Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2427-2432

  Szado, Tania ^a   Vanderheyden, Veerle ^c   Parys, Jan B ^c   De Smedt, Humbert ^c   Rietdorf, Katja ^a   Kotelevets, Larissa ^d   Chastre, Eric ^d   Khan, Farid ^a   Landegren, Ulf ^e   Söderberg, Ola ^e   Bootman, Martin D ^a   Roderick, H Llewelyn ^a,b  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cancer; Cell death; Signaling

Indexed keywords

CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PROTEIN KINASE B; SERINE;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; TUMOR CELL; ANIMAL; CELL LINE; CERCOPITHECUS; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; APOPTOSIS; CALCIUM; CELL LINE; CERCOPITHECUS AETHIOPS; GLIOBLASTOMA; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SERINE;

EID: 40649096621     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711324105     Document Type: Article

References (37)

1. Manning BD, Cantley LC (2007) AKT/PKB signaling: Navigating downstream. Cell 129:1261-1274.
2. Hanada M, Feng J, Hemmings BA (2004) Structure, regulation, and function of PKB/AKT: A major therapeutic target. Biochim Biophys Acta 1697:3-16.
3. Brunet A, Datta SR, Greenberg ME (2001) Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 11:297-305.
4. Thompson JE, Thompson CB (2004) Putting the rap on Akt. J Clin Oncol 22:4217-4226.
5. Luo J, Manning BD, Cantley LC (2003) Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell 4:257-262.
6. Leslie NR, Downes CP (2004) PTEN function: How normal cells control it and tumor cells lose it. Biochem J 382:1-11.
7. Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signaling. Nat Rev Mol Cell Biol 1:11-21.
8. 3-linked mitochondrial calcium signals. EMBO J 18:6349-6361.
9. Orrenius S, Zhivotovsky B, Nicotera P (2003) Regulation of cell death: The calcium-apoptosis link. Nat Rev Mol Cell Biol 4:552-565.
10. 3 receptors channel calcium into cell death. Curr Biol 14:R933-R935.
11. 3R) and its regulators: Sometimes good and sometimes bad teamwork. Sci STKE, 10.1126/stke.3632006re15.
12. 3R. Nat Cell Biol 7:1021-1028.
13. Chen R, et al. (2004) Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. J Cell Biol 166:193-203.
14. Boehning D, et al. (2003) Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol 5:1051-1061.
15. Khan MT, et al. (2006) Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors. J Biol Chem 281:3731-3737.
16. 2+ signals. J Biol Chem 276:26411-26420.
17. Boehning D, Joseph SK (2000) Functional properties of recombinant type I, type III inositol 1, 4,5-trisphosphate receptor isoforms expressed in COS-7 cells. J Biol Chem 275:21492-21499.
18. Wagner LE, 2nd, Betzenhauser MJ, Yule DI (2006) ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A. J Biol Chem 281:17410-17419.
19. Söderberg O, et al. (2006) Direct observation in situ of individual endogenous protein complexes by proximity ligation. Nat Methods 3:995-1000.
20. Kotelevets L, et al. (2001) The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness. J Cell Biol 155:1129-1135.
21. 2+ liaison. Sci STKE, 10.1126/stke. 2152004re1.
22. 2+ channels. J Cell Biol 175:901-911.
23. Pogue SL, Kurosaki T, Bolen J, Herbst R (2000) B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. J Immunol 165:1300-1306.
24. 2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors. Biochem Soc Trans 31:954-957.
25. Bare DJ, et al. (2005) Cardiac type inositol 1,4,5-triphosphate receptor: Interaction and modulation by calcium calmodulin-dependent protein kinase II. J Biol Chem 280:15915-15920.
26. Tang TS, et al. (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39:227-239.
27. Schug ZT, Joseph SK (2006) The role of the S4-S5 linker and C-terminal tail in inositol 1,4,5-trisphosphate receptor function. J Biol Chem 281:24431-24440.
28. Patterson RL, Boehning D, Snyder SH (2004) Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem 73:437-465.
29. Pawson T, Scott JD (1997) Signaling through scaffold, anchoring, and adaptor proteins. Science 278:2075-2080.
30. 3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci 119:5160-5168.
31. 2+ elevations and the mitochondrial permeability transition pore. J Cell Sci 115:485-497.
32. Criollo A, et al. (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14:1029-1039.
33. Dufner A, et al. (1999) Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation. Mol Cell Biol 19:4525-4534.
34. Parker AK, Gergely FV, Taylor CW (2004) Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains. J Biol Chem 279:23797-23805.
35. 2+-binding proteins. EMBO J 23:312-321.
36. Wojcikiewicz RJ (1995) Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types. J Biol Chem 270:11678-11683.
37. Manders EM, et al. (1992) Dynamics of three-dimensional replication patterns during the S-phase, analyzed by double labeling of DNA, confocal microscopy. J Cell Sci 103:857-862.