The α1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-κB signalling to induce breast cancer cell apoptosis

European Journal of Cancer

Volumn 44, Issue 1, 2008, Pages 160-166

  Hui, Hongxiang ^a   Fernando, Manory A ^a   Heaney, Anthony P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Breast cancer; Doxazosin; EGFR; NF B

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DOXAZOSIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR E2F; TUMOR NECROSIS FACTOR ALPHA; ADRENERGIC RECEPTOR BLOCKING AGENT; ANTINEOPLASTIC AGENT;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION; BREAST TUMOR; CELL COMMUNICATION; CELL CULTURE; DRUG EFFECT; METABOLISM; PATHOLOGY; WESTERN BLOTTING;

ADRENERGIC ANTAGONISTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL COMMUNICATION; DOXAZOSIN; HUMANS; NF-KAPPA B; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 37149057007     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2007.10.002     Document Type: Article

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