Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase

Molecular Pharmacology

Volumn 80, Issue 2, 2011, Pages 228-239

  Thatcher, Jayne E ^a   Buttrick, Brian ^a   Shaffer, Scott A ^a   Shimshoni, Jakob A ^a   Goodlett, David R ^a   Nelson, Wendel L ^a   Isoherranen, Nina ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16 HYDROXYRETINOIC ACID; 18 HYDROXYRETINOIC ACID; 4 ( 6 HYDROXY 7 TRICYCLO[3.3.1.13,7]DEC 1 YL 2 NAPHTHALENYL)BENZOIC ACID; 4 [ 2 ( 5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHALENYL) 1 PROPENYL]BENZOIC ACID; 4 HYDROXYRETINOIC ACID; 4 OXORETINOIC ACID; ALITRETINOIN; BENZOIC ACID DERIVATIVE; CD 1530; CYTOCHROME P450 26A1; IMIDAZOLE DERIVATIVE; ISOTRETINOIN; KETOCONAZOLE; LIAROZOLE; LIGAND; N [ 4 [ 2 (DIMETHYLAMINO) 1 ( 1H IMIDAZOLE 1 YL)PROPYL]PHENYL] 2 BENZOTHIAZOLAMINE; OXYGENASE; PIOGLITAZONE; R 116010; RETINOIC ACID; RETINOIC ACID DERIVATIVE; RETINOIC ACID HYDROXYLASE; RETINOIC ACID RECEPTOR ALPHA AGONIST; RETINOIC ACID RECEPTOR BETA AGONIST; RETINOID DERIVATIVE; ROSIGLITAZONE; TALAROZOLE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG INHIBITION; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; LIVER; METABOLITE; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TANDEM MASS SPECTROMETRY;

ANIMALS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; KETOCONAZOLE; LIGANDS; LIVER; MIXED FUNCTION OXYGENASES; PROTEASE INHIBITORS; RATS; SUBSTRATE SPECIFICITY; TRETINOIN;

EID: 79960203908     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.072413     Document Type: Article

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