Stereoselective formation and metabolism of 4-hydroxy-retinoic acid enantiomers by cytochrome p450 enzymes

Journal of Biological Chemistry

Volumn 287, Issue 50, 2012, Pages 42223-42232

  Shimshoni, Jakob A ^a   Roberts, Arthur G ^b,c   Scian, Michele ^a   Topletz, Ariel R ^a   Blankert, Sean A ^c   Halpert, James R ^b   Nelson, Wendel L ^a   Isoherranen, Nina ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE METABOLITES; ACTIVE SITE; ALL-TRANS-RETINOIC ACID; BIOLOGICAL PROCESS; CELL DIFFERENTIATION; CHIRAL CENTERS; CHIRAL COLUMN; CYP26A1; CYTOCHROME P450; HOMOLOGY MODELS; HYDROGEN ATOMS; PRIMARY METABOLITE; RETINOIDS; SPECIFIC ORIENTATION; STEREO-SELECTIVE; STEREOSELECTIVE FORMATION; VITAMIN A;

CELL DEATH; CHIRALITY; ENANTIOMERS; HYDROGEN; HYDROXYLATION; METABOLITES; PORPHYRINS; STEREOSELECTIVITY;

ENZYMES;

CYTOCHROME P450 26A1; CYTOCHROME P450 3A4; RETINOIC ACID;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME METABOLISM; ENZYME REGULATION; ENZYME STRUCTURE; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROXYLATION; MOLECULAR DOCKING; PRIORITY JOURNAL; STEREOCHEMISTRY;

CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYLATION; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STEREOISOMERISM; TRETINOIN;

ATRA;

EID: 84871327740     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.404475     Document Type: Article

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