Characterization of a high-affinity human antibody with a disulfide bridge in the third complementarity-determining region of the heavy chain

Journal of Molecular Recognition

Volumn 25, Issue 3, 2012, Pages 125-135

  Almagro, Juan Carlos ^a   Raghunathan, Gopalan ^b   Beil, Eric ^a   Janecki, Dariusz J ^a   Chen, Qiang ^b   Dinh, Thai ^b   Lacombe, Ann ^b   Connor, Judy ^b   Ware, Mark ^b   Kim, Paul H ^b   Swanson, Ronald V ^b   Fransson, Johan ^b  

^a CENTOCOR INC   (United States)

^b 3210 Merryfield Row   (United States)

Author keywords

antibody; CDR H3; complementarity determining region 3; disulfide bridge; dynamic simulation; mass spectrometry; phage display; structure modeling

Indexed keywords

CYSTEINE; CYTOKINE; DISULFIDE; EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PEPTIDE FRAGMENT; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ARTICLE; CELL CULTURE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; PEPTIDE LIBRARY; PEPTIDE MAPPING; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SOLUBILITY; TRANSITION TEMPERATURE;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; BINDING SITES, ANTIBODY; CELLS, CULTURED; COMPLEMENTARITY DETERMINING REGIONS; CYSTEINE; CYTOKINES; DISULFIDES; EPITOPES; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PEPTIDE MAPPING; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; STAT3 TRANSCRIPTION FACTOR; TRANSITION TEMPERATURE;

CAMELIDAE; CHONDRICHTHYES;

EID: 84858247303     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.1168     Document Type: Article

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