The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase

Journal of Biological Chemistry

Volumn 287, Issue 52, 2012, Pages 43810-43824

  Sykes, Alex M ^a,b   Palstra, Nickless ^a   Abankwa, Daniel ^a,c   Hill, Justine M ^a   Skeldal, Sune ^a   Matusica, Dusan ^a   Venkatraman, Prahatha ^a,d   Hancock, John F ^a,e   Coulson, Elizabeth J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d PURDUE UNIVERSITY   (United States)

^e UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE SITES; ENZYMATIC ACTIVITIES; HELICAL STRUCTURES; HOMODIMERIZATION; HOMODIMERS; INTRAMEMBRANE PROTEOLYSIS; KEY ELEMENTS; MOLECULAR MECHANISM; NEURONAL DEATH; P75 NEUROTROPHIN RECEPTOR; SECRETASES; SIGNIFICANT IMPACTS; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE RECEPTORS; TRANSMEMBRANE SEQUENCES; TRANSMEMBRANES;

ACTIVATION ANALYSIS; AMINO ACIDS; ENZYME ACTIVITY; SUBSTRATES;

DIMERIZATION;

ALANINE; GAMMA SECRETASE; GLYCINE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; PROTEIN TYROSINE KINASE A;

AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NEUROMODULATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN;

AMINO ACID MOTIFS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL DEATH; CYSTEINE; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PC12 CELLS; PROTEIN MULTIMERIZATION; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RATS; RECEPTOR, TRKA; RECEPTORS, GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR;

EID: 84871604254     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.382903     Document Type: Article

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