Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development

Nature Genetics

Volumn 31, Issue 1, 2002, Pages 84-88

  Niederreither, Karen ^a,d   Abu Abed, Suzan ^b   Schuhbaur, Brigitte ^c   Petkovich, Martin ^b,c   Chambon, Pierre ^c   Dollé, Pascal ^c  

^a l'alimentation et l'Environnement   (France)

^b QUEEN S UNIVERSITY   (Canada)

^c Baylor College of Medicine ^*

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; CYTOCHROME P450; OXIDOREDUCTASE; PROTEIN DERIVATIVE; RETINALDEHYDE DEHYDROGENASE 1A2; RETINOIC ACID; RETINOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; GENE DISRUPTION; GENE MUTATION; HETEROZYGOSITY; MOUSE; MOUSE MUTANT; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINA BIFIDA; SPINAL CORD;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; EMBRYONIC AND FETAL DEVELOPMENT; GENES, REPORTER; HETEROZYGOTE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; PHENOTYPE; RETINAL DEHYDROGENASE; RETINOIDS; SIGNAL TRANSDUCTION; SPINAL DYSRAPHISM; TRETINOIN;

ANIMALIA; MAMMALIA;

EID: 0036578757     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng876     Document Type: Article

References (22)

1. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase
2. Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
3. The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification
4. Retinoic acid hydroxylase (Cyp26a1) is a key enzyme in neuronal differentiation of embryonal carcinoma cells
5. The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
6. The retinoic acid-inactivating enzyme Cyp26a1 is essential for establishing an uneven distribution of retinoic acid along the anterior-posterior axis within the mouse embryo
7. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase
8. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
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13. Regionalized metabolic activity establishes boundaries of retinoic acid signalling
14. Restricted expression and retinoic acid-induced downregulation of the retinaldehyde type 2 (RALDH-2) gene during mouse development
15. Complementary domains of retinoic acid production and degradation in the early chick embryo
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18. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli 3
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