Saez JM. Origin, differentiation and regulation of fetal and adult Leydig cells. Mol Cell Endocrinol 179: 47-74, 2001.
    • (2001) Mol Cell Endocrinol , vol.179 , pp. 47-74
    • Habert, R.1    Lejeune, H.2    Saez, J.M.3
  • 25
    • 0033605376 scopus 로고    scopus 로고
    • Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells
    • Heiskanen KM, Bhat MB, Wang HW, Ma J, Nieminen AL. Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J Biol Chem 274: 5654-5658, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 5654-5658
    • Heiskanen, K.M.1    Bhat, M.B.2    Wang, H.W.3    Ma, J.4    Nieminen, A.L.5
  • 26
    • 0242709928 scopus 로고    scopus 로고
    • Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium
    • Hixon ML, Boekelheide K. Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium. J Androl 24: 891-898, 2003.
    • (2003) J Androl , vol.24 , pp. 891-898
    • Hixon, M.L.1    Boekelheide, K.2
  • 28
    • 37149057007 scopus 로고    scopus 로고
    • The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis
    • Hui H, Fernando MA, Heaney AP. The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis. Eur J Cancer 44: 160-166, 2008.
    • (2008) Eur J Cancer , vol.44 , pp. 160-166
    • Hui, H.1    Fernando, M.A.2    Heaney, A.P.3
  • 29
    • 84862113237 scopus 로고    scopus 로고
    • Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology
    • Hyman BT, Yuan J. Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci 13: 395-406, 2012.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 395-406
    • Hyman, B.T.1    Yuan, J.2
  • 30
    • 0036090357 scopus 로고    scopus 로고
    • Folliclestimulating hormone amplifies insulin-like growth factor I-mediated activation of AKT/protein kinase B signaling in immature rat Sertoli cells
    • Khan SA, Ndjountche L, Pratchard L, Spicer LJ, Davis JS. Folliclestimulating hormone amplifies insulin-like growth factor I-mediated activation of AKT/protein kinase B signaling in immature rat Sertoli cells. Endocrinology 143: 2259-2267, 2002.
    • (2002) Endocrinology , vol.143 , pp. 2259-2267
    • Khan, S.A.1    Ndjountche, L.2    Pratchard, L.3    Spicer, L.J.4    Davis, J.S.5
  • 31
    • 0034458160 scopus 로고    scopus 로고
    • Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate
    • Kim JM, Luo L, Zirkin BR. Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate. Endocrinology 141: 1846-1853, 2000.
    • (2000) Endocrinology , vol.141 , pp. 1846-1853
    • Kim, J.M.1    Luo, L.2    Zirkin, B.R.3
  • 32
    • 0031945458 scopus 로고    scopus 로고
    • Cell cycle regulation and apoptosis
    • King KL, Cidlowski JA. Cell cycle regulation and apoptosis. Annu Rev Physiol 60: 601-617, 1998.
    • (1998) Annu Rev Physiol , vol.60 , pp. 601-617
    • King, K.L.1    Cidlowski, J.A.2
  • 33
    • 79952593869 scopus 로고    scopus 로고
    • Immobilization stress reduces oxygen consumption of the isolated interstitial rats' testes cells
    • Kojic Z, Scepanovic LJ, Kostic T. Immobilization stress reduces oxygen consumption of the isolated interstitial rats' testes cells. Acta Physiol Hung 98: 45-50, 2011.
    • (2011) Acta Physiol Hung , vol.98 , pp. 45-50
    • Kojic, Z.1    Scepanovic, L.J.2    Kostic, T.3
  • 34
    • 77956132994 scopus 로고    scopus 로고
    • Structural complexity of the testis and PKG I/StAR interaction regulate the Leydig cell adaptive response to repeated immobilization stress
    • Kostic TS, Stojkov NJ, Janjic MM, Andric SA. Structural complexity of the testis and PKG I/StAR interaction regulate the Leydig cell adaptive response to repeated immobilization stress. Int J Androl 33: 717-729, 2010.
    • (2010) Int J Androl , vol.33 , pp. 717-729
    • Kostic, T.S.1    Stojkov, N.J.2    Janjic, M.M.3    Andric, S.A.4
  • 35
    • 52149114222 scopus 로고    scopus 로고
    • The adaptive response of adult rat Leydig cells to repeated immobilization stress: The role of protein kinase A and steroidogenic acute regulatory protein
    • Kostic TS, Stojkov NJ, Janjic MM, Maric D, Andric SA. The adaptive response of adult rat Leydig cells to repeated immobilization stress: the role of protein kinase A and steroidogenic acute regulatory protein. Stress 11: 370-380, 2008
    • (2008) Stress , vol.11 , pp. 370-380
    • Kostic, T.S.1    Stojkov, N.J.2    Janjic, M.M.3    Maric, D.4    Andric, S.A.5
  • 36
    • 0014864977 scopus 로고
    • Elevation of adrenal tyrosine hydroxylase and phenylethanolamine-N-methyl transferase by repeated immobilization of rats
    • Kvetnansky R, Weise VK, Kopin IJ. Elevation of adrenal tyrosine hydroxylase and phenylethanolamine-N-methyl transferase by repeated immobilization of rats. Endocrinology 87: 744-749, 1970.
    • (1970) Endocrinology , vol.87 , pp. 744-749
    • Kvetnansky, R.1    Weise, V.K.2    Kopin, I.J.3
  • 38
    • 33646353671 scopus 로고    scopus 로고
    • Bigenomic functional regulation of all 13 cytochrome c oxidase subunit transcripts in rat neurons in vitro and in vivo
    • Liang HL, Ongwijitwat S, Wong-Riley MT. Bigenomic functional regulation of all 13 cytochrome c oxidase subunit transcripts in rat neurons in vitro and in vivo. Neuroscience 140: 177-190, 2006.
    • (2006) Neuroscience , vol.140 , pp. 177-190
    • Liang, H.L.1    Ongwijitwat, S.2    Wong-Riley, M.T.3
  • 39
    • 79955575350 scopus 로고    scopus 로고
    • Anti-angiogenic effects and mechanism of prazosin
    • Liao CH, Guh JH, Chueh SC, Yu HJ. Anti-angiogenic effects and mechanism of prazosin. Prostate 71: 976-984, 2011.
    • (2011) Prostate , vol.71 , pp. 976-984
    • Liao, C.H.1    Guh, J.H.2    Chueh, S.C.3    Yu, H.J.4
  • 42
    • 0029745725 scopus 로고    scopus 로고
    • Effects of acute and chronic immobilization stress on rat Leydig cell steroidogenesis
    • Maric D, Kostic T, Kovacevic R. Effects of acute and chronic immobilization stress on rat Leydig cell steroidogenesis. J Steroid Biochem Mol Biol 58: 351-355, 1996.
    • (1996) J Steroid Biochem Mol Biol , vol.58 , pp. 351-355
    • Maric, D.1    Kostic, T.2    Kovacevic, R.3
  • 43
    • 0027499451 scopus 로고
    • Catecholamines stimulate testicular steroidogenesis in vitro in the Siberian hamster, Phodopus sungorus
    • Mayerhofer A, Bartke A, Began T. Catecholamines stimulate testicular steroidogenesis in vitro in the Siberian hamster, Phodopus sungorus. Biol Reprod 48: 883-888, 1993.
    • (1993) Biol Reprod , vol.48 , pp. 883-888
    • Mayerhofer, A.1    Bartke, A.2    Began, T.3
  • 44
    • 0024389401 scopus 로고
    • Catecholamine effects on testicular testosterone production in the gonadally active and the gonadally regressed adult golden hamster
    • Mayerhofer A, Bartke A, Steger RW. Catecholamine effects on testicular testosterone production in the gonadally active and the gonadally regressed adult golden hamster. Biol Reprod 40: 752-761, 1989.
    • (1989) Biol Reprod , vol.40 , pp. 752-761
    • Mayerhofer, A.1    Bartke, A.2    Steger, R.W.3
  • 45
    • 0028329759 scopus 로고
    • Reciprocal changes in plasma corticosterone and testosterone in stressed male rats maintained in a visible burrow system: Evidence for a mediating role of testicular 11 beta-hydroxysteroid dehydrogenase
    • Monder C, Sakai RR, Miroff Y, Blanchard DC, Blanchard RJ. Reciprocal changes in plasma corticosterone and testosterone in stressed male rats maintained in a visible burrow system: evidence for a mediating role of testicular 11 beta-hydroxysteroid dehydrogenase. Endocrinology 134: 1193-1198, 1994.
    • (1994) Endocrinology , vol.134 , pp. 1193-1198
    • Monder, C.1    Sakai, R.R.2    Miroff, Y.3    Blanchard, D.C.4    Blanchard, R.J.5
  • 46
    • 0026758695 scopus 로고
    • Role of glucocorticoids in the stress-induced suppression of testicular steroidogenesis in adult male rats
    • Orr TE, Mann DR. Role of glucocorticoids in the stress-induced suppression of testicular steroidogenesis in adult male rats. Horm Behav 26: 350-363, 1992.
    • (1992) Horm Behav , vol.26 , pp. 350-363
    • Orr, T.E.1    Mann, D.R.2
  • 47
    • 0027965713 scopus 로고
    • Acute immobilization stress disrupts testicular steroidogenesis in adult male rats by inhibiting the activities of 17 alpha-hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors
    • Orr TE, Taylor MF, Bhattacharyya AK, Collins DC, Mann DR. Acute immobilization stress disrupts testicular steroidogenesis in adult male rats by inhibiting the activities of 17 alpha-hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors. J Androl 15: 302-308, 1994
    • (1994) J Androl , vol.15 , pp. 302-308
    • Orr, T.E.1    Taylor, M.F.2    Bhattacharyya, A.K.3    Collins, D.C.4    Mann, D.R.5
  • 48
    • 0025940470 scopus 로고
    • Multiple mechanisms for regulation of 3 betahydroxysteroid dehydrogenase/delta 5--delta 4-isomerase, 17 alpha-hydroxylase/C17-20 lyase cytochrome P450, and cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid levels in primary cultures of mouse Leydig cells
    • Payne AH, Sha LL. Multiple mechanisms for regulation of 3 betahydroxysteroid dehydrogenase/delta 5--delta 4-isomerase, 17 alpha-hydroxylase/C17-20 lyase cytochrome P450, and cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid levels in primary cultures of mouse Leydig cells. Endocrinology 129: 1429-1435, 1991.
    • (1991) Endocrinology , vol.129 , pp. 1429-1435
    • Payne, A.H.1    Sha, L.L.2
  • 49
    • 80051792747 scopus 로고    scopus 로고
    • Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: Role of the mitochondrial glucocorticoid receptor
    • Psarra AM, Sekeris CE. Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor. Biochim Biophys Acta 1813: 1814-1821, 2011.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1814-1821
    • Psarra, A.M.1    Sekeris, C.E.2
  • 50
    • 84859959656 scopus 로고    scopus 로고
    • A molecular view on signal transduction by the apoptosome
    • Reubold TF, Eschenburg S. A molecular view on signal transduction by the apoptosome. Cell Signal 24: 1420-1425, 2012.
    • (2012) Cell Signal , vol.24 , pp. 1420-1425
    • Reubold, T.F.1    Eschenburg, S.2
  • 51
    • 31344468014 scopus 로고    scopus 로고
    • Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis
    • Sionov RV, Cohen O, Kfir S, Zilberman Y, Yefenof E. Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis. J Exp Med 203: 189-201, 2006.
    • (2006) J Exp Med , vol.203 , pp. 189-201
    • Sionov, R.V.1    Cohen, O.2    Kfir, S.3    Zilberman, Y.4    Yefenof, E.5
  • 52
    • 84861127016 scopus 로고    scopus 로고
    • Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells
    • Stojkov NJ, Janjic MM, Bjelic MM, Mihajlovic AI, Kostic TS, Andric SA. Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells. Am J Physiol Endocrinol Metab 302: E1239-E1251, 2012.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Stojkov, N.J.1    Janjic, M.M.2    Bjelic, M.M.3    Mihajlovic, A.I.4    Kostic, T.S.5    Andric, S.A.6
  • 53
    • 56349110781 scopus 로고    scopus 로고
    • All-trans-retinoic acid induces apoptosis in Leydig cells via activation of the mitochondrial death pathway and antioxidant enzyme regulation
    • Tucci P, Cione E, Perri M, Genchi G. All-trans-retinoic acid induces apoptosis in Leydig cells via activation of the mitochondrial death pathway and antioxidant enzyme regulation. J Bioenerg Biomembr 40: 315-323, 2008.
    • (2008) J Bioenerg Biomembr , vol.40 , pp. 315-323
    • Tucci, P.1    Cione, E.2    Perri, M.3    Genchi, G.4
  • 54
    • 0036660617 scopus 로고    scopus 로고
    • Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A
    • Valks DM, Cook SA, Pham FH, Morrison PR, Clerk A, Sugden PH. Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A. J Mol Cell Cardiol 34: 749-763, 2002.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 749-763
    • Valks, D.M.1    Cook, S.A.2    Pham, F.H.3    Morrison, P.R.4    Clerk, A.5    Sugden, P.H.6
  • 55
    • 0031890109 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by ()-deprenyl
    • Wadia JS, Chalmers-Redman RM, Ju WJ, Carlile GW, Phillips JL, Fraser AD, Tatton WG. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by ()-deprenyl. J Neurosci 18: 932-947, 1998.
    • (1998) J Neurosci , vol.18 , pp. 932-947
    • Wadia, J.S.1    Chalmers-Redman, R.M.2    Ju, W.J.3    Carlile, G.W.4    Phillips, J.L.5    Fraser, A.D.6    Tatton, W.G.7
  • 56
    • 0034970775 scopus 로고    scopus 로고
    • MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes
    • Xiao L, Pimental DR, Amin JK, Singh K, Sawyer DB, Colucci WS. MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J Mol Cell Cardiol 33: 779-787, 2001.
    • (2001) J Mol Cell Cardiol , vol.33 , pp. 779-787
    • Xiao, L.1    Pimental, D.R.2    Amin, J.K.3    Singh, K.4    Sawyer, D.B.5    Colucci, W.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.