Asiatic acid protects primary neurons against C 2-ceramide- induced apoptosis

European Journal of Pharmacology

Volumn 679, Issue 1-3, 2012, Pages 51-59

  Zhang, Xiangnan ^a   Wu, Jiaying ^a   Dou, Yuan ^a   Xia, Binbin ^a   Rong, Weibo ^a   Rimbach, Gerald ^b   Lou, Yijia ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Apoptosis; Asiatic acid; C 2 ceramide; Mitochondrion; Neuron

Indexed keywords

ASIATIC ACID; CASPASE 3; CERAMIDE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE OMI;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELL COUNT; CELL CULTURE; CELL DEATH; CELL LOSS; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; PENTACYCLIC TRITERPENES; PRIMARY CELL CULTURE; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84862787535     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.01.006     Document Type: Article

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