Glucagon-like peptide 1 potentiates glucotoxicity-diminished insulin secretion via stimulation of cAMP-PKA signaling in INS-1E cells and mouse islets

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 2, 2013, Pages 483-490

  Luo, Guochun ^a,c   Kong, Xiangchen ^a,b   Lu, Lina ^a,b   Xu, Xiaohui ^a   Wang, Hui ^d   Ma, Xiaosong ^a,b  

^a SHENZHEN UNIVERSITY   (China)

^b Shenzhen University   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^d WUHAN UNIVERSITY   (China)

Author keywords

cAMP; GLP 1; Glucotoxicity; Insulin secretion; PKA

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCAGON LIKE PEPTIDE 1; INSULIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; GENE SILENCING; GLUCOTOXICITY; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOXICITY; WESTERN BLOTTING;

ANIMALS; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; RATS; SECOND MESSENGER SYSTEMS;

EID: 84871387656     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.11.016     Document Type: Article

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