Targeting CAL as a negative regulator of ΔF508-CFTR cell-surface expression: An RNA interference and structure-based mutagenetic approach

Journal of Biological Chemistry

Volumn 282, Issue 11, 2007, Pages 8099-8109

  Wolde, Michael ^a   Fellows, Abigail ^a   Cheng, Jie ^b   Kivenson, Aleksandr ^a   Coutermarsh, Bonita ^a   Talebian, Laleh ^a   Karlson, Katherine ^a   Piserchio, Andrea ^c   Mierke, Dale F ^c   Stanton, Bruce A ^a   Guggino, William B ^b   Madden, Dean R ^a,d  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BROWN UNIVERSITY   (United States)

^d 7200 Vail Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR); EPITHELIAL CHLORIDE; INTRACELLULAR TRAFFICKING; PEPTIDE-BINDING MODULES;

BINDING SITES; CELL MEMBRANES; MOLECULAR INTERACTIONS; MOLECULAR STRUCTURE; MUTAGENESIS; PEPTIDES;

GENE EXPRESSION;

PDZ PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; CARRIER PROTEIN; CFTR PROTEIN, HUMAN; GOPC PROTEIN, HUMAN; MEMBRANE PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOCHEMISTRY; BIOPHYSICS; CARBOXY TERMINAL SEQUENCE; CELL HETEROGENEITY; CELL SURFACE; CYSTIC FIBROSIS; DISEASE ASSOCIATION; DOSE RESPONSE; EPITHELIUM CELL; IN VITRO STUDY; LYSOSOME; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INTERACTION; RNA INTERFERENCE; TARGET CELL; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE; CELL STRAIN COS1; CERCOPITHECUS; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS;

EID: 34247258972     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611049200     Document Type: Article

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