Luteolin and fisetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in human gingival fibroblasts

Molecular Biology Reports

Volumn 40, Issue 1, 2013, Pages 477-485

  Gutiérrez Venegas, Gloria ^a   Contreras Sánchez, Anabel ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Human gingival fibroblasts; Lipopolysaccharide; Mitogen activated protein kinase; Porphyromonas gingivalis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2; FISETIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MORIN; MYRICETIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR;

ARTICLE; CARBOHYDRATE ANALYSIS; DISEASE CONTROL; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GINGIVA; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; NONHUMAN; NORMAL HUMAN; PERIODONTITIS; PHARMACOLOGICAL BLOCKING; PORPHYROMONAS GINGIVALIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION;

CELLS, CULTURED; CHRONIC PERIODONTITIS; CYCLOOXYGENASE 2; ENZYME ACTIVATION; FIBROBLASTS; FLAVONOIDS; GINGIVA; HUMANS; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; LUTEOLIN; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PORPHYROMONAS GINGIVALIS; PROTEIN BIOSYNTHESIS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION, GENETIC;

NEGIBACTERIA; PORPHYROMONAS GINGIVALIS;

EID: 84871312627     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2083-0     Document Type: Article

References (57)

1. Ara T, Kurata K, Hirai K, Uchihashi T, Uematsu T, Imamura Y, Furusawa K, Kurihara S, Wang PL (2009) Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease. J Periodontal Res 44(1):21-27
2. Dongari-Bagtzoglou AI, Ebersole JL (1996) Production of inflammatory mediators and cytokines by human gingival fibroblasts following bacterial challenge. J Periodontal Res 31(2):90-98
3. Gutiérrez-Venegas G, Maldonado-Frías S, Ontiveros-Granados A, Kawasaki-Cárdenas P (2005) Role of p38 in nitric oxide synthase and cyclooxygenase expression, and nitric oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides. Life Sci 77(1):60-73
4. Sismey-Durrant HJ, Hopps RM (1991) Effect of lipopolysaccharide from Porphyromonas gingivalis on prostaglandin E2 and interleukin-1-beta release from rat periosteal and human gingival fibroblasts in vitro. Oral Microbiol Immunol 6(6):378-380
5. Sundararaj KP, Samuvel DJ, Li Y, Sanders JJ, Lopes-Virella MF, Huang Y (2009) Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture: cross-talking between fibroblasts and U937 macrophages exposed to high glucose. J Biol Chem 284(20):13714-13724
6. Inomata M, Into T, Murakami Y (2010) Suppressive effect of the antimicrobial peptide LL-37 on expression of IL-6, IL-8 and CXCL10 induced by Porphyromonas gingivalis cells and extracts in human gingival fibroblasts. Eur J Oral Sci 118(6):574-581
7. Casarin RC, Ribeiro Edel P, Mariano FS, Nociti FH Jr, Casati MZ, Gonçalves RB (2010) Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis. J Periodontal Res 45(5):635-642
8. Zhang D, Chen L, Li S, Zhiyuan G, Yan J (2008) Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS. Innate Immun 14(2):99-107
9. Souza PP, Palmqvist P, Lundgren I, Lie A, Costa-Neto CM, Lundberg P, Lerner UH (2010) Stimulation of IL-6 cytokines in fibroblasts by Toll-like receptors 2. J Dent Res 89(8):802-807
10. Rock FL, Hardiman G, Timans JC, Kastelein R, Bazan JF (1998) A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci 95(2):588-593
11. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388(6640):394-397
12. Janeway CA Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197-216
13. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F (1999) Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274(16):10689-10692
14. Cario E, Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC, Podolsky DK (2000) Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J Immunol 164(2):966-972
15. Means TK, Lien E, Yoshimura A, Wang S, Golenbock DT, Fenton MJ (1999) The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J Immunol 163(12):6748-6755
16. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189(110):1777-1782
17. Arimilli S, Johnson JB, Alexander-Miller MA, Parks GD (2007) TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways. Virology 365(1):144-156
18. Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW (2004) Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol 173(120):7115-7119
19. Kawai T, Takeuchi O, Fujita T, Inoue J, Mühlradt PF, Sato S, Hoshino K, Akira S (2001) Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167(10):5887-5894
20. Zhang FX, Kirschning CJ, Mancinelli R, Xu XP, Jin Y, Faure E, Mantovani A, Rothe M, Muzio M, Arditi M (1999) Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 274(12):7611-7614
21. Rhee SH, Hwang D (2000) Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J Biol Chem 275(440):34035-34040
22. Kao SJ, Lei HC, Kuo CT, Chang MS, Chen BC, Chang YC, Chiu WT, Lin CH (2005) Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages. Immunology 115(3):366-374
23. Villar A, Gasco MA, Alcaraz MJ (1984) Anti-inflammatory and anti-ulcer properties of hypolaetin-8-glucoside, a novel plant flavonoid. J Pharm Pharmacol 36(12):820-823
24. Hasani A, Leighl N (2011) Classification and toxicities of vascular disrupting agents. Clin Lung Cancer 12(1):18-25
25. Ban M, Tonai T, Kohno T, Matsumoto K, Horie T, Yamamoto S, Moskowitz MA, Levine LA (1989) Flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. Stroke 20(2):248-252
26. Robak J, Gryglewski RJ (1988) Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 37(5):837-841
27. Davila JC, Lenherr A, Acosta D (1989) Protective effect of flavonoids on drug-induced hepatotoxicity in vitro. Toxicology 57(3):267-286
28. Ruch RJ, Cheng SJ, Klaunig JE (1989) Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis 10(6):1003-1008
29. Gitika B, Sai Ram M, Sharma SK, Ilavazhagan G, Banerjee PK (2006) Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide. Free Radic Res 40(1):95-102
30. Lee JC, Lee KY, Kim J, Na CS, Jung NC, Chung GH, Jang YS (2004) Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. Food Chem Toxicol 42(9):1383-1388
31. Lu X, Jung J, Cho HJ, Lim DY, Lee HS, Chun HS, Kwon DY, Park JH (2005) Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. J Nutr 135(12):2884-2890
32. Maher P, Akaishi T, Abe K (2006) Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci 103(44):16568-16573
33. Tzeng SH, Ko WC, Ko FN, Teng CM (1991) Inhibition of platelet aggregation by some flavonoids. Thromb Res 64(1):91-100
34. Vladutiu GD, Middleton E Jr (1986) Effects of flavonoids on enzyme secretion and endocytosis in normal and mucolipidosis II fibroblasts. Life Sci 39(8):717-726
35. Tordera M, Ferrándiz ML, Alcaraz MJ (1994) Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils. Z Naturforsch C 49(3-4):235-240
36. Chien CS, Shen KH, Huang JS, Ko SC, Shih YW (2010) Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells. Mol Cell Biochem 333(1-2):169-180
37. Kim JS, Jobin C (2005) The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology 115(3):375-387
38. Selvendiran K, Koga H, Ueno T, Yoshida T, Maeyama M, Torimura T, Yano H, Kojiro M, Sata M (2006) Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer Res 66(9):4826-4834
39. Mittra B, Saha A, Chowdhury AR, Pal C, Mandal S, Mukhopadhyay S, Bandyopadhyay S, Majumder HK (2000) Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mol Med 6(6):527-541
40. Gutiérrez-Venegas G, Kawasaki-Cárdenas P, Arroyo-Cruz SR, Maldonado-Frías S (2006) Luteolin inhibits lipopolysaccharide actions on human gingival fibroblasts. Eur J Pharmacol 541(1-2):10-95
41. Hämäläinen M, Nieminen R, Asmawi MZ, Vuorela P, Vapaatalo H, Moilanen E (2011) Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. Planta Med 77(13):1504-1511
42. Gutiérrez-Venegas G, Jiménez-Estrada M, Maldonado S (2007) The effect of flavonoids on transduction mechanisms in lipopolysaccharide- treated human gingival fibroblasts. Int Immunopharmacol 7(9):1199-1210
43. Gutiérrez-Venegas G, Kawasaki-Cárdenas P, Arroyo-Cruz SR, Maldonado-Frías S (2006) Luteolin inhibits lipopolysaccharide actions on human gingival fibroblasts. Eur J Pharmacol 541(1-2):95-105
44. Bartold PM (1987) Proteoglycans of the periodontium. Structure, role and function. J Periodontal Res 22:431-444
45. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
46. Fort P, Marty L, Piechaczyk M, Sabrouty SE, Dani C, Jeanteur P, Blanchard JM (1985) Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res 13:1431-1442
47. Oido-Mori M, Rezzonico R, Wang PL, Kowashi Y, Dayer JM, Baehni PC, Chizzolini C (2001) Porphyromonas gingivalis gingipain-R enhances interleukin-8 but decreases gamma interferon-inducible protein 10 production by human gingival fibroblasts in response to T-cell contact. Infect Immun 69(7):4493-4501
48. Martin M, Rehani K, Jope RS, Michalek SM (2010) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6(8):777-784
49. Suliman HB, Sweeney TE, Withers CM, Piantadosi CA (2005) Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. J Cell Sci 123(Pt 15):2565-2575
50. Yang H, Young DW, Gusovsky F, Chow JC (2000) Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J Biol Chem 275(27):20861-20866
51. Chen CC, Wang JK (1999) p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol Pharmacol 55(3):481-488
52. Chen C, Chen YH, Lin WW (1999) Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages. Immunology 97(1):124-129
53. Shen T, Park YC, Kim SH, Lee J, Cho JY (2010) Nuclear factor-kappaB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene. Biol Pharm Bull 33(7):1159-1164
54. Ahn SC, Kim GY, Kim JH, Baik SW, Han MK, Lee HJ, Moon DO, Lee CM, Kang JH, Kim BH, Oh YH, Park YM (2004) Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kappaB. Biochem Biophys Res Commun 313(1):148-155
55. Shen T, Park YC, Kim SH, Lee J, Cho JY (2010) Nuclear factor-kappaB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene. Biol Pharm Bull 33(7):1159-1164
56. Into T, Inomata M, Shibata K, Murakami Y (2010) Effect of the antimicrobial peptide LL-37 on Toll-like receptors 2-, 3- and 4-triggered expression of IL-6, IL-8 and CXCL10 in human gingival fibroblasts. Cell Immunol 264(1):104-109
57. O'Neill PG, Ford-Hutchinson AW (1993) Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 330:156-160