Identification of a kinetically distinct activity of 11β- hydroxysteroid dehydrogenase in rat leydig cells

Endocrinology

Volumn 138, Issue 6, 1997, Pages 2435-2442

  Ge, Ren Shan ^a   Gao, Hui Bao ^a,d   Nacharaju, Vijaya L ^c   Gunsalus, Glen L ^a   Hardy, Matthew P ^a,b  

^a POPULATION COUNCIL   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARBENOXOLONE; GLUCOCORTICOID; MINERALOCORTICOID RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TESTOSTERONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; HORMONE ACTION; IMMUNOBLOTTING; LEYDIG CELL; MALE; MICHAELIS CONSTANT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; REDUCTION; TESTOSTERONE SYNTHESIS;

EID: 0030925023     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.6.5165     Document Type: Article

References (59)

1. Chrousos GP, Gold PW 1992 The concepts of stress and stress system disorders. JAMA 267:1244-1252
2. McKenna TJ, Lorber D, Lacroix A, Rabin D 1979 Testicular activity in Cushing's disease. Acta Endocrinol (Copenh) 91:501-510
3. Charpenet G, Tache Y, Forest MG, Hauour F, Saez JM, Bernier M, Ducharme JR, Collu R 1981 Effects of chronic intermittent immobilization stress on rat testicular androgenic function. Endocrinology 109:1254-1258
4. Gao HB, Shan LX, Monder C, Hardy MP 1996 Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro. Endocrinology 137:1714-1718
5. Stalker A, Hermo L, Antakly T 1989 Covalent affinity labeling, radioautography, and immunocytochemistry localize the glucocorticoid receptor in rat testicular Leydig cells. Am J Anat 186:369-377
6. Ortlip SA, Li SA, Li JJ 1981 Characterization of specific glucocorticoid receptor in the Syrian hamster testis. Endocrinology 109:1331-1338
7. Schultz R, Isola J, Parvinen M, Honkaniemi J, Wilkstrom AC, Gustafsson JA, Pelto-Huikko M 1993 Localization of the glucocorticoid receptor in testis and accessory sexual organs of male rat. Mol Cell Endocrinol 95:115-120
8. Hales DB, Payne AH 1989 Glucocorticoid-mediated repression of P450scc mRNA and de novo synthesis in cultured Leydig cells. Endocrinology 124:2099-2104
9. Monder C, Miroff Y, Marandici A, Hardy MP 1994 11β-hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells. Endocrinology 134:1199-1204
10. Monder C, Lakshmi V, Miroff Y 1991 Kinetic studies on rat liver 11β-hydroxysteroid dehydrogenase. Biochim Biophys Acta 1115:23-29
11. Yang K, Yu M 1994 Evidence for distinct isoforms of 11β-hydroxysteroid dehydrogenase in the ovine liver and kidney. J Steroid Biochem Mol Biol 49:245-250
12. Lakshmi V, Monder C 1988 Purification and characterization of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex. Endocrinology 123:390-2398
13. Tannin GM, Agarwal AK, Monder C, New MI, White PC 1991 The human gene for 11β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 266:16653-16658
14. Agarwal AK, Monder C, Eckstein B, White PC 1989 Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase. J Biol Chem 264: 18939-18943
15. Rajan V, Chapman KE, Lyons V, Jamieson P, Mullins JJ, Edwards CR, Seckl JR 1995 Cloning, sequencing and tissue-distribution of mouse 11β-hydroxysteroid dehydrogenase-1 cDNA. J Steroid Biochem Mol Biol 52:141-147
16. Rusvai E, Naray-Fejes-Toth A 1993 A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells. J Biol Chem 268:10717-10720
17. Brown RW, Chapman KE, Edwards CR, Seckl JR 1993 Human placental 11β-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform. Endocrinology 132:2614-2621
18. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS 1994 Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105:R11-R17
19. Zhou MY, Gomez-Sanchez EP, Cox DL, Cosby D, Gomez-Sanchez CE 1995 Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11β-hydroxysteroid dehydrogenase. Endocrinology 136:3729-3734
20. Cole TJ 1995 Cloning of the mouse 11β-hydroxysteroid dehydrogenase type II gene: tissue specific expression and localization in distal convoluted tubules and collecting ducts of the kidney. Endocrinology 136:4693-4696
21. Agarwal AK, Monder C, White PC 1995 Cloning of cDNA encoding an NAD(+)-dependent isoform of 11β-hydroxysteroid dehydrogenase in sheep kidney. Endocr Res 21:389-397
22. Naray-Fejes-Toth A, Fejes-Toth G 1995 Expression cloning of the aldosterone target cell-specific 11β-hydroxysteroid dehydrogenase from rabbit collecting duct cells. Endocrinology 136:2579-2586
23. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM 1987 Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:269-275
24. Roland BL, Funder JW 1996 Localization of 11β-hydroxysteroid dehydrogenase type 2 in rat tissues-in situ studies. Endocrinology 137:1123-1128
25. Li KXZ, Smith RE, Ferrari P, Funder JW, Krozowski ZS 1996 Rat 11β-hydroxysteroid dehydrogenase type 2 enzyme is expressed at low levels in the placenta and is modulated by adrenal steroids in the kidney. Mol Cell Endocrinol 120:67-75
26. Phillips DM, Lakshmi V, Monder C 1989 Corticosteroid 11β-dehydrogenase in rat testis. Endocrinology 125:209-216
27. Munck A, Naray-Fejes-Toth A 1992 The ups and downs of glucocorticoid physiology. Permissive and suppressive effects revisited. Mol Cell Endocrinol 90:C1-C4
28. Monder C, White PC 1993 11β-hydroxysteroid dehydrogenase. Vitam Horm 47:187-271
29. Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CR 1995 Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 80:3155-3159
30. Hundertmark S, Buhler H, Ragosch V, Dinkelborg L, Arabin B, Weitzel HK 1995 Correlation of surfactant phosphatidylcholine synthesis an 11β-hydroxysteroid dehydrogenase in the fetal lung. Endocrinology 136:2573-2578
31. Duperrex H, Kenouch S, Gaeggeler HP, Seckl JR, Edwards CR, Farman N, Rossier BC 1993 Rat liver 11β-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid encodes oxoreductase activity in a mineralocorticoid-responsive toad bladder cell line. Endocrinology 132:612-619
32. Low SC, Chapman KE, Edwards CR, Seckl JR 1994 'Liver-type' 11β-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells. J Mol Endocrinol 13:167-174
33. Voice MW, Seckl JR, Edwards CRW, Chapman KE 1996 11β-hydroxysteroid dehydrogenase type 1 expression in 2s faza hepatoma cells is hormonally regulated-a model system for the study of hepatic glucocorticoid metabolism. Biochem J 317:621-625
34. Jamieson PM, Chapman KE, Edwards CR, Seckl JR 1995 11β-hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology 136:4754-4761
35. Rajan V, Edwards CRW, Seckl JR 1996 11β-hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. J Neurosci 16:65-70
36. Lakshmi V, Monder C 1985 Evidence for independent 11-oxidase and 11-reductase activities of 11β-hydroxysteroid dehydrogenase: enzyme latency, phase transitions, and lipid requirements. Endocrinology 116:552-560
37. Monder C, Lakshmi V 1990 Corticosteroid 11β-dehydrogenase of rat tissues: immunological studies. Endocrinology 126:2435-2443
38. Pertoft H, Smedsrød B 1987 Separation and characterisation of liver cells. In: Pretlow TG, Pretlow TP (eds) Cell Separation: Methods and Selected Applications. Academic Press, Orlando, FL, pp 1-23
39. Klinefelter GR, Kelce WR, Hardy MP 1993 Isolation and culture of Leydig cells from adult rats. Methods Toxicol 3A:166-181
40. Payne AH, Downing JR, Wong KL 1980 Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 106:1424-1429
41. Anonymous 1994 SAAM II User Guide, SAAM Institute, University of Washington, Seattle, WA
42. Carson ER, Cobelli C, Finkelstein L 1982 The Mathematical Modeling of Metabolic and Endocrine Systems: Model Formulation, Identification, and Validation. John Wiley & Sons, New York
43. Agarwal AK, Mune T, Monder C, White PC 1995 Mutations in putative glycosylation sites of rat 11β-hydroxysteroid dehydrogenase affect enzymatic activity. Biochim Biophys Acta 1248:70-74
44. Leckie C, Chapman KE, Edwards CR, Seckl JR 1995 LLC-PK1 cells model 11β-hydroxysteroid dehydrogenase type 2 regulation of glucocorticoid access to renal mineralocorticoid receptors. Endocrinology 136:5561-5569
45. Todd-Turla KM, Schnermann J, Fejes-Toth G, Naray-Fejes-Toth A, Smart A, Killen PD, Briggs JP 1993 Distribution of mineralocorticoid and glucocorticoid receptor mRNA along the nephron. Am J Physiol 264:F781-F791
46. Shan L-X, Hardy DO, Catterall JF, Hardy MP 1994 Effects of luteinizing hormone (LH) and androgen on steady state levels of messenger ribonucleic acid for LH receptors, androgen acceptors, and steroidogenic enzymes in rat Leydig cell progenitors in vivo. Endocrinology 136:1686-1693
47. Gomez-Sanchez EP, Cox D, Foecking M, Ganjam V, Gomez-Sanchez CE 1996 11β-hydroxysteroid dehydrogenase of the choriocarcinoma cell line JEG-3 and their inhibition by glycyrrhetinic acid and other natural substances. Steroids 61:110-115
48. Naray-Fejes-Toth A, Watlington CO, Fejes-Toth G 1991 11β-Hydroxysteroid dehydrogenase activity in the renal target cells of aldosterone. Endocrinology 129:17-21
49. Edwards CR, Stewart PM, Burt D, Brett L, McIntyre MA, Sutanto WS, de Kloet ER, Monder C 1988 Localization of 11β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet 2:986-989
50. Naray-Fejes-Rusvai E, Naray-Fejes-Toth A 1993 A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells. J Biol Chem 268:10717-10720
51. Murray M, Horsfield BP 1990 17β-hydroxysteroid oxidoreductase activity: age-dependent profile in rat liver and kinetic properties of the hepatic microsomal enzyme in relation to cytochrome P450-dependent steroid hydroxylation. J Steroid Biochem 36:569-574
52. Oshima H, Yoshida K, Troen P 1980 A further study of 17β-hydroxysteroid oxidoreductase in the human testis: mechanism of in vitro activation. Endocrinol Jpn 27:107-115
53. Vittek J, Gordon GG, Rappaport SC, Southren AL 1979 Cellular regulation of the metabolism of androgens in rat oral mucosa. II. Product activation of 17β-hydroxysteroid oxidoreductase enzyme system. J Dent Res 58:638-641
54. Hennebold JD, Ryu SY, Mu HH, Galbraith A, Daynes RA 1996 11β-hydroxysteroid dehydrogenase modulation of glucocorticoid activities in lymphoid organs. Am J Physiol 39:R1296-R1306
55. Krozowski Z, Obeyesekere V, Smith R, Mercer W 1992 Tissue-specific expression of an 11β-hydroxysteroid dehydrogenase with a truncated N-terminal domain. A potential mechanism for differential intracellular localisation within mineralocorticoid target cells. J Biol Chem 267:2569-2574
56. Mercer W, Obeyesekere V, Smith R, Krozowski Z 1993 Characterization of 11β-HSD1B gene expression and enzymatic activity. Mol Cell Endocrinol 92:247-251
57. Krozowski Z, Stuchbery S, White P, Monder C, Funder JW 1990 Characterization of 11β-hydroxysteroid dehydrogenase gene expression: identification of multiple unique forms of messenger ribonucleic acid in the rat kidney. Endocrinology 127:3009-3013
58. Krozowski ZS, Provencher PH, Smith RE, Obeyesekere VR, Mercer WR, Albiston AL 1994 Isozymes of 11β-hydroxysteroid dehydrogenase: which enzyme endows mineralocorticoid specificity? Steroids 59:116-120
59. Rundle SE, Funder JW, Lakshmi V, Monder C 1989 The intrarenal localization of mineralocorticoid receptors and 11β-dehydrogenase: immunocytochemical studies. Endocrinology 125:1700-1704