COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments

Journal of Cell Biology

Volumn 153, Issue 5, 2001, Pages 957-970

  Benharouga, Mohamed ^a   Haardt, Martin ^a,b   Kartner, Norbert ^b   Lukacs, Gergely L ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cystic fibrosis; Functional complementation; Lysosomal proteolysis; Structural destabilization; Ubiquitination

Indexed keywords

CHLORIDE CHANNEL; CYCLIC AMP; PROTEASOME; TRANSMEMBRANE CONDUCTANCE REGULATOR; UBIQUITIN;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CYSTIC FIBROSIS; FRAMESHIFT MUTATION; GLYCOSYLATION; GOLGI COMPLEX; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN SYNTHESIS; STOP CODON; THERMOSTABILITY;

ANIMALS; BREFELDIN A; CELL LINE; CELL MEMBRANE; CODON, TERMINATOR; CRICETINAE; CYSTEINE ENDOPEPTIDASES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOSOMES; FRAMESHIFT MUTATION; GLYCOSYLATION; GOLGI APPARATUS; KINETICS; LYSOSOMES; MULTIENZYME COMPLEXES; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SEQUENCE DELETION; TEMPERATURE; THERMODYNAMICS; UBIQUITINS;

ANIMALIA;

EID: 0035947777     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.5.957     Document Type: Article

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