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Volumn 6, Issue 6, 2000, Pages 527-541

Luteolin, an Abundant Dietary Component is a Potent Anti-leishmanial Agent that Acts by Inducing Topoisomerase II-mediated Kinetoplast DNA Cleavage Leading to Apoptosis

Author keywords

kDNA Minicircles; Luteolin; Potent Antileishmanial Agents; Quercetin; Splenic Parasite

Indexed keywords

ANTIPROTOZOAL AGENT; DNA FRAGMENT; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; FLAVONOID; KINETOPLAST DNA; LUTEOLIN; QUERCETIN;

EID: 0034199017     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.1007/BF03401792     Document Type: Article
Times cited : (225)

References (34)
  • 1
    • 0020626421 scopus 로고
    • Flavonoids, a class of natural products of high pharmacological potency
    • 1:CAS:528:DyaL3sXktVSjtrw%3D, 6342623
    • B. Havsteen Flavonoids, a class of natural products of high pharmacological potency Biochem. Pharmacol. 1983 32 1141 1148 10.1016/0006-2952(83)90262-9 1:CAS:528:DyaL3sXktVSjtrw%3D 6342623
    • (1983) Biochem. Pharmacol , vol.32 , pp. 1141-1148
    • Havsteen, B.1
  • 2
    • 0023675545 scopus 로고
    • Occurrence of flavonoid aglycones in medicinal plants
    • E. Wollenweber Occurrence of flavonoid aglycones in medicinal plants Prog. Clin. Biol. Res. 1988 280 44 55
    • (1988) Prog. Clin. Biol. Res , vol.280 , pp. 44-55
    • Wollenweber, E.1
  • 3
    • 85005732363 scopus 로고
    • Flavonols and flavonones in food plants
    • 1:CAS:528:DyaE2sXjs1Sr
    • K. Herrmann Flavonols and flavonones in food plants J. Food Technol. 1976 11 433 448 10.1111/j.1365-2621.1976.tb00743.x 1:CAS:528:DyaE2sXjs1Sr
    • (1976) J. Food Technol , vol.11 , pp. 433-448
    • Herrmann, K.1
  • 4
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in Netharlands
    • 1:CAS:528:DyaK2cXntlOg, 8415127
    • M.G.L. Hertog P.C.H. Hollman M.B. Katan D. Krombout Intake of potentially anticarcinogenic flavonoids and their determinants in adults in Netharlands Nutr. Cancer 1993 20 21 29 10.1080/01635589309514267 1:CAS:528:DyaK2cXntlOg 8415127
    • (1993) Nutr. Cancer , vol.20 , pp. 21-29
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3    Krombout, D.4
  • 5
    • 0016821736 scopus 로고
    • The effect of flavonoids on aerobic glycolysis and growth of tumor cells
    • 124207, 1:CAS:528:DyaE2MXlsVanurY%3D
    • E.M. Suolinna R.N. Buchsbaun E. Racker The effect of flavonoids on aerobic glycolysis and growth of tumor cells Cancer Res. 1975 35 1865 1872 124207 1:CAS:528:DyaE2MXlsVanurY%3D
    • (1975) Cancer Res , vol.35 , pp. 1865-1872
    • Suolinna, E.M.1    Buchsbaun, R.N.2    Racker, E.3
  • 6
    • 0024461716 scopus 로고
    • The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin
    • M.H. Castillo E. Perkins J.H. Campbell et al. The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin American J. Surg. 1989 188 351 355 10.1016/0002-9610(89)90132-3
    • (1989) American J. Surg , vol.188 , pp. 351-355
    • Castillo, M.H.1    Perkins, E.2    Campbell, J.H.3
  • 7
    • 0027459147 scopus 로고
    • Flavone acetic acid-from laboratory to clinic and back
    • 1:CAS:528:DyaK3sXitVCmt7Y%3D, 8457711
    • M.C. Bibby J.A. Double Flavone acetic acid-from laboratory to clinic and back Anticancer Drugs 1993 4 3 17 10.1097/00001813-199302000-00001 1:CAS:528:DyaK3sXitVCmt7Y%3D 8457711
    • (1993) Anticancer Drugs , vol.4 , pp. 3-17
    • Bibby, M.C.1    Double, J.A.2
  • 8
    • 0026489380 scopus 로고
    • Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle
    • M. Yoshida M. Yamato T. Nakaido Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle Cancer Res. 1992 55 6676 6681
    • (1992) Cancer Res , vol.55 , pp. 6676-6681
    • Yoshida, M.1    Yamato, M.2    Nakaido, T.3
  • 9
    • 0025505649 scopus 로고
    • Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth
    • 1:CAS:528:DyaK3MXisVSis7w%3D, 2131036
    • G. Scambia F.O. Ranelletti P.P. Benedetti et al. Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth Anticancer Drugs 1990 1 45 48 10.1097/00001813-199010000-00008 1:CAS:528:DyaK3MXisVSis7w%3D 2131036
    • (1990) Anticancer Drugs , vol.1 , pp. 45-48
    • Scambia, G.1    Ranelletti, F.O.2    Benedetti, P.P.3
  • 10
    • 0026749228 scopus 로고
    • The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth
    • 1:CAS:528:DyaK38XlvVCgurk%3D, 1625476
    • L. Teofili L. Pierelli M.S. Iovino et al. The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth Leuk. Res. 1992 16 497 503 10.1016/0145-2126(92)90176-8 1:CAS:528:DyaK38XlvVCgurk%3D 1625476
    • (1992) Leuk. Res , vol.16 , pp. 497-503
    • Teofili, L.1    Pierelli, L.2    Iovino, M.S.3
  • 11
    • 0025239010 scopus 로고
    • Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by quercetin
    • 1:CAS:528:DyaK3cXitFSlt7g%3D, 2155185
    • J. Hofmann H.H. Fielig B.R. Winterhalter D.R. Berger H. Grunicke Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by quercetin Int. J. Cancer 1990 45 536 539 10.1002/ijc.2910450327 1:CAS:528:DyaK3cXitFSlt7g%3D 2155185
    • (1990) Int. J. Cancer , vol.45 , pp. 536-539
    • Hofmann, J.1    Fielig, H.H.2    Winterhalter, B.R.3    Berger, D.R.4    Grunicke, H.5
  • 12
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • 1:CAS:528:DyaK28XktFamur0%3D, 8811192
    • J.C. Wang DNA topoisomerases Annu. Rev. Biochem. 1996 65 635 692 10.1146/annurev.bi.65.070196.003223 1:CAS:528:DyaK28XktFamur0%3D 8811192
    • (1996) Annu. Rev. Biochem , vol.65 , pp. 635-692
    • Wang, J.C.1
  • 13
    • 0025189757 scopus 로고
    • Induction of mammalian topoisomerase II dependent DNA cleavage by non-intercalative flavonoids, genistein and orobol
    • 1:CAS:528:DyaK3cXhslWkt7c%3D, 2154993
    • Y. Yamashita S.Z. Kowada H. Nakano Induction of mammalian topoisomerase II dependent DNA cleavage by non-intercalative flavonoids, genistein and orobol Biochem. Pharmacol. 1990 39 737 744 10.1016/0006-2952(90)90153-C 1:CAS:528:DyaK3cXhslWkt7c%3D 2154993
    • (1990) Biochem. Pharmacol , vol.39 , pp. 737-744
    • Yamashita, Y.1    Kowada, S.Z.2    Nakano, H.3
  • 14
    • 0026574138 scopus 로고
    • Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives
    • 1:CAS:528:DyaK38Xktl2ku7c%3D, 1313232, 1130870
    • C.A. Austin S. Patel K. Ono H. Nakane L.M. Fisher Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives Biochem. J. 1992 282 883 889 10.1042/bj2820883 1:CAS:528:DyaK38Xktl2ku7c%3D 1313232 1130870
    • (1992) Biochem. J , vol.282 , pp. 883-889
    • Austin, C.A.1    Patel, S.2    Ono, K.3    Nakane, H.4    Fisher, L.M.5
  • 15
    • 0030031184 scopus 로고    scopus 로고
    • Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I
    • 1:CAS:528:DyaK28Xns1Sjug%3D%3D, 8567688
    • F. Boege T. Straub A. Kehr et al. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I J. Biol. Chem. 1996 271 2262 2270 10.1074/jbc.271.4.2262 1:CAS:528:DyaK28Xns1Sjug%3D%3D 8567688
    • (1996) J. Biol. Chem , vol.271 , pp. 2262-2270
    • Boege, F.1    Straub, T.2    Kehr, A.3
  • 16
    • 0000453339 scopus 로고
    • American cutaneous and mucocutaneous leishmaniasis
    • Peters W., Killick-Kendrick R., (eds), London, Academic Press
    • B.C. Walton W. Peters R. Killick-Kendrick W. Peters R. Killick-Kendrick American cutaneous and mucocutaneous leishmaniasis The Leishmaniasis in Biology and Medicine 1987 London Academic Press 636 664
    • (1987) The Leishmaniasis in Biology and Medicine , pp. 636-664
    • Walton, B.C.1    Peters, W.2    Killick-Kendrick, R.3
  • 17
    • 0028008676 scopus 로고
    • Medicinal plants in the fight against leishmaniasis
    • 1:STN:280:DC%2BD2cznsVKksQ%3D%3D, 15275504
    • M.M. Iwu J.E. Jackson B.G. Schuster Medicinal plants in the fight against leishmaniasis Parasitol. Today 1994 10 65 68 10.1016/0169-4758(94)90398-0 1:STN:280:DC%2BD2cznsVKksQ%3D%3D 15275504
    • (1994) Parasitol. Today , vol.10 , pp. 65-68
    • Iwu, M.M.1    Jackson, J.E.2    Schuster, B.G.3
  • 18
    • 0028844115 scopus 로고
    • The structure and replication of kinetoplast DNA
    • 1:CAS:528:DyaK2MXovVWjt7k%3D, 8561456
    • T.A. Shapiro P.T. Englund The structure and replication of kinetoplast DNA Annu. Rev. Microbiol. 1995 49 117 143 10.1146/annurev.mi.49.100195.001001 1:CAS:528:DyaK2MXovVWjt7k%3D 8561456
    • (1995) Annu. Rev. Microbiol , vol.49 , pp. 117-143
    • Shapiro, T.A.1    Englund, P.T.2
  • 19
    • 0025021003 scopus 로고
    • Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs
    • 1:CAS:528:DyaK3cXhtlWqsbk%3D, 2153980, 53387
    • T.A. Shapiro P.T. Englund Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs Proc. Natl. Acad. Sci. U.S.A. 1990 87 950 954 10.1073/pnas.87.3.950 1:CAS:528:DyaK3cXhtlWqsbk%3D 2153980 53387
    • (1990) Proc. Natl. Acad. Sci. U.S.A , vol.87 , pp. 950-954
    • Shapiro, T.A.1    Englund, P.T.2
  • 20
    • 0024506391 scopus 로고
    • Drug-promoted cleavage of kinetoplast DNA minicircles, the evidence for type II topoisomerase activity in trypanosome mitochondria
    • 2537308, 1:CAS:528:DyaL1MXhsFWjsbs%3D
    • T.A. Shapiro V.A. Klein P.T. Englund Drug-promoted cleavage of kinetoplast DNA minicircles, the evidence for type II topoisomerase activity in trypanosome mitochondria J. Biol. Chem. 1989 264 4173 4178 2537308 1:CAS:528:DyaL1MXhsFWjsbs%3D
    • (1989) J. Biol. Chem , vol.264 , pp. 4173-4178
    • Shapiro, T.A.1    Klein, V.A.2    Englund, P.T.3
  • 21
    • 0025937195 scopus 로고
    • An ATP independent catenating enzyme from the kineplast hemoflagellate Leishmania donovani
    • 1:CAS:528:DyaK3MXmt1Krsr0%3D, 1656969
    • A.K. Chakraborty H.K. Majumder An ATP independent catenating enzyme from the kineplast hemoflagellate Leishmania donovani Biochem. Biophys. Res. Commun. 1991 180 279 285 10.1016/S0006-291X(05)81289-6 1:CAS:528:DyaK3MXmt1Krsr0%3D 1656969
    • (1991) Biochem. Biophys. Res. Commun , vol.180 , pp. 279-285
    • Chakraborty, A.K.1    Majumder, H.K.2
  • 22
    • 0027674773 scopus 로고
    • A type I DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani
    • 1:CAS:528:DyaK2cXhtVSjtLY%3D
    • A.K. Chakraborty A. Gupta H.K. Majumder A type I DNA topoisomerase from the kinetoplast hemoflagellate Leishmania donovani Ind. J. Biochem. Biophys. 1993 30 257 263 1:CAS:528:DyaK2cXhtVSjtLY%3D
    • (1993) Ind. J. Biochem. Biophys , vol.30 , pp. 257-263
    • Chakraborty, A.K.1    Gupta, A.2    Majumder, H.K.3
  • 23
    • 0032407673 scopus 로고    scopus 로고
    • Diospyrin, a bisnaphthoquinone: novel inhibitor of type I DNA topoisomerase of Leishmania donovani
    • 1:CAS:528:DyaK1MXovFWn, 9855627
    • S. Ray B. Hazra B. Mittra A. Das H.K. Majumder Diospyrin, a bisnaphthoquinone: novel inhibitor of type I DNA topoisomerase of Leishmania donovani Mol. Pharmacol. 1998 54 994 999 10.1124/mol.54.6.994 1:CAS:528:DyaK1MXovFWn 9855627
    • (1998) Mol. Pharmacol , vol.54 , pp. 994-999
    • Ray, S.1    Hazra, B.2    Mittra, B.3    Das, A.4    Majumder, H.K.5
  • 25
    • 0009868252 scopus 로고
    • Two isomeric flavonones from
    • 1:CAS:528:DyaL2cXktlGrurs%3D
    • B. Achari U.S. Chaudhury P.K. Dutta Two isomeric flavonones from Vitex negundo. Phytochemistry 1984 23 703 704 10.1016/S0031-9422(00)80420-3 1:CAS:528:DyaL2cXktlGrurs%3D
    • (1984) Vitex negundo. Phytochemistry , vol.23 , pp. 703-704
    • Achari, B.1    Chaudhury, U.S.2    Dutta, P.K.3
  • 26
    • 0022802625 scopus 로고
    • A simple procedure for the preparation of pure kinetoplast DNA network free of nuclear DNA from the kinetoplast hemoflagellate Leishmania donovani
    • 1:CAS:528:DyaL2sXhsFCjsA%3D%3D, 3026202
    • S. Dasgupta S. Adhya H.K. Majumder A simple procedure for the preparation of pure kinetoplast DNA network free of nuclear DNA from the kinetoplast hemoflagellate Leishmania donovani Anal. Biochem. 1986 158 189 194 10.1016/0003-2697(86)90608-1 1:CAS:528:DyaL2sXhsFCjsA%3D%3D 3026202
    • (1986) Anal. Biochem , vol.158 , pp. 189-194
    • Dasgupta, S.1    Adhya, S.2    Majumder, H.K.3
  • 27
    • 0022369270 scopus 로고
    • Leishmania donovani: Amastigote inhibition and mode of action of berberine
    • 1:CAS:528:DyaL28XotFGktw%3D%3D, 4076392
    • A.K. Ghosh F.K. Bhattacharya D.K. Ghosh Leishmania donovani: Amastigote inhibition and mode of action of berberine Exp. Parasitol. 1985 60 404 413 10.1016/0014-4894(85)90047-5 1:CAS:528:DyaL28XotFGktw%3D%3D 4076392
    • (1985) Exp. Parasitol , vol.60 , pp. 404-413
    • Ghosh, A.K.1    Bhattacharya, F.K.2    Ghosh, D.K.3
  • 29
    • 84981840703 scopus 로고
    • An eight day method for screening compounds against Leishmania donovani in the golden hamster
    • L.A. Strauber E.M. Franchino J. Grun An eight day method for screening compounds against Leishmania donovani in the golden hamster J. Protozool. 1989 5 269 273 10.1111/j.1550-7408.1958.tb02565.x
    • (1989) J. Protozool , vol.5 , pp. 269-273
    • Strauber, L.A.1    Franchino, E.M.2    Grun, J.3
  • 30
    • 0024853052 scopus 로고
    • Topoisomerase-targeting antitumor drugs
    • 2557085
    • P. D’Arpa L.F. Liu Topoisomerase-targeting antitumor drugs Biochim. Biophys. Acta 1989 989 163 177 2557085
    • (1989) Biochim. Biophys. Acta , vol.989 , pp. 163-177
    • D’Arpa, P.1    Liu, L.F.2
  • 31
    • 0029919619 scopus 로고    scopus 로고
    • Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis
    • M.E.C. Moriera H.A.D. Portillo R.V. Milder M.F. Balanco J. Barcinski Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis J. Cell. Physiol. 1996 167 305 313 10.1002/(SICI)1097-4652(199605)167:2<305::AID-JCP15>3.0.CO;2-6
    • (1996) J. Cell. Physiol , vol.167 , pp. 305-313
    • Moriera, M.E.C.1    Portillo, H.A.D.2    Milder, R.V.3    Balanco, M.F.4    Barcinski, J.5
  • 32
    • 0028800947 scopus 로고
    • Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl 2 and Ab 1
    • B.S. Martin L.P.M. Reutelingsperger A.J. McGahon R.C.A.A. VanSchiee D.M. La Face D.R. Greenn Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl 2 and Ab 1 J. Exp. Med. 1995 182 1345 1350 10.1084/jem.182.5.1545
    • (1995) J. Exp. Med , vol.182 , pp. 1345-1350
    • Martin, B.S.1    Reutelingsperger, L.P.M.2    McGahon, A.J.3    VanSchiee, R.C.A.A.4    La Face, D.M.5    Greenn, D.R.6
  • 33
    • 0032998656 scopus 로고    scopus 로고
    • Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes in vitro and are effective in treating murine visceral leishmaniasis
    • 1:CAS:528:DyaK1MXitFGhsLc%3D, 10223591
    • G. Chakrabarti A. Basu P.P. Manna S.B. Mahato N.B. Mandal S. Bandyopadhyay Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes in vitro and are effective in treating murine visceral leishmaniasis J. Antimicrob. Chemother. 1999 43 359 366 10.1093/jac/43.3.359 1:CAS:528:DyaK1MXitFGhsLc%3D 10223591
    • (1999) J. Antimicrob. Chemother , vol.43 , pp. 359-366
    • Chakrabarti, G.1    Basu, A.2    Manna, P.P.3    Mahato, S.B.4    Mandal, N.B.5    Bandyopadhyay, S.6
  • 34
    • 0026489662 scopus 로고
    • Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation
    • 1333822
    • G. Del Bino S. Bruno P.N. Yi Z. Darzynkiewicz Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation Cell. Prolif. 1992 25 537 548 10.1111/j.1365-2184.1992.tb01458.x 1333822
    • (1992) Cell. Prolif , vol.25 , pp. 537-548
    • Del Bino, G.1    Bruno, S.2    Yi, P.N.3    Darzynkiewicz, Z.4


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