Deprival of testicular innervation induces apoptosis of Leydig cells via caspase-8-dependent signaling: A novel survival pathway revealed

Biochemical and Biophysical Research Communications

Volumn 382, Issue 1, 2009, Pages 165-170

  Gong, Yong Guang ^a   Wang, Yi Qiu ^b   Gu, Min ^b   Feng, Ming Ming ^b   Zhang, Wei ^b   Ge, Ren Shan ^c  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Apoptosis; Leydig cells; Testicular innervation

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; FOLLITROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CHROMATIN CONDENSATION; CONTROLLED STUDY; DENERVATION; ENZYME MECHANISM; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; IN VIVO STUDY; INFERIOR SPERMATIC NERVE; INNERVATION; LEYDIG CELL; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SPERM; STEROIDOGENESIS; SUPERIOR SPERMATIC NERVE; TESTIS CELL;

ANIMALS; APOPTOSIS; CASPASE 8; CELL SURVIVAL; DENERVATION; FOLLICLE STIMULATING HORMONE; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TESTIS;

RATTUS;

EID: 63149132002     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.02.159     Document Type: Article

References (33)

1. Schleich F., and Legros J.J. Effects of androgen substitution on lipid profile in the adult and aging hypogonadal male. Eur. J. Endocrinol. 151 (2004) 415-424
2. Gao W., Bohl C.E., and Dalton J.T. Chemistry and structural biology of androgen receptor. Chem. Rev. 105 (2005) 3352-3370
3. Huhtaniemi I., and Toppari J. Endocrine, paracrine and autocrine regulation of testicular steroidogenesis. Adv. Exp. Med. Biol. 377 (1995) 33-54
4. Zirkin B.R., and Chen H. Regulation of Leydig cell steroidogenic function during aging. Biol. Reprod. 63 (2000) 977-981
5. Kuntz A., and Morris R.E. Components and distribution of the spermatic nerves and the nerves of the vas deferens. J. Comp. Neurol. 85 (1946) 33-44
6. Setchell B.P., Maddocks S., and Brooks D.E. Anatomy, vasculature, innervation, and fluids of the male reproductive tract. The Physiology of Reproduction. second ed. (1994), Raven Press, New York
7. Zhu B.C., Chiocchio S.R., Suburo A.M., and Tramezzani J.H. Monoaminergic and peptidergic contributions of the superior and the inferior spermatic nerves to the innervation of the testis in the rat. J. Androl. 16 (1995) 248-258
8. Suburo A.M., Chiocchio S.R., Cantó Soler M.V., Nieponice A., and Tramezzani J.H. Peptidergic innervation of blood vessels and interstitial cells in the testis of the cat. J. Androl. 23 (2002) 121-134
9. Tainio H. Peptidergic innervation of the human testis and epididymis. Acta Histochem. 96 (1994) 415-420
10. Wrobel K.H., and Moustafa M.N. On the innervation of the donkey testis. Ann. Anat. 82 (2000) 13-22
11. Anakwe O.O., Murphy P.R., and Moger W.H. Characterization of beta-adrenergic binding sites on rodent Leydig cells. Biol. Reprod. 33 (1985) 815-826
12. Mayerhofer A., Steger R.W., Gow G., and Bartke A. Catecholamines stimulate testicular testosterone release of the immature golden hamster via interaction with alpha- and beta-adrenergic receptors. Acta Endocrinol. 127 (1992) 526-530
13. Campos M.B., Chiocchio S.R., Calandra R.S., and Ritta M.N. Effect of bilateral denervation of the immature rat testis on testicular gonadotropin receptors and in vitro androgen production. Neuroendocrinology 57 (1993) 189-194
14. Frankel A.I., and Ryan E.L. Testicular innervation is necessary for the response of plasma testosterone levels to acute stress. Biol. Reprod. 124 (1981) 491-495
15. Chiocchio S.R., Suburo A.M., Vladucic E., Zhu B.C., Charreau E., Décima E.E., and Tramezzani J.H. Differential effects of superior and inferior spermatic nerves on testosterone secretion and spermatic blood flow in cats. Endocrinology 140 (1999) 1036-1043
16. Frankel A.I., Mock E.J., and Chapman J.C. Hypophysectomy and hemivasectomy can inhibit the testicular hemicastration response of the mature rat. Biol. Reprod. 30 (1984) 804-808
17. Lee S., Miselis R., and Rivier C. Anatomical and functional evidence for a neural hypothalamic-testicular pathway that is independent of the pituitary. Endocrinology 143 (2002) 4447-4454
18. Selvage D.J., and Rivier C. Importance of the paraventricular nucleus of the hypothalamus as a component of a neural pathway between the brain and the testes that modulates testosterone secretion independently of the pituitary. Endocrinology 144 (2003) 594-598
19. Selvage D.J., Parsons L., and Rivier C. Role played by brainstem neurons in regulating testosterone secretion via a direct neural pathway between the hypothalamus and the testes. Endocrinology 147 (2006) 3070-3075
20. Kim J.M., Luo L., and Zirkin B.R. Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate. Endocrinology 141 (2000) 1846-1853
21. Paula-Lopes F.F., and Hansen P.J. Heat shock-induced apoptosis in preimplantation bovine embryos is a developmentally regulated phenomenon. Biol. Reprod. 66 (2002) 1169-1177
22. Chiloeches A., Sánchez-Pacheco A., Gil-Araujo B., Aranda A., and Lasa M. Thyroid hormone-mediated activation of the ERK/dual specificity phosphatase 1 pathway augments the apoptosis of GH4C1 cells by down-regulating nuclear factor-kappaB activity. Mol. Endocrinol. 22 (2008) 2466-2480
23. Ueda E.K., Lo H.L., Bartolini P., and Walker A.M. S179D prolactin primarily uses the extrinsic pathway and mitogen-activated protein kinase signaling to induce apoptosis in human endothelial cells. Endocrinology 147 (2006) 4627-4637
24. Bantel H., Ruck P., Gregor M., and Schulze-Osthoff K. Detection of elevated caspase activation and early apoptosis in liver diseases. Eur. J. Cell Biol. 80 (2001) 230-239
25. Telford W.G., Komoriya A., and Packard B.Z. Detection of localized caspase activity in early apoptotic cells by laser scanning cytometry. Cytometry 47 (2002) 81-88
26. Ishikawa T., Kondo Y., Goda K., and Fujisawa M. Overexpression of endothelial nitric oxide synthase in transgenic mice accelerates testicular germ cell apoptosis induced by experimental cryptorchidism. J. Androl. 26 (2005) 281-288
27. Wang Z.Q., Todani T., Watanabe Y., Toki A., Ogura K., Miyamoto O., Toyoshima T., and Itano T. Germ-cell degeneration in experimental unilateral cryptorchidism role of apoptosis. Pediatr. Surg. Int. 14 (1998) 9-13 35
28. Lysiak J.J., Turner S.D., and Turner T.T. Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis. Biol. Reprod. 63 (2000) 1465-1472
29. Turner T.T., Tung K.S., Tomomasa H., and Wilson L.W. Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biol. Reprod. 57 (1997) 1267-1274
30. Clark M.J., Schopp L.H., Mazurek M.O., Zaniletti I., Lammy A.B., Martin T.A., Thomas F.P., and Acuff M.E. Testosterone levels among men with spinal cord injury relationship between time since injury and laboratory values. Am. J. Phys. Med. Rehabil. 87 (2008) 758-767
31. Celik B., Sahin A., Caglar N., Erhan B., Gunduz B., Gultekin O., and Karabulut M. Sex hormone levels and functional outcomes a controlled study of patients with spinal cord injury compared with healthy subjects. Am. J. Phys. Med. Rehabil. 86 (2007) 784-790
32. Li J., and Yuan J. Caspases in apoptosis and beyond. Oncogene 20 (2008) 6194-6206
33. Salvesen G.S., and Riedl S.J. Caspase mechanisms. Adv. Exp. Med. Biol. 615 (2008) 13-23