Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function

European Journal of Immunology

Volumn 42, Issue 12, 2012, Pages 3381-3393

  Pierau, Mandy ^a   Na, Shin Young ^b   Simma, Narasimhulu ^a   Lowinus, Theresa ^a   Marx, Alexander ^c   Schraven, Burkhart ^a   Bommhardt, Ursula H ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

B cell; NFAT; PKB Akt; SDF1 ; STAT5

Indexed keywords

AKT1 PROTEIN; B LYMPHOCYTE RECEPTOR; CALCIUM ION; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STAT5 PROTEIN; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CALCIUM MOBILIZATION; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; EFFECTOR CELL; ENZYME ACTIVATION; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; CALCIUM; CELL MOVEMENT; IMMUNOGLOBULIN G; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 3; PRECURSOR CELLS, B-LYMPHOID; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, B-CELL; STAT5 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA;

EID: 84871291784     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242397     Document Type: Article

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