Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2

Journal of Dental Research

Volumn 89, Issue 8, 2010, Pages 802-807

  Souza, P P C ^a,b   Palmqvist, P ^a   Lundgren, I ^a   Lie, A ^a   Costa Neto, C M ^b   Lundberg, P ^a   Lerner, U H ^a,c  

^a UMEÅ UNIVERSITY   (Sweden)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

gingival fibroblasts; IL 11; IL 6; LIF; TLR

Indexed keywords

INTERLEUKIN 11; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LIPOPOLYSACCHARIDE; MESSENGER RNA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG POTENTIATION; FIBROBLAST; GENE SILENCING; GINGIVA; HUMAN; METABOLISM; NONPARAMETRIC TEST; OSTEOLYSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS;

ANALYSIS OF VARIANCE; BONE RESORPTION; CELLS, CULTURED; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GINGIVA; HUMANS; INTERLEUKIN-11; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; LIPOPOLYSACCHARIDES; PORPHYROMONAS GINGIVALIS; RNA, MESSENGER; RNA, SMALL INTERFERING; STATISTICS, NONPARAMETRIC; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 77955485089     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510366898     Document Type: Article

References (27)

1. Ahlén J., Andersson S., Mukohyama H., Roth C., Bé signckman A., Conaway HH, et al. (2002). Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones. Bone 31: 242-251.
2. Brennan FM, McInnes IB (2008). Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118: 3537-3545.
3. Burns E., Bachrach G., Shapira L., Nussbaum G. (2006). TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuated induced alveolar bone resorption. J Immunol 177: 8296-8300.
4. Coats SR, Jones JW, Do CT, Braham PH, Bainbridge BW, To TT, et al. (2009). Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4ĝ€2- phosphatase activities. Cell Microbiol 11: 1587-1599.
5. Derouet D., Rousseau F., Alfonsi F., Froger J., Hermann J., Barbier F., et al. (2004). Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci USA 101: 4827-4832.
6. Dixon DR, Bainbridge BW, Darveau RP (2004). Modulation of the innate immune response within the periodontium. Periodontol 2000 35: 53-74.
7. Hajishengallis G., Wang M., Liang S., Triantafilou M., Triantafilou K. (2008). Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proc Natl Acad Sci USA 105: 13532-13537.
8. Hashimoto M., Asai Y., Ogawa T. (2004). Separation and structural analysis of lipoprotein in lipopolysaccharide preparation from Porphyromonas gingivalis. Int Immunol 16: 1431-1437.
9. Hatakeyama J., Tamai R., Sugiyama A., Akashi S., Sugawara S., Takada H. (2003). Contrasting responses of human gingival and periodontal ligament fibroblasts to bacterial cell-surface components through the CD14/Toll-like receptor system. Oral Microbiol Immunol 18: 14-23.
10. Hosokawa Y., Hosokawa I., Ozaki K., Nakae H., Matsuo T. (2008). CC chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts. J Periodontal Res 43: 471-477.
11. Kawai T., Akira S. (2006). TLR signaling. Cell Death Differ 13 (5). 816-825.
12. Kawai T., Akira S. (2007). TLR signaling. Semin Immunol 19 (1). 24-32.
13. Lerner UH (2006). Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res 85: 596-607.
14. Lerner U., Hé signnstrom L. (1987). Human gingival fibroblasts secrete nondialyzable, prostanoid-independent products which stimulate bone resorption in vitro. J Periodontal Res 22: 284-289.
15. Mahanonda R., Pichyangkul S. (2007). Toll-like receptors and their role in periodontal health and disease. Periodontol 2000 43: 41-55.
16. Mahanonda R., Sa-Ard-Iam N., Montreekachon P., Pimkhaokham A., Yongvanichit K., Fukuda MM, et al. (2007). IL-8 and IDO expression by human gingival fibroblasts via TLRs. J Immunol 178: 1151-1157.
17. Murakami M., Kamimura D., Hirano T. (2004). New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Factors 22: 75-77.
18. OBrien CA, Gubrij I., Lin SC, Saylors RL, Manolagas SC (1999). STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines and interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone. J Biol Chem 274: 19301-19308.
19. Palmqvist P., Persson E., Conaway HH, Lerner UH (2002). Interleukin-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of RANKL, OPG and RANK in mouse calvariae. J Immunol 169: 3353-3362.
20. Palmqvist P., Lundberg P., Lundgren I., Hé signnström L., Lerner UH (2008). IL-1β and TNF-± regulate IL-6-type cytokines in gingival fibroblasts. J Dent Res 87: 558-563.
21. Richards CD, Langdon C., Deschamps P., Pennica D., Shaughnessy SG (2000). Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukemia inhibitory factor, cardiotrophin-1 and interleukin-6: synergy with dexamethasone. Cytokine 12: 613-621.
22. Romas E., Udagawa N., Zhou H., Tamura T., Saito M., Taga T., et al. (1996). The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. J Exp Med 183: 2581-2591.
23. Senaldi G., Varnum BC, Sarmiento U., Starnes C., Lile J., Scully S., et al. (1999). Novel neurotrophin-1/B cell-stimulatory factor-3: a cytokine of the IL-6 family. Proc Natl Acad Sci USA 96: 11458-11463.
24. Sims NA (2008). gp130 signalling in bone cell biology: multiple roles revealed by analysis of genetically altered mice. Mol Cell Endocrinol 310: 30-39.
25. Tamura T., Udagawa N., Takahashi N., Miyaura C., Tanaka S., Yamada Y., et al. (1993). Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc Natl Acad Sci USA 90: 11924-11928.
26. Uehara A., Takada H. (2007). Functional TLRs and NODs in human gingival fibroblasts. J Dent Res 86: 249-254.
27. Uematsu S., Akira S. (2006). Toll-like receptors and innate immunity. J Mol Med 84: 712-725.