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Volumn 62, Issue 1, 2013, Pages 92-102

Ginsenoside Rg1 facilitates neural differentiation of mouse embryonic stem cells via GR-dependent signaling pathway

Author keywords

Akt; Embryonic stem cells; Ginsenoside Rg1; Glucocorticoid receptor; MAPK; Neurodifferentiation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; BETA TUBULIN; DEXAMETHASONE; GINSENOSIDE RG 1; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROFILAMENT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETINOIC ACID;

EID: 84871715047     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.09.016     Document Type: Article
Times cited : (48)

References (50)
  • 1
    • 80053386765 scopus 로고    scopus 로고
    • Glucocorticoids dexamethasone and hydrocortisone inhibit proliferation and accelerate maturation of chicken cerebellar granule neurons
    • P. Aden, R.E. Paulsen, J. Maehlen, E.M. Loberg, I.L. Goverud, K. Liestol, and J. Lomo Glucocorticoids dexamethasone and hydrocortisone inhibit proliferation and accelerate maturation of chicken cerebellar granule neurons Brain Res. 1418 2011 32 41
    • (2011) Brain Res. , vol.1418 , pp. 32-41
    • Aden, P.1    Paulsen, R.E.2    Maehlen, J.3    Loberg, E.M.4    Goverud, I.L.5    Liestol, K.6    Lomo, J.7
  • 3
    • 33746325064 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis
    • M. Aouadi, F. Bost, L. Caron, K. Laurent, Y. Le Marchand Brustel, and B. Binetruy P38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis Stem cells 24 2006 1399 1406
    • (2006) Stem Cells , vol.24 , pp. 1399-1406
    • Aouadi, M.1    Bost, F.2    Caron, L.3    Laurent, K.4    Le Marchand Brustel, Y.5    Binetruy, B.6
  • 5
    • 11144270229 scopus 로고    scopus 로고
    • Injectable dexamethasone administration enhances cortical GABAergic neuronal differentiation in a novel model of postnatal steroid therapy in mice
    • O. Baud, C. Verney, P. Evrard, and P. Gressens Injectable dexamethasone administration enhances cortical GABAergic neuronal differentiation in a novel model of postnatal steroid therapy in mice Pediatr. Res. 57 2005 149 156
    • (2005) Pediatr. Res. , vol.57 , pp. 149-156
    • Baud, O.1    Verney, C.2    Evrard, P.3    Gressens, P.4
  • 7
    • 79958051229 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex
    • C.B. Chan, X. Liu, S. Pradoldej, C. Hao, J. An, M. Yepes, H.R. Luo, and K. Ye Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex J. Neurosci. 31 2011 8083 8092
    • (2011) J. Neurosci. , vol.31 , pp. 8083-8092
    • Chan, C.B.1    Liu, X.2    Pradoldej, S.3    Hao, C.4    An, J.5    Yepes, M.6    Luo, H.R.7    Ye, K.8
  • 8
    • 0027269835 scopus 로고
    • Inhibition of mouse GATA-1 function by the glucocorticoid receptor: Possible mechanism of steroid inhibition of erythroleukemia cell differentiation
    • T.J. Chang, B.M. Scher, S. Waxman, and W. Scher Inhibition of mouse GATA-1 function by the glucocorticoid receptor: possible mechanism of steroid inhibition of erythroleukemia cell differentiation Mol. Endocrinol. 7 1993 528 542
    • (1993) Mol. Endocrinol. , vol.7 , pp. 528-542
    • Chang, T.J.1    Scher, B.M.2    Waxman, S.3    Scher, W.4
  • 9
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • S. Cowley, H. Paterson, P. Kemp, and C.J. Marshall Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells Cell 77 1994 841 852
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 10
    • 0021891053 scopus 로고
    • The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium
    • T.C. Doetschman, H. Eistetter, M. Katz, W. Schmidt, and R. Kemler The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium J. Embryol. Exp. Morphol. 87 1985 27 45
    • (1985) J. Embryol. Exp. Morphol. , vol.87 , pp. 27-45
    • Doetschman, T.C.1    Eistetter, H.2    Katz, M.3    Schmidt, W.4    Kemler, R.5
  • 11
    • 79960481117 scopus 로고    scopus 로고
    • Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects
    • J. Du, B. Cheng, X. Zhu, and C. Ling Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects J. Immunol. 187 2011 942 950
    • (2011) J. Immunol. , vol.187 , pp. 942-950
    • Du, J.1    Cheng, B.2    Zhu, X.3    Ling, C.4
  • 12
    • 75749099851 scopus 로고    scopus 로고
    • Controlling destiny through chemistry: Small-molecule regulators of cell fate
    • A.J. Firestone, and J.K. Chen Controlling destiny through chemistry: small-molecule regulators of cell fate ACS Chem. Biol. 5 2010 15 34
    • (2010) ACS Chem. Biol. , vol.5 , pp. 15-34
    • Firestone, A.J.1    Chen, J.K.2
  • 13
    • 0037312827 scopus 로고    scopus 로고
    • STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation
    • Z.E. Floyd, and J.M. Stephens STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation Diabetes 52 2003 308 314
    • (2003) Diabetes , vol.52 , pp. 308-314
    • Floyd, Z.E.1    Stephens, J.M.2
  • 14
    • 54949109808 scopus 로고    scopus 로고
    • PI3K/Akt: Getting it right matters
    • T.F. Franke PI3K/Akt: getting it right matters Oncogene 27 2008 6473 6488
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 15
    • 84859023456 scopus 로고    scopus 로고
    • MAPKs in development: Insights from dictyostelium signaling pathways
    • J.A. Hadwiger, and H.N. Nguyen MAPKs in development: insights from dictyostelium signaling pathways Biomol. Concepts 2 2011 39 46
    • (2011) Biomol. Concepts , vol.2 , pp. 39-46
    • Hadwiger, J.A.1    Nguyen, H.N.2
  • 16
    • 0035021950 scopus 로고    scopus 로고
    • ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
    • T. Harada, T. Morooka, S. Ogawa, and E. Nishida ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 Nat. Cell Biol. 3 2001 453 459
    • (2001) Nat. Cell Biol. , vol.3 , pp. 453-459
    • Harada, T.1    Morooka, T.2    Ogawa, S.3    Nishida, E.4
  • 17
    • 0033305164 scopus 로고    scopus 로고
    • Thiazolidinedione effects on glucocorticoid receptor-mediated gene transcription and differentiation in osteoblastic cells
    • T.E. Johnson, R. Vogel, S.J. Rutledge, G. Rodan, and A. Schmidt Thiazolidinedione effects on glucocorticoid receptor-mediated gene transcription and differentiation in osteoblastic cells Endocrinology 140 1999 3245 3254
    • (1999) Endocrinology , vol.140 , pp. 3245-3254
    • Johnson, T.E.1    Vogel, R.2    Rutledge, S.J.3    Rodan, G.4    Schmidt, A.5
  • 18
    • 1042291164 scopus 로고    scopus 로고
    • Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells
    • P. Laprise, M.J. Langlois, M.J. Boucher, C. Jobin, and N. Rivard Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells J. Cell Physiol. 199 2004 32 39
    • (2004) J. Cell Physiol. , vol.199 , pp. 32-39
    • Laprise, P.1    Langlois, M.J.2    Boucher, M.J.3    Jobin, C.4    Rivard, N.5
  • 19
    • 0030838299 scopus 로고    scopus 로고
    • Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor
    • Y.J. Lee, E. Chung, K.Y. Lee, Y.H. Lee, B. Huh, and S.K. Lee Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor Mol. Cell Endocrinol. 133 1997 135 140
    • (1997) Mol. Cell Endocrinol. , vol.133 , pp. 135-140
    • Lee, Y.J.1    Chung, E.2    Lee, K.Y.3    Lee, Y.H.4    Huh, B.5    Lee, S.K.6
  • 20
    • 0032479977 scopus 로고    scopus 로고
    • Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation
    • S. Leppa, R. Saffrich, W. Ansorge, and D. Bohmann Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation EMBO J. 17 1998 4404 4413
    • (1998) EMBO J. , vol.17 , pp. 4404-4413
    • Leppa, S.1    Saffrich, R.2    Ansorge, W.3    Bohmann, D.4
  • 21
    • 77953307436 scopus 로고    scopus 로고
    • Pharmacology of ginsenosides: A literature review
    • K.W. Leung, and A.S. Wong Pharmacology of ginsenosides: a literature review Chin. Med. 5 2010 20
    • (2010) Chin. Med. , vol.5 , pp. 20
    • Leung, K.W.1    Wong, A.S.2
  • 22
    • 68249141248 scopus 로고    scopus 로고
    • Proliferation- and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann cells
    • M.C. Lu, T.Y. Lai, J.M. Hwang, H.T. Chen, S.H. Chang, F.J. Tsai, H.L. Wang, C.C. Lin, W.W. Kuo, and C.Y. Huang Proliferation- and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann cells Cell Biochem. Funct. 27 2009 186 192
    • (2009) Cell Biochem. Funct. , vol.27 , pp. 186-192
    • Lu, M.C.1    Lai, T.Y.2    Hwang, J.M.3    Chen, H.T.4    Chang, S.H.5    Tsai, F.J.6    Wang, H.L.7    Lin, C.C.8    Kuo, W.W.9    Huang, C.Y.10
  • 24
    • 77953622055 scopus 로고    scopus 로고
    • Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury
    • J. Ma, W. Li, R. Tian, and W. Lei Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury Neurosci. Lett. 478 2010 66 71
    • (2010) Neurosci. Lett. , vol.478 , pp. 66-71
    • Ma, J.1    Li, W.2    Tian, R.3    Lei, W.4
  • 25
    • 33745728406 scopus 로고    scopus 로고
    • Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis
    • J.L. Mayer, L. Klumpers, S. Maslam, E.R. de Kloet, M. Joels, and P.J. Lucassen Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis J. Neuroendocrinol. 18 2006 629 631
    • (2006) J. Neuroendocrinol. , vol.18 , pp. 629-631
    • Mayer, J.L.1    Klumpers, L.2    Maslam, S.3    De Kloet, E.R.4    Joels, M.5    Lucassen, P.J.6
  • 26
    • 0030038741 scopus 로고    scopus 로고
    • Early environmental regulation of forebrain glucocorticoid receptor gene expression: Implications for adrenocortical responses to stress
    • M.J. Meaney, J. Diorio, D. Francis, J. Widdowson, P. LaPlante, C. Caldji, S. Sharma, J.R. Seckl, and P.M. Plotsky Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress Dev. Neurosci. 18 1996 49 72
    • (1996) Dev. Neurosci. , vol.18 , pp. 49-72
    • Meaney, M.J.1    Diorio, J.2    Francis, D.3    Widdowson, J.4    Laplante, P.5    Caldji, C.6    Sharma, S.7    Seckl, J.R.8    Plotsky, P.M.9
  • 27
    • 0024002468 scopus 로고
    • Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene
    • J. Milbrandt Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene Neuron 1 1988 183 188
    • (1988) Neuron , vol.1 , pp. 183-188
    • Milbrandt, J.1
  • 29
    • 80051982748 scopus 로고    scopus 로고
    • Critical Role of PI3K/Akt/GSK3beta in Motoneuron specification from human neural stem cells in response to FGF2 and EGF
    • L. Ojeda, J. Gao, K.G. Hooten, E. Wang, J.R. Thonhoff, T.J. Dunn, T. Gao, and P. Wu Critical Role of PI3K/Akt/GSK3beta in Motoneuron specification from human neural stem cells in response to FGF2 and EGF PLoS One 6 2011 e23414
    • (2011) PLoS One , vol.6 , pp. 23414
    • Ojeda, L.1    Gao, J.2    Hooten, K.G.3    Wang, E.4    Thonhoff, J.R.5    Dunn, T.J.6    Gao, T.7    Wu, P.8
  • 32
    • 2242448020 scopus 로고    scopus 로고
    • The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway
    • D. Rueda, B. Navarro, A. Martinez-Serrano, M. Guzman, and I. Galve-Roperh The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway J. Biol. Chem. 277 2002 46645 46650
    • (2002) J. Biol. Chem. , vol.277 , pp. 46645-46650
    • Rueda, D.1    Navarro, B.2    Martinez-Serrano, A.3    Guzman, M.4    Galve-Roperh, I.5
  • 33
    • 74649085850 scopus 로고    scopus 로고
    • Building a framework for embryonic microenvironments and cancer stem cells
    • A. Ruiz-Vela, C. Aguilar-Gallardo, and C. Simon Building a framework for embryonic microenvironments and cancer stem cells Stem Cell Rev. 5 2009 319 327
    • (2009) Stem Cell Rev. , vol.5 , pp. 319-327
    • Ruiz-Vela, A.1    Aguilar-Gallardo, C.2    Simon, C.3
  • 34
    • 77956240156 scopus 로고    scopus 로고
    • Translation of stem cell therapy for neurological diseases
    • S.C. Schwarz, and J. Schwarz Translation of stem cell therapy for neurological diseases Transl. Res. 156 2010 155 160
    • (2010) Transl. Res. , vol.156 , pp. 155-160
    • Schwarz, S.C.1    Schwarz, J.2
  • 35
    • 33646197380 scopus 로고    scopus 로고
    • Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for met-triggered cortical neuron migration
    • J. Segarra, L. Balenci, T. Drenth, F. Maina, and F. Lamballe Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for met-triggered cortical neuron migration J. Biol. Chem. 281 2006 4771 4778
    • (2006) J. Biol. Chem. , vol.281 , pp. 4771-4778
    • Segarra, J.1    Balenci, L.2    Drenth, T.3    Maina, F.4    Lamballe, F.5
  • 36
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • R. Seger, and E.G. Krebs The MAPK signaling cascade FASEB J. 9 1995 726 735
    • (1995) FASEB J. , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 37
    • 0037683293 scopus 로고    scopus 로고
    • Ginsenoside Rg1 increases ischemia-induced cell proliferation and survival in the dentate gyrus of adult gerbils
    • L. Shen, and J. Zhang Ginsenoside Rg1 increases ischemia-induced cell proliferation and survival in the dentate gyrus of adult gerbils Neurosci. Lett. 344 2003 1 4
    • (2003) Neurosci. Lett. , vol.344 , pp. 1-4
    • Shen, L.1    Zhang, J.2
  • 38
    • 34249072490 scopus 로고    scopus 로고
    • NMDA receptor and iNOS are involved in the effects of ginsenoside Rg1 on hippocampal neurogenesis in ischemic gerbils
    • L. Shen, and J. Zhang NMDA receptor and iNOS are involved in the effects of ginsenoside Rg1 on hippocampal neurogenesis in ischemic gerbils Neurol. Res. 29 2007 270 273
    • (2007) Neurol. Res. , vol.29 , pp. 270-273
    • Shen, L.1    Zhang, J.2
  • 39
    • 49449102627 scopus 로고    scopus 로고
    • Neural commitment of embryonic stem cells: Molecules, pathways and potential for cell therapy
    • D.M. Suter, and K.H. Krause Neural commitment of embryonic stem cells: molecules, pathways and potential for cell therapy J. Pathol. 215 2008 355 368
    • (2008) J. Pathol. , vol.215 , pp. 355-368
    • Suter, D.M.1    Krause, K.H.2
  • 40
    • 0027494657 scopus 로고
    • Regulation of neuronal differentiation by retinoic acid alone and in cooperation with thyroid hormone or hydrocortisone
    • H.S. Ved, and R.A. Pieringer Regulation of neuronal differentiation by retinoic acid alone and in cooperation with thyroid hormone or hydrocortisone Dev. Neurosci. 15 1993 49 53
    • (1993) Dev. Neurosci. , vol.15 , pp. 49-53
    • Ved, H.S.1    Pieringer, R.A.2
  • 41
    • 62549088238 scopus 로고    scopus 로고
    • Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner
    • Z. Wang, H. Wang, J. Wu, D. Zhu, X. Zhang, L. Ou, Y. Yu, and Y. Lou Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner Chem. Biol. Interact. 179 2009 375 385
    • (2009) Chem. Biol. Interact. , vol.179 , pp. 375-385
    • Wang, Z.1    Wang, H.2    Wu, J.3    Zhu, D.4    Zhang, X.5    Ou, L.6    Yu, Y.7    Lou, Y.8
  • 42
    • 0031032760 scopus 로고    scopus 로고
    • The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors
    • O. Wessely, E.M. Deiner, H. Beug, and M. von Lindern The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors EMBO J. 16 1997 267 280
    • (1997) EMBO J. , vol.16 , pp. 267-280
    • Wessely, O.1    Deiner, E.M.2    Beug, H.3    Von Lindern, M.4
  • 43
    • 43149116558 scopus 로고    scopus 로고
    • Fluorescent high-throughput screening of chemical inducers of neuronal differentiation in skeletal muscle cells
    • D.R. Williams, G.H. Kim, M.R. Lee, and I. Shin Fluorescent high-throughput screening of chemical inducers of neuronal differentiation in skeletal muscle cells Nat. Protoc. 3 2008 835 839
    • (2008) Nat. Protoc. , vol.3 , pp. 835-839
    • Williams, D.R.1    Kim, G.H.2    Lee, M.R.3    Shin, I.4
  • 44
    • 84862007373 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway
    • J. Wu, Z. Pan, Z. Wang, W. Zhu, Y. Shen, R. Cui, J. Lin, H. Yu, Q. Wang, J. Qian, Y. Yu, D. Zhu, and Y. Lou Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway Neuropharmacology. 63 2012 349 361
    • (2012) Neuropharmacology. , vol.63 , pp. 349-361
    • Wu, J.1    Pan, Z.2    Wang, Z.3    Zhu, W.4    Shen, Y.5    Cui, R.6    Lin, J.7    Yu, H.8    Wang, Q.9    Qian, J.10    Yu, Y.11    Zhu, D.12    Lou, Y.13
  • 45
    • 17844375379 scopus 로고    scopus 로고
    • Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells
    • J. Xie, J. Qian, J. Yang, S. Wang, M.E. Freeman 3rd, and Q. Yi Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells Exp. Hematol. 33 2005 564 572
    • (2005) Exp. Hematol. , vol.33 , pp. 564-572
    • Xie, J.1    Qian, J.2    Yang, J.3    Wang, S.4    Freeman III, M.E.5    Yi, Q.6
  • 46
    • 78649782421 scopus 로고    scopus 로고
    • Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells
    • H. Xu, H. Jiang, J. Wang, and J. Xie Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells J. Cell Biochem. 111 2010 1537 1545
    • (2010) J. Cell Biochem. , vol.111 , pp. 1537-1545
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4
  • 47
    • 82555176456 scopus 로고    scopus 로고
    • Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions
    • L. Yang, W. Guo, Q. Zhang, H. Li, X. Liu, Y. Yang, J. Zuo, and W. Liu Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions J. Mol. Biol. 414 2011 654 666
    • (2011) J. Mol. Biol. , vol.414 , pp. 654-666
    • Yang, L.1    Guo, W.2    Zhang, Q.3    Li, H.4    Liu, X.5    Yang, Y.6    Zuo, J.7    Liu, W.8
  • 48
    • 1842426600 scopus 로고    scopus 로고
    • Differential effects of corticosterone and dexamethasone on hippocampal neurogenesis in vitro
    • I.T. Yu, S.H. Lee, Y.S. Lee, and H. Son Differential effects of corticosterone and dexamethasone on hippocampal neurogenesis in vitro Biochem. Biophys. Res. Commun. 317 2004 484 490
    • (2004) Biochem. Biophys. Res. Commun. , vol.317 , pp. 484-490
    • Yu, I.T.1    Lee, S.H.2    Lee, Y.S.3    Son, H.4
  • 49
    • 84862787535 scopus 로고    scopus 로고
    • Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis
    • X. Zhang, J. Wu, Y. Dou, B. Xia, W. Rong, G. Rimbach, and Y. Lou Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis Eur. J. Pharmacol. 679 2012 51 59
    • (2012) Eur. J. Pharmacol. , vol.679 , pp. 51-59
    • Zhang, X.1    Wu, J.2    Dou, Y.3    Xia, B.4    Rong, W.5    Rimbach, G.6    Lou, Y.7
  • 50
    • 65649122287 scopus 로고    scopus 로고
    • Proliferation effect of neural stem cell of ginsenoside Rg1 in vitro
    • P. Zhuang, Y. Zhang, and T. Pang Proliferation effect of neural stem cell of ginsenoside Rg1 in vitro Zhongguo Zhong Yao Za Zhi 34 2009 443 446
    • (2009) Zhongguo Zhong Yao Za Zhi , vol.34 , pp. 443-446
    • Zhuang, P.1    Zhang, Y.2    Pang, T.3


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