메뉴 건너뛰기




Volumn 1274, Issue 1, 2012, Pages 68-76

Functional defect in regulatory T cells in myasthenia gravis

Author keywords

FOXP3; GM CSF; Myasthenia gravis; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 84871302507     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06840.x     Document Type: Article
Times cited : (67)

References (58)
  • 1
    • 64349115066 scopus 로고    scopus 로고
    • Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
    • Meriggioli, M.N. & D.B. Sanders. 2009. Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet Neurol. 8: 475-490.
    • (2009) Lancet Neurol. , vol.8 , pp. 475-490
    • Meriggioli, M.N.1    Sanders, D.B.2
  • 2
    • 0021329452 scopus 로고
    • Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis
    • Berrih, S., E. Morel, C. Gaud, et al. 1984. Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis. Neurology 34: 66-71.
    • (1984) Neurology , vol.34 , pp. 66-71
    • Berrih, S.1    Morel, E.2    Gaud, C.3
  • 3
    • 0035205671 scopus 로고    scopus 로고
    • True epithelial hyperplasia in the thymus of early-onset myasthenia gravis: implications for immunopathogenesis
    • Roxanis, I., K. Micklem & N. Willcox. 2001. True epithelial hyperplasia in the thymus of early-onset myasthenia gravis: implications for immunopathogenesis. J. Neuroimmunol. 112: 163-173.
    • (2001) J. Neuroimmunol. , vol.112 , pp. 163-173
    • Roxanis, I.1    Micklem, K.2    Willcox, N.3
  • 5
    • 84866116138 scopus 로고    scopus 로고
    • A candidate gene for autoimmune myasthenia gravis
    • Landoure G., M.A. Knight, H. Stanescu, et al. 2012. A candidate gene for autoimmune myasthenia gravis. Neurology 79: 342-347.
    • (2012) Neurology , vol.79 , pp. 342-347
    • Landoure, G.1    Knight, M.A.2    Stanescu, H.3
  • 6
    • 84860727608 scopus 로고    scopus 로고
    • Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population
    • Epub 2012 May 9
    • Maniaol, A.H., A. Elsais, A.R. Lorentzen, et al. 2012. Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population. PLoS One. 7(5): e36603. Epub 2012 May 9.
    • (2012) PLoS One. , vol.7 , Issue.5
    • Maniaol, A.H.1    Elsais, A.2    Lorentzen, A.R.3
  • 7
    • 0025094362 scopus 로고
    • Immunodominant regions for T helper-cell sensitization on the human nicotinic receptor alpha subunit in myasthenia gravis
    • Protti, M.P., A. A. Manfredi, C. Straub, et al. 1990. Immunodominant regions for T helper-cell sensitization on the human nicotinic receptor alpha subunit in myasthenia gravis. Proc. Natl. Acad. Sci. USA 87: 7792-7796.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7792-7796
    • Protti, M.P.1    Manfredi, A.A.2    Straub, C.3
  • 8
    • 0031923077 scopus 로고    scopus 로고
    • T-cell recognition of muscleacetylcholine receptor subunits in generalized and ocular myasthenia gravis
    • Wang, Z.Y., D. K. Okita, J. Jr. Howard, et al. 1998. T-cell recognition of muscleacetylcholine receptor subunits in generalized and ocular myasthenia gravis. Neurology 50: 1045-1054.
    • (1998) Neurology , vol.50 , pp. 1045-1054
    • Wang, Z.Y.1    Okita, D.K.2    Howard Jr., J.3
  • 9
    • 0016436051 scopus 로고
    • Cellular immune response to acetylcholine receptor rich-fraction, in patients with myasthenia gravis
    • Abramsky, O., A. Aharonov, C. Webb & S. Fuchs. 1975. Cellular immune response to acetylcholine receptor rich-fraction, in patients with myasthenia gravis. Clin. Exp. Immunol. 19: 11-16.
    • (1975) Clin. Exp. Immunol. , vol.19 , pp. 11-16
    • Abramsky, O.1    Aharonov, A.2    Webb, C.3    Fuchs, S.4
  • 10
    • 0018372596 scopus 로고
    • Cellular immunity to acetylcholine receptor in myasthenia gravis: relationship to histocompatibility type and antigenic site
    • Richman, D.P., J.P. Antel, J.W. Patrick & B.G.W. Arnason. 1979. Cellular immunity to acetylcholine receptor in myasthenia gravis: relationship to histocompatibility type and antigenic site. Neurology 29: 291-296.
    • (1979) Neurology , vol.29 , pp. 291-296
    • Richman, D.P.1    Antel, J.P.2    Patrick, J.W.3    Arnason, B.G.W.4
  • 11
    • 0022542062 scopus 로고
    • Myasthenia gravis: stimulation of anti-receptor autoantibodies by autoreactive T cell lines
    • Hohlfeld, R., I. Kalies, B. Kohleisen, et al. 1986. Myasthenia gravis: stimulation of anti-receptor autoantibodies by autoreactive T cell lines. Neurology 36: 618-621.
    • (1986) Neurology , vol.36 , pp. 618-621
    • Hohlfeld, R.1    Kalies, I.2    Kohleisen, B.3
  • 12
    • 0034507693 scopus 로고    scopus 로고
    • Impact of negative selection on the T cell repertoire reactive to a self peptide: a large fraction of T cell clones escapesclonal deletion
    • Bouneaud, C., P. Kourilsky & P. Buosso. 2000. Impact of negative selection on the T cell repertoire reactive to a self peptide: a large fraction of T cell clones escapesclonal deletion. Immunity 13: 829-840.
    • (2000) Immunity , vol.13 , pp. 829-840
    • Bouneaud, C.1    Kourilsky, P.2    Buosso, P.3
  • 14
    • 33746356813 scopus 로고    scopus 로고
    • Human regulatory T cells and their role in autoimmune disease
    • Baecher-Allan, C. & D.A. Hafler. 2006. Human regulatory T cells and their role in autoimmune disease. Immunol. Rev. 212: 203-216.
    • (2006) Immunol. Rev. , vol.212 , pp. 203-216
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 15
    • 33747602533 scopus 로고    scopus 로고
    • Regulatory T cells in human autoimmune diseases
    • Torgerson, T.R. 2006. Regulatory T cells in human autoimmune diseases. Springer Semin. Immunopathol. 28: 63-76.
    • (2006) Springer Semin. Immunopathol. , vol.28 , pp. 63-76
    • Torgerson, T.R.1
  • 16
    • 77954141914 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in the human immune system
    • Sakaguchi, S., M. Miyara, C.M. Costantino, et al. 2010. FOXP3+ regulatory T cells in the human immune system. Nat. Rev. Immunol. 10: 490-500.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 490-500
    • Sakaguchi, S.1    Miyara, M.2    Costantino, C.M.3
  • 17
    • 0037385330 scopus 로고    scopus 로고
    • FOXP3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J.D., M.A. Gavin & A.Y. Rudensky. 2003. FOXP3 programs the development and function of CD4+CD25+ regulatory T cells. Nat.Immunol. 4: 330-336.
    • (2003) Nat.Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 18
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor FOXP3
    • Hori, S., T. Nomura & S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor FOXP3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 19
    • 78649526238 scopus 로고    scopus 로고
    • Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases
    • Buckner, J.H. 2010. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. 10: 849-859.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 849-859
    • Buckner, J.H.1
  • 20
    • 77956163134 scopus 로고    scopus 로고
    • Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy
    • Moes, N., F. Rieux-Laucat, B. Begue, et al. 2010. Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy. Gastroenterology 139: 770-778.
    • (2010) Gastroenterology , vol.139 , pp. 770-778
    • Moes, N.1    Rieux-Laucat, F.2    Begue, B.3
  • 21
    • 33846900430 scopus 로고    scopus 로고
    • high T regulatory cell function in patients with active systemic lupus erythematosus
    • high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 178: 2579-2588.
    • (2007) J. Immunol. , vol.178 , pp. 2579-2588
    • Valencia, X.C.1    Yarboro, G.2    Illei, P.3
  • 22
    • 37149003363 scopus 로고    scopus 로고
    • high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with areduced frequency of FOXP3-positive cells and reducedFOXP3 expression at the single-cell level
    • high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with areduced frequency of FOXP3-positive cells and reducedFOXP3 expression at the single-cell level. Immunology 123: 79-89.
    • (2008) Immunology , vol.123 , pp. 79-89
    • Venken, K.1    Hellings, N.2    Thewissen, M.3
  • 23
    • 47249145164 scopus 로고    scopus 로고
    • Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127-/low regulatory T cells in patients with active systemic lupus erythematosus
    • Venigalla, R.K., T. Tretter, S. Krienke, et al. 2008. Reduced CD4+, CD25- T cell sensitivity to the suppressive function of CD4+, CD25high, CD127-/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum. 58: 2120-2130.
    • (2008) Arthritis Rheum. , vol.58 , pp. 2120-2130
    • Venigalla, R.K.1    Tretter, T.2    Krienke, S.3
  • 24
    • 43249122144 scopus 로고    scopus 로고
    • Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance
    • Vargas-Rojas, M.I., J.C. Crispín, Y. Richaud-Patin, et al. 2008. Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus 17: 289-294.
    • (2008) Lupus , vol.17 , pp. 289-294
    • Vargas-Rojas, M.I.1    Crispín, J.C.2    Richaud-Patin, Y.3
  • 25
    • 61449187505 scopus 로고    scopus 로고
    • Regulatory T cells overturned: the effectors fight back
    • Walker, L.S. 2009. Regulatory T cells overturned: the effectors fight back. Immunology 126: 466-474.
    • (2009) Immunology , vol.126 , pp. 466-474
    • Walker, L.S.1
  • 26
    • 68149158968 scopus 로고    scopus 로고
    • Regulatory T cells directly suppress B cells in systemic lupus erythematosis
    • Iikuni, N., E.V. Lourenco, B.H. Hahn, et al. 2009. Regulatory T cells directly suppress B cells in systemic lupus erythematosis. J. Immunol. 183: 1518-1522.
    • (2009) J. Immunol. , vol.183 , pp. 1518-1522
    • Iikuni, N.1    Lourenco, E.V.2    Hahn, B.H.3
  • 27
    • 23944443477 scopus 로고    scopus 로고
    • Circulating and thymic CD4+CD25+ T regulatory cells in myasthenia gravis: effect of immunosuppressive treatment
    • Fattorossi, A., A. Battaglia, A. Buzzonetti, et al. 2005. Circulating and thymic CD4+CD25+ T regulatory cells in myasthenia gravis: effect of immunosuppressive treatment. Immunology 116: 134-141.
    • (2005) Immunology , vol.116 , pp. 134-141
    • Fattorossi, A.1    Battaglia, A.2    Buzzonetti, A.3
  • 28
    • 38049024061 scopus 로고    scopus 로고
    • Decrease of Foxp3+ regulatory T cells and elevation of CD19+BAFF-R+ B cells and soluble ICAM-1 in myasthenia gravis
    • Li, X., B.G. Xiao, J.Y. Xi, et al. 2008. Decrease of Foxp3+ regulatory T cells and elevation of CD19+BAFF-R+ B cells and soluble ICAM-1 in myasthenia gravis. Clin. Immunol. 126: 180-188.
    • (2008) Clin. Immunol. , vol.126 , pp. 180-188
    • Li, X.1    Xiao, B.G.2    Xi, J.Y.3
  • 29
    • 77955665522 scopus 로고    scopus 로고
    • Clinical implication of peripheral CD4+ CD25+ regulatory T cells and Th17 cells in myasthenia gravis patients
    • Masuda, M., M. Matsumoto, S. Tanaka, et al. 2010. Clinical implication of peripheral CD4+ CD25+ regulatory T cells and Th17 cells in myasthenia gravis patients. J. Neuroimmunol. 225: 123-131.
    • (2010) J. Neuroimmunol. , vol.225 , pp. 123-131
    • Masuda, M.1    Matsumoto, M.2    Tanaka, S.3
  • 30
    • 59649099258 scopus 로고    scopus 로고
    • The role of FoxP3+CD4+CD25hi Tregs in the pathogenesis of myasthenia gravis
    • Zhang, Y., H. Wang, L. Chi, et al. 2009. The role of FoxP3+CD4+CD25hi Tregs in the pathogenesis of myasthenia gravis. Immunol. Lett. 122: 52-57.
    • (2009) Immunol. Lett. , vol.122 , pp. 52-57
    • Zhang, Y.1    Wang, H.2    Chi, L.3
  • 31
    • 1842684125 scopus 로고    scopus 로고
    • Circulating CD4+CD25 +and CD4+CD25+Tcells in myasthenia gravis and in relation to thymectomy
    • Huang, Y.M., R. Pirskanen, R. Giscombe, et al. 2004. Circulating CD4+CD25 +and CD4+CD25+Tcells in myasthenia gravis and in relation to thymectomy. Scand. J. Immunol. 59: 408-414.
    • (2004) Scand. J. Immunol. , vol.59 , pp. 408-414
    • Huang, Y.M.1    Pirskanen, R.2    Giscombe, R.3
  • 32
    • 77949388453 scopus 로고    scopus 로고
    • Undiminished regulatory T cells in the thymus of patients with myasthenia gravis
    • Matsui, N., S. Nakane, F. Saito, et al. 2010. Undiminished regulatory T cells in the thymus of patients with myasthenia gravis. Neurology 74: 816-820.
    • (2010) Neurology , vol.74 , pp. 816-820
    • Matsui, N.1    Nakane, S.2    Saito, F.3
  • 33
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • Balandina, A., S. Lécart, P. Dartevelle, et al. 2005. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 105: 735-741.
    • (2005) Blood , vol.105 , pp. 735-741
    • Balandina, A.1    Lécart, S.2    Dartevelle, P.3
  • 34
    • 33750463102 scopus 로고    scopus 로고
    • Cell surface markers of regulatory T cells are not associated with increased forkheadbox p3 expression in blood CD4+ T cells from HIV-infected patients responding to antiretroviral therapy
    • Lim, A.Y., P. Price, M.W. Beilharz, et al. 2006. Cell surface markers of regulatory T cells are not associated with increased forkheadbox p3 expression in blood CD4+ T cells from HIV-infected patients responding to antiretroviral therapy. Immunol. Cell. Biol. 84: 530-536.
    • (2006) Immunol. Cell. Biol. , vol.84 , pp. 530-536
    • Lim, A.Y.1    Price, P.2    Beilharz, M.W.3
  • 35
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki, N., B. Santner-Nanan, J. Martinson, et al. 2006. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203: 1693-1700.
    • (2006) J. Exp. Med. , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 36
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FOXP3 and suppressive function of human CD4+ T reg cells
    • Liu W., A.L. Putnam, Z. Xu-Yu, et al. 2006. CD127 expression inversely correlates with FOXP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203: 1701-1711.
    • (2006) J. Exp. Med. , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 38
    • 63849183918 scopus 로고    scopus 로고
    • Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    • Voo, K.S., Y.H. Wang, F.R. Santori, et al. 2009. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc. Natl. Acad. Sci. USA 106: 4793-4798.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4793-4798
    • Voo, K.S.1    Wang, Y.H.2    Santori, F.R.3
  • 39
    • 84866735302 scopus 로고    scopus 로고
    • Changes of Treg-associated molecules on CD4(+)CD25(+) Treg cells in myasthenia gravis and effects of immunosuppressants
    • Xu, W.H., A.M. Zhang, M.S. Ren, et al. 2012. Changes of Treg-associated molecules on CD4(+)CD25(+) Treg cells in myasthenia gravis and effects of immunosuppressants. J. Clin. Immunol. 32: 975-983.
    • (2012) J. Clin. Immunol. , vol.32 , pp. 975-983
    • Xu, W.H.1    Zhang, A.M.2    Ren, M.S.3
  • 40
    • 33645778289 scopus 로고    scopus 로고
    • MHC class II expression identifies functionally distinct human regulatory T cells
    • Baecher-Allan, C., E. Wolf & D.A. Hafler. 2006. MHC class II expression identifies functionally distinct human regulatory T cells. J. Immunol. 176: 4622-4631.
    • (2006) J. Immunol. , vol.176 , pp. 4622-4631
    • Baecher-Allan, C.1    Wolf, E.2    Hafler, D.A.3
  • 41
    • 0024215811 scopus 로고
    • In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes
    • Brocke, S., C. Brautbar, L. Steinman, et al. 1988. In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes. J. Clin. Invest. 82: 1894-1900.
    • (1988) J. Clin. Invest. , vol.82 , pp. 1894-1900
    • Brocke, S.1    Brautbar, C.2    Steinman, L.3
  • 42
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara, M., Y. Yoshioka, A. Kitoh, et al. 2009. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 43
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi, S., T. Yamaguchi, T. Nomura, et al. 2008. Regulatory T cells and immune tolerance. Cell. 133: 775-787.
    • (2008) Cell. , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3
  • 44
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA +subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann, P., R. Eder, T.J. Boeld, et al. 2006. Only the CD45RA +subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108: 4260-4267.
    • (2006) Blood , vol.108 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3
  • 45
    • 79959560094 scopus 로고    scopus 로고
    • Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells
    • d'Hennezel, E., E. Yurchenko, E. Sgouroudis, et al. 2011. Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells. J. Immunol. 186: 6788-6797.
    • (2011) J. Immunol. , vol.186 , pp. 6788-6797
    • d'Hennezel, E.1    Yurchenko, E.2    Sgouroudis, E.3
  • 46
    • 70249137304 scopus 로고    scopus 로고
    • Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients
    • Luther, C., E. Adamopoulou, C. Stoeckle, et al. 2009. Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients. J. Immunol. 183: 841-848.
    • (2009) J. Immunol. , vol.183 , pp. 841-848
    • Luther, C.1    Adamopoulou, E.2    Stoeckle, C.3
  • 47
    • 38349137792 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function
    • Kessel, A., H. Ammuri, R. Peri, et al. 2007. Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function. J. Immunol. 179: 5571-5575.
    • (2007) J. Immunol. , vol.179 , pp. 5571-5575
    • Kessel, A.1    Ammuri, H.2    Peri, R.3
  • 48
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells
    • Hoffman P., R. Eder, L.A. Kunz-Schughart, et al. 2004. Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells. Blood 104: 895-903.
    • (2004) Blood , vol.104 , pp. 895-903
    • Hoffman, P.1    Eder, R.2    Kunz-Schughart, L.A.3
  • 49
    • 18144396195 scopus 로고    scopus 로고
    • In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
    • Earle, K.E., Q. Tang, X. Zhou, et al. 2005. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin. Immunol. 115: 3-9.
    • (2005) Clin. Immunol. , vol.115 , pp. 3-9
    • Earle, K.E.1    Tang, Q.2    Zhou, X.3
  • 50
    • 0036679853 scopus 로고    scopus 로고
    • GM-CSF in inflammation and autoimmunity
    • Hamilton, J.A. 2002. GM-CSF in inflammation and autoimmunity. Trends Immunol. 23: 403-408.
    • (2002) Trends Immunol. , vol.23 , pp. 403-408
    • Hamilton, J.A.1
  • 51
    • 61349134275 scopus 로고    scopus 로고
    • GMCSF-induced CD11c+CD8a- -dendritic cells facilitate FOXP3+ and IL-10 +regulatory T cell expansion resulting in suppression of autoimmune thyroiditis
    • Ganesh, B.B., D.M. Cheatem, J.R. Sheng, et al. 2009. GMCSF-induced CD11c+CD8a- -dendritic cells facilitate FOXP3+ and IL-10 +regulatory T cell expansion resulting in suppression of autoimmune thyroiditis. Int. Immunol. 21: 269-282.
    • (2009) Int. Immunol. , vol.21 , pp. 269-282
    • Ganesh, B.B.1    Cheatem, D.M.2    Sheng, J.R.3
  • 52
    • 35748929090 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of regulatory T cells
    • Gaudreau, S., C. Guindi, M. Menard, et al. 2007. Granulocyte-macrophage colony stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of regulatory T cells. J. Immunol. 179: 3638-3647.
    • (2007) J. Immunol. , vol.179 , pp. 3638-3647
    • Gaudreau, S.1    Guindi, C.2    Menard, M.3
  • 53
    • 33749526878 scopus 로고    scopus 로고
    • Suppression of experimental autoimmune myasthenia gravis (EAMG) by granulocyte-macrophage colony-stimulating factor (GMCSF) is associated with an expansion of FOXP3+ regulatory T cells
    • Sheng, J.R., L.C. Li, B.B. Ganesh, et al. 2006. Suppression of experimental autoimmune myasthenia gravis (EAMG) by granulocyte-macrophage colony-stimulating factor (GMCSF) is associated with an expansion of FOXP3+ regulatory T cells. J. Immunol. 177: 5296-5306.
    • (2006) J. Immunol. , vol.177 , pp. 5296-5306
    • Sheng, J.R.1    Li, L.C.2    Ganesh, B.B.3
  • 54
    • 46749120143 scopus 로고    scopus 로고
    • Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia
    • Sheng, J.R., L.C. Li, B.B. Ganesh, et al. 2008. Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia. Clin. Immunol. 128: 172-180.
    • (2008) Clin. Immunol. , vol.128 , pp. 172-180
    • Sheng, J.R.1    Li, L.C.2    Ganesh, B.B.3
  • 55
    • 83555178432 scopus 로고    scopus 로고
    • GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis
    • Sheng, J.R., T. Muthusamy, B.S. Prabhakar, et al. 2011. GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis. J. Neuroimmunol. 240-241: 65-73.
    • (2011) J. Neuroimmunol. , vol.240-241 , pp. 65-73
    • Sheng, J.R.1    Muthusamy, T.2    Prabhakar, B.S.3
  • 56
    • 84865316022 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: Effects on regulatory T cells
    • Rowin, J., M. Thiruppathi, E. Arhebamen, et al. 2012. Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: Effects on regulatory T cells. Muscle Nerve 46: 449-453.
    • (2012) Muscle Nerve , vol.46 , pp. 449-453
    • Rowin, J.1    Thiruppathi, M.2    Arhebamen, E.3
  • 57
    • 65049086842 scopus 로고    scopus 로고
    • Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists
    • Adorini, L. & G. Penna. 2009. Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum. Immunol. 70: 345-352.
    • (2009) Hum. Immunol , vol.70 , pp. 345-352
    • Adorini, L.1    Penna, G.2
  • 58
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia, M., A. Stabilini, B. Migliavacca, et al. 2006. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J. Immunol. 177: 8338-8347.
    • (2006) J. Immunol. , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.