Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury

Neuroscience Letters

Volumn 478, Issue 2, 2010, Pages 66-71

  Ma, Junxiong ^a   Li, Wenxian ^a   Tian, Ruifeng ^b   Lei, Wei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Functional recovery; Ginsenoside Rg1; Nerve crush injury; Nerve regeneration

Indexed keywords

GINSENOSIDE RG 1; MECOBALAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CRUSH; NERVE FIBER REGENERATION; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; AXONS; ELECTROPHYSIOLOGY; GINSENOSIDES; MALE; NERVE CRUSH; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PANAX; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE;

EID: 77953622055     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.04.064     Document Type: Article

References (24)

1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat. Res. 1946, 94:239-247.
2. Alanko J., Kurahashi Y., Yoshimoto T., Yamamoto S., Baba K. Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases. Biochem. Pharmacol. 1994, 48:1979-1981.
3. Attele A.S., Wu J.A., Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 1999, 58:1685-1693.
4. Bain J.R., Mackinnon S.E., Hunter D.A. Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast. Reconstr. Surg. 1989, 83:129-138.
5. Campbell W.W. Evaluation and management of peripheral nerve injury. Clin. Neurophysiol. 2008, 119:1951-1965.
6. Chen X.C., Chen Y., Zhu Y.G., Fang F., Chen L.M. Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol. Sin. 2002, 23:829-834.
7. Chen X.C., Zhou Y.C., Chen Y., Zhu Y.G., Fang F., Chen L.M. Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress. Acta Pharmacol. Sin. 2005, 26:56-62.
8. Chen X.C., Zhu Y.G., Wang X.Z., Zhu L.A., Huang C. Protective effect of ginsenoside Rg1 on dopamine-induced apoptosis in PC12 cells. Acta Pharmacol. Sin. 2001, 22:673-678.
9. Chen X.C., Zhu Y.G., Zhu L.A., Huang C., Chen Y., Chen L.M., Fang F., Zhou Y.C., Zhao C.H. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur. J. Pharmacol. 2003, 473:1-7.
10. Delgado-Garcia J.M., Del Pozo F., Spencer R.F., Baker R. Behavior of neurons in the abducens nucleus of the alert cat. III. Axotomized motoneurons. Neuroscience 1988, 24:143-160.
11. Fu S.Y., Gordon T. The cellular and molecular basis of peripheral nerve regeneration. Mol. Neurobiol. 1997, 14:67-116.
12. Fujimoto Y., Sakuma S., Komatsu S., Sato D., Nishida H., Xiao Y.Q., Baba K., Fujita T. Inhibition of 15-hydroxyprostaglandin dehydrogenase activity in rabbit gastric antral mucosa by panaxynol isolated from oriental medicines. J. Pharm. Pharmacol. 1998, 50:1075-1078.
13. Huang J., Hu X., Lu L., Ye Z., Wang Y., Luo Z. Electrical stimulation accelerates motor functional recovery in autograft-repaired 10mm femoral nerve gap in rats. J. Neurotrauma 2009, 26:1805-1813.
14. Jia L., Zhao Y., Liang X.J. Current evaluation of the millennium phytomedicine-ginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr. Med. Chem. 2009, 16:2924-2942.
15. Leung K.W., Yung K.K., Mak N.K., Chan Y.S., Fan T.P., Wong R.N. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology 2007, 52:827-835.
16. Lu M.C., Lai T.Y., Hwang J.M., Chen H.T., Chang S.H., Tsai F.J., Wang H.L., Lin C.C., Kuo W.W., Huang C.Y. Proliferation- and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann cells. Cell Biochem. Funct. 2009, 27:186-192.
17. Nicholson D.W., Thornberry N.A. Caspases: killer proteases. Trends Biochem. Sci. 1997, 22:299-306.
18. Radtke C., Aizer A.A., Agulian S.K., Lankford K.L., Vogt P.M., Kocsis J.D. Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair. Brain Res. 2009, 1254:10-17.
19. Schumacher M., Guennoun R., Stein D.G., De Nicola A.F. Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacol. Ther. 2007, 116:77-106.
20. Shi Y.Q., Huang T.W., Chen L.M., Pan X.D., Zhang J., Zhu Y.G., Chen X.C., Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice. J. Alzheimers Dis. 2010, 19:977-989.
21. Songcharoen P. Management of brachial plexus injury in adults. Scand J. Surg. 2008, 97:317-323.
22. Teng C.M., Kuo S.C., Ko F.N., Lee J.C., Lee L.G., Chen S.C., Huang T.F. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim. Biophys. Acta 1989, 990:315-320.
23. Werdin F., Grüssinger H., Jaminet P., Kraus A., Manoli T., Danker T., Guenther E., Haerlec M., Schaller H.E., Sinis N. An improved electrophysiological method to study peripheral nerve regeneration in rats. J. Neurosci. Methods 2009, 182:71-77.
24. Wu C.F., Bi X.L., Yang J.Y., Zhan J.Y., Dong Y.X., Wang J.H., Wang J.M., Zhang R., Li X. Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. Int. Immunopharmacol. 2007, 7:313-320.