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Volumn 12, Issue 1, 2011, Pages 18-25

Classification and toxicities of vascular disrupting agents

Author keywords

ASA404; AVE8062; CA4P; ZD6126

Indexed keywords

AMLODIPINE; ATENOLOL; BEVACIZUMAB; BNC 105P; CARBOPLATIN; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4 PHOSPHATE; CYT 997; DILTIAZEM; DOCETAXEL; GLYCERYL TRINITRATE; HEART ENZYME; METOPROLOL; MITOFLAXONE; MPC 6827A; N ACETYLCOLCHINOL PHOSPHATE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; NIFEDIPINE; OMBRABULIN; PACLITAXEL; PLINABULIN; SOBLIDOTIN; TUBULIN; UNCLASSIFIED DRUG; VADIMEZAN; VASCULAR TARGETING AGENT;

EID: 79551570717     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.3816/CLC.2011.n.002     Document Type: Review
Times cited : (29)

References (49)
  • 1
    • 34247249906 scopus 로고    scopus 로고
    • Vascular disrupting agents in clinical development
    • Hinnen P, Eskens F. Vascular disrupting agents in clinical development. Br J Cancer 2007;96:1159-65.
    • (2007) Br. J. Cancer , vol.96 , pp. 1159-1165
    • Hinnen, P.1    Eskens, F.2
  • 2
    • 57749202046 scopus 로고    scopus 로고
    • Vascular targeted therapies in oncology
    • Siemann D, Horsman M. Vascular targeted therapies in oncology. Cell Tissue Res 2009;335:241-8.
    • (2009) Cell. Tissue Res. , vol.335 , pp. 241-248
    • Siemann, D.1    Horsman, M.2
  • 3
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe P. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004;10:415-27.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 415-427
    • Thorpe, P.1
  • 4
    • 0022529486 scopus 로고
    • Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester)
    • Kerr D, Kaye S, Graham J, et al. Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). Cancer Res 1986;46:3142-6.
    • (1986) Cancer Res. , vol.46 , pp. 3142-3146
    • Kerr, D.1    Kaye, S.2    Graham, J.3
  • 5
    • 0023608388 scopus 로고
    • Phase I and pharmacokinetic study of flavone acetic acid
    • Kerr D, Kaye S, Cassidy J, et al. Phase I and pharmacokinetic study of flavone acetic acid. Cancer Res 1987;47:6776-81.
    • (1987) Cancer Res. , vol.47 , pp. 6776-6781
    • Kerr, D.1    Kaye, S.2    Cassidy, J.3
  • 6
    • 0036021233 scopus 로고    scopus 로고
    • 5, 6-dimethylxanthenone-4-acetic acid (DMXAA): A new biological response modifier for cancer therapy
    • Zhou S, Kestell P, Baguley B, et al. 5, 6-dimethylxanthenone-4-acetic acid (DMXAA): a new biological response modifier for cancer therapy. Invest New Drugs 2002;20:281-95.
    • (2002) Invest. New Drugs , vol.20 , pp. 281-295
    • Zhou, S.1    Kestell, P.2    Baguley, B.3
  • 7
    • 0024406105 scopus 로고
    • Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma
    • Kerr D, Maughan T, Newlands E, et al. Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma. Br J Cancer 1989;60:104-6.
    • (1989) Br. J. Cancer , vol.60 , pp. 104-106
    • Kerr, D.1    Maughan, T.2    Newlands, E.3
  • 8
    • 0026100365 scopus 로고
    • Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
    • Rewcastle G, Atwell G, Li Z, et al. Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids. J Med Chem 1991;34:217-22.
    • (1991) J. Med. Chem. , vol.34 , pp. 217-222
    • Rewcastle, G.1    Atwell, G.2    Li, Z.3
  • 9
    • 0037341637 scopus 로고    scopus 로고
    • Antivascular therapy of cancer: DMXAA
    • Baguley B. Antivascular therapy of cancer: DMXAA. Lancet Oncol 2003;4:141-8.
    • (2003) Lancet Oncol. , vol.4 , pp. 141-148
    • Baguley, B.1
  • 10
    • 33645659565 scopus 로고    scopus 로고
    • 5, 6-Dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: A phase I safety study of a vascular disrupting agent
    • McKeage M, Fong P, Jeffery M, et al. 5, 6-Dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: a phase I safety study of a vascular disrupting agent. Clin Cancer Res 2006;12:1776-84.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1776-1784
    • McKeage, M.1    Fong, P.2    Jeffery, M.3
  • 11
    • 40749154865 scopus 로고    scopus 로고
    • IFN-beta-dependent inhibition of tumor growth by the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Roberts Z, Ching L, Vogel S. IFN-beta-dependent inhibition of tumor growth by the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid (DMXAA). J Interferon Cytokine Res 2008;28:133-9.
    • (2008) J. Interferon. Cytokine Res. , vol.28 , pp. 133-139
    • Roberts, Z.1    Ching, L.2    Vogel, S.3
  • 12
    • 29244466134 scopus 로고    scopus 로고
    • Activation of tumor-associated macrophages by the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma
    • Jassar A, Suzuki E, Kapoor V, et al. Activation of tumor-associated macrophages by the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma. Cancer Res 2005;65:11752-61.
    • (2005) Cancer Res. , vol.65 , pp. 11752-11761
    • Jassar, A.1    Suzuki, E.2    Kapoor, V.3
  • 13
    • 57749113532 scopus 로고    scopus 로고
    • Colchicine site inhibitors of microtubule integrity as vascular disrupting agents
    • Lee RM, Gewirtz DA. Colchicine site inhibitors of microtubule integrity as vascular disrupting agents. Drug Dev Res 2008;69:352-8.
    • (2008) Drug Dev. Res. , vol.69 , pp. 352-358
    • Lee, R.M.1    Gewirtz, D.A.2
  • 14
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • Dark G, Hill S, Prise V, et al. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res 1997;57:1829-34.
    • (1997) Cancer Res. , vol.57 , pp. 1829-1834
    • Dark, G.1    Hill, S.2    Prise, V.3
  • 15
    • 0035937376 scopus 로고    scopus 로고
    • Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue
    • Griggs J, Hesketh R, Smith G, et al. Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue. Br J Cancer 2001;84:832-5.
    • (2001) Br. J. Cancer , vol.84 , pp. 832-835
    • Griggs, J.1    Hesketh, R.2    Smith, G.3
  • 16
    • 0038488600 scopus 로고    scopus 로고
    • Clinical trial design for target specific anticancer agents
    • Hoekstra R, Verweij J, Eskens F. Clinical trial design for target specific anticancer agents. Invest New Drugs 2003;21:243-50.
    • (2003) Invest. New Drugs , vol.21 , pp. 243-250
    • Hoekstra, R.1    Verweij, J.2    Eskens, F.3
  • 17
    • 46749143345 scopus 로고    scopus 로고
    • Molecular imaging of hypoxia
    • Krohn K, Link J, Mason R. Molecular imaging of hypoxia. J Nucl Med 2008;49(suppl 2):129S-48S.
    • (2008) J. Nucl. Med. , vol.49 , Issue.2 SUPPL.
    • Krohn, K.1    Link, J.2    Mason, R.3
  • 18
    • 0042386691 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging
    • Galbraith S, Maxwell R, Lodge M, et al. Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging. J Clin Oncol 2003;21:2831-42.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2831-2842
    • Galbraith, S.1    Maxwell, R.2    Lodge, M.3
  • 19
    • 0037096814 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and trans-lational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
    • Dowlati A, Robertson K, Cooney M, et al. A phase I pharmacokinetic and trans-lational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res 2002;62:3408-16.
    • (2002) Cancer Res. , vol.62 , pp. 3408-3416
    • Dowlati, A.1    Robertson, K.2    Cooney, M.3
  • 20
    • 0037106501 scopus 로고    scopus 로고
    • Effects of 5, 6-dimethylxanthenone-4-ace-tic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging
    • Galbraith S, Rustin G, Lodge M, et al. Effects of 5, 6- dimethylxanthenone-4-ace-tic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging. J Clin Oncol 2002;20:3826-40.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3826-3840
    • Galbraith, S.1    Rustin, G.2    Lodge, M.3
  • 21
    • 0642307227 scopus 로고    scopus 로고
    • Phase I trial of the antivascular agent com-bretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow
    • Stevenson J, Rosen M, Sun W, et al. Phase I trial of the antivascular agent com-bretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol 2003;21:4428-38.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4428-4438
    • Stevenson, J.1    Rosen, M.2    Sun, W.3
  • 22
    • 2542523230 scopus 로고    scopus 로고
    • Magnetic resonance imaging measurements of the response of murine and human tumors to the vascular-targeting agent ZD6126
    • Evelhoch J, LoRusso P, He Z, et al. Magnetic resonance imaging measurements of the response of murine and human tumors to the vascular-targeting agent ZD6126. Clin Cancer Res 2004;10:3650-7.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3650-3657
    • Evelhoch, J.1    LoRusso, P.2    He, Z.3
  • 23
    • 70349338935 scopus 로고    scopus 로고
    • AVE8062: A new combretastatin derivative vascular disrupting agent
    • Delmonte A, Sessa C. AVE8062: a new combretastatin derivative vascular disrupting agent. Expert Opin Investig Drugs 2009;18:1541-8.
    • (2009) Expert Opin. Investig Drugs , vol.18 , pp. 1541-1548
    • Delmonte, A.1    Sessa, C.2
  • 24
    • 42249095520 scopus 로고    scopus 로고
    • A randomised phase 2 trial of combre-tastatin A4 phosphate (CA4P) in combination with paclitaxel and carboplatin to evaluate safety and efficacy in subjects with advanced imageable malignancies.)
    • abstract 14060
    • Akerley WL, Schabel M, Morrell G, et al. A randomised phase 2 trial of combre-tastatin A4 phosphate (CA4P) in combination with paclitaxel and carboplatin to evaluate safety and efficacy in subjects with advanced imageable malignancies.). J Clin Oncol 2007;25(18 suppl): 616s (abstract 14060).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 SUPPL.
    • Akerley, W.L.1    Schabel, M.2    Morrell, G.3
  • 25
    • 0042386700 scopus 로고    scopus 로고
    • Phase I clinical trial of weekly combre-tastatin A4 phosphate: Clinical and pharmacokinetic results
    • Rustin G, Galbraith S, Anderson H, et al. Phase I clinical trial of weekly combre-tastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol 2003;21:2815-22.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2815-2822
    • Rustin, G.1    Galbraith, S.2    Anderson, H.3
  • 26
    • 40549125995 scopus 로고    scopus 로고
    • Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors
    • LoRusso PM, Gadgeel SM, Wozniak A, et al. Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors. Invest New Drugs 2008;26:159-67.
    • (2008) Invest. New Drugs , vol.26 , pp. 159-167
    • LoRusso, P.M.1    Gadgeel, S.M.2    Wozniak, A.3
  • 27
    • 60749109735 scopus 로고    scopus 로고
    • A phase I study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors
    • abstract 3550
    • Nathan PD, Judson I, Padhani A, et al. A phase I study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors. J Clin Oncol 2008;26(20 suppl): 165s (abstract 3550).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.20 SUPPL.
    • Nathan, P.D.1    Judson, I.2    Padhani, A.3
  • 28
    • 78649669135 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacody-namic evaluation of BNC105P, a novel anticancer agent that is both a vascular disrupting agent (VDA) and an inhibitor of cancer cell proliferation
    • abstract e14512
    • Desai J, Wong S, Chong G, et al. Phase I, pharmacokinetic, and pharmacody-namic evaluation of BNC105P, a novel anticancer agent that is both a vascular disrupting agent (VDA) and an inhibitor of cancer cell proliferation. J Clin Oncol 2009;27(15 suppl): (abstract e14512).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 SUPPL.
    • Desai, J.1    Wong, S.2    Chong, G.3
  • 29
    • 33846478656 scopus 로고    scopus 로고
    • DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
    • O'Connor J, Jackson A, Parker G, et al. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer 2007;96:189-95.
    • (2007) Br. J. Cancer , vol.96 , pp. 189-195
    • O'Connor, J.1    Jackson, A.2    Parker, G.3
  • 30
    • 0037222218 scopus 로고    scopus 로고
    • Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5, 6-dimethylxanthe-none-4-acetic acid (DMXAA)
    • Siim BG, Lee A, Shalal-Zwain S, et al. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5, 6-dimethylxanthe-none-4-acetic acid (DMXAA). Cancer Chemother Pharmacol 2003;51:43-52.
    • (2003) Cancer Chemother. Pharmacol. , vol.51 , pp. 43-52
    • Siim, B.G.1    Lee, A.2    Shalal-Zwain, S.3
  • 31
    • 0038575250 scopus 로고    scopus 로고
    • Clinical aspects of a phase I trial of 5, 6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
    • Jameson MB, Thompson P, Baguley B, et al. Clinical aspects of a phase I trial of 5, 6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. Br J Cancer 2003;88:1844-50.
    • (2003) Br. J. Cancer , vol.88 , pp. 1844-1850
    • Jameson, M.B.1    Thompson, P.2    Baguley, B.3
  • 32
    • 0033052183 scopus 로고    scopus 로고
    • Plasma disposition, metabolism and excretion of the experimental antitumour agent 5, 6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit
    • Kestell P, Paxton J, Rewcastle G, et al. Plasma disposition, metabolism and excretion of the experimental antitumour agent 5, 6-dimethylxanthenone-4- acetic acid in the mouse, rat and rabbit. Cancer Chemother Pharmacol 1999;43:323-30.
    • (1999) Cancer Chemother. Pharmacol. , vol.43 , pp. 323-330
    • Kestell, P.1    Paxton, J.2    Rewcastle, G.3
  • 33
    • 0038576231 scopus 로고    scopus 로고
    • 5, 6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study
    • Rustin G, Bradley C, Galbraith S, et al. 5, 6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. Br J Cancer 2003;88:1160-7.
    • (2003) Br. J. Cancer , vol.88 , pp. 1160-1167
    • Rustin, G.1    Bradley, C.2    Galbraith, S.3
  • 34
    • 0036707387 scopus 로고    scopus 로고
    • Viagra (sildenafil citrate) and ophthalmology
    • Laties A, Zrenner E. Viagra (sildenafil citrate) and ophthalmology. Prog Retin Eye Res 2002;21:485-506.
    • (2002) Prog. Retin Eye Res. , vol.21 , pp. 485-506
    • Laties, A.1    Zrenner, E.2
  • 35
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage M, Von Pawel J, Reck M, et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008;99:2006-12.
    • (2008) Br. J. Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.1    Von Pawel, J.2    Reck, M.3
  • 36
    • 67449123059 scopus 로고    scopus 로고
    • Phase II study of ASA404 (vadimezan, 5, 6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m (2) combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage M, Reck M, Jameson M, et al. Phase II study of ASA404 (vadimezan, 5, 6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m (2) combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Lung Cancer 2009;65:192-7.
    • (2009) Lung Cancer , vol.65 , pp. 192-197
    • McKeage, M.1    Reck, M.2    Jameson, M.3
  • 37
    • 85206959032 scopus 로고    scopus 로고
    • AACR.org. Web site. Available at, Accessed: March 15, 2010
    • AACR.org. [Web site]. Available at http://www.aacr.org/home/public-media/ aacr-press-releases.aspx?d=1731. Accessed: March 15, 2010.
  • 38
    • 1642494772 scopus 로고    scopus 로고
    • Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer
    • Cooney M, Radivoyevitch T, Dowlati A, et al. Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose phase I study in patients with advanced cancer. Clin Cancer Res 2004;10:96-100.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 96-100
    • Cooney, M.1    Radivoyevitch, T.2    Dowlati, A.3
  • 39
    • 70449109160 scopus 로고    scopus 로고
    • Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats
    • Ke Q, Bodyak N, Rigor D, et al. Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats. Vascul Pharmacol 2009;51:337-43.
    • (2009) Vascul Pharmacol. , vol.51 , pp. 337-343
    • Ke, Q.1    Bodyak, N.2    Rigor, D.3
  • 40
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • Tozer G, Prise V, Wilson J, et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res 1999;59:1626-34.
    • (1999) Cancer Res. , vol.59 , pp. 1626-1634
    • Tozer, G.1    Prise, V.2    Wilson, J.3
  • 41
    • 76449086344 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate (CA4P) car-boplatin and paclitaxel in patients with platinum-resistant ovarian cancer: Final phase II trial results
    • abstract 5502
    • Zweifel M, Jayson G, Reed N, et al. Combretastatin A-4 phosphate (CA4P) car-boplatin and paclitaxel in patients with platinum-resistant ovarian cancer: Final phase II trial results. J Clin Oncol 2009;27: (15 suppl): 277s (abstract 5502).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 SUPPL.
    • Zweifel, M.1    Jayson, G.2    Reed, N.3
  • 42
    • 20044395276 scopus 로고    scopus 로고
    • Phase I trial of combretastatin a-4 phosphate with carboplatin
    • Bilenker J, Flaherty K, Rosen M, et al. Phase I trial of combretastatin a-4 phosphate with carboplatin. Clin Cancer Res 2005;11:1527-33.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1527-1533
    • Bilenker, J.1    Flaherty, K.2    Rosen, M.3
  • 43
    • 33745175081 scopus 로고    scopus 로고
    • A phase Ib trial of combretastatin A-4 phosphate (CA4P) in combination with carboplatin or paclitaxel chemotherapy in patients with advanced cancer
    • abstract 3103
    • Rustin GJ, Nathan PD, Boxall J, et al. A phase Ib trial of combretastatin A-4 phosphate (CA4P) in combination with carboplatin or paclitaxel chemotherapy in patients with advanced cancer. J Clin Oncol 2005;23: (16 suppl): 217s (abstract 3103).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 SUPPL.
    • Rustin, G.J.1    Nathan, P.D.2    Boxall, J.3
  • 44
    • 33645732100 scopus 로고    scopus 로고
    • Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors
    • Beerepoot L, Radema S, Witteveen E, et al. Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors. J Clin Oncol 2006;24:1491-8.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1491-1498
    • Beerepoot, L.1    Radema, S.2    Witteveen, E.3
  • 45
    • 38449099577 scopus 로고    scopus 로고
    • Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats
    • Gould S, Westwood F, Curwen J, et al. Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats. J Natl Cancer Inst 2007;99:1724-8.
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 1724-1728
    • Gould, S.1    Westwood, F.2    Curwen, J.3
  • 46
    • 79551537510 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and pharmacodynamic study of AVE8062, a novel vascular disrupting agent, in patients (pts) with advanced solid tumors - Preliminary results
    • Meeting Abstracts
    • Sessa C, Soria JC, Tolcher A, et al. A phase I pharmacokinetic and pharmacodynamic study of AVE8062, a novel vascular disrupting agent, in patients (pts) with advanced solid tumors - preliminary results. Ann Oncol 2009;20(S3): iii24 (Meeting Abstracts).
    • (2009) Ann Oncol , vol.20 , Issue.S3
    • Sessa, C.1    Soria, J.C.2    Tolcher, A.3
  • 47
    • 33646741205 scopus 로고    scopus 로고
    • The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: Results of a phase 1 study
    • Hande K, Hagey A, Berlin J, et al. The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin Cancer Res 2006;12:2834-40.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2834-2840
    • Hande, K.1    Hagey, A.2    Berlin, J.3
  • 48
    • 44649138596 scopus 로고    scopus 로고
    • A phase II study of ABT-751 in patients with advanced non-small cell lung cancer
    • Mauer A, Cohen E, Ma P, et al. A phase II study of ABT-751 in patients with advanced non-small cell lung cancer. J Thorac Oncol 2008;3:631-6.
    • (2008) J. Thorac. Oncol. , vol.3 , pp. 631-636
    • Mauer, A.1    Cohen, E.2    Ma, P.3
  • 49
    • 77951907080 scopus 로고    scopus 로고
    • A phase IB study of ABT-751 in combination with docetaxel in patients with advanced castration-resistant prostate cancer
    • Michels J, Ellard S, Le L, et al. A phase IB study of ABT-751 in combination with docetaxel in patients with advanced castration-resistant prostate cancer. Ann Oncol 2010;21:305-11.
    • (2010) Ann Oncol , vol.21 , pp. 305-311
    • Michels, J.1    Ellard, S.2    Le, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.