4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 10, 1996, Pages 4879-4884

  Achkar, Charles C ^a   Derguini, Fadila ^b,e   Blumberg, Bruce ^d   Langston, Alexander ^a   Levin, Arthur A ^c,f   Speck, Jeffrey ^c   Evans, Ronald M ^d   Bolado Jr , Jack ^d   Nakanishi, Koji ^b   Buck, Jochen ^a   Gudas, Lorraine J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Columbia University ^*  (United States)

^c Hoffmann La Roche Department of Toxicology and Pathology   (United States)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f ISIS PHARMACEUTICALS   (United States)

Author keywords

4 hydroxyretinol; embryonic pattern formation; vitamin A metabolism

Indexed keywords

4 HYDROXYRETINOL; 4 OXORETINOL; ALITRETINOIN; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOL; RETINOL DERIVATIVE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLASTULA; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; TERATOCARCINOMA; TRANSACTIVATION; VITAMIN METABOLISM; XENOPUS;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION; HUMANS; MICE; RECEPTORS, RETINOIC ACID; RETINOIDS; SIGNAL TRANSDUCTION; STEREOISOMERISM; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED; VITAMIN A; XENOPUS LAEVIS;

EID: 9344235001     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.10.4879     Document Type: Article

References (40)

1. Gudas, L. J., Roberts, A. B. & Sporn, M. B. (1994) in The Retinoids: Biology, Chemistry, and Medicine, eds. Sporn, M. B., Roberts, A. B. & Goodman, D. S. (Raven, New York), 2nd Ed., pp. 443-520.
2. Moon, R. C., Mehta, R. G. & Rao, K. V. N. (1994) in The Retinoids: Biology, Chemistry, and Medicine, eds. Sporn, M. B., Roberts, A. B. & Goodman, D. S. (Raven, New York), 2nd Ed., pp. 573-595.
3. Hofmann, C. & Eichele, G. (1994) in The Retinoids: Biology, Chemistry, and Medicine, eds. Sporn, M. B., Roberts, A. B. & Goodman, D. S. (Raven, New York), 2nd Ed., pp. 387-441.
4. Mangelsdorf, D. J., Umesono, K. & Evans, R. M. (1994) in The Retinoids: Biology, Chemistry, and Medicine, eds. Sporn, M. B., Roberts, A. B. & Goodman, D. S. (Raven, New York), 2nd Ed., pp. 319-349.
5. Blaner, W. S. & Olson, J. A. (1994) in The Retinoids: Biology, Chemistry, and Medicine, eds. Sporn, M. B., Roberts, A. B. & Goodman, D. S. (Raven, New York), 2nd Ed., pp. 229-255.
6. Ostrowski, J., Hammer, L., Roalsvig, T., Pokornowski, K. & Reczek, P. R. (1995) Proc. Natl. Acad. Sci. USA 92, 1812-1816.
7. Buck, J., Derguini, F., Levi, E., Nakanishi, K. & Hämmerling, U. (1991) Science 254, 1654-1656.
8. Buck, J., Grun, F., Derguini, F., Chen, Y., Kimura, S., Noy, N. & Hammerling, U. (1993) J. Exp. Med. 178, 675-680.
9. Chen, M., Achkar, C. C. & Gudas, L. J. (1994) Mol. Pharmacol. 46, 88-96.
10. Boylan, J. F. & Gudas, L. J. (1991) J. Cell. Biol. 112, 965-979.
11. McClean, S. W., Ruddel, M. E., Gross, E. G., Degiovanna, J. & Peck, G. L. (1982) Clin. Chem. 284, 693-696.
12. Surmatis, J. D. (1967) U. S. Patent 3, 311,656; (1967) Chem. Abstr. 67, 22052d.
13. Boehm, M. F., Gawinowicz, M. A., Foucault, A., Derguini, F. & Nakanishi, K. (1990) J. Am. Chem. Soc. 112, 7779-7782.
14. Haag, A., Eschenmoser, W. & Eugster, C. H. (1980) Helv. Chim. Acta 63, 10-15.
15. Katsuta, Y., Ito, M., Yoshihara, K., Nakanishi, K., Kikkawa, T. & Fujiwara, T. (1994) J. Org. Chem. 59, 6917-6921.
16. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C.. Rosenberg, M., Lovey, A. & Grippo, J. F. (1992) Nature (London) 355, 359-361.
17. Nervi, C., Poindexter, E. C., Grignani, F., Pandolfi, P. P., LoCoco, F., Avvisati, G., Pelicci, P. G. & Jetten, A. M. (1992) Cancer Res. 52, 3687-3692.
18. Nervi, C., Grippo, J. F., Sherman, M. I., George, M. D. & Jetten, A. M. (1989) Proc. Natl. Acad. Sci. USA 86, 5854-5858.
19. DeLean, A., Munson, P. J. & Rodbard, D. (1978) Am. J. Physiol. 235, E97-E102.
20. Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M. & Thaller, C. (1992) Cell 68, 397-406.
21. Rugh, R. (1965) Experimental Embryology (Burgess, Minneapolis, MN), 3rd Ed.
22. Moon, R. T. & Christian, J. L. (1989) Technique 1, 76-89.
23. Nieuwkoop, P. D. & Faber, J., eds. (1975) Normal Tables of Xenopus laevis (Daudin, Amsterdam), 2nd Ed.
24. Williams, J. B. & Napoli, J. L. (1985) Proc. Natl. Acad. Sci. USA 82, 4658-4662.
25. Allenby, G., Bocquel, M.-T., Saunders, M., Kazmer, S., Speck, J., Rosenberg, M., Lovey, A., Kastner, P., Grippo, J. F., Chambon, P. & Levin, A. A. (1993) Proc. Natl. Acad. Sci. USA 90, 30-34.
26. Allenby, G., Janocha, R., Kazmer, S., Speck, J., Grippo, J. F. & Levin, A. A. (1994) J. Biol. Chem. 269, 16689-16695.
27. Repa, J. J., Hanson, K. K. & Clagett-Dame, M. (1993) Proc. Natl. Acad. Sci. USA 90, 7293-7297.
28. Umesono, K., Giguére, V., Glass, C. K., Rosenfeld, M. G. & Evans, R. M. (1988) Nature (London) 336, 262-265.
29. Perimann, T., Rangarajan, P. N., Umesono, K. & Evans, R. M. (1993) Genes Dev. 7, 1411-1422.
30. LaRosa, G. J. & Gudas, L. J. (1988) Proc. Natl. Acad. Sci. USA 85, 329-333.
31. LaRosa, G. J. & Gudas, L. J. (1988) Mol. Cell. Biol. 8, 3906-3917.
32. Vasios, G. W., Gold, J. D., Petkovich, M., Chambon, P. & Gudas, L. J. (1989) Proc. Natl. Acad. Sci. USA 86, 9099-9103.
33. Pijnappel, W. W. M., Hendriks, H. F. J., Folkers, G. E., van den Brink, C. E., Dekker, E. J., Edelenbosch, C., van der Saag, P. T. & Durston, A. J. (1993) Nature (London) 366, 340-344.
34. Scharf, S. R. & Gerhart, J. C. (1983) Dev. Biol. 99, 75-87.
35. Gubler, M. L. & Sherman, M. I. (1985) J. Biol. Chem. 260, 9552-9558.
36. Leo, M. A. & Lieber, C. S. (1985) J. Biol. Chem. 260, 5228-5231.
37. Leo, M. A., Lasker, J. M., Raucy, J. L., Kim, C.-I., Black, M. & Lieber, C. S. (1989) Arch. Biochem. Biophys. 269, 305-312.
38. Roberts, E. S., Vaz, A. D. N. & Coon, M. J. (1992) Mol. Pharmacol. 41, 427-433.
39. Tate, B. F., Allenby, G., Janocha, R., Kazmer, S., Speck, J., Sturzenbecker, L. J., Abarzua, P., Levin, A. A. & Grippo, J. F. (1994) Mol. Cell. Biol. 14, 2323-2330.
40. Boylan, J. F. & Gudas, L. J. (1992) J. Biol. Chem. 267, 21486-21491.