Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility

Journal of Biological Chemistry

Volumn 287, Issue 52, 2012, Pages 43630-43638

  Valentine, Cathleen D ^a   Lukacs, Gergely L ^b   Verkman, Alan S ^a   Haggie, Peter M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; CHLORIDE CHANNELS; CONTROL MECHANISM; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; DIFFUSION MEASUREMENTS; LIVE CELL; LOW TEMPERATURES; LYSOSOMAL DEGRADATION; MEMBRANE MOBILITY; OVER-EXPRESSION; QUANTITATIVE COMPARISON; SCAFFOLD PROTEIN; SINGLE PARTICLE TRACKING; SURFACE INSTABILITY; THAPSIGARGINS; UBIQUITINATION; WILD TYPES;

AMINO ACIDS; CHLORINE COMPOUNDS; MOLECULAR BIOLOGY; PROTEINS; QUALITY CONTROL; SCAFFOLDS (BIOLOGY); SURFACE DIFFUSION;

CELL MEMBRANES;

BINDING PROTEIN; CELL PROTEIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GOLGI REASSEMBLY STACKING PROTEIN 55; HEAT SHOCK COGNATE PROTEIN 70; PDZ PROTEIN; PROTEIN CHIP; THAPSIGARGIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; ENDOCYTOSIS; LOW TEMPERATURE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN TRANSPORT; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CELL MOVEMENT; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOGS; ENDOCYTOSIS; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HSC70 HEAT-SHOCK PROTEINS; HUMANS; LYSOSOMES; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; SEQUENCE DELETION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84871603170     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.421172     Document Type: Article

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