메뉴 건너뛰기




Volumn 77, Issue 13, 2011, Pages 1504-1511

Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages

Author keywords

cyclooxygenase 2; flavonoids; inflammation; macrophages; prostaglandin E synthase; prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 2; DAIDZEIN; FLAVONE; FLAVONOID; GENISTEIN; GENISTIN; ISORHAMNETIN; KAEMPFEROL; LUTEOLIN 7 GLUCOSIDE; MESSENGER RNA; MORIN; NARINGENIN; PELARGONIDIN; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; QUERCETIN; TAXIFOLIN;

EID: 80052274024     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1270762     Document Type: Article
Times cited : (105)

References (31)
  • 1
    • 4143107932 scopus 로고    scopus 로고
    • Cyclooxygenase isozymes: The biology of prostaglandin synthesis and inhibition
    • DOI 10.1124/pr.56.3.3
    • Simmons D L., Botting R M., Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 2004 56 387-437 (Pubitemid 39096597)
    • (2004) Pharmacological Reviews , vol.56 , Issue.3 , pp. 387-437
    • Simmons, D.L.1    Botting, R.M.2    Hla, T.3
  • 3
    • 0035478595 scopus 로고    scopus 로고
    • 2 is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membrane-associated prostaglandin E synthase
    • Devaux Y, Seguin C, Grosjean S, de Talance N, Camaeti V, Burlet A, Zannad F, Meistelman C, Mertes P-M, Longrois D. Lipopolysaccharide-induced increase of prostaglandin E(2) is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membrane-associated prostaglandin E synthase. J Immunol 2001 167 3962-3971 (Pubitemid 32910842)
    • (2001) Journal of Immunology , vol.167 , Issue.7 , pp. 3962-3971
    • Devaux, Y.1    Seguin, C.2    Grosjean, S.3    De Talance, N.4    Camaeti, V.5    Burlet, A.6    Zannad, F.7    Meistelman, C.8    Mertes, P.-M.9    Longrois, D.10
  • 4
    • 0036604215 scopus 로고    scopus 로고
    • 2 synthase gene induced by the toll-like receptor 4/MyD88/NF-IL6 pathway
    • Uematsu S, Matsumoto M, Takeda K, Akira S. Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol 2002 168 5811-5816 (Pubitemid 34556168)
    • (2002) Journal of Immunology , vol.168 , Issue.11 , pp. 5811-5816
    • Uematsu, S.1    Matsumoto, M.2    Takeda, K.3    Akira, S.4
  • 5
    • 69949158726 scopus 로고    scopus 로고
    • Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): Cyclooxygenase (COX) inhibition and beyond
    • Rao P, Knaus E E. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. J Pharm Pharm Sci 2008 11 81s-110s
    • (2008) J Pharm Pharm Sci , vol.11
    • Rao, P.1    Knaus, E.E.2
  • 6
    • 34748817976 scopus 로고    scopus 로고
    • Membrane prostaglandin E synthase-1: A novel therapeutic target
    • DOI 10.1124/pr.59.3.1
    • Samuelsson B, Morgenstern R, Jakobsson P J. Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol Rev 2007 59 207-224 (Pubitemid 47481434)
    • (2007) Pharmacological Reviews , vol.59 , Issue.3 , pp. 207-224
    • Samuelsson, B.1    Morgenstern, R.2    Jakobsson, P.-J.3
  • 7
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands
    • Hertog M G., Hollman P C., Katan M B., Kromhout D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer 1993 20 21-29 (Pubitemid 23225364)
    • (1993) Nutrition and Cancer , vol.20 , Issue.1 , pp. 21-29
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3    Kromhout, D.4
  • 9
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: Chemistry, bioavailability and effects on health
    • Crozier A, Jaganath I B., Clifford M N. Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 2009 26 1001-1043
    • (2009) Nat Prod Rep , vol.26 , pp. 1001-1043
    • Crozier, A.1    Jaganath, I.B.2    Clifford, M.N.3
  • 10
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton Jr E, Kandaswami C, Theoharides T C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000 52 673-751
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 11
    • 32144437073 scopus 로고    scopus 로고
    • Inhibitory effect of dietary phenolic compounds on Chlamydia pneumoniae in cell cultures
    • DOI 10.1016/j.bcp.2005.12.006, PII S0006295205008130
    • Alvesalo J, Vuorela H, Tammela P, Leinonen M, Saikku P, Vuorela P. Inhibitory effect of dietary phenolic compounds on Chlamydia pneumoniae in cell cultures. Biochem Pharmacol 2006 71 735-741 (Pubitemid 43208829)
    • (2006) Biochemical Pharmacology , vol.71 , Issue.6 , pp. 735-741
    • Alvesalo, J.1    Vuorela, H.2    Tammela, P.3    Leinonen, M.4    Saikku, P.5    Vuorela, P.6
  • 12
    • 34548452667 scopus 로고    scopus 로고
    • Isoflavones at concentrations present in soy infant formula inhibit rotavirus infection in vitro
    • Andres A, Donovan S M., Kuhlenschmidt T B., Kuhlenschmidt M S. Isoflavones at concentrations present in soy infant formula inhibit rotavirus infection in vitro. J Nutr 2007 137 2068-2073 (Pubitemid 47367267)
    • (2007) Journal of Nutrition , vol.137 , Issue.9 , pp. 2068-2073
    • Andres, A.1    Donovan, S.M.2    Kuhlenschmidt, T.B.3    Kuhlenschmidt, M.S.4
  • 13
    • 50449111165 scopus 로고    scopus 로고
    • Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity
    • Benavente-Garcia O, Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem 2008 56 6185-6205
    • (2008) J Agric Food Chem , vol.56 , pp. 6185-6205
    • Benavente-Garcia, O.1    Castillo, J.2
  • 14
    • 34548562078 scopus 로고    scopus 로고
    • Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages
    • Hämäläinen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007 2007 45673
    • (2007) Mediators Inflamm , vol.2007 , pp. 45673
    • Hämäläinen, M.1    Nieminen, R.2    Vuorela, P.3    Heinonen, M.4    Moilanen, E.5
  • 15
    • 10944235044 scopus 로고    scopus 로고
    • Anti-inflammatory plant flavonoids and cellular action mechanisms
    • DOI 10.1254/jphs.CRJ04003X
    • Kim H P., Son K H., Chang H W., Kang S S. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci 2004 96 229-245 (Pubitemid 40013328)
    • (2004) Journal of Pharmacological Sciences , vol.96 , Issue.3 , pp. 229-245
    • Kim, H.P.1    Son, K.H.2    Chang, H.W.3    Kang, S.S.4
  • 16
    • 0032831286 scopus 로고    scopus 로고
    • Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
    • Liang Y C., Huang Y T., Tsai S H., Lin-Shiau S Y., Chen C F., Lin J K. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 1999 20 1945-1952
    • (1999) Carcinogenesis , vol.20 , pp. 1945-1952
    • Liang, Y.C.1    Huang, Y.T.2    Tsai, S.H.3    Lin-Shiau, S.Y.4    Chen, C.F.5    Lin, J.K.6
  • 17
    • 0035846885 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1
    • DOI 10.1016/S0024-3205(00)00999-1, PII S0024320500009991
    • Raso G M., Meli R, Di Carlo G, Pacilio M, Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 2001 68 921-931 (Pubitemid 32168067)
    • (2001) Life Sciences , vol.68 , Issue.8 , pp. 921-931
    • Raso, G.M.1    Meli, R.2    Di Carlo, G.3    Pacilio, M.4    Di Carlo, R.5
  • 18
    • 33750219894 scopus 로고    scopus 로고
    • Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators
    • DOI 10.1016/j.bcp.2006.08.001, PII S0006295206004965
    • Mamani-Matsuda M, Kauss T, Al-Kharrat A, Rambert J, Fawaz F, Thiolat D, Moynet D, Coves S, Malvy D, Mossalayi M D. Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol 2006 72 1304-1310 (Pubitemid 44604286)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.10 , pp. 1304-1310
    • Mamani-Matsuda, M.1    Kauss, T.2    Al-Kharrat, A.3    Rambert, J.4    Fawaz, F.5    Thiolat, D.6    Moynet, D.7    Coves, S.8    Malvy, D.9    Mossalayi, M.D.10
  • 19
    • 0030800625 scopus 로고    scopus 로고
    • Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinase
    • DOI 10.1038/sj.bjp.0701345
    • Ruetten H, Thiemermann C. Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Br J Pharmacol 1997 122 59-70 (Pubitemid 27376020)
    • (1997) British Journal of Pharmacology , vol.122 , Issue.1 , pp. 59-70
    • Ruetten, H.1    Thiemermann, C.2
  • 20
    • 0036586887 scopus 로고    scopus 로고
    • Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line
    • Banerjee T, Van der Vliet A, Ziboh V A. Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Prostaglandins Leukot Essent Fatty Acids 2002 66 485-492
    • (2002) Prostaglandins Leukot Essent Fatty Acids , vol.66 , pp. 485-492
    • Banerjee, T.1    Van Der Vliet, A.2    Ziboh, V.A.3
  • 21
    • 33846582444 scopus 로고    scopus 로고
    • The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells
    • DOI 10.1016/j.ejphar.2006.11.014, PII S0014299906012659
    • Garcia-Mediavilla V, Crespo I, Collado P S., Esteller A, Sanchez-Campos S, Tunon M J., González-Gallego J. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol 2007 557 221-229 (Pubitemid 46186282)
    • (2007) European Journal of Pharmacology , vol.557 , Issue.2-3 , pp. 221-229
    • Garcia-Mediavilla, V.1    Crespo, I.2    Collado, P.S.3    Esteller, A.4    Sanchez-Campos, S.5    Tunon, M.J.6    Gonzalez-Gallego, J.7
  • 23
    • 67349224725 scopus 로고    scopus 로고
    • Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma
    • Sivaramakrishnan V, Niranjali Devaraj S. Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem Biol Interact 2009 180 353-359
    • (2009) Chem Biol Interact , vol.180 , pp. 353-359
    • Sivaramakrishnan, V.1    Niranjali Devaraj, S.2
  • 25
    • 21344453327 scopus 로고    scopus 로고
    • Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: Structure-activity relationship and molecular mechanisms involved
    • DOI 10.1016/j.bcp.2005.05.003, PII S0006295205002893
    • Hou D X., Yanagita T, Uto T, Masuzaki S, Fujii M. Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Biochem Pharmacol 2005 70 417-425 (Pubitemid 40905113)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.3 , pp. 417-425
    • Hou, D.-X.1    Yanagita, T.2    Uto, T.3    Masuzaki, S.4    Fujii, M.5
  • 26
    • 0028132265 scopus 로고
    • Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells
    • Akarasereenont P, Mitchell J A., Appleton I, Thiemermann C, Vane J R. Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells. Br J Pharmacol 1994 113 1522-1528 (Pubitemid 24364443)
    • (1994) British Journal of Pharmacology , vol.113 , Issue.4 , pp. 1522-1528
    • Akarasereenont, P.1    Mitchell, J.A.2    Appleton, I.3    Thiemermann, C.4    Vane, J.R.5
  • 27
    • 0036789798 scopus 로고    scopus 로고
    • Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation
    • Jovanovic D V., Mineau F, Notoya K, Reboul P, Martel-Pelletier J, Pelletier J P. Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation. J Rheumatol 2002 29 2165-2175
    • (2002) J Rheumatol , vol.29 , pp. 2165-2175
    • Jovanovic, D.V.1    Mineau, F.2    Notoya, K.3    Reboul, P.4    Martel-Pelletier, J.5    Pelletier, J.P.6
  • 28
    • 33746686905 scopus 로고    scopus 로고
    • Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells
    • DOI 10.1079/BJN20061639
    • Lau T Y., Leung L K. Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells. Br J Nutr 2006 96 169-176 (Pubitemid 44160911)
    • (2006) British Journal of Nutrition , vol.96 , Issue.1 , pp. 169-176
    • Lau, T.Y.1    Leung, L.K.2
  • 30
    • 18744408157 scopus 로고    scopus 로고
    • Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
    • Li X, Afif H, Cheng S, Martel-Pelletier J, Pelletier J P., Ranger P, Fahmi H. Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. J Rheumatol 2005 32 887-895 (Pubitemid 40676500)
    • (2005) Journal of Rheumatology , vol.32 , Issue.5 , pp. 887-895
    • Li, X.1    Afif, H.2    Cheng, S.3    Martel-Pelletier, J.4    Pelletier, J.-P.5    Ranger, P.6    Fahmi, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.