Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: Effects on regulatory T cells

Muscle and Nerve

Volumn 46, Issue 3, 2012, Pages 449-453

  Rowin, Julie ^a   Thiruppathi, Muthusamy ^a   Arhebamen, Ebinehita ^a   Sheng, Jianrong ^a   Prabhakar, Bellur S ^a   Meriggioli, Matthew N ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Foxp3; GM CSF; Immunology; Myasthenia; Regulatory T cells; Sargramostim

Indexed keywords

CHOLINERGIC RECEPTOR ANTIBODY; IMMUNOGLOBULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3;

AGED; ARTICLE; AUTOIMMUNE DISEASE; CASE REPORT; CELL COUNT; CONTROLLED STUDY; DIPLOPIA; DRUG DOSE REDUCTION; DRUG EFFECT; DYSPHAGIA; DYSPNEA; FATIGUE; HUMAN; IMAGING; LYMPHOCYTE PROLIFERATION; MALE; MYASTHENIA GRAVIS; NECK MUSCLE; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

AGED; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MALE; MYASTHENIA GRAVIS; T-LYMPHOCYTES, REGULATORY; TREATMENT OUTCOME;

EID: 84865316022     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.23488     Document Type: Article

References (10)

1. - dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis. Int Immunol 2009; 21: 269-282.
2. Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A. Granulocyte-macrophage colony stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of regulatory T cells. J Immunol 2007; 179: 3638-3647.
3. + regulatory T cells. J Immunol 2006; 177: 5296-5306.
4. Sheng JR, Li L, Ganesh BB, Prabhakar BS, Meriggioli MN. Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia. Clin Immunol 2008; 128: 172-180.
5. Sanders DB, Tucker-Lipscomb B, Massey JM. A simple manual muscle test for myasthenia gravis: validation and comparison with QMG score. Ann NY Acad Sci 2003; 998: 440-444.
6. Brocke S, Brautbar C, Steinman L, Abramsky O, Rothbard J, Neumann D, et al. In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes. J Clin Invest 1988; 82: 1894-1900.
7. high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 2008; 123: 79-89.
8. Moes N, Rieux-Laucat F, Begue B, Verdier J, Neven B, Tapey N, et al. Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy. Gastroenterology 2010; 139: 770-778.
9. Torgerson TR. Regulatory T cells in human autoimmune diseases. Semin Immunopathol 2006; 28: 63-76.
10. high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007; 178: 2579-2588.