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Volumn 2, Issue 1-2, 2011, Pages 39-46

MAPKs in development: Insights from Dictyostelium signaling pathways

Author keywords

Dictyostelium; ERK2; extracellular signal regulated kinase 1 (ERK1); G protein; mitogen activated protein kinase (MAPK)

Indexed keywords

DICTYOSTELIUM; EUKARYOTA;

EID: 84859023456     PISSN: 18685021     EISSN: 1868503X     Source Type: Journal    
DOI: 10.1515/bmc.2011.004     Document Type: Review
Times cited : (16)

References (74)
  • 1
    • 0036364093 scopus 로고    scopus 로고
    • Diversity of G protein-coupled receptor signaling pathways to ERK/MAP kinase
    • Belcheva MM, Coscia CJ. Diversity of G protein-coupled receptor signaling pathways to ERK/MAP kinase. Neurosignals 2002; 11: 34-44.
    • (2002) Neurosignals , vol.11 , pp. 34-44
    • Belcheva, M.M.1    Coscia, C.J.2
  • 2
    • 34547216984 scopus 로고    scopus 로고
    • Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae
    • Chen RE, Thorner J. Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 2007; 1773: 1311-40.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1311-1340
    • Chen, R.E.1    Thorner, J.2
  • 3
    • 36849000872 scopus 로고    scopus 로고
    • Canonical and alternative MAPK signaling
    • Pimienta G, Pascual J. Canonical and alternative MAPK signaling. Cell Cycle 2007; 6: 2628-32.
    • (2007) Cell Cycle , vol.6 , pp. 2628-2632
    • Pimienta, G.1    Pascual, J.2
  • 4
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007; 26: 3100-12.
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 5
    • 75749131083 scopus 로고    scopus 로고
    • Convergence and specificity in the Arabidopsis MAPK nexus
    • Andreasson E, Ellis B. Convergence and specificity in the Arabidopsis MAPK nexus. Trends Plant Sci 2010; 15: 106-13.
    • (2010) Trends Plant Sci , vol.15 , pp. 106-113
    • Andreasson, E.1    Ellis, B.2
  • 6
    • 0032710357 scopus 로고    scopus 로고
    • Role of pathways for signal transducers and activators of transcription, and mitogen-activated protein kinase in adipocyte differentiation
    • Aubert J, Belmonte N, Dani C. Role of pathways for signal transducers and activators of transcription, and mitogen-activated protein kinase in adipocyte differentiation. Cell Mol Life Sci 1999; 56: 538-42.
    • (1999) Cell Mol Life Sci , vol.56 , pp. 538-542
    • Aubert, J.1    Belmonte, N.2    Dani, C.3
  • 7
    • 14544298335 scopus 로고    scopus 로고
    • The role of MAPKs in adipocyte differentiation and obesity
    • Bost F, Aouadi M, Caron L, Binetruy B. The role of MAPKs in adipocyte differentiation and obesity. Biochimie 2005; 87: 51-6.
    • (2005) Biochimie , vol.87 , pp. 51-56
    • Bost, F.1    Aouadi, M.2    Caron, L.3    Binetruy, B.4
  • 9
    • 70349304424 scopus 로고    scopus 로고
    • Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations
    • Nakamura T, Gulick J, Pratt R, Robbins J. Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations. Proc Natl Acad Sci USA 2009; 106: 15436-41.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15436-15441
    • Nakamura, T.1    Gulick, J.2    Pratt, R.3    Robbins, J.4
  • 10
    • 58149395502 scopus 로고    scopus 로고
    • Noonan, Costello and cardio-faciocutaneous syndromes: Dysregulation of the Ras-MAPK pathway
    • Tidyman WE, Rauen KA. Noonan, Costello and cardio-faciocutaneous syndromes: dysregulation of the Ras-MAPK pathway. Expert Rev Mol Med 2008; 10: e37.
    • (2008) Expert Rev Mol Med , vol.10 , pp. e37
    • Tidyman, W.E.1    Rauen, K.A.2
  • 11
    • 0036467578 scopus 로고    scopus 로고
    • Anchorage-dependent ERK signaling - Mechanisms and consequences
    • Howe AK, Aplin AE, Juliano RL. Anchorage-dependent ERK signaling - mechanisms and consequences. Curr Opin Genet Dev 2002; 12: 30-5.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 30-35
    • Howe, A.K.1    Aplin, A.E.2    Juliano, R.L.3
  • 12
    • 70349732865 scopus 로고    scopus 로고
    • Adhesion-mediated apoptosis resistance in cancer
    • Westhoff MA, Fulda S. Adhesion-mediated apoptosis resistance in cancer. Drug Resist Updat 2009; 12: 127-36.
    • (2009) Drug Resist Updat , vol.12 , pp. 127-136
    • Westhoff, M.A.1    Fulda, S.2
  • 14
    • 1842863982 scopus 로고    scopus 로고
    • Study of MAPK signaling using knockout mice
    • Pages G, Pouyssegur J. Study of MAPK signaling using knockout mice. Methods Mol Biol 2004; 250: 155-66.
    • (2004) Methods Mol Biol , vol.250 , pp. 155-166
    • Pages, G.1    Pouyssegur, J.2
  • 15
    • 77951926870 scopus 로고    scopus 로고
    • MAP kinases have different functions in Dictyostelium G protein-mediated signaling
    • Nguyen HN, Raisley B, Hadwiger JA. MAP kinases have different functions in Dictyostelium G protein-mediated signaling. Cell Signal 2010; 22: 836-47.
    • (2010) Cell Signal , vol.22 , pp. 836-847
    • Nguyen, H.N.1    Raisley, B.2    Hadwiger, J.A.3
  • 16
    • 34548808594 scopus 로고    scopus 로고
    • Classification and functional annotation of eukaryotic protein kinases
    • Miranda-Saavedra D, Barton GJ. Classification and functional annotation of eukaryotic protein kinases. Proteins 2007; 68: 893-914.
    • (2007) Proteins , vol.68 , pp. 893-914
    • Miranda-Saavedra, D.1    Barton, G.J.2
  • 18
    • 0033988763 scopus 로고    scopus 로고
    • MAP kinases in plant signal transduction: How many, and what for?
    • Ligterink W. MAP kinases in plant signal transduction: how many, and what for? Results Probl Cell Differ 2000; 27: 11-27.
    • (2000) Results Probl Cell Differ , vol.27 , pp. 11-27
    • Ligterink, W.1
  • 19
    • 0031026008 scopus 로고    scopus 로고
    • The protein kinases of budding yeast: Six score and more
    • Hunter T, Plowman GD. The protein kinases of budding yeast: six score and more. Trends Biochem Sci 1997; 22: 18-22.
    • (1997) Trends Biochem Sci , vol.22 , pp. 18-22
    • Hunter, T.1    Plowman, G.D.2
  • 22
    • 0037154295 scopus 로고    scopus 로고
    • MAP kinase cascades: Scaffolding signal specificity
    • van Drogen F, Peter M. MAP kinase cascades: scaffolding signal specificity. Curr Biol 2002; 12: R53-5.
    • (2002) Curr Biol , vol.12 , pp. R53-R55
    • Van Drogen, F.1    Peter, M.2
  • 23
    • 34248587328 scopus 로고    scopus 로고
    • G protein regulation of MAPK networks
    • Goldsmith ZG, Dhanasekaran DN. G protein regulation of MAPK networks. Oncogene 2007; 26: 3122-42.
    • (2007) Oncogene , vol.26 , pp. 3122-3142
    • Goldsmith, Z.G.1    Dhanasekaran, D.N.2
  • 24
    • 58149351369 scopus 로고    scopus 로고
    • A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy
    • Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ. A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med 2009; 15: 75-83.
    • (2009) Nat Med , vol.15 , pp. 75-83
    • Lorenz, K.1    Schmitt, J.P.2    Schmitteckert, E.M.3    Lohse, M.J.4
  • 26
    • 2442526725 scopus 로고    scopus 로고
    • Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA
    • Maeda M, Lu S, Shaulsky G, Miyazaki Y, Kuwayama H, Tanaka Y, Kuspa A, Loomis WF. Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Science 2004; 304: 875-8.
    • (2004) Science , vol.304 , pp. 875-878
    • Maeda, M.1    Lu, S.2    Shaulsky, G.3    Miyazaki, Y.4    Kuwayama, H.5    Tanaka, Y.6    Kuspa, A.7    Loomis, W.F.8
  • 27
    • 52449095361 scopus 로고    scopus 로고
    • The RSK family of kinases: Emerging roles in cellular signalling
    • Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 2008; 9: 747-58.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 747-758
    • Anjum, R.1    Blenis, J.2
  • 28
    • 0037444809 scopus 로고    scopus 로고
    • Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity
    • Bardwell AJ, Abdollahi M, Bardwell L. Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. Biochem J 2003; 370: 1077-85.
    • (2003) Biochem J , vol.370 , pp. 1077-1085
    • Bardwell, A.J.1    Abdollahi, M.2    Bardwell, L.3
  • 29
    • 0031882123 scopus 로고    scopus 로고
    • The Elk-1 ETS-domain transcription factor contains a mitogenactivated protein kinase targeting motif
    • Yang SH, Yates PR, Whitmarsh AJ, Davis RJ, Sharrocks AD. The Elk-1 ETS-domain transcription factor contains a mitogenactivated protein kinase targeting motif. Mol Cell Biol 1998; 18: 710-20.
    • (1998) Mol Cell Biol , vol.18 , pp. 710-720
    • Yang, S.H.1    Yates, P.R.2    Whitmarsh, A.J.3    Davis, R.J.4    Sharrocks, A.D.5
  • 31
    • 0037400611 scopus 로고    scopus 로고
    • Molecular recognitions in the MAP kinase cascades
    • Tanoue T, Nishida E. Molecular recognitions in the MAP kinase cascades. Cell Signal 2003; 15: 455-62.
    • (2003) Cell Signal , vol.15 , pp. 455-462
    • Tanoue, T.1    Nishida, E.2
  • 32
    • 50349093357 scopus 로고    scopus 로고
    • Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs
    • Sheridan DL, Kong Y, Parker SA, Dalby KN, Turk BE. Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs. J Biol Chem 2008; 283: 19511-20.
    • (2008) J Biol Chem , vol.283 , pp. 19511-19520
    • Sheridan, D.L.1    Kong, Y.2    Parker, S.A.3    Dalby, K.N.4    Turk, B.E.5
  • 33
    • 34447329284 scopus 로고    scopus 로고
    • Distinct functions for ERKs?
    • Lloyd AC. Distinct functions for ERKs? J Biol 2006; 5: 13.
    • (2006) J Biol , vol.5 , pp. 13
    • Lloyd, A.C.1
  • 34
    • 0030023040 scopus 로고    scopus 로고
    • Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium - Role of heterotrimeric G proteins
    • Maeda M, Aubry L, Insall R, Gaskins C, Devreotes PN, Firtel RA. Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium - role of heterotrimeric G proteins. J Biol Chem 1996; 271: 3351-4.
    • (1996) J Biol Chem , vol.271 , pp. 3351-3354
    • Maeda, M.1    Aubry, L.2    Insall, R.3    Gaskins, C.4    Devreotes, P.N.5    Firtel, R.A.6
  • 35
    • 0036080376 scopus 로고    scopus 로고
    • Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis
    • Sobko A, Ma H, Firtel RA. Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev Cell 2002; 2: 745-56.
    • (2002) Dev Cell , vol.2 , pp. 745-756
    • Sobko, A.1    Ma, H.2    Firtel, R.A.3
  • 36
    • 14044266923 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae
    • Flatauer LJ, Zadeh SF, Bardwell L. Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae. Mol Cell Biol 2005; 25: 1793-803.
    • (2005) Mol Cell Biol , vol.25 , pp. 1793-1803
    • Flatauer, L.J.1    Zadeh, S.F.2    Bardwell, L.3
  • 37
    • 29144502234 scopus 로고    scopus 로고
    • The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network
    • Remenyi A, Good MC, Bhattacharyya RP, Lim WA. The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol Cell 2005; 20: 951-62.
    • (2005) Mol Cell , vol.20 , pp. 951-962
    • Remenyi, A.1    Good, M.C.2    Bhattacharyya, R.P.3    Lim, W.A.4
  • 44
    • 33745602760 scopus 로고    scopus 로고
    • Transcriptional regulation of Dictyostelium pattern formation
    • Williams JG. Transcriptional regulation of Dictyostelium pattern formation. EMBO Rep 2006; 7: 694-8.
    • (2006) EMBO Rep , vol.7 , pp. 694-698
    • Williams, J.G.1
  • 48
    • 0026065341 scopus 로고
    • Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum
    • Saxe CL 3rd, Johnson R, Devreotes PN, Kimmel AR. Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum. Dev Genet 1991; 12: 6-13.
    • (1991) Dev Genet , vol.12 , pp. 6-13
    • Saxe, C.L.1    Johnson, R.2    Devreotes, P.N.3    Kimmel, A.R.4
  • 49
    • 0027405826 scopus 로고
    • Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development
    • Johnson RL, Saxe CL 3rd, Gollop R, Kimmel AR, Devreotes PN. Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development. Genes Dev 1993; 7: 273-82.
    • (1993) Genes Dev , vol.7 , pp. 273-282
    • Johnson, R.L.1    Saxe, C.L.2    Gollop, R.3    Kimmel, A.R.4    Devreotes, P.N.5
  • 50
    • 0028018909 scopus 로고
    • The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium
    • Louis JM, Ginsburg GT, Kimmel AR. The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium. Genes Dev 1994; 8: 2086-96.
    • (1994) Genes Dev , vol.8 , pp. 2086-2096
    • Louis, J.M.1    Ginsburg, G.T.2    Kimmel, A.R.3
  • 51
    • 0027510551 scopus 로고
    • CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum
    • Saxe CL 3rd, Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR. CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. Genes Dev 1993; 7: 262-72.
    • (1993) Genes Dev , vol.7 , pp. 262-272
    • Saxe, C.L.1    Ginsburg, G.T.2    Louis, J.M.3    Johnson, R.4    Devreotes, P.N.5    Kimmel, A.R.6
  • 52
    • 0025832630 scopus 로고
    • Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium
    • Sun TJ, Devreotes PN. Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium. Genes Dev 1991; 5: 572-82.
    • (1991) Genes Dev , vol.5 , pp. 572-582
    • Sun, T.J.1    Devreotes, P.N.2
  • 53
    • 0030020853 scopus 로고    scopus 로고
    • Differential distribution of cAMP receptors cAR2 and cAR3 during Dictyostelium development
    • Yu Y, Saxe CL 3rd. Differential distribution of cAMP receptors cAR2 and cAR3 during Dictyostelium development. Dev Biol 1996; 173: 353-6.
    • (1996) Dev Biol , vol.173 , pp. 353-356
    • Yu, Y.1    Saxe, C.L.2
  • 54
    • 0027938452 scopus 로고
    • Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum
    • Gaskins C, Maeda M, Firtel RA. Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum. Mol Cell Biol 1994; 14: 6996-7012.
    • (1994) Mol Cell Biol , vol.14 , pp. 6996-7012
    • Gaskins, C.1    Maeda, M.2    Firtel, R.A.3
  • 56
    • 0030879854 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium
    • Maeda M, Firtel RA. Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium. J Biol Chem 1997; 272: 23690-5.
    • (1997) J Biol Chem , vol.272 , pp. 23690-23695
    • Maeda, M.1    Firtel, R.A.2
  • 57
    • 0030904277 scopus 로고    scopus 로고
    • Chemoattractants induce tyrosine phosphorylation of ERK2 in Dictyostelium discoideum by diverse signalling pathways
    • Kosaka C, Pears CJ. Chemoattractants induce tyrosine phosphorylation of ERK2 in Dictyostelium discoideum by diverse signalling pathways. Biochem J 1997; 324: 347-52.
    • (1997) Biochem J , vol.324 , pp. 347-352
    • Kosaka, C.1    Pears, C.J.2
  • 58
    • 33749473004 scopus 로고    scopus 로고
    • Nonadaptive regulation of ERK2 in Dictyostelium: Implications for mechanisms of cAMP relay
    • Brzostowski JA, Kimmel AR. Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay. Mol Biol Cell 2006; 17: 4220-7.
    • (2006) Mol Biol Cell , vol.17 , pp. 4220-4227
    • Brzostowski, J.A.1    Kimmel, A.R.2
  • 59
    • 0030055549 scopus 로고    scopus 로고
    • Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum
    • Knetsch ML, Epskamp SJ, Schenk PW, Wang Y, Segall JE, Snaar-Jagalska BE. Dual role of cAMP and involvement of both G-proteins and ras in regulation of ERK2 in Dictyostelium discoideum. EMBO J 1996; 15: 3361-8.
    • (1996) EMBO J , vol.15 , pp. 3361-3368
    • Knetsch, M.L.1    Epskamp, S.J.2    Schenk, P.W.3    Wang, Y.4    Segall, J.E.5    Snaar-Jagalska, B.E.6
  • 60
    • 0031951334 scopus 로고    scopus 로고
    • MAP kinase function in amoeboid chemotaxis
    • Wang Y, Liu J, Segall JE. MAP kinase function in amoeboid chemotaxis. J Cell Sci 1998; 111: 373-83.
    • (1998) J Cell Sci , vol.111 , pp. 373-383
    • Wang, Y.1    Liu, J.2    Segall, J.E.3
  • 61
    • 0030023902 scopus 로고    scopus 로고
    • The dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways
    • Gaskins C, Clark AM, Aubry L, Segall JE, Firtel RA. The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways. Genes Dev 1996; 10: 118-28.
    • (1996) Genes Dev , vol.10 , pp. 118-128
    • Gaskins, C.1    Clark, A.M.2    Aubry, L.3    Segall, J.E.4    Firtel, R.A.5
  • 62
    • 33746218906 scopus 로고    scopus 로고
    • EppA, a putative substrate of DdERK2, regulates cyclic AMP relay and chemotaxis in Dictyostelium discoideum
    • Chen S, Segall JE. EppA, a putative substrate of DdERK2, regulates cyclic AMP relay and chemotaxis in Dictyostelium discoideum. Eukaryot Cell 2006; 5: 1136-46.
    • (2006) Eukaryot Cell , vol.5 , pp. 1136-1146
    • Chen, S.1    Segall, J.E.2
  • 63
    • 70350221740 scopus 로고    scopus 로고
    • The Gα4 G protein subunit interacts with the MAP kinase ERK2 using a D-motif that regulates developmental morphogenesis in Dictyostelium
    • Nguyen HN, Hadwiger JA. The Gα4 G protein subunit interacts with the MAP kinase ERK2 using a D-motif that regulates developmental morphogenesis in Dictyostelium. Dev Biol 2009; 335: 385-95.
    • (2009) Dev Biol , vol.335 , pp. 385-395
    • Nguyen, H.N.1    Hadwiger, J.A.2
  • 64
    • 0028173089 scopus 로고
    • The G alpha subunit Gα4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium
    • Hadwiger JA, Lee S, Firtel RA. The G alpha subunit Gα4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium. Proc Natl Acad Sci USA 1994; 91: 10566-70.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10566-10570
    • Hadwiger, J.A.1    Lee, S.2    Firtel, R.A.3
  • 65
    • 0029020634 scopus 로고
    • The G protein β subunit is essential for multiple responses to chemoattractants in Dictyostelium
    • Wu L, Valkema R, Van Haastert PJ, Devreotes PN. The G protein β subunit is essential for multiple responses to chemoattractants in Dictyostelium. J Cell Biol 1995; 129: 1667-75.
    • (1995) J Cell Biol , vol.129 , pp. 1667-1675
    • Wu, L.1    Valkema, R.2    Van Haastert, P.J.3    Devreotes, P.N.4
  • 66
    • 0026587818 scopus 로고
    • Analysis of Gα4, a G-protein subunit required for multicellular development in Dictyostelium
    • Hadwiger JA, Firtel RA. Analysis of Gα4, a G-protein subunit required for multicellular development in Dictyostelium. Genes Dev 1992; 6: 38-49.
    • (1992) Genes Dev , vol.6 , pp. 38-49
    • Hadwiger, J.A.1    Firtel, R.A.2
  • 67
    • 0030753611 scopus 로고    scopus 로고
    • The dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase
    • Ma H, Gamper M, Parent C, Firtel RA. The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase. EMBO J 1997; 16: 4317-32.
    • (1997) EMBO J , vol.16 , pp. 4317-4332
    • Ma, H.1    Gamper, M.2    Parent, C.3    Firtel, R.A.4
  • 68
    • 0029917072 scopus 로고    scopus 로고
    • Mutations in the Dictyostelium heterotrimeric G protein α subunit Gα5 alter the kinetics of tip morphogenesis
    • Hadwiger JH, Natarajan K, Firtel RA. Mutations in the Dictyostelium heterotrimeric G protein α subunit Gα5 alter the kinetics of tip morphogenesis. Development 1996; 122: 1215-24.
    • (1996) Development , vol.122 , pp. 1215-1224
    • Hadwiger, J.H.1    Natarajan, K.2    Firtel, R.A.3
  • 69
    • 77749301906 scopus 로고    scopus 로고
    • Gα5 subunit-mediated signalling requires a D-motif and the MAPK ERK1 in Dictyostelium
    • Raisley B, Nguyen HN, Hadwiger JA. Gα5 subunit-mediated signalling requires a D-motif and the MAPK ERK1 in Dictyostelium. Microbiology (Reading) 2010; 156: 789-97.
    • (2010) Microbiology (Reading) , vol.156 , pp. 789-797
    • Raisley, B.1    Nguyen, H.N.2    Hadwiger, J.A.3
  • 70
    • 0035336844 scopus 로고    scopus 로고
    • Signaling at zero G: G-proteinindependent functions for 7-TM receptors
    • Brzostowski JA, Kimmel AR. Signaling at zero G: G-proteinindependent functions for 7-TM receptors. Trends Biochem Sci 2001; 26: 291-7.
    • (2001) Trends Biochem Sci , vol.26 , pp. 291-297
    • Brzostowski, J.A.1    Kimmel, A.R.2
  • 71
    • 36549018694 scopus 로고    scopus 로고
    • Developmental morphology and chemotactic responses are dependent on Gα subunit specificity in Dictyostelium
    • Hadwiger JA. Developmental morphology and chemotactic responses are dependent on Gα subunit specificity in Dictyostelium. Dev Biol 2007; 312: 1-12.
    • (2007) Dev Biol , vol.312 , pp. 1-12
    • Hadwiger, J.A.1
  • 72
    • 0037165954 scopus 로고    scopus 로고
    • Regulation of MAPK function by direct interaction with the mating-specific Gα in yeast
    • Metodiev MV, Matheos D, Rose MD, Stone DE. Regulation of MAPK function by direct interaction with the mating-specific Gα in yeast. Science 2002; 296: 1483-6.
    • (2002) Science , vol.296 , pp. 1483-1486
    • Metodiev, M.V.1    Matheos, D.2    Rose, M.D.3    Stone, D.E.4
  • 73
    • 38949150874 scopus 로고    scopus 로고
    • The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2
    • Blackwell E, Kim HJ, Stone DE. The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2. BMC Cell Biol 2007; 8: 44.
    • (2007) BMC Cell Biol , vol.8 , pp. 44
    • Blackwell, E.1    Kim, H.J.2    Stone, D.E.3
  • 74
    • 51649125641 scopus 로고    scopus 로고
    • RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
    • Bessard A, Fremin C, Ezan F, Fautrel A, Gailhouste L, Baffet G. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene 2008; 27: 5315-25.
    • (2008) Oncogene , vol.27 , pp. 5315-5325
    • Bessard, A.1    Fremin, C.2    Ezan, F.3    Fautrel, A.4    Gailhouste, L.5    Baffet, G.6


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