Circulating CD4+CD25+ and CD4+CD25 - T cells in myasthenia gravis and in relation to thymectomy

Scandinavian Journal of Immunology

Volumn 59, Issue 4, 2004, Pages 408-414

  Huang, Y M ^a,b   Pirskanen, R ^a   Giscombe, R ^a   Link, H ^a   Lefvert, A K ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; FAS ANTIGEN; HLA ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ADULT; ANTIGEN ANTIBODY COMPLEX; ANTIGEN DETECTION; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; LYMPHOCYTE; MALE; MEMORY CELL; MYASTHENIA GRAVIS; PRIORITY JOURNAL; T LYMPHOCYTE; THYMECTOMY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD4; ANTIGENS, CD45; ANTIGENS, CD95; FEMALE; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES; THYMECTOMY;

EID: 1842684125     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0300-9475.2004.01410.x     Document Type: Article

References (35)

1. Sakaguchi S, Regulatory T. Cells: key controllers of immunological self-tolerance. Cell 2000;101:455-8.
2. Belghith M, Bluestone JA, Barriot S, Mégret J, Bach JF, Chatenoud L. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 2003;9:1202-8.
3. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologie self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;160:1151-64.
4. Saoudi S, Seddon B, Fowell D, Mason D. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J Exp Med 1996;184:2393-8.
5. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 1998;160:1212-8.
6. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999;162:5317-26.
7. Bagavant H, Thompson C, Ohno K, Setiady Y, Tung KSK. Differential effect of neonatal thymectomy on systemic and organ-specific autoimmune disease. Int Immunol 2002;14:1397-406.
8. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000;192:1213-22.
9. + T cells with regulatory properties from human blood. J Exp Med 2001;193:1303-10.
10. + thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 2001;31:1247-54.
11. + T-cell population in healthy humans and in patients with thymic hypoplasia. Clin Diagn Lab Immunol 2002;9:1129-31.
12. Cao D, Malmstrom V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target otgan of patients with rheumatoid arthritis. Eur J Immunol 2003;33:213-23.
13. Vincent A. Uravelling the pathogenesis of myasthenia gravis. Nat Rev Immunol 2002;2:797-804.
14. Drachman DB. Myasthenia gravis. N Engl J Med 1994;330:1797-810.
15. Gronseth GS, Barohn RJ. Practice parameter: thymectomy for the Quality Standards. Neurology 2000;55:7-15.
16. Alpert LI, Paptestas A, Kark A, Osserman RS, Ossetman K. A histological reappraisal of the thymus in myasthenia gravis. A correlative study of thymic pathology and response to thymectomy. Arch Pathol 1971;91:55-61.
17. + T cells in thymus, cord and adult blood. Immunology 2002;106:190-9.
18. + regulatory T cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001;193:1311-7.
19. Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas AK. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol 2003;4:664-9.
20. Oosterhuis HHGH. Studies in myasthenia gravis. Part 1. A clinical study of 180 patients. J Neurol Sci 1964;1:512-46.
21. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001;182:18-32.
22. + T cells and treatment wit tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced CD8(+) T cell-dependent immune defense of B16 melanoma. Cancer Res 2001;61:8643-6.
23. Woo EY, Yeh H, Chu CS et al. Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol 2002;168:4272-6.
24. Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med 2002;196:401-6.
25. Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002;196:389-99.
26. Jiang S, Lechler RI. Regulatory T cells in the control of transplantation tolerance and autoimmunity. Am J Transplant 2003; 3:516-24.
27. Waldmann TA. The interleukin-2 receptor. J Biol Chem 1991;266:2681-4.
28. high regulatory cells in human peripheral blood. J Immunol 2001;167:1245-53.
29. + T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 2001;31:1122-31.
30. Åhlberg R, Yi Q, Pirskanen R et al. The effect of thymectomy on autoreactive T-and B-lymphocytes in myasthenia gravis. J Neuroimmunol 1997;74:45-54.
31. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol 2002;168:5979-83.
32. Bardos T, Czipri M, Vermes C, Finnegan A, Mikecz K, Zhang J. CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis. Arthritis Res Ther 2003;5:106-13.
33. high T regulatory cells and their IL-10 production in multiple sclerosis. J Neuroimmunol 2003;144:125-31.
34. + T cells. Curr Opin Immunol 2003;15:690-6.
35. + T-regulatory cell subset has optimal suppressive and proliferative potential. Am J Transplant 2004;4:65-78.